Tag: M.W=550-600

Van Allen, Derek published the artcileCopper-Catalyzed Synthesis of Unsymmetrical Triarylphosphines, Application In Synthesis of 25753-84-8, the publication is Journal of Organic Chemistry (2003), 68(11), 4590-4593, database is CAplus and MEDLINE.

Various triarylphosphines were prepared in good yields by coupling diphenylphosphine and aryl iodides with catalytic amounts of CuI in the presence of either K₂CO₃ or Cs₂CO₃. CuI was chosen after screening various copper salts, such as CuBr and CuCl, and complexes, i.e., Cu(PPh₃)₃Br (1), Cu(neocup)PPh₃Br (neocup = neocuproine) (2), Cu(phen)PPh₃Br (phen = phenanthroline) (3), and Cu(neocup)₂Br·H₂O (4). Catalysts 1–4 were prepared and identified by comparison with previously published x-ray crystallog. data. In an example cross-coupling reaction, 1-naphthyldiphenylphosphine was prepared via reaction of diphenylphosphine and 1-iodonaphthalene in the presence of CuI and Cs₂CO₃, and analyzed by x-ray crystallog. This method tolerates a variety of functional groups, such as ketones and esters, and does not require the use of expensive additives or harsh reaction conditions, and is palladium free.

Journal of Organic Chemistry published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C24H12, Application In Synthesis of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Piou, Tiffany published the artcileDirect Arylation of Azoles Enabled by Pd/Cu Dual Catalysis, SDS of cas: 25753-84-8, the publication is Organic Letters (2021), 23(6), 1996-2001, database is CAplus and MEDLINE.

A practical approach toward the synthesis of 2-arylazoles via direct arylation was described. The transformation relied on a Pd/Cu cocatalyst system that operated with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.

Organic Letters published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, SDS of cas: 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Giribabu, L. published the artcileHighly Efficient Sulfimidation of 1,3-Dithianes by Cu(I) Complexes, Safety of Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Synthetic Communications (2008), 38(4), 619-625, database is CAplus.

Four Cu(I) complexes were tested for sulfimidation of 1,3-dithianes in the presence of [N-(p-tolysulfonyl)imino]phenyliodinane (PhI:NTs) as the nitrene-transfer agent. Newly prepared Cu(TMPhen)(PPh₃)Br (TMPhen = 3,4,7,8-tetramethyl-1,10-phenanthroline) is an efficient catalyst with >90% yield of the corresponding product with less reaction time as compared to Cu(PPh₃)₃Br (1) Cu(Phen)(PPh₃)Br (2), and Cu(neocuproin)(PPh₃)Br (3).

Synthetic Communications published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Safety of Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Worayuthakarn, Rattana published the artcileSynthesis of benzoindoloquinolizines via a Cu(I)-mediated C-N bond formation, Formula: C30H24BrCuN2P, the publication is Tetrahedron (2012), 68(13), 2864-2875, database is CAplus.

An effective synthesis of the multi ring-fused benzoindoloquinolizines has been accomplished by Cu(I)-mediated and MW-assisted C-N_amide bond formation of benzo[a]quinolizin-4-ones. The deamination of tetrahydro-2H-pyrido[2,1-a]isoquinolines was also studied and was found to give benzoquinolizines. The benzo[a]quinolizin-4-ones were prepared based on the annulations of C-1 substituted 3,4-dihydroisoquinolines and azlactones.

Tetrahedron published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C39H35N5O8, Formula: C30H24BrCuN2P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Babgi, Bandar A. published the artcileSynthesis, structures, DNA-binding, cytotoxicity and molecular docking of CuBr(PPh₃)(diimine), Category: bromides-buliding-blocks, the publication is Polyhedron (2020), 114847, database is CAplus.

The copper(I) coordination compounds of general formula [CuBr(PPh₃)(N^ΛN)] (N^ΛN = 2,2′-bipyridine (1), 1,10-phenanthroline (2), 4,4′-dimethyl-2,2′-bipyridine (3), 4,4′-dimethoxy-2,2′-bipyridine (4), 3-(2-pyridyl)-4,5-diphenyl-1,2,4-triazine (5), 4,7-diphenyl-1,10-phenanthroline (6), 5-nitro-1,10-phenanthroline (7), dipyrido[3,2-a:2′,3′-c]phenazine(8)) have been synthesized and characterized by elemental anal., ³¹P NMR spectroscopy and mass spectrometry. The structure of 5 and 7 were confirmed by X-ray crystallog. 5 Is the second example to be reported with an unusual 4 N-triazine-ligated coordination mode of the 3-(2-pyridyl)-4,5-diphenyl-1,2,4-triazine. Calculated energies of the two possible bidentate modes of the ligand (2 N- and 4 N-triazine) at the copper center showed no significant difference, consistent with the absence of the steric hindrance at the metal center. Preliminary biol. studies were conducted, highlighting the effect of the diimine ligands. 5 And 8 exhibited good cytotoxicity against prostate (PC-3), leukemia (MOLT-4) and breast (MCF-7) cancer cell lines, consistent with the presence of nitrogen heteroatoms and extended delocalized systems correlating with strong cytotoxic performance. Binding affinity studies against ct-DNA and docking studies with B-DNA and MDM2 protein highlighted the strong π interactions of 5 and 8, with the planarity of the diimine ligand of the latter contributing to its better binding and cytotoxicity. The present results afford structural design requirements for new copper(I) coordination compounds with enhanced biol./physiochem. properties.

Polyhedron published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mitrofanov, Alexander published the artcileStructural and Electrochemical Studies of Copper(I) Complexes with Diethoxyphosphoryl-1,10-phenanthrolines, COA of Formula: C30H24BrCuN2P, the publication is European Journal of Inorganic Chemistry (2014), 2014(21), 3370-3386, database is CAplus.

Two series of copper(I) complexes with diethoxyphosphoryl-substituted 1,10-phenanthroline ligands were synthesized and characterized in the solid state and in solution The first comprised mixed-ligand Cu^I complexes with phenanthroline and triphenylphosphine. The second series includes bis-chelates with two phenanthroline ligands. According to the x-ray data for the six complexes, the ditopic phenanthroline ligands exhibit bidentate coordination to the copper(I) atom through two nitrogen atoms in both series. Solution equilibrium involving different phenanthroline copper(I) species were studied by ¹H and ³¹P NMR spectroscopy, electrochem., and spectroelectrochem. The solution speciation of these labile complexes is different for these two series and depends on the nature of solvent and the location of the phosphorus substituent on the phenanthroline backbone. Coordinating solvents can replace a bromide, triphenylphosphine, and even a phenanthroline ligand in the inner coordination sphere of the metal center. Copper(I) complexes with α-substituted phenanthrolines easily dissociate even in noncoordinating solvents such as CH₂Cl₂ and CHCl₃. Ligand-exchange reactions leading to less sterically hindered species were observed under the used solution conditions. The coordination mode of the phenanthroline chelators does not change under any of the used solution conditions, and binding of the phosphoryl group to the metal center was never observed by spectroscopic or spectroelectrochem. methods.

European Journal of Inorganic Chemistry published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, COA of Formula: C30H24BrCuN2P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Song, Bingrui published the artcilePalladium/Copper-Catalyzed Di-α-arylation of Acetic Acid Esters, Name: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Advanced Synthesis & Catalysis (2011), 353(10), 1688-1694, database is CAplus.

A bimetallic palladium/copper catalyst system was found to effectively promote the diarylation of alkyl acetates with aryl halides under unprecedentedly mild conditions. The phenanthroline-copper-phosphine catalyst stabilizes the enolate intermediate to the extent that the deprotonation of esters can be achieved even with the mild base potassium phosphate. The palladium tri-tert-butylphosphine co-catalyst mediates the coupling of the resulting copper enolate with a wide variety of aryl halides with selective formation of the corresponding diarylacetic acid esters.

Advanced Synthesis & Catalysis published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C10H14O, Name: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhou, Jianwei published the artcileESR studies of the photolysis of (Ph₃P)₃Cu_nX_n and (Ph₃P)(biL)CuX, Application In Synthesis of 25753-84-8, the publication is Huaxue Xuebao (1987), 45(1), 74-6, database is CAplus.

Active radicals in the photolysis of (Ph₃P)₃Cu_nX_n (n = 1, 2; X = Cl, Br, I, CN) and (Ph₃P)(biL)CuX (X = Cl, Br, I; biL = 2,2′-dipyridyl, 1,10-phenanthroline) were investigated by combination of spin trapping technique, chromatog. and ESR spectroscopy. The formation of free radicals Ph. and Ph₂P. was confirmed by the hyperfine structure of the ESR spectra of the spin adducts formed between Ph. or Ph₂P. and phenyl-tert-butylnitrone.

Huaxue Xuebao published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Motornov, Vladimir published the artcileCopper(I)-Catalyzed Regioselective Chan-Lam N2-Vinylation of 1,2,3-Triazoles and Tetrazoles, Formula: C30H24BrCuN2P, the publication is Advanced Synthesis & Catalysis (2019), 361(14), 3306-3311, database is CAplus.

Copper-catalyzed coupling of π-deficient NH-azoles with vinylboronic acids or vinyltrifluoroborate salt provided a direct route to N2-vinyl-1,2,3-triazoles and N2-vinyltetrazoles. The coupling reaction was efficiently catalyzed by (phen)Cu(PPh₃)Br with low catalyst loading (5 mol%) under base-free conditions. The method was applicable for vinylation of unsubstituted, monosubstituted and disubstituted 1,2,3-triazoles with various functionalities with high N2-selectivity.

Advanced Synthesis & Catalysis published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Formula: C30H24BrCuN2P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Patil, Nandkumar M. published the artcileHeterogenized copper catalysts for the amination of aryl halide: Synthesis, characterization and catalytic applications, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), the publication is Applied Catalysis, A: General (2010), 372(1), 73-81, database is CAplus.

This research investigated the synthesis, characterization and catalytic activity of heterogenized copper complexes for the selective amination of aryl halides. Amination reactions using homogeneous copper catalyst systems are not generally selective and it is also difficult to recover the catalyst from the homogeneous system for recycling. To overcome these difficulties, our efforts were directed towards the development of cheaper heterogeneous catalyst systems, which can be easily recovered and recycled. Heterogenized analogs of the homogeneous Cu complexes were prepared using two methods: (a) encapsulation of copper complexes in zeolite-Y and (b) tethering of copper complexes on various supports like zeolite-Y, silica, charcoal, or clay. The encapsulated and tethered copper catalysts on zeolite-Y were characterized using EPR, diffuse reflectance UV-vis, XRD, IAS, ICPES, SEM, and TEM. The results confirmed that the copper complexes were truly heterogenized in zeolite-Y support. Encapsulated and tethered copper complexes were tested for amination of aryl iodide. The effects of various reaction parameters were examined using tethered Cu(Phen)(PPh₃)Br-PTA-Y catalyst to determine optimum conditions. A recycle study of encapsulated and tethered Cu catalyst was carried out to test their robustness for possible com. exploitation.

Applied Catalysis, A: General published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Recommanded Product: Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary