Tag: M.W=350-400

Griggs, Billy G. published the artcileAssignment of the carbon-13 chemical shifts of ethidium bromide and analogs in deuterium oxide solution, Application of Dimidium bromide, the publication is Organic Magnetic Resonance (1980), 14(5), 371-3, database is CAplus.

The ¹³C NMR of the title compounds (I; R = Et, Me, R¹ = Ph, X = Br; R = Me, R¹ = H, X = Cl), in D₂O, were assigned. The assignments were based on fully coupled spectra, selective ¹H decoupling, chem. shift arguments, the effect of pD on chem. shifts, and spectra obtained from a selected 180°-τ-90° pulse sequence in conjunction with gated irradiation to obtain nuclear Overhauser enhancement intensification.

Organic Magnetic Resonance published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Application of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Braude, Irwin A. published the artcileMechanism of interaction of sodium dodecyl sulfate with mouse interferon, Synthetic Route of 518-67-2, the publication is Journal of Biological Chemistry (1979), 254(16), 7758-64, database is CAplus and MEDLINE.

Na dodecyl sulfate (SDS) and other alkyl sulfates, provided they contained a min. of 12 C atoms (or ≥22 Å in length), stabilized mouse interferon (MIF) in the presence of urea, 2-mercaptoethanol, and heat. When MIF was treated with the alkyl sulfates in the absence of urea and 2-mercaptoethanol, all alkyl sulfates inactivated MIF to the same extent, suggesting that the stabilizing effect of SDS on MIF most likely occurs during the refolding process. Unlike SDS, other amphiphiles such as dodecylamine, Li dodecyl sulfate, and Na 1-dodecane sulfonate did not have an appreciable stabilizing effect on MIF, thus emphasizing the necessity of specific counter-ions and polar groups for SDS to affect MIF stability. Subsequent to its reaction with SDS, MIF no longer was bound to controlled pore glass (CPG) beads. This is most likely due to SDS masking the protein’s silanol-binding sites. Furthermore, after it had reacted with interferon, a portion (∼20 to 50%) of the SDS was no longer retained by the anion exchange resin AG1-X10. Conversely, interferon (which does not bind to AG1-X2, a resin with a larger pore size than AG1-X10) was retained by the resin AG1-X2 after it has reacted with SDS. In addition, SDS-treated MIF was able to bind to the immobilized hydrophobic ligand hexyl-agarose under conditions where the majority of the MIF itself was not retained. Some SDS co-eluted with MIF from AG1-X10, indicating that SDS binds to MIF. Furthermore, since SDS-treated MIF was retained by AG1-X2 and hexyl-agarose, at least some of the detergent’s polar and hydrophobic regions are located at the surface of the interferon mol.

Journal of Biological Chemistry published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

MacGregor, James T. published the artcileMetabolism and biliary excretion of phenanthridinium salts. I. Nature of the biliary metabolites, Quality Control of 518-67-2, the publication is Biochemical Pharmacology (1971), 20(10), 2833-46, database is CAplus and MEDLINE.

Up to 50% of the i.v. dose of phenanthridinium salts, 3,8-diamino-6-(p-aminophenyl)-5-methylphenanthridinium chloride (150C47) (I) [33779-70-3] 3,8-diamino-6-phenyl-5-ethylphenanthridinium bromide (ethidium) [518-67-2], and 2-amino-6-(p-carbethoxyaminophenyl)-5-methylphenanthridinium sulfate (carbidium) [32378-55-5] was excreted in the bile of rats with ligated renal pedicles within 1 hr postadministration. The major biliary metabolites were the resp. monoacetyl amino conjugates for I and ethidium and an acetyl conjugate for carbidium. Unchanged ethidium, carbidium and I accounted for 20-25, 20, and 15%, resp., of the biliary metabolites.

Biochemical Pharmacology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Quality Control of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grzadka, E. published the artcileAdsorption and elektrokinetic properties of the system: carboxymethylcellulose/manganese oxide/surfactant, Computed Properties of 518-67-2, the publication is Cellulose (Dordrecht, Netherlands) (2012), 19(1), 23-36, database is CAplus.

The adsorption of CM-cellulose (CMC) in the presence of the surfactants: anionic SDS, nonionic polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-Ph ether (Triton X-100) and their mixtures SDS/polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-Ph ether with different molar ratios (1:1; 1:3 and 3:1) from the electrolyte solutions (NaCl, CaCl₂) on the manganese dioxide surface (MnO₂) was studied. In every measured system the increase of CMC adsorption in the presence of surfactants was observed This increase was the smallest in the presence of SDS, a bit larger in the presence of polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-Ph ether and the largest when the mixtures of SDS/polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-Ph ether were used. Among the measured mixtures, the mixture of SDS/polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-Ph ether with the molar ratio 1:3 caused the largest increase of CMC adsorption amount These results are a consequence of formation of complexes between the CM-cellulose macromols. and the surfactant mols. In order to determine the electrokinetic properties of the system the surface charge d. of MnO₂ and the zeta potential measurements were conducted in the presence of the CMC macromols. and the surfactants. The obtained data showed that the adsorption of CMC or CMC/surfactants complexes on the manganese dioxide surface strongly influences the structure of the elec. double layer MnO₂/electrolyte solution

Cellulose (Dordrecht, Netherlands) published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Computed Properties of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nahakpam, Lokendrajit published the artcilePolymer-Supported Tribromide as a New Solid Phase and Recyclable Catalyst for the Synthesis of 2-(N-Arylamino)benzothiazoles Under Solvent-Free Microwave Irradiation Conditions, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Heterocyclic Chemistry (2015), 52(1), 267-272, database is CAplus.

The solid-phase synthesis of 2-(N-arylamino)benzothiazoles I (R¹ = H, 4-CH₃, 5-CH₃, 4-OCH₃; R² = H, 2-CH₃, 4-Cl, etc.) was achieved by reacting substituted thioureas with polymer-supported tribromide in high yield under microwave irradiation The method has several advantages such as short reaction time, good yields, and environmentally benign procedure. The catalyst could be recovered conventionally and reused at least four times without loss of its activity.

Journal of Heterocyclic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Application of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Barber, H. J. published the artcileTechnical preparation of dimidium bromide: a new phenanthridine synthesis, Application of Dimidium bromide, the publication is Journal of the Society of Chemical Industry, London, Transactions and Communications (1950), 82-96, database is CAplus.

The Morgan-Walls POCl₃ (I) cyclization of 4,4′-dinitro-2-benzamidobiphenyl (II) to 3,8-dinitro-6-phenylphenanthridine (C.A. numbering) (III) (cf. C.A. 42, 682a) involves the readily isolated intermediate 4,4′-dinitro-2-(α-chlorobenzylideneamino)biphenyl (IV), which cyclizes readily only in the presence of inorganic halide catalysts (V). A simpler method for the preparation of III is the V-catalyzed reaction of 4,4′-dinitro-2-aminobiphenyl (VI) and PhCCl₃. 3,8-Diamino-6-butoxy-6-phenyl-5-methyl-5,6-dihydrophenanthridine (VII) is valuable for the preparation of III salts. IV, prepared in 83% yield by adding 127 g. PCl₅ in 800 ml. PhCl to a stirred suspension of 148 g. II in 800 ml. PhCl at 125°, refluxing 15 min., distilling off I, and cooling, m. 157-8°; refluxing in PhNO₂ (VIII) with V until HCl evolution ceased gave III. The most effective V was I; results with a number of other V are reported. The concentration of V had little effect on the yields as long as it was above 0.02 mol.; the optimum temperature was 210°. III was converted to 3,8-dinitro-6-phenyl-5-methylphenanthridinium methosulfate (IX), m. 258-60°, in 88% yield by treating a VIII solution with Me₂SO₄ at 180° for 45 min.; another 10% was recovered from the crystallization mother liquors as 3,8-dinitro-6-phenyl-6-hydroxy-5-methyl-5,6-dihydrophenanthridine (X) by addition of 2 N NH₄OH. BzCl (368 ml.) was added during 10 min. to 777 g. VI in 3 l. VIII at 200°, the mixture held at 185-90° for 30 min., cooled to 130-40° by boiling under reduced pressure, 654 g. PCl₅ in 2 l. VIII at 120° added during 10 min., the mixture distilled to a solution temperature of 210°, 20 ml. SnCl₄ added, the mixture cooled to 190° after 2 hrs., 600 ml. Me₂SO₄ added, and the solution was poured after 45 min. at 180° into 4 l. cold H₂O, the VIII removed by steam distillation, and the residue treated with NaCl solution to precipitate 80% 3,8-dinitro-6-phenyl-5-methylphenanthridinium chloride. VI (259 g.), 1.5 l. VIII, and 500 ml. C₆H₆ were distilled to a solution temperature of 210°, cooled to 185°, 120 ml. BzCl added during 20 min., the mixture refluxed 15 min., cooled to 205°, 122 ml. I added, the mixture refluxed 2 hrs., the I distilled, 284 ml. Me₂SO₄ added to the residue at 190°, the temperature held at 175° for 45 min., the mixture poured into hot H₂O, the VIII steam-distilled, the residue diluted to 8 l., filtered, and the filtrate cooled to give 75% IX; the mother liquor with NH₄OH gave 20% X. IV was converted to 71% 2-(α-ethoxybenzylideneamino) analog, yellow crystals from EtOAc, m. 161-2°, with Na in alc. The HCl salt (XI) of N,N’-bis(4,4′-dinitro-2-biphenylyl)benzamidine (XII), prepared in 100% yield by heating 25.9 g. VI, 8 ml. PhCCl₃, and 1.2 ml. SnCl₄ in 120 ml. VIII for 90 min. at 170°, m. 247-50° (decomposition) (slow heating) or 365-70° (rapid heating); XII, prepared by crystallizing XI from C₅H₅N, m. 180-90° (with loss of solvent of crystallization), then at 248-50°. III, m. 273-4°, was prepared by adding 0.005 mol. V in 5 ml. VIII to 12.9 g. VI in 45 ml. VIII, adding 8 ml. PhCCl₃, refluxing 90 min., and cooling. 6-Phenylphenanthridine (XIII), m. 105-6°, and its 8-, m. 238-9°, and 2-nitro derivative, m. 239°, were similarly prepared in 46, 78, and 90% yields, resp. VII was prepared by adding 36 ml. SnCl₄ in 480 ml. PhCCl₃ during 40 min. to 777 g. VI in 3.5 l. boiling VIII, refluxing 1 hr., distilling off 540 ml. distillate, adding 570 ml. Me₂SO₄ to the residue at 190°, holding at 180° for 45 min., steam-distilling to remove the VIII, diluting the residue to 17 l., adding 2 N NaOH until the red pseudobase just began to fail to redissolve, filtering hot, adding at 80° to a boiling stirred suspension of 1413 g. reduced Fe in 9 l. H₂O, refluxing with stirring for 45 min., filtering, diluting to 29 l., adding 1.2 l. concentrated NH₄OH, reboiling, cooling, filtering, stirring with 2.8 l. BuOH, and adding enough 30% NaOH to make the aqueous layer 1.5 N; after 5 min., filtering and washing with H₂O, BuOH, and Et₂O gave 67% VII. VII was also prepared in 99.5% yield by reducing IX with reduced Fe and treating the product with BuOH and NaOH as above. The complex of XII with PhCl, methylated with Me₂SO₄ in VIII, gave 29% of the N-Me derivative, m. 344-5°; cyclization of this with PhCCl₃ and SnCl₄ in VIII gave III and 4,4′-dinitro-2-(N-methylbenzamido)biphenyl, m. 235-6°. VII (825 g.), 224 ml. 82.5% HBr, and 5.16 l. H₂O refluxed 30 min., 2.06 l. distilled off, and the residue boiled 5 min. with 16.5 g. charcoal and filtered gave 88.7% 3,8-diamino-6-phenyl-5-methylphenanthridinium bromide (“dimidium bromide”), m. 248° (decomposition). The chloride was prepared in 78% yield by refluxing 10 g. VII, 1.43 g. NH₄Cl, and 15 ml. H₂O 15 min., filtering, evaporating to 20 ml., cooling, and adding 295 ml. Me₂CO.

Journal of the Society of Chemical Industry, London, Transactions and Communications published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Application of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ford, E. J. H. published the artcileCellular damage and changes in biliary excretion in a liver lesion of cattle, HPLC of Formula: 518-67-2, the publication is Journal of Pathology and Bacteriology (1962), 39-48, database is CAplus and MEDLINE.

Liver lesions, produced in adult cattle only, by parenteral administration of dimidium bromide can be used to assess a number of tests of hepatic dysfunction. Symptoms of early histol. changes, as detected by liver biopsies, first appeared 30-40 days after injection, and were reflected by marked increases in the serum levels of glutamic-oxalacetic transaminase, lactic dehydrogenase, isocitric dehydrogenase, and glutamic dehydrogenase. The level of glutamic-pyruvic transaminase was unchanged. Significant changes in serum enzyme levels occur even when histol. demonstrable damage is slight. These serum enzyme levels are sensitive indicators of early and mild hepatocellular damage. The later stages of hepatic lesion (40-50 days after injection) are accompanied by a fall in the rate of Bromsulphalein excretion. The phylloerythrin retention which was observed is likely to have been the underlying cause of the photosensitization observed in the original dimidium intoxication in Africa.

Journal of Pathology and Bacteriology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, HPLC of Formula: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dymock, Brian W. published the artcileNovel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Medicinal Chemistry (2005), 48(13), 4212-4215, database is CAplus and MEDLINE.

The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of mol. chaperone Hsp90 has been used to design 5-amide analogs. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clin. evaluated 17-AAG.

Journal of Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Balthazar, Zsolt published the artcileTwo-phase titration of anionic surfactants, I. Study of the transition point of the titration carried out according to ISO 2271, Formula: C20H18BrN3, the publication is Magyar Kemiai Folyoirat (1977), 83(7), 294-7, database is CAplus.

Some properties of the Disulphine Blue [64366-33-2]-dimidium bromide [518-67-2] indicator system, prescribed by the international standard, were examined by UV-visible spectrometry. The dyes appeared in the CHCl3 phase only in the presence of an oppositely charged surfactant. In the modeling of practical end-points, the absorbance of the CHCl3 phase was markedly influenced by the presence of an anionic or cationic surfactant. The titration end-point determined photometrically using the 2 indicators was identical within exptl. error.

Magyar Kemiai Folyoirat published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Formula: C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mozhenok, T. P. published the artcileEffects of some DNA-intercalators and antioxidative compounds on the phagosome-lysosome fusion and F-actin content in murine peritoneal macrophages, Product Details of C20H18BrN3, the publication is Tsitologiya (1998), 40(6), 585-590, database is CAplus.

Effect of DNA-intercalators ethidium bromide (EB, 0.005 and 0.015 mM) and dimidium bromide (DB, 0.005 and 0.010 mM) and antioxidative compounds acetylsalicylic acid (ASA, 0.05 and 0.50 mM) and β-carotene (0.01, 0.02, 0.05 mM) on the phagosome-lysosome (P-L) fusion and F-actin content in murine peritoneal macrophages were studied. EB, DB, ASA and β-carotene were found to stimulate P-L fusion and the effect depending on the concentration of compounds tested. The strongest influence was evoked by 0.5 mM of ASA and 0.05 mM of β-carotene. The compounds tested enhanced F-actin content in macrophages, especially by the action of β-carotene (0.05 mM). The obtained data indicate a correlation between P-L fusion stimulation and F-actin content under the influence of compounds tested in murine peritoneal macrophages.

Tsitologiya published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Product Details of C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary