Tag: M.W=300-400

Adding some certain compound to certain chemical reactions, such as: 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 955959-84-9. 955959-84-9

474 mg (1.00 mmol) of Intermediate (F), 388 mg (1.20 mmol) of 4-(4-bromophenyl)dibenzo[b,d]furan, 91.6 mg(0.100 mmol) of Pd2(dba)3, 100 mL (50percent in toluene, 0.200 mmol) of tri-tert-butylphosphine (ttbp), and 192 mg (2.00mmol) of sodium tert-butoxide were added to 10 mL of xylene, and then, the mixture was heated at a temperature of145¡ãC while stirring. When the reaction stopped, the reaction product was cooled to room temperature and then subjectedto silica gel to perform filtering under a reduced pressure, and the filtration solution was concentrated under a reducedpressure. The product was subjected to silica gel column chromatography (ethylacetate: n-hexane = 1: 4 volume tovolume). The product was refined by recrystallization using toluene/methanol to obtain 537 mg (yield of 75percent) of Compound3 as a target compound. LC-Mass (calculated: 716.26 g/mol, found: M+1 = 717 g/mol)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4-(4-Bromophenyl)dibenzo[b,d]furan.

Reference:
Patent; Samsung Electronics Co., Ltd; Samsung SDI Co., Ltd.; Jung, Yongsik; Son, Jhunmo; Lee, Seungjae; Kim, Youngkwon; Kim, Hyungsun; Chung, Yeonsook; EP2878599; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 53592-10-2, name is 2,4-Dibromo-1,1′-biphenyl, molecular formula is C12H8Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 53592-10-2.

General procedure: 10.0 g (81.4 mmol) of pyridine-3-boronic acid (CAS No.: 1692-25-7), 29.2 g (81.4 mmol) of 2-bromo-3′-iodobiphenyl (CAS No.: 1776936-09-4) and 93 ml of an aqueous 2 M Na2CO3 solution (186 mmol) are suspended in 75 ml of ethanol and 120 ml of toluene. To this suspension is added 0.94 g (0.82 mmol) of tetrakis(triphenyl)phosphinepalladium(0). The reaction mixture is heated under reflux for 16 h. After cooling, the organic phase is removed, filtered through silica gel, washed three times with 150 ml of water and then concentrated to dryness. After the crude product has been filtered through silica gel with heptane/ethyl acetate, 19 g (79%) of 3-(2′-bromobiphenyl-3-yl)pyridine are obtained.

The synthetic route of 2,4-Dibromo-1,1′-biphenyl has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Patent GmbH; WIRGES, Christian; MUJICA-FERNAUD, Teresa; MONTENEGRO, Elvira; VOGES, Frank; MAIER-FLAIG, Florian; EBERLE, Thomas; (167 pag.)US2020/55822; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary