Tag: M.W=400-500

Related Products of 117635-21-9,Some common heterocyclic compound, 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene, molecular formula is C18H28Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the dry box the mixture of boronic acid 5, (3.69g, 15.58mmol), 1 ,4- dibromo-2,5-dihexylbenzene (3.15g, 7.8mmol), Aliquat 336 (0.8g),Pd(PPh3) (0.858g, 0.742mmol) in degassed toluene (50ml_) was prepared. Outside dry box, the degassed Na2CO3 (3.93g, 37.1 1 mmol in 50 ml_ of water) solution was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 90C for 18hrs. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica columnchromatography (10-50% DCM in hexane) provided the desired product (3.7g, 80% yield) as a solid. This diboc-protected material wasdeprotected by the overnight reaction at room temperature with TFA solution (2ml_ of TFA in 50ml_ of DCM). The reaction mixture was concentrated under reduced pressure followed by the neutralization with saturated NaHCO3. Ethyl acetate extraction, drying over anhydrous MgSO4, concentration of the organic layer under reduced pressure, then silica column chromatography (10-50% ethyl acetate in hexane) provided the desired diamine material, 6, (1 .89g, 75% yield) as a viscous liquid.

The synthetic route of 117635-21-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 7314-86-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7314-86-5, name is 1,3,5,7-Tetrabromoadamantane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,3-dibromobenzene (70 mL) was added to a mixture of 1,3,5,7-tetrabromoadamantane (5.0 g, 11.1 mmol) and AlCl3 powder (4.0 g,30.0 mmol), at 0 C. The mixture was then stirred at ambient temperaturefor 36 h. After quenching the reaction by adding ice water, theorganic layer was diluted with chloroform and filtered. The filtrate waswashed with deionised water and brine and then dried over magnesiumsulfate. After evaporation to remove volatiles, 1,3,5,7-tetrakis(1,3-bibromophenyl)adamantane was obtained as a white solid from thecrystallization in chloroform (9.6 g, 81% yield). 1H NMR (DMSO-d6,400 MHz): delta (ppm) 7.80 (s, 8H), 7.69 (s, 4H), 2.05 (s, 12H); 13C NMR(CDCl3-d3, 400 MHz): delta (ppm) 150.7, 131.5, 126.2, 122.4, 45.3, 38.3.Anal. Calcd for C34H24Br8: C, 38.10; H, 2.26; Found: C, 38.11; H, 2.21.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3,5,7-Tetrabromoadamantane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Xiong; Guo, Jianwei; Tong, Rui; Topham, Paul D.; Wang, Jiawei; Reactive and functional polymers; vol. 130; (2018); p. 126 – 132;,
Bromide – Wikipedia,
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Reference of 117635-21-9, The chemical industry reduces the impact on the environment during synthesis 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene, I believe this compound will play a more active role in future production and life.

[N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-[1,1′-biphenyl]-4-amine](15) (1.2g, 3.3mmol)And 1,4-dibromo-2,5-dihexylbenzene] (16) (0.6 g, 1.5 mmol)To this reaction flask is added toluene / EtOH / 2N K2CO3 (aq) (2v: 1v: 1v) solvent.Degassing using a vacuum pump. Pd (PPh3) 4 (347 mg, 0.3 mmol) was added to the reaction flask and stirred at 90 for one day. Ethanol was removed using a vacuum evaporator and organic matter was extracted with dichloromethane (DCM). The organic layer was dried over MgSO4, filtered and purified by column to obtain 730 mg (yield 66%) of Intermediate 17

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dihexylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LG Chem, Ltd.; Kang Seong-gyeong; Bae Jae-sun; Lee Jae-cheol; Yoon Seok-hui; Lee Dong-gu; Kim Yong-uk; Lee Ho-gyu; (54 pag.)KR2018/92270; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 117635-21-9, These common heterocyclic compound, 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A toluene (400 mL) solution of benzophenoeimine (18.1 g, 100 mmol), 1,4-dibromo-hexyl benzene (20 g, 50 mmol), t-BuONa (10 g), and (DPPF)2PdCl2 (2 g) was refluxed under argon. The mixture was refluxed for 72 hours and then cooled to room temperature. Water (70 mL) and aqeous HC1 (37%, 70 mL) were added to the mixture, which was then refluxed for 10 hours and cooled to room temperature. The solvent was removed by rotary evaporator. The solid was stirred with ethyl ether (300 mL) for 2 days, then filtered, washed with a small amount of ether, and dried, which was stirred in ether (200 mL) with aqueous NaOH (5 M, 300 mL), The ether phase was separated and dried over MgSO4 and run through a short, silica gel column (6 cm×6 cm). The solvent was removed to leave a dark brown solid, which was dissolved in eihanol (50 mL). After sitting overnight, 2,5-dihyxylbenzene-1,4-diamine needles had formed in the solution. The needles were collected through filtration (yield: 6 g, 43%). [0065] FIG. 1a depicts a 1H NMR spectrum of 2,5-dihyxylbenzene-1,4-diamine in CDCl3. [0066] FIG. 1b depicts a ChemDraw-simulated 1H NMR spectrum of 2,5-dihyxylbenzene-1,4-diamine. [0067] FIG. 2a depicts a 13C NMR spectrum of 2,5-dihyxylbenzene-1,4-diamine in CDCl3. [0068] FIG. 2b depicts a ChemDraw-simulated 13C NMR spectrum of 2,5-dihyxylbenzene-1,4-diamine.

Statistics shows that 1,4-Dibromo-2,5-dihexylbenzene is playing an increasingly important role. we look forward to future research findings about 117635-21-9.

Reference:
Patent; PHILLIPS 66 COMPANY; Huang, Hui; US2014/58110; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 7314-86-5,Some common heterocyclic compound, 7314-86-5, name is 1,3,5,7-Tetrabromoadamantane, molecular formula is C10H12Br4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound (1) of Example Ia was reacted with sodium cyanide in DMSO under irradiation at 254 nm as described in G. S. Lee et al., Org. Lett. Vol. 6, No. 11, 2004, 1705-1707, scheme 2a, (c). Tetracyanoadamantane was obtained in 63% yield.

The synthetic route of 7314-86-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GE HEALTHCARE AS; WO2009/21948; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 117635-21-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In the reaction vessel, 1,4-dibromo-2,5-dihexylbenzene (0.81 g, 2.0 0 mmol),20 ml of tetrahydrofuran was added, and at -78 C.,The mixture was stirred. Thereafter, 1.6 M n-butyllithium (n-BuLi) hexane solution (2.53 ml, 4.00 mmol) was added dropwise and after stirring for 1 hour, 3,5-diphenyl- 1-chlorotriazine was added , And the mixture was stirred at room temperature for 3 hours.After completion of the reaction, water was added to the reaction mixture,The mixture was extracted with chloroform, and the organic layer was concentrated. after that,Tetrahydrofuran was added to and dissolved in the resulting residue,Purification was carried out by reprecipitation twice using methanol to obtain a compound B.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dihexylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMSUNG ELECTRONICS COMPANY LIMITED; SHIBATA, KATSUNORI; ISHII, HIROTO; MOTOYAMA, TAKAO; (23 pag.)JP2016/108255; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 117635-21-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In the dry box the mixture of boronic acid pinacol ester,3, (5.6g, 16.82mmol), 1 ,4-dibromo-2,5-dihexylbenzene (3.4g, 8.4mmol), Aliquat 336 (0.8g), and Pd(PPh3) (0.486g, 0.421 mmol) in degassed toluene (100ml_) was prepared. Outside dry box, the degassed Na2CO3 (2.67g, 25.23mmol in 50 ml_ of water) solution was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 90C for 42hrs. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica column chromatography (0-3% ethyl acetate in hexane) provided the desired product (2.1 1 g, 38% yield) as a viscous liquid. This diboc-protected material was deprotected by the overnight reaction at room temperature with TFA solution (5ml_ of TFA in 50ml_ of DCM). The reaction mixture was concentrated under reduced pressure followed by the neutralization with saturated NaHCO3. Ethyl acetate extraction, drying over anhydrous MgSO4, concentration of the organic layer under reduced pressure, then silica column chromatography (30% ethyl acetate in hexane) provided the desired diamine material,7, (1 .16g, 80% yield) as a viscous liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2,5-dihexylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 117635-21-9,Some common heterocyclic compound, 117635-21-9, name is 1,4-Dibromo-2,5-dihexylbenzene, molecular formula is C18H28Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-dibromo-2,5-dihexyl benzene (8.05 mmoles, 3.255 g), boronic ester 7 (17.7 mmoles, 7.545 g), Na2CO3 (40.3 mmoles, 4.268 g) and Aliquat 336 (0.500 g) were suspended in toluene (100 mL) in a 250 mL two-necked-round-bottom-flask with stir bar and condenser. Reaction mixture degassed for 30 minutes. Pd(PPh3)4 (0.403 mmoles, 0.465 g) added as a powder to reaction mixture. Reaction mixture degassed for a further 15 minutes, whilst simultaneously degassing water (50 mL). Water added via syringe to reaction vessel. Reaction heated to 90 C. for two days. Resulting reaction mixture diluted with ethyl acetate (150 mL), washed with ethyl acetate (3×100 mL). Organic layer washed with brine (2×100 mL), dried over magnesium sulfate, filtered and concentrated. Purification by column chromatography on silica gel using 1:3 dichloromethane: Hexanes to yield white powder (56%, 3.8 g). 1H NMR (500 MHz, CD2Cl2) delta=7.45 (d, J=8.5 Hz, 4H), 7.33-7.31 (m, 5H), 7.26-7.19 (m, 5H), 6.65 (s, 2H), 2.71-2.63 (m, 9H), 1.54 (s, 18H), 1.31-1.20 (m, 14H), 1.15 (t, J=7.49, 7H), 0.83 (t, J=6.85 Hz, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,5-dihexylbenzene, its application will become more common.

Reference:
Patent; E.I DU PONT DE NEMOURS AND COMPANY; US2012/65432; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 117635-21-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 117635-21-9 as follows.

In the dry box the mixture of boronic acid pinacol ester,4, (6.44g, 18.55mmol), 1 ,4-dibromo-2,5-dihexylbenzene (3.75g, 9.27mmol), Aliquat 336 (0.8g), and Pd(PPh3) (0.536g, 0.464mmol) in degassed toluene (l OOmL) was prepared. Outside dry box, the degassed Na2CO3 (2.95g, 27.83mmol in 50 ml_ of water) solution was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 90C for 38hrs. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica column chromatography (0-4% ethyl acetate in hexane) provided the desired product (3.62g, 60% yield) as a white solid. This diboc-protected material was deprotected by the overnight reaction at room temperature with TFA solution (4ml_ of TFA in 30ml_ of DCM). The reaction mixture was concentrated under reduced pressure followed by the neutralization with saturated NaHCO3. Ethyl acetate extraction, drying over anhydrous MgSO4, concentration of the organic layer under reduced pressure, then silica column chromatography (30% ethyl acetate in hexane) provided the desired diamine material,8, (2.5g, 99% yield).

According to the analysis of related databases, 117635-21-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 117635-21-9 as follows. SDS of cas: 117635-21-9

1,4-dibromo-2,5-dihexyl benzene (8.05 mmoles, 3.255g), boronic ester 26 (17.7 mmoles, 7.545g), Na2CO3 (40.3 mmoles, 4.268g) and Aliquat 336 (0.500g) were suspended in toluene (100 mL) in a 250 mL two-necked- round-bottom-flask with stir bar and condenser. The reaction mixture degassed and Pd(PPh3)4 (0.403 mmoles, 0.465g) added followed by addition of degassed water (50 mL). Reaction heated to 90C for two days. Resulting reaction mixture diluted with ethyl acetate (150 mL), washed with ethyl acetate (3 x 100 mL). Organic layer washed with brine (2 x 100 mL), dried over magnesium sulfate, filtered and concentrated. Purification by column chromatography on silica gel using 1 :3 DCM: Hexanes to yield white powder (56%, 3.8g). 1 H NMR (500 MHz, CD2CI2) delta = 7.45 (d, J = 8.5Hz, 4H), 7.33-7.31 (m, 5H), 7.26-7.19 (m, 5H), 6.65 (s, 2H), 2.71 -2.63 (m, 9H0, 1 .54 (s, 18H), 1 .31 -1 .20 (m, 14H), 1 .15 (t, J = 7.49, 7H), 0.83 (t, J = 6.85Hz, 6H).

According to the analysis of related databases, 117635-21-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary