Tag: M.W=300-400

955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 955959-84-9

General procedure: 26.8 g (100 mmol) of 8H-quino[4,3,2-kl]acridine [111180-95-5], 35.6 g (100 mmol), 5?-iodo-1,1:3?,1?-terphenyl [87666-86-2], 27.6 mg / g (200 mmol) of potassium carbonate, 28.4 g g (200 mmol) of sodium sulfate, copper powder of 1.3gg (20mmol), Glass Beads (Diameter: 3 mm) And a mixture of 300 ml of nitrobenzene is heated under reflux while stirring well for 16 hours under reflux. After cooling down, Add 1000 ml of methanol, Suction and filter the solid, Wash 3 times with 300 ml of methanol each time. This solid is extracted from 1000 ml of water by stirring with high temperature. After suction filtration, Wash every 2 times with 200 ml of hot water each time. After washing 3 times with 200 ml of methanol each time, Dry under reduced pressure. The resulting crude product is o-xylene (initial dose: 250 ml) 5 times a high temperature extract, Next, 2 times fractional sublimation (p is about 10-5 mbar, T about 310 C). Yield: 28.3 mug g (57 mmol), 57%; Purity: 99.99% by HPLC.

Statistics shows that 955959-84-9 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)dibenzo[b,d]furan.

Reference:
Patent; Merck Patent GMBH; Syu Toe-ssel-pil-rip; Pa Reu-ham-a-mi-reu; Yo Syu-ten-do-mi-ni-keu; Ru De-mang-o-rel-ri; Geu Ro-sseu-man-to-bi-a-seu; Keu Roe-beo-yo-na-seu; (57 pag.)KR2019/86028; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows., 955959-84-9

Under nitrogen environment (N2 purging), Compound H was dissolved in tetrahydrofuran and then 1.2 equivalents of n-butyllithium were added slowly at -78 C. The reaction mixture was stirred at -78 C for 1 hour, and then the reaction mixture was stirred at room temperature for 2 hours.Again the reaction mixture was cooled to -78 trimethyl borate was added and slowly raised to room temperature and stirred for 2 hours. HCl (5.0%) diluted in the reaction mixture was slowly poured and stirred for 1 hour while maintaining the pH between 5 and 6, and then extracted with dichloromethane. The organic layer was extracted with brine and DI water, and then water was removed with MgSO 4. After removing the organic solvent, compound I was obtained.

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Reference:
Patent; LG Display Co., Ltd.; Yoon Gyeong-jin; Noh Hyo-jin; (33 pag.)KR2019/63923; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows., 10016-52-1

30.0 g (92.03 mmol) of 2,8-dibromodibenzo [b, d] furan, 25.1 g (184.06 mmol) of 1- (3-hydroxyphenyl) ethanone in a 500 mL reactor,1.8 g (9.20 mmol) of iodo copper,1,10-phenanthroline 3.3 g (18.41 mmol),Add 38.2 g (276.09 mmol) of anhydrous potassium carbonate, add 400 ml of N, N-dimethylformamide and stir at reflux for 24 hours under a nitrogen atmosphere.After completion of the reaction, extracted with ethyl acetate, distilled water,Filtered by anhydrous magnesium sulfate,Purified by silica gel chromatography, 20.9 g (52% yield) of an intermediate compound [2-1] as an off-white solid were prepared

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Teuri L Co., Ltd.; Kang Ji-seung; Moon Bong-seok; Jin Seong-min; Hong Won-gi; Ha Min-su; Lee Gyu-seong; Jin Sang-jun; Park No-gil; Lee Hyeon-u; Byun U-geun; (50 pag.)KR2019/139404; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

344-03-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 344-03-6 as follows.

Unitine , 4 -bromotetrafluorobenzene, 0.11 muM 1 unitunitunito-cyanophenylboronic acid 0.1 muM 4 – 0 . 001molPd under a nitrogen atmosphere2(Dba)3Unitunitunits, 0.002 muM s-phos, 0 . 2molK3PO4The unitz reacted 300 ml 12h. 100 ml was found in a mixed solution consisting of unit_transformants ‘-type 100 C’-type ‘.’. Obtained M1

According to the analysis of related databases, 1,4-Dibromotetrafluorobenzene, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Tsinghua University; Duan Lian; Zhang Dongdong; Song Xiaozeng; Gao Wenzheng; Huang Xinxin; (33 pag.)CN110066227; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 344-03-6, name is 1,4-Dibromotetrafluorobenzene, molecular formula is C6Br2F4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 344-03-6.

A mixture of 5,5′-bis(tri-n-butylstannyl)-2,2′-dithiophene (4.62 g, 4.87 mmol), 1,4-dibromoperfluorobenzene (6.00 g, 19.48 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.12 g, 0.10 mmol) in dry DMF (20 mL) was deareated twice with nitrogen. The reaction mixture was then heated at 85¡ã C. for 20 h during which time a precipitate formed. After cooling, the orange solid was collected and washed several times with hexane and ether to afford the crude product which was purified by gradient sublimation (2.14 g, 3.42 mmol, 70.2percent yield). M.p. 231¡ã C. 1H NMR (CDCl3) delta 7.60 (2H, d, 2J=4.1), 7.34 (2H, d); 19F NMR (CDCl3) delta -133.58 (4F), -138.56 (4F). Anal. Calcd for C20H4Br2F8S2: C, 38.72; H, 0.65; F, 24.51. Found: C, 38.75; H, 0.78; F, 24.29.

The synthetic route of 1,4-Dibromotetrafluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Marks, Tobin J.; Facchetti, Antonio; US2008/293937; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

10016-52-1, A common compound: 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

In a nitrogen atmosphere, a flask containing 2,8-dibromodibenzo[b,d]furan (2.5 g), (10-phenylanthracen-9-yl) boronic acid (5.7 g), Pd-132 (0.27 g), tetrabutylammonium bromide (0.25 g), potassium carbonate (3.2 g), water (10 ml), and toluene (100 ml) was stirred at a reflux temperature for two hours. The reaction liquid was cooled to room temperature and subjected to liquid separation. The obtained organic layer was washed with water. This solution was decolorized using silica gel and concentrated under reduced pressure. The precipitated solid was washed with heptane to obtain compound (2A-201) (2.5 g). The structure of the compound thus obtained was identified by an NMR analysis. 1H-NMR (400 MHz, CDCl3):delta=8.06?8.05 (m,2H), 7.93?7.90 (m,2H), 7.77?7.70 (m,8H), 7.65?7.55 (m,8H), 7.55?7.47 (m,4H), 7.36?7.31 (m,8H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kwansei Gakuin Educational Foundation; JNC Corporation; HATAKEYAMA, Takuji; TAJIMA, Akio; BABA, Daisuke; FUJITA, Yukihiro; YAMAGA, Yuko; IMAI, Hiroyuki; (139 pag.)US2019/312207; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 955959-84-9

To a 250 mL round bottom flask was added 4-phenylaniline (1.80 g, 10.64 mmol), D1 (3.78 g, 11.70 mmol), Tris (dibenzylideneacetone) dipalladium (0) (0.15 g, -Bis (diphenylphosphino) -1,1′-binaphthalene (BINAP) (0.20 g, 0.32 mmol) and sodium tert-butoxide (1.43 g, 14.89 mmol) were dissolved in toluene (100 mL) After completion of the reaction, the reaction mixture was stirred for 24 hours. Toluene was removed, and the residue was extracted with dichloromethane and water. The residue was subjected to vacuum distillation. The silica gel column was distilled under reduced pressure to obtain Compound D2 (3.05 g, 7.41 mmol).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 955959-84-9.

Reference:
Patent; LG Display Co., Ltd.; Lee Seung-jae; Pin Jong-gwan; Seo Bo-min; Ryu Yeong-ju; (41 pag.)KR2018/60582; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 558-13-4, name is Carbontetrabromide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 558-13-4

To an ice cold solution of the hexanol (ca. 19.8 mmoles) and carbon tetrabromide (21.98 mmoles) in methylene chloride (50 ml) was added triphenylphosphine (22.30 mmoles) in methylene chloride (50 ml) and the resulting solution was stirred for 2.5 hours. The volatiles were evaporated and the residue was taken up in ether (100 ml), cooled in ice, and filtered The filtrate was evaporated and distilled to afford 6-phenylhexyl bromide as an oil.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 558-13-4.

Reference:
Patent; SmithKline Beckman Corporation; US4730005; (1988); A;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52997-43-0, name is 7-(Bromomethyl)pentadecane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The general procedure (Table 1, entry 5 and 6) for the synthesis of alkylation of aniline (N-alkylation) and phenol (O-alkylation) is as follows. A two neck flask with a three-way stopcock and a rubber septum was charged with aniline (4 mmol, 0.373 g), 1-bromododecane (15 mmol, 3.74 g), K2CO3 (8 mmol, 1.11 g) and dry DMF (3.0 mL). The flask was heated at 120 C overnight. The first posttreatment: After checking of TLC and 1H NMR spectrum (Figure S3(a)), KOtBu (12 mmol, 1.346 g) was added to the flask at room temperature, then the mixture was heated to reflux overnight. The reaction was quenched by the addition of sat. NH4Cl aqueous solution, extracted into CH2Cl2 (50 ¡Á 3 mL), washed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the reaction mixture (including target dialkylated aniline and corresponding olefin, Figure S3(b)).The second posttreatment: Since the N-alkylation was almost quantitative reaction, the expected amount of olefin in the mixture was equal to the excess amount of starting alkylhalide (7.0 mmol in the above case). It could be assumed that 7.0 mmol of olefin should be treated with the small excess of 9-BBN (10.5 mmol, 1.5 eq vs olefin). A two neck flask with a three-way stopcock and a rubber septum was charged with the above reaction mixture and dry THF (20 mL). 0.5 M 9-BBN in THF (10.5 mmol, 21 mL) was added to the flask at 0 C and then the flask allowed to warm to room temperature and stirred for one hour. To quench the remaining 9-BBN in the reaction, aminoalcohol (2-dimethylaminoethanol, 4.5 mmol, 0.405 g) was added to the flask and stirred for another one hour. The final reaction mixture was quenched by the addition of water (5 mL), extracted into EtOAc (50 ¡Á 3 mL), washed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the crude mixture (Figure S5(a)). The third post-treatment: The crude product was purified by short silica-gel column chromatography (5 cm (diameter of column) ¡Á 10 cm (length of deposition of silicag-gel was enough for this scale) with n-hexane as eluent to give the dialkylated aniline (Figure S5(b)).

The synthetic route of 7-(Bromomethyl)pentadecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Okamoto, Ken; Lu, Fengniu; Nakanishi, Takashi; Bulletin of the Chemical Society of Japan; vol. 91; 8; (2018); p. 1258 – 1263;,
Bromide – Wikipedia,
bromide – Wiktionary

955959-84-9, A common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, molecular formula is C18H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 1) d.) 500 mg (1.55 mmol) 4-(4-bromophenyl)dibenzofuran, 760 mg (1 .70 mmol) 2-(9H-carbazol-3- yl)-6-phenyl-benzimidazolo[1 ,2-a]benzimidazole, 990 mg (4.64 mmol) potassium phosphate tribasic, 60 mg (0.31 mmol) copper iodide in 10 ml dioxane are stirred under nitrogen at 100¡ãC. 1.24 g (36.1 mmol) cis, trans 1 ,2-diaminocyclohexane are added. The reaction mixture is stirred for 48 h. The reaction mixture is poured in methanol. The product is filtered off and is washed with water, methanol 10 percent tatraic acid. Column chromatography on silica gel with chloroform gives the product. Yield 690 mg (65 percent) MS (APCI(pos), m/z): 691 (M+1).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; SCHAeFER, Thomas; KAWAMURA, Masahiro; NAGASHIMA, Hideaki; (314 pag.)WO2017/56052; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary