Tag: M.W=350-400

Reddy, K. Rajendar published the artcileCetyltrimethylammonium Bromide as an Efficient Catalyst for Regioselective Bromination of Alkoxy Naphthalenes with Trimethyl Benzyl Ammonium Tribromide: Synthetic and Kinetic Approach, Application In Synthesis of 111865-47-5, the publication is International Journal of Chemical Kinetics (2014), 46(1), 10-23, database is CAplus.

Bromination of 2-alkoxynaphthalene (2-ANP) and its derivatives with trimethylbenzylammonium tribromide (TMBATB) did not proceed smoothly even under reflux conditions. But the addition of microconcns. of cetyltrimethyl ammonium bromide (CTAB) to the reaction afforded dramatic rate accelerations as well as good-to-excellent yield of the products ranging from 70% to 90%. Reactions underwent regioselective monobromination at 1-position of 2-alkoxynaphthalene. The rate of bromination has been followed conductometrically. The reaction kinetics indicated first-order kinetics in [2-ANP] as well as in [TMBATB]. Kinetic results in the presence of CTAB were explained on the basis of the Raghavan-Srinivasan model as applied to micelle-mediated bimol. reactions.

International Journal of Chemical Kinetics published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chung, Yun Mi published the artcilePhenol-containing bis(oxazolines): synthesis and fluorescence sensing of amines, Category: bromides-buliding-blocks, the publication is Tetrahedron (2006), 62(50), 11645-11651, database is CAplus.

The fluorescence sensing of primary amines as their neutral forms was studied with bis(oxazolinyl)phenols (Me-BOP, Ph-BOP), which are efficiently synthesized starting from mesitylene in six steps and in overall 12-22% yields. The BOP sensors showed fluorescence enhancement toward butylamine and several arylethylamines, whereas they showed fluorescence quenching toward secondary and branched amines. The opposite fluorescence behavior is explained by an increased conformational restriction at the excited state, at which a proton transfer complex between the host and guest forms that is stabilized in a tripodal hydrogen bonding mode. This is the 1st example in which fluorescence enhancement is observed in amine sensing with phenolic fluorophores. Enantiomeric α-chiral organoamines were also sensed with different fluorescent intensity changes by Ph-BOP, complementing the previous tris(oxazolines) that sense enantiomeric α-chiral organoammonium ions.

Tetrahedron published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sankaranarayanan, Ananthakrishnan published the artcileNaphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure, Related Products of bromides-buliding-blocks, the publication is Molecular Pharmacology (2009), 75(2), 281-295, database is CAplus and MEDLINE.

Small-conductance (KCa2.1-2.3) and intermediate-conductance (KCa3.1) calcium-activated K⁺ channels are critically involved in modulating calcium-signaling cascades and membrane potential in both excitable and nonexcitable cells. Activators of these channels constitute useful pharmacol. tools and potential new drugs for the treatment of ataxia, epilepsy, and hypertension. Here, we used the neuroprotectant riluzole as a template for the design of KCa2/3 channel activators that are potent enough for in vivo studies. Of a library of 41 benzothiazoles, we identified 2 compounds, anthra[2,1-d]thiazol-2-ylamine (SKA-20) and naphtho[1,2-d]thiazol-2-ylamine (SKA-31), which are 10 to 20 times more potent than riluzole and activate KCa2.1 with EC₅₀ values of 430 nM and 2.9 μM, KCa2.2 with an EC₅₀ value of 1.9 μM, KCa2.3 with EC₅₀ values of 1.2 and 2.9 μM, and KCa3.1 with EC₅₀ values of 115 and 260 nM. Likewise, SKA-20 and SKA-31 activated native KCa2.3 and KCa3.1 channels in murine endothelial cells, and the more “drug-like” SKA-31 (half-life of 12 h) potentiated endothelium-derived hyperpolarizing factor-mediated dilations of carotid arteries from KCa3.1(+/+) mice but not from KCa3.1(-/-) mice. Administration of 10 and 30 mg/kg SKA-31 lowered mean arterial blood pressure by 4 and 6 mm Hg in normotensive mice and by 12 mm Hg in angiotensin-II-induced hypertension. These effects were absent in KCa3.1-deficient mice. In conclusion, with SKA-31, we have designed a new pharmacol. tool to define the functional role of the KCa2/3 channel activation in vivo. The blood pressure-lowering effect of SKA-31 suggests KCa3.1 channel activation as a new therapeutic principle for the treatment of hypertension.

Molecular Pharmacology published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ramu, Avner published the artcileReduced ouabain-sensitive potassium entry as a possible mechanism of multidrug-resistance in P388 cells, Application of Dimidium bromide, the publication is Biochemical Pharmacology (1991), 42(9), 1699-704, database is CAplus and MEDLINE.

Multidrug-resistant P388 cells were found to be resistant also to a variety of ammonium, phosphonium and arsonium compounds As previously shown for anthracyclines and vinca alkaloids, the resistance to the permanently charged lipophilic cationic compounds could be circumvented by verapamil. Relative to drug-sensitive cells, K⁺ uptake and plasma membrane Mg-ATPase activity in multidrug-resistant cells are ouabain resistant. The intracellular K⁺ concentration in drug-resistant cells is maintained at a normal level by increased activity of the furosemide sensitive transport system. It is suggested that the reduced activity of the electrogenic Na⁺-K⁺ pump in multidrug-resistant cells could result in a lower transmembrane potential and therefore reduced accumulation of cationic lipophilic compounds

Biochemical Pharmacology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Application of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lowy, Dan A. published the artcileA new high-efficiency reagent for the potentiometry of cationic surfactants, Related Products of bromides-buliding-blocks, the publication is Process Control and Quality (1993), 4(2), 125-37, database is CAplus.

A new heteropolyanionic reagent has been used for the accurate determination of quaternary ammonium salts (QAS) in various matrixes containing strongly interfering species. The octapotassium 1-cobalto(II)[1-aqua]-1-molybdo-16-tungsto-2-phosphate (HPA) is a successful titrant of several alkyltrimethylammonium salts (with an alkyl chain of C_12-18), both in the potentiometric and the two-phase titration procedure. In order to prove the high efficiency of the proposed reagent, comparative titrations have been carried out for hexadecyltrimethylammonium bromide with HPA, sodium tetraphenylborate (TFB) and sodium dodecylsulfate (DDS). The dimidium bromide and disulfine VN 150 indicator mixture has been utilized in two-phase titrations, while the endpoint of the potentiometric titrations was detected by means of a QAS-selective liquid-membrane electrode. The relative error of the average of eight titrations by means of the three reagents decreased in the order TFB > DDS > HPA, corresponding to the increase of the association equilibrium constant: [(CH₃)₃RN]₈HPA·19H₂O > [(CH₃)₃RN]DDS > [(CH₃)₃RN]TFB.

Process Control and Quality published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Rupa R. published the artcileNovel protocol for the synthesis of organic ammonium tribromides and investigation of 1,1′-(ethane-1,2-diyl)dipiperidinium bis(tribromide) in the silylation of alcohols and thiols, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Chemistry Letters (2014), 43(10), 1545-1547, database is CAplus.

A novel and efficient protocol for the synthesis of organic ammonium tribromides (OATBs) is developed by using inexpensive and eco-friendly periodic acid as an oxidant for the conversion of Br^– to Br₃^–. The method does not use any mineral acid and metal oxidants. The protocol is utilized to synthesize a new bis(tribromide) viz., 1,1′-(ethane-1,2-diyl)dipiperidinium bis(tribromide) (EDPBT). EDPBT is investigated as a catalyst in the silylation of alcs. and thiols by HMDS (hexamethyldisilazane) under solvent-free conditions.

Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dey, Rupa Rani published the artcileNovel Metal- and Mineral-Acid-Free Synthesis of Organic Ammonium Tribromides and Application of Ethylenephenanthrolium Bistribromide for Bromination of Active Methylene Group of 1,3-Diketones and β-Ketoesters, Application In Synthesis of 111865-47-5, the publication is Synthetic Communications (2015), 45(6), 714-726, database is CAplus.

A novel procedure for the preparation of organic ammonium tribromides (OATBs) is described from their corresponding bromides. Quaternary ammonium bromides (QABs) and a N,N’-heterocyclic dibromide are efficiently oxidized to their corresponding monotribromides and bistribromide by m-chloroperbenzoic acid (MCPBA) in the presence of 2 and 4 equiv of KBr, resp. The reactions are carried out in an aqueous medium without the use of any mineral acid or metal catalyst/promoters. A variety of tribromides are synthesized in very good yields including a hitherto unknown reagent, 1,10-(ethane-1, 2-diyl)phenanthrolinediium bistribromide (EPDBT). EPDBT is investigated as brominating agent and found to be highly effective for selective bromination of active methylene groups of a variety of 1,3-diketones and β-ketoesters.

Synthetic Communications published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Doerfler, H. D. published the artcileMiscibility behavior of ternary lipid/phospholipid/water systems, Formula: C20H18BrN3, the publication is Colloid and Polymer Science (1990), 268(6), 559-66, database is CAplus.

Differential-scanning-calorimetry was applied to study the lyotropic and thermotropic properties of the 2 ternary systems dimyristoylcephaline (di-(C14:0)-PE)/palmitic acid (C₁₅COOMe)/H₂O in dispersions with excess H₂O (50 weight%). The phase diagrams of both systems showed that the 2 systems differ in their miscibility behavior. The system di(C14:0)-PE/C₁₅COOH/H₂O is completely miscible in its high-temperature phase. In the low-temperature phase, a miscibility gap was found within the concentration range of C₁₅COOH was also indicated by a maximum value of the transition enthalpy of the pseudo-binary mixtures In the pseudo-binary system di(C14:0)-PCCOOMe/H₂O, the tendency towards demixing is much more pronounced. It was observed that the incorporated C₁₅COOMe melted above its normal m.p., but below the transition temperature of di-(C14:0)-PE/H₂O system; therefore, the phase transition started at lower temperature In the low-temperature phase, both lipids are partially miscible. The demixing range of the phase diagram lies within the concentration region of C₁₅COOMe. Up to mol fraction x_C15COOMe = 0.43 C₁₅COOMe can be incorporated into the L_β-phase of the system di-(Cl14:0)-PE/H₂O.

Colloid and Polymer Science published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Formula: C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sparks, Richard B. published the artcileBenzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors, Quality Control of 111865-47-5, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 736-740, database is CAplus and MEDLINE.

Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible inhibitors of PTP1B with improved caco-2 permeability. An X-ray co-crystal structure of inhibitor 5/PTP1B at 2.2 Å resolution demonstrated that the benzothiazole benzimidazole forms bi-dentate H-bonds to Asp48, and the benzothiazole interacts with the surface of the protein in a solvent exposed region towards the C-site. The design, synthesis, and SAR of this novel series of benzothiazole benzimidazole containing (S)-IZD inhibitors of PTP1B are presented herein.

Bioorganic & Medicinal Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C9H8BNO2, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Anghel, D. F. published the artcileAnionic surfactant analysis from micellar solutions, Recommanded Product: Dimidium bromide, the publication is Revue Roumaine de Chimie (1978), 23(2), 251-3, database is CAplus.

The content of Na alkylarenesulfonate or petroleum sulfonate in micellar solutions used for petroleum recovery was determined by the 2-phase titration method using methylene blue [61-73-4], bromcresol green [76-60-8], or dimidium bromide [518-67-2]-Disulphine Blue VN [129-17-9] mixture as the indicator. The last 2 indicators gave the most accurate determinations, but the bromcresol green method gave high values when the hydrocarbon of the micellar solution contained fatty acids. The presence of crude oil caused difficulties in end-point determination Nonionic surfactants and alcs. did not interfere.

Revue Roumaine de Chimie published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary