Tag: M.W=350-400

Ryley, J. F. published the artcileThe chemotherapy of Babesia infections, Computed Properties of 518-67-2, the publication is Annals of Tropical Medicine & Parasitology (1957), 38-49, database is CAplus and MEDLINE.

A screening test is described for anti-Babesia drugs by using mice infected with B. rodhaini. The maximum tolerated dose and min. effective dose (as mg./20 g. × 3) are, resp.: acapron, 0.1 and 0.01; dimidium bromide, 0.5 and 0.01; ethidium bromide, 1 and 0.025; pentamidine (as base), 0.75 and 0.25; propamidine (as base), 0.5 and >0.5; stilbamidine (as base), 0.75 and 0.1; trypan blue, >5 and >5; acriflavine, 0.5 and 0.1; berenil, 0.25 and 0.1; antrycide dimethyl sulfate, 0.5 and 0.1; 4-amino-6-(2-amino-1,6-dimethyl-4-pyrimidinylamino)-2-phenyl-1-methylquinolinium dichloride (Compound 10,073), 0.5 and 0.005; bis(1,2-dimethyl-4-methylamino-6-quinolyl)-amine bis(methyl sulfate) (Compound 14,911), 1 and 0.005. Mepacrine, chloroquine, paludrine, and Daraprim had no effect against B. rodhaini. Compound 10,073, in doses up to 8 mg./kg., was effective in treating B. bovis in calves with no apparent toxicity. Reversible toxic symptoms were elicited with 10 mg./kg.

Annals of Tropical Medicine & Parasitology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Computed Properties of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Beveridge, Elizabeth published the artcileActivity of phenanthridine compounds against Babesia rodhaini in mice, Recommanded Product: Dimidium bromide, the publication is Annals of Tropical Medicine & Parasitology (1956), 85-91, database is CAplus.

A series of phenanthridine compounds previously reported to have trypanocidal activity (C.A. 44, 8545e) was tested against B. rodhaini in mice. General requirements for babesicidal activity are the same as for trypanocidal activity. For high potency against B. rodhaini there must be: (1) a 10-quaternary group; (2) at least one free amino or easily hydrolyzed acylamino group in the 2, 3, 6, or 7 position of the phenanthrene nucleus; (3) an alkyl, phenyl, or p-aminophenyl group in position 9. Urethan derivatives have little activity; and acylation of amino groups does not greatly diminish babesicidal potency, in contrast to the effect on trypanocidal action.

Annals of Tropical Medicine & Parasitology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Braun, Aleksander published the artcileQuantitative determination of anionic surfactants by two-phase titration, Category: bromides-buliding-blocks, the publication is Barwniki – Srodki Pomocnicze (1979), 23(1), 16-20, database is CAplus.

The mixed indicators Disulphine Blue VN 150 [129-17-9] and 3,8-diamino-6-phenylphenanthridine methobromide [518-67-2] gave statistically more reliable results in the determination of Na alkylarenesulfonates by acidimetric titration than only 1 indicator, e.g. cetylpyridinium bromide. The historical development of 1- and 2-indicator procedures for surfactant determinations is described. A statistical comparison of the 2 methods is given.

Barwniki – Srodki Pomocnicze published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Buschmann, N. published the artcileIndicator for the two-phase titration of ionic surfactants is possibly mutagenic, Product Details of C20H18BrN3, the publication is Rivista Italiana delle Sostanze Grasse (1995), 72(11), 513, database is CAplus.

For the two-phase titration of anionic or cationic surfactants, the most frequently used indicator is a mixed indicator system consisting of dimidium bromide and Disulphine Blue. Recently, we noticed a similarity between ethidium bromide and dimidium bromide (I). Ethidium bromide is well known as a strong mutagenic and cancerogenic agent, reacting with DNA either by intercalation or external binding. The literature shows that I reacts with DNA in a similar way. When mixing aqueous solutions of DNA and I a change in the color of the solution can be observed, as well as a strong enhancement in the fluorescence intensity. Both the literature and the exptl. findings make it very likely that I shows mutagenic and cancerogenic properties that are similar to those of ethidium bromide. This estimation is shared by the USA National Cancer Institute. Up to now, only little is known about the ways of incorporation for both dyes. Ethidium bromide shows mutagenic and cancerogenic properties when coming in contact with the mucous membrane. The author has no information whether I will be incorporated if an aqueous solution is in contact with the intact epidermis. That would be the most probable way of incorporation when carrying out a two phase titration For that reason, the appropriate safety precautions should be taken when working with I: protection gloves and goggles and addnl., when working with the solid substance, dust mask. When titrating anionic surfactants, I will be found in the aqueous phase at the end of the titration The dye should be removed from the solution by adsorption on activated charcoal or on a polymeric resin like Amberlite XAD-16. After our experience an amount of 10 g activated charcoal is sufficient for the removal of I from one liter of the aqueous phase.

Rivista Italiana delle Sostanze Grasse published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Product Details of C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Buschmann, N. published the artcileDoes the two-phase titration of surfactants require a mutagenic indicator?, Recommanded Product: Dimidium bromide, the publication is Journal of the American Oil Chemists’ Society (1995), 72(10), 1243, database is CAplus.

Appropriate safety precautions are recommended when using the indicator mixture of dimidium bromide and disulphine blue, as dimidium bromide is chem. similar to ethidium bromide which is a known mutagen. When titrating anionic surfactants, dimidium bromide is found in the aqueous phase at the end of the titration; the dye should be removed by adsorption on activated charcoal which must be disposed of according to regulatory guidelines.

Journal of the American Oil Chemists’ Society published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Fener published the artcileSynthesis of ibuprofen by rearrangement, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Zhongguo Yiyao Gongye Zazhi (1992), 23(1), 1-2, database is CAplus.

On the basis of the Giordano’s method, ibuprofen was synthesized with some improvements in 75% overall yield from isobutylbenzene. The mild reaction conditions, convenient work-up and higher purity of the product were advantages of this method.

Zhongguo Yiyao Gongye Zazhi published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Recommanded Product: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Guo, Libing published the artcileSynthesis of N-(4-biphenyl)-(9,9-dimethyl-2-fluorenyl)amine, Category: bromides-buliding-blocks, the publication is Huaxue Tongbao (2010), 73(8), 750-752, database is CAplus.

2-Bromofluorene was prepared from fluorene and benzyltrimethylammonium tribromide in dichloromethane-methanol solution at room temperature, followed by a reaction with iodomethane in THF in the presence of potassium tert-butanolate and formation of 9,9-dimethyl-2-bromo-9H-fluorene. The synthesis of the target compound was achieved by a Buchwald-Hartwig reaction of the above-mentioned aryl bromide with [1,1′-biphenyl]-4-amine and the product thus obtained was confirmed by ¹H-NMR, ¹³C-NMR, MS, IR spectra and elemental anal.

Huaxue Tongbao published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Guanghui published the artcileDouble N,B-Type Bidentate Boryl Ligands Enabling a Highly Active Iridium Catalyst for C-H Borylation, Synthetic Route of 1075719-78-6, the publication is Journal of the American Chemical Society (2015), 137(25), 8058-8061, database is CAplus and MEDLINE.

Boryl ligands hold promise in catalysis due to their very high electron-donating property. In this communication double N,B-type boryl anions were designed as bidentate ligands to promote an sp² C-H borylation reaction. A sym. pyridine-containing tetraaminodiborane(4) compound was readily prepared as the ligand precursor that could be used, in combination with [Ir(OMe)(COD)]₂, to in situ generate a highly active catalyst for a broad range of (hetero)arene substrates including highly electron-rich and/or sterically hindered ones. This work provides the 1st example of a bidentate boryl ligand in supporting homogeneous organometallic catalysis.

Journal of the American Chemical Society published new progress about 1075719-78-6. 1075719-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(3,4-Dibromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C3H12Cl2N2, Synthetic Route of 1075719-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Liqiang published the artcileSynthesis of 6-bromoquinolines using benzyltrimethylammonium tribromide, Category: bromides-buliding-blocks, the publication is Youji Huaxue (2010), 30(8), 1250-1254, database is CAplus.

Several 6-bromoquinoline derivatives were designed and the synthesis of the target compounds was achieved in high yield by a reaction of 2-aminobenzophenone [i.e., (2-aminophenyl)(phenyl)methanone] with α-methylene carbonyl compounds in the presence of benzyltrimethylammonium tribromide as a phase-transfer catalyst in acetonitrile at room temperature and the products thus obtained were confirmed by ¹H-NMR, ¹³C-NMR spectra and elemental anal. The title compounds thus reported included 8-bromo-10-phenyl-11H-indeno[1,2-b]quinolin-11-one, 2-bromo-12-phenylbenz[b]acridine-6,11-dione and 6-bromo-4-phenylquinoline derivatives, 7-bromo-9-phenyl-1H-cyclopenta[b]quinoline derivatives, etc.

Youji Huaxue published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C5H8N2O, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Fan published the artcileHole Transport Materials Based on 6,12-Dihydroindeno[1,2-b]fluorine with Different Periphery Groups: A New Strategy for Dopant-Free Perovskite Solar Cells, Quality Control of 111865-47-5, the publication is Advanced Functional Materials (2019), 29(24), n/a, database is CAplus.

Although several hole-transporting materials (HTMs) have been designed to obtain perovskite solar cells (PSCs) devices with high performance, the dopant-free HTMs for efficient and stable PSCs remain rare. Herein, a rigid planar 6,12-dihydroindeno[1,2-b]fluorine (IDF) core with different numbers of bulky periphery groups to construct dopant-free HTMs of IDF-SFXPh, IDF-DiDPA, and IDF-TeDPA is modified. Thanks to the contributions of the planar IDF core and the twisted SFX periphery groups, the dopant-free IDF-SFXPh-based PSCs device achieves a device performance of 17.6%, comparable to the doped 2,2′,7,7′-tetrakis(N,N-di-p-methoxyphenylamine)-9,9′-spirobifluorene (spiro-OMeTAD)-based device (17.6%), with much enhanced device stability under glovebox and ambient conditions.

Advanced Functional Materials published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary