Tag: M.W=600-700

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105309-59-9, name is Tetrakis(4-bromophenyl)methane, A new synthetic method of this compound is introduced below., HPLC of Formula: C25H16Br4

B is prepared according to the procedure described in reference 5.[0186] A 250 mL Schlenk flask was charged with A (4g, 6.3 mmol), B (6.79 g, 37.7 mmol), CsF (9.5 g, 63.9 mmol),and Pd(P(Ph)3)4 0.3 g. 120 ml DME was degassed and transferred. A water condenser was then equipped. The flaskwas heated to reflux under the nitrogen for 48 hours. The solvent was dried on rotary evaporator. The residue wasdissolved by CH2Cl2, and purified by column chromatography to get C 4.1g (Yield. 76%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THE TEXAS A&M UNIVERSITY SYSTEM; Zhou, Hong-Cai; Feng, Dawei; Wang, Kecheng; EP2876112; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 105309-59-9, A common heterocyclic compound, 105309-59-9, name is Tetrakis(4-bromophenyl)methane, molecular formula is C25H16Br4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of Ar-X (2.0 mmol), TeocNHOTBS (3; 640 mg, 2.2 mmol), Bippyphos (2; 51 mg, 0.10 mmol), and Pd2dba3 (23 mg, 0.025 mmol) in toluene (8 mL) was treated with Cs2CO3 (1.3 g, 4.0 mmol). N2 was bubbled through the mixture for 30 min, and then the mixture was heated and stirred at 80 C for 16 h under N2. The resulting mixture was purified directly by column chromatography (EtOAc/hexanes).

The synthetic route of 105309-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Beaudoin, Daniel; Wuest, James D.; Tetrahedron Letters; vol. 52; 17; (2011); p. 2221 – 2223;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 105309-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105309-59-9, name is Tetrakis(4-bromophenyl)methane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 250 mE Schlenk flask was charged with A (4 g,6.3 mmol), 13 (6.79 g, 37.7 mmol), CsF (9.5 g, 63.9 mmol),and Pd(P(Ph)3)4 0.3 g. 120 ml DME was degassed and transferred. A water condenser was then equipped. The flask washeated to reflux under the nitrogen for 48 hours. The solventwas dried on rotary evaporator. The residue was dissolved byCH2C12, and purified by column chromatography to get C 4.1g (Yield. 76%).

The synthetic route of Tetrakis(4-bromophenyl)methane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhou, Hong-Cai; Feng, Dawei; Wang, Kecheng; US2015/152123; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 105309-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105309-59-9, name is Tetrakis(4-bromophenyl)methane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The H4MTBC bridging ligand was prepared in two steps as shown in FIG. 11. First, the intermediate tetramethyl 4?,4??,4???,4????-methanetetrayltetrakis([1,1?-biphenyl]-4-carboxylate) (Me4MTBC) (CAS: 1208241-39-7) was synthesized using a modified procedure from the literature. Tetrakis(4-bromophenyl)methane (723 mg, 1.14 mmol, 1 equiv.), Pd(PPh3)4 (132 mg, 0.114 mmol, 0.1 equiv.), 4-(methoxycarbonyl)phenylboronic acid (1.23 g, 6.82 mmol, 6 equiv.) and CsF (3.11 g, 20.46 mmol, 18 equiv.) were charged in a 120 mL high-pressure reaction tube and pumped into an N2 glove box. To the reaction tube was added 60 mL of degassed dimethoxyethane, and the tube was capped and stirred at 85 C. for 3 days. Progress of the reaction was monitored by thin layer chromatography (TLC) (1% EtOAc/CHCl3). After cooling to room temperature, the reaction mixture was transferred to a round-bottom flask and evaporated with a rotavap. The resulting solid was dissolved with CHCl3 and filtered through celite to remove CsF and Pd nanoparticles. The filtrate was evaporated with a rotavap, then purified by flash column chromatography on silica gel using 1% EtOAc/Hexane as eluent to give white solid as pure product (572 mg, 59% yield). 1H NMR (500 MHz, CDCl3): delta 8.10 (d, 3JH=8.3 Hz, 8H), 7.68 (d, 3JHH=8.3 Hz, 8H), 7.59 (d, 3JHH=8.4 Hz, 8H), 7.44 (d, 3JHH=8.5 Hz, 8H), 3.94 (s, 12H).

The synthetic route of Tetrakis(4-bromophenyl)methane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The University of Chicago; Lin, Wenbin; Manna, Kuntal; Ji, Pengfei; (83 pag.)US2018/361370; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 105309-59-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105309-59-9 name is Tetrakis(4-bromophenyl)methane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of tetrakis(4-bromophenyl)methane (0.6360 g,1 mmol) and N-(tert-butoxycarbonyl)-pyrrol-2-ylboronic acid(1.0128 g, 4.8 mmol) in 30 mL of THF was added 10 mL of a saturatedaqueous solution of potassium carbonate, and then degassedby bubbling nitrogen gas for 15 min. After adding Pd(PPh3)4 (57 mg,0.05 mmol) under a nitrogen atmosphere, the reaction mixturewasstirred at 80 C for 12 h, and then cooled to room temperature. Theresulting mixture was extracted with ethyl acetate three times. Thecombined organic layer was washed with deionized water anddried over sodium sulfate. After concentration under reducedpressure, the residual oil was purified by column chromatographyusing n-hexane: ethyl acetate (30: 1) as the eluent to give thedesired product as a light yellow solid in 81% yield. 1H NMR(400 MHz, DMSO-d6, d): 7.35 (t, J 2.0 Hz, 4 H), 7.30 (d, J 8.0 Hz,8 H), 7.26 (d, J 8.0 Hz, 8 H), 6.27 (s, 8 H), 1.29 (s, 36 H). 13C NMR(600 MHz, CDCl3, d): 149.92, 145.93, 134.96, 132.37, 130.58, 128.67,123.22, 115.03, 110.98, 84.10, 64.85, 28.05.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Tetrakis(4-bromophenyl)methane, and friends who are interested can also refer to it.

Reference:
Article; Yang, Yanqin; Zhang, Qiang; Zheng, Jifu; Zhang, Suobo; Polymer; vol. 54; 13; (2013); p. 3254 – 3260;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 61326-44-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(3) The third step: under argon protection, add to the double-mouth bottle4,4 ‘, 4 “, 4” -tetrabromostatrene,Dimethoxydianiline, palladium acetate, sodium tert-butoxide, tri-tert-butylphosphine,The reaction was stopped for 27 hours. The reaction was quenched. Saturated ammonium chloride solution was added and the mixture was extracted three times with dichloromethane. The organic layer was dried over anhydrous MgSO4. The crude product was purified by silica gel column chromatography ( Petroleum ether: dichloromethane: ethyl acetate = 6: 1: 0.5, v / v) to give a yellow solid which was recrystallized from tetrahydrofuran / petroleum ether. The product TPE-OMe-oo, the product of the formula is shown in formula (VII):

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,2,2-Tetrakis(4-bromophenyl)ethene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sun Yat-sen University; Shao Guang; Kuang Daibin; He Yanjian; Chen Jian; (17 pag.)CN105037179; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 61326-44-1, A common heterocyclic compound, 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, molecular formula is C26H16Br4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(3) The third step: under argon protection, add to the double-mouth bottle4,4 ‘, 4 “, 4” -tetrabromostatrene,3,4’-dimethoxydiphenylamine, palladium acetate, sodium tert-butoxide and tri-tert-butylphosphine were added, and 10 mL of toluene was added. The mixture was stirred and placed in an oil bath at 110 ¡ã C for 21 hours to stop the reaction. Saturated The ammonium chloride solution was extracted three times with dichloromethane and the organic layer was dried over anhydrous MgSO4. The crude product was subjected to silica gel column chromatography (petroleum ether: dichloromethane = 1: 2, v / v) to give a yellow solid, Methyl chloride / petroleum ether recrystallization. The product TPE-OMe-mp, the product of formula (IV):

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sun Yat-sen University; Shao Guang; Kuang Daibin; He Yanjian; Chen Jian; (17 pag.)CN105037179; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

61326-44-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, A new synthetic method of this compound is introduced below.

The 1- (4- (4- (1H-1,2,4-triazol-1-yl) phenoxy) phenyl) -1H-1,2,4-triazoleThe preparation method,Its characteristics in the use of “one pot”In DMF polar solvents,1,1,2,2-tetrakis (4-bromophenyl) ethylene, triazole,The molar ratio of 4,4′-dibromodiphenyl e

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Tianjin Normal University; Wang, Ying; (11 pag.)CN104557985; (2017); B;,
Bromide – Wikipedia,

61326-44-1, Name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, 61326-44-1, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

General procedure: The synthesis of intermediate tetra-brominated TPE has been reported in previous literatureS1. The solid reactant 2 (100 mg, 0.15 mmol) and solid reactant 3 (0.9 mmol), catalyst palladium acetate (1.73 mg, 0.0077 mmol) and triphenylphosphine (4.04 mg, 0.0154 mmol) was added into the cube which was pumped three times, then anhydrous and anaerobic DMF (5 ml) and bubbled triethylamine(1 ml) was injected. After quickly switching the stopper, the reaction system would flux for two days. When completed, the reaction was cooled to room temperature, then poured into a large amount of water and extracted three times with dichloromethane, and finally washed with saturated saline multiple times to obtain the organic phase. After the organic phase was dried over anhydrous sodium sulfate, the dichloromethane was swirled off by rotary evaporation. TPE-Py was purified by silica gel column chromatography (petroleum ether : ethyl acetate = 1:5) to obtain the solid yellow powder, otherwise TPE-Ph was eluted by petroleum ether/dichloromethane (1:2) to acquire the orange powder.

Statistics shows that 1,1,2,2-Tetrakis(4-bromophenyl)ethene is playing an increasingly important role. we look forward to future research findings about 61326-44-1.

Reference:
Article; Ma, Xiaoxie; Hu, Linli; Han, Xie; Yin, Jun; Chinese Chemical Letters; vol. 29; 10; (2018); p. 1489 – 1492;,
Bromide – Wikipedia,
bromide – Wiktionary

61326-44-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4 g of 3-methoxycarbonylbenzene borate, 1 g of 4Br-TPE and 0.47 g of tetratriphenylphosphine The palladium was uniformly mixed, vacuumed for 5 min and nitrogen-filled for 5 min for 3 times. 100 mL of a toluene ethanol solution with a volume ratio of 9:1 and 12 mL of a 1 mol/L solution of tripotassium phosphate were injected and refluxed at 110 ¡ã C for 24 h until the starting of the reaction. . The mixture was cooled to room temperature, filtered (dichloromethane), and the filtrate was evaporated to dryness.Finally, the column is treated to obtain pure 1,1,2,2-tetra[[3-benzomethoxycarbonyl)benzene]ethylene;

The synthetic route of 61326-44-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hangzhou Normal University; Liu Xungao; Tao Chenlei; Xu Yuan; Zhang Yijian; Xu Bobo; Wang Pei; (18 pag.)CN109651126; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary