Tag: M.W=350-400

Miura, Yozo published the artcileMagnetic Interaction of Pyridyl-Substituted Thioaminyl Stable Free Radicals, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Organic Chemistry (2003), 68(4), 1225-1234, database is CAplus and MEDLINE.

N-(2-Pyridylthio)-2,6-diaryl-4-R-phenylaminyls (R = Ph, 4-ClC₆H₄, MeCO, CN, EtOCO) and N-(4-pyridylthio)-2,6-diaryl-4-R-phenylaminyls (R = Ph, 4-ClC₆H₄, EtOCO) were prepared and isolated as radical crystals. Their ESR spectra were measured, and the NS and pyridyl N and anilino meta and pyridyl ortho and para proton hyperfine coupling constants were determined The spin-d. calculations based on the d. functional theory were performed by the UBecke 3LYP hybrid method using the STO 6-31G basis set. x-ray crystallog. analyses were performed for three radicals, and their structures were discussed. The magnetic susceptibility measurements were carried out for the nine kinds of isolated radicals with a SQUID magnetometer. One radical showed ferromagnetic coupling (2J/k_B = 44 K), and the others showed antiferromagnetic behavior. The magnetic interactions observed are explained from the crystal structures.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wien, R. published the artcileChemotherapeutic action of amidine and phenanthridinium compounds in Trypanosoma congolense infections, SDS of cas: 518-67-2, the publication is British Journal of Pharmacology and Chemotherapy (1946), 65-80, database is CAplus and MEDLINE.

These compounds were tested against 5 strains of T. congolense in mice: 7-Amino-9-p-aminophenyl-10-methylphenanthridinium chloride and 4,4′-diamidino-α,β-dimethylstilbene di-HCl were compared as to activity. The former compound was twice as toxic and active against the acute strains, the therapeutic indexes being the same, but it was less active against 1 chronic strain. An evaluation of 2,7-diamino-9-phenyl-10-methyl-phenanthridinium bromide (1553) showed that by subcutaneous injection in acute infections the C.D. 50(50% of animals free of trypanosomes for at least 28 days, 42 for chronic strains) was 0.0004 mg./g., the LD 50 was 0.061 mg./g. and the therapeutic index 152. A very complete study of the correlation between chem. structure and activity against T. congolense of diamidine and phenanthridinium compounds is reported. The pharmacol. actions of compound 1553 are reported. The compound has a depressant action on the circulation and respiratory center and, in high doses, a toxic action on liver and kidneys.

British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C17H14F3N3O2S, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Woolfe, G. published the artcileTrypanocidal action of phenanthridine compounds: effect of changing the quaternary groups of known trypanocides, Safety of Dimidium bromide, the publication is British Journal of Pharmacology and Chemotherapy (1956), 330-3, database is CAplus and MEDLINE.

cf. Ann. Trop. Med. Parasitol. 46, 285(1952). The effect on trypanocidal activity of replacing the Me quaternating group of 6-(4-aminophenyl)-8-aminophenanthridinium halide and 3,8-diamino-6-alkyl (or aryl)-phenanthridinium halide with Et, Pr, or allyl was examined Trypanocidal activity measured against Trypanosoma congolense, T. brucei, T. rhodesiense, and T. gambiense was generally enhanced and was greatest with compounds originally of high activity. Toxicities for mice were also reported.

British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C28H29NO4, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dougherty, G. published the artcileA comparison of the base-pair specificities of three phenanthridine drugs using solution spectroscopy, Safety of Dimidium bromide, the publication is International Journal of Biochemistry (1982), 14(6), 493-504, database is CAplus and MEDLINE.

Absorption spectra of ethidium  [1239-45-8], dimidium  [518-67-2], and prothidium bromides  [14222-46-9] bound to natural DNAs of differing G-C content were obtained using a novel mixing scheme and analyzed according to the excluded site binding model. Ethidium bromide showed a strong G-C specificity at low binding ratios, especially at low ionic concentration Dimidium bromide showed a less strong G-C specificity. For both drugs, the binding site size reflected a situation close to nearest-neighbor exclusion. Prothidium bromide showed no specificity in its binding. The binding modes were different than for the other 2 phenanthridines, suggesting that the primary mode is sideways intercalation.

International Journal of Biochemistry published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dougherty, Geoffrey published the artcileThe unwinding of circular DNA by intercalating agents as determined by gel electrophoresis, SDS of cas: 518-67-2, the publication is Bioscience Reports (1983), 3(5), 453-60, database is CAplus and MEDLINE.

An accurate and precise method is described to determine the unwinding angle of the circular DNA helix of plasmid pBR322/RcβG by ethidium bromide and other intercalating agents of electrophoresis in 1.4% agarose gels containing chloroquine, followed by densitometry of the photog. negs. of the gels. Under the electrophoresis conditions used, native (form I) DNA and partially relaxed samples, running faster or slower than it, were resolved. Contaminating nicked (form II) DNA did not interfere, since it was clearly separated during electrophoresis.

Bioscience Reports published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gill, B. S. published the artcileSurra. XI. Chemotherapeutic susceptibility of Trypanosoma evansi, Synthetic Route of 518-67-2, the publication is Indian Journal of Animal Sciences (1973), 43(4), 226-9, database is CAplus.

The median effective and curative doses of 39 trypanocidal agents are reported for T. evansi infections in rats. These two parameters indicated the comparative chemotherapeutic susceptibility of the organism, which is the causative agent for surra disease in domestic animals. Arsenicals, antimonials, acriflavine, diamidines, sulfonated naphthylamine derivatives, aminoquinaldine derivatives, phenanthridines, nitrofurazone, and terephthalanilide compounds were tested.

Indian Journal of Animal Sciences published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grzadka, E. published the artcileCompetitive adsorption in the system: carboxymethylcellulose/surfactant/electrolyte/Al₂O₃, Recommanded Product: Dimidium bromide, the publication is Cellulose (Dordrecht, Netherlands) (2011), 18(2), 291-308, database is CAplus.

The adsorption of CM-cellulose (CMC) in the presence or absence of the surfactants: anionic SDS, nonionic Triton X-100 and their mixture SDS/TX-100 from the electrolyte solutions (NaCl, CaCl₂) on the alumina surface (Al₂O₃) was studied. In each measured system the increase of CMC adsorption in the presence of surfactants was observed This increase was the smallest in the presence of SDS, a bit larger in the presence of Triton X-100 and the largest when the mixture of SDS/Triton X-100 was used. These results are a consequence of formation of complexes between the CMC and the surfactant particles. Moreover, the dependence between the amount of surfactants’ adsorption and the CMC initial concentration was measured. It comes out that the surfactants’ adsorption amount is not dependent on the CMC initial concentration and moreover, it is unchanged in the whole measured concentration range. The influence of kind of electrolyte, its ionic strength as well as pH of a solution on the amount of the CMC adsorption at alumina surface was also measured. The amount of CMC adsorption is larger in the presence of NaCl than in the presence of CaCl₂ as the background electrolyte. It is a result of the complexation reaction between Ca²⁺ ions and the functional groups of CMC belonging to the same macromol. As far as the electrolyte ionic strength is concerned the increase of CMC adsorption amount accompanying the increase of electrolyte ionic strength is observed The reason for that is the ability of electrolyte cations to screen every electrostatic repulsion in the adsorption system. Another observation is that the increase of pH caused the decrease of CMC adsorption. The explanation of this phenomenon is connected with the influence of pH on both dissociation degree of polyelectrolyte and kind and concentration of surface active groups of the adsorbent.

Cellulose (Dordrecht, Netherlands) published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Henderson, J. Frank published the artcileInhibition of purine metabolism in Ehrlich ascites carcinoma cells by phenanthridinium compounds related to ethidium bromide, Name: Dimidium bromide, the publication is Cancer Research (1963), 491-5, database is CAplus and MEDLINE.

The effect of 10 phenanthridinium derivatives on the incorporation of adenine and glycine into the nucleic acids and proteins of Ehrlich ascites carcinoma cells in vitro, has been studied. Only 1 compound markedly inhibited incorporation of glycine into nucleic acids and proteins, whereas all the drugs inhibited incorporation of adenine into nucleic acids.

Cancer Research published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Name: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lerman, L. S. published the artcileSymposium on molecular action of mutagenic and carcinogenic agents. Acridine mutagens and DNA structure, Recommanded Product: Dimidium bromide, the publication is Journal of Cellular and Comparative Physiology (1964), 64(2;Pt. II;Suppl. 1), 1-13, discussion 13-18, database is CAplus.

Evidence for intercalation of acridine compounds between 2 otherwise sequential base pairs was obtained by studies of sedimentation, low angle x-ray scattering, flow dichroism, flow-polarized fluorescence, and chem. reactivity. Such binding requires a local untwisting and extension of the double helix. The intercalated mols. have a decreased chem. reactivity. They increase the stability of the double helix as shown by an increase in the thermal transition temperature Intercalation into complexes formed between polyadenylic and polyuridylic acids makes the double helix more stable than the triple. Intercalation seems to be a prerequisite for mutagenicity of the insertion-deletion type but the acridine structure is not essential and not all intercalating mols. are mutagenic.

Journal of Cellular and Comparative Physiology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Chang-chun published the artcileSelective bromination of p-hydroxybenzaldehyde, COA of Formula: C10H16Br3N, the publication is Huaxue Shijie (2008), 49(8), 481-483, database is CAplus.

The selective bromination of 4-hydroxybenzaldehyde (HBD) with benzyltrimethylammonium tribromide in dichloromethane-methanol was studied. A method for the synthesis of 3-bromo-4-hydroxybenzaldehyde is reported here. The effects of reaction conditions were determined When the mol ratio of 4-hydroxybenzaldehyde to benzyltrimethylammonium tribromide was 1.0:1.05, volume ratio of dichloromethane to methanol was 5:1, reaction temperature was 30° and reaction time was 1 h, the yield of monobromide reached 92.5% and the selectivity of monobromide reached 99%.

Huaxue Shijie published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, COA of Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary