Tag: M.W=550-600

Ignatenko, Vasily A. published the artcileBranch-Selective Synthesis of Oxindole and Indene Scaffolds: Transition Metal-Controlled Intramolecular Aryl Amidation Leading to C3 Reverse-Prenylated Oxindoles, Application In Synthesis of 25753-84-8, the publication is Organic Letters (2010), 12(16), 3594-3597, database is CAplus and MEDLINE.

In an effort to access biol. important scaffolds, a concise branch-selective synthesis of C3 tertiary oxindoles by Cu(I)-catalyzed aryl amidation and 2,2-dimethylindene by Pd(0)-catalyzed Heck cyclization has been accomplished from acyclic reverse-prenylated intermediates. Oxindole C3-enolate generation using NaH followed by alkylation in the presence of appropriate electrophiles provides a novel route to quaternary C3 reverse-prenylated oxindoles.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Application In Synthesis of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gruijters, Bas W. T. published the artcileCatalyst Recycling via Hydrogen-Bonding-Based Affinity Tags, Application In Synthesis of 25753-84-8, the publication is Organic Letters (2006), 8(15), 3163-3166, database is CAplus and MEDLINE.

A novel procedure for catalyst recycling is described. Copper(I)-based catalysts, equipped with an affinity tag, are isolated from crude reaction mixtures on the basis of quadruple hydrogen-bonding interactions using a resin functionalized with complementary affinity tags. Recycled catalysts were successfully used to catalyze a tandem Sonogashira coupling/5-endo-dig cyclization and a Cu-catalyzed [3+2] Huisgen cycloaddition reaction in high yields.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Application In Synthesis of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Song-Lin published the artcileIsolation and characterization of copper(III) trifluoromethyl complexes and reactivity studies of aerobic trifluoromethylation of arylboronic acids, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is RSC Advances (2016), 6(75), 70902-70906, database is CAplus.

The isolation, characterization and reactivity of transition metal trifluoromethyl complexes are fundamental and challenging topics in trifluoromethylation chem. The authors report herein the synthesis and isolation of two [(phen)Cu^I(PPh₃)₂]⁺[Cu^III(CF₃)₄]^– (2, phen = 1,10-phenanthroline) and (phen)Cu^III(CF₃)₃ (3) as well as known complex (bpy)Cu^III(CF₃)₃ (4, bpy = 2,2-bipyridine) at room temperature 2 And 3 were fully characterized using ¹H, ¹⁹F, ³¹P NMR, elemental analyses and x-ray crystallog. Reactivity studies indicate that 2 is unreactive toward arylboronic acids. In contrast, 3 and 4 react with various aryl and heteroaryl boronic acids to deliver trifluoromethylated arenes in good to quant. yields under mild conditions. The presence of a fluoride additive in DMF under aerobic conditions is crucial to these reactions. This study provides fundamental information about the structure and reactivity of elusive Cu(III) trifluoromethyl complexes that are proposed as relevant reactive intermediates in many trifluoromethylation reactions.

RSC Advances published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C6H5NO, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mitrofanov, A. Yu. published the artcileCu(I) complexes with diethoxyphosphoryl-1,10-phenanthrolines in catalysis of C-C and C-heteroatom bonds formation, Safety of Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Inorganica Chimica Acta (2015), 297-301, database is CAplus.

Diethoxyphosphoryl substituted 1,10-phenanthroline Cu(I) complexes were tested as catalysts in the Sonogashira-type reaction, α-arylation of phosphoryl-stabilized C-H acids, C-N, C-P bond forming reactions (substitution reactions) and in the reaction of phenylacetylene and bis(pinacolato)diboron (addition reaction). The complexes demonstrate fairly high catalytic activity and in some cases their efficiency is superior to that of the parent Cu(phen)(PPh₃)Br (phen = phenanthroline).

Inorganica Chimica Acta published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Safety of Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gujadhur, Rattan K. published the artcileFormation of Aryl-Nitrogen, Aryl-Oxygen, and Aryl-Carbon Bonds Using Well-Defined Copper(I)-Based Catalysts, Computed Properties of 25753-84-8, the publication is Organic Letters (2001), 3(26), 4315-4317, database is CAplus and MEDLINE.

The authors report mild synthetic protocols for the formation of aryl-carbon, aryl-nitrogen, and aryl-oxygen bonds based on soluble, well-defined copper(I) catalysts. These protocols do not require the use of palladium and/or expensive ligands. E.g., Cu(Phen)(PPh₃)Br catalyzed the coupling of PhCCH with PhI to give 80% PhCCPh.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Computed Properties of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mashat, Khlood H. published the artcileSynthesis, structures, DNA-binding and anticancer activities of some copper(I)-phosphine complexes, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Polyhedron (2019), 164-172, database is CAplus.

Copper(I) complexes with a phenanthroline-phosphine set of ligands were synthesized by refluxing methanolic solutions of CuBr₂ with at least a four fold molar excess of the phosphine ligands, followed by the treatment of the formed {CuBr(PR₃)₃ complexes [R = Ph (1a), 4-fluorophenyl (1b), cyclohexyl (1c) or 4-methoxyphenyl (1d)]} with 1 molar equivalent of 1,10-phenanthroline in DCM. The tris(4-methoxyphenyl)phosphine ligand afforded [Cu(P[C₆H₄-4-OMe]₃)₂(phen)]Br (2d), while the other phosphines produced complexes CuBr(PR₃)(phen) [R = Ph (2a), 4-fluorophenyl (2b) or cyclohexyl (2c)]. The new complexes were characterized by elemental anal., ³¹P NMR spectroscopy and mass spectrometry. Addnl. confirmation of the structures of 1b, 2b, 2c and 2d were determined by single crystal x-ray diffraction. A DNA-binding study of the complexes 2a–2d against ct-DNA showed binding constant values that correspond to the intercalation mode of binding. The notable variations in the binding constants of the complexes suggest some contribution from the phosphine ligands. The lipophilicity of the complexes was evaluated theor. and the calculated log P value of complex 2d is pos. and high, being in the same range of relatively easy membrane penetrating drugs. The calculated log P values of complexes 2a–2c are neg., indicating a low membrane permeability. Complexes 2a–2d were examined against four different cancer cell lines. The choice of the phosphine ligand appears to influence the copper(I)-phosphine anticancer activities against the different cancer cell lines. The data suggested that complexes 2a and 2d show potential anticancer activity against prostate and breast cancers. The four copper complexes were docked against four different proteins associated with prostate or breast cancers activities, highlighting some of the structural-DNA interactions.

Polyhedron published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

La Monica, Girolamo published the artcileReactions of carbon dioxide with tetrahydroborato copper(I) complexes in moist solvents: synthesis and reactions of [(phen)₂Cu][(HO)₃B(O₂CH)] and (phen)(Ph₃P)Cu(O₂COH) (phen = 1,10-phenanthroline), Application In Synthesis of 25753-84-8, the publication is Inorganica Chimica Acta (1988), 143(2), 239-45, database is CAplus.

CO₂ reacts with Cu(phen)(PPh₃)(BH₄) (I; phen = 1,10-phenanthroline) in moist THF and in the presence of free phen affording [Cu(phen)₂][(HO)₃B(O₂CH)] (II). II can be obtained from I and aqueous HCO₂H in the presence of phen and from Cu(phen)₂(BH₄) and aqueous HCO₂H or CO₂ in moist THF. The reaction of I with CO₂ in moist MeOH gives Cu(phen)(PPh₃)(O₂COH) (III). The action of ROH on II gave [Cu(phen)₂](O₂CH), the B atom being eliminated as B(OR)₃. II reacts with an alc. Ph₃P solution giving Cu(phen)(PPh₃)(O₂CH). The reaction of II with PhCH₂Br gives HCO₂CH₂Ph. The reactivity of III toward neutral ligands such as phen and cyclohexylisocyanide (CyNC) was studied, [Cu(phen)₂](HCO₃) and [Cu(phen)(CNCy)₂](HCO₃), being obtained, resp.

Inorganica Chimica Acta published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Application In Synthesis of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fuchibe, Kohei published the artcileCopper(I)-Catalyzed [4 + 1] Cycloaddition of Silyl Dienol Ethers with Sodium Bromodifluoroacetate: Access to β,β-Difluorocyclopentanone Derivatives, COA of Formula: C30H24BrCuN2P, the publication is Organic Letters (2016), 18(18), 4502-4505, database is CAplus and MEDLINE.

Silyl dienol ethers readily underwent copper(I)-catalyzed [4 + 1] cycloaddition with sodium bromodifluoroacetate to afford 4,4-difluorocyclopent-1-en-1-yl silyl ethers. On the basis of high-resolution mass spectroscopy anal., annulation presumably proceeded via a copper(I) difluorocarbene complex, which represents an unprecedented example of [4 + 1] cycloadditions promoted by a transition metal difluorocarbene complex.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, COA of Formula: C30H24BrCuN2P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary