Tag: M.W=300-400

10016-52-1, Adding some certain compound to certain chemical reactions, such as: 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10016-52-1.

13.04 g of 2,8-dibromodibenzofuran, 6.77 g of diphenylamine, 0.180 g of palladium(II) acetate, 4.610 g of sodium t-butoxide, and 700 ml of xylene were loaded into a 1-1 three-necked flask, and 32 ml of a 0.1-mol/l solution of tri-t-butylphosphine in xylene were slowly dropped into the flask while the mixture was stirred with a stirrer. Then, a nitrogen atmosphere was established in the container, and the resultant mixture was subjected to a reaction at 110C for 7.5 hours. After that, the resultant was subjected to each of a separation treatment and purification by column chromatography three times. As a result, 10.23 g of a white solid were obtained. The solid was identified as Intermediate 24 by FD-MS.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10016-52-1.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2159217; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, The chemical industry reduces the impact on the environment during synthesis 52997-43-0, name is 7-(Bromomethyl)pentadecane, I believe this compound will play a more active role in future production and life.

In a two-necked RBF (100 mL), compound 3 (3.34 g, 10 mmol), KOH(2.81 g, 50 mmol) and KI (0.17 g, 1 mmol) were mixed in the dry THF(50 mL). The mixture was degassed with N2 flow for 20 min, and 1-bromo-2-hexyldecane (3.66 g, 12 mmol) was added. The solution wasstirred at 65 C for 12 h under N2 before it was cooled to room temperature.The organic layer was extracted with DCM and dried overNa2SO4, and the solvent was removed by rotary evaporation. The residuewas purified by silica gel chromatography (PE as the eluent) toyield the yellow viscous liquid (5.14 g, 92%). 1H NMR (400 MHz,CDCl3) delta 7.54 (d, J=8.4 Hz, 1H), 7.47 (s, 1H), 7.25 (m, 3H), 7.08 (s,1H), 7.06-7.04 (m, 1H), 4.05 (d, J=7.5 Hz, 2H), 2.04 (s, 1H),1.29-1.23 (m, 24H), 0.89-0.84 (m, 6H). 13C NMR (100 MHz, CDCl3) delta145.81, 142.05, 139.07, 138.47, 127.99, 124.58, 123.70, 122.37,120.57, 119.80, 115.82, 114.62, 113.05, 107.11, 49.77, 38.29, 31.86,31.78, 31.62, 29.90, 29.70, 29.58, 29.51, 29.27, 26.38, 26.35, 22.65,22.62, 14.09, 14.06. MALDI-TOF-MS (m/z) 559.27 for [M]+.

The chemical industry reduces the impact on the environment during synthesis 52997-43-0. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhou, Xingbao; Lu, Jurong; Huang, Hongyan; Yun, Yikai; Li, Zhaoning; You, Fei; Zhao, Baomin; Qin, Tianshi; Gao, Deqing; Huang, Wei; Dyes and Pigments; vol. 160; (2019); p. 16 – 24;,
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201138-91-2, Adding some certain compound to certain chemical reactions, such as: 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 201138-91-2.

In a innert atmoshphere pubchem (http://pubchem.ncbi.nlm.nih.gov/) 4,6-dibromodibenzofuran(4,6-dibromodibenzofuran) 100g (307mmol) in dimethylformamide (DMF) and then dissolved in 0.9 L, here bis(pinacolato)diboron (bis (pinacolato)diboron) 78.0g (307 mmol) and (1,1′-bis (diphenylphosphine) ferrocene) palladium dichloride (II) (1,1′-bis (diphenylphosphine) ferrocene) dichloropalladium (II)), 2.51g (3.07 mmol), potassium acetate and 90.4g (921 put mmol) was heated to reflux at 100 for 3 hours. After the reaction was completed, the reaction solution into water and then filter the mixture, and dried in a vacuum oven. Thus the resulting residue was separated and purified by flash column chromatography gave Compound I-2 56.1g (49%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 201138-91-2.

Reference:
Patent; Cheil Industries Co., Ltd.; Lee, Han Ir; Sin, Ji Hun; Yu, Dong Gyu; Gyu, Uhn Sun; Han, Su Jin; Hong, Jin Suk; (33 pag.)KR2015/83385; (2015); A;,
Bromide – Wikipedia,
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Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 201138-91-2

General procedure: The triolborate, dibromides (0.2 mmol), Pd(PPh3)4 (10 mol %), and K2CO3 (2 equiv) were placed in flask under an atmosphere of nitrogen. DMF (15 mL) was added, and heated at 80 C for 14 h. After cooling to room temperature, 15 mL water was added, extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on silica gel.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 201138-91-2, its application will become more common.

Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, Adding some certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0.

General procedure: General procedure for the synthesis of a1-a6: To a solution of indoline-2,3-diones (10 mmol) in DMF (40 mL) was added K2CO3(15 mmol, 2.073 g) and 7-(bromomethyl)pentadecane (11 mmol,3.358 g) under nitrogen. The mixture was stirred at 70 C and monitoredby TLC. After the reaction completed, water was added, andextracted with EtOAc. The organic layer was combined and dried withMgSO4. After evaporation of the solvent, the residue was purified bycolumn chromatograph (eluent: Petroleum/EtOAc=20:1) to give thetarget compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Article; Hu, Qian; Jiang, Hua; Cui, Zhihua; Chen, Weiguo; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Adding some certain compound to certain chemical reactions, such as: 615-54-3, name is 1,2,4-Tribromobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 615-54-3. 615-54-3

Under a nitrogen stream, 16.9 g (0.10 mol) of Exemplified Compound 1-1 was dissolved in 390 m of dehydrated THF, adjusted to -5 C. with an ice-water bath, and 59.4 ml of 1.6M nBuLi (¡Á 0.95 mol ratio to Exemplified Compound 1). -1) was added dropwise for 10 min (the water content of THF was measured by a coulometric titration method and found to be 15 ppm. This corresponds to 3.25 ¡Á 10 -4 mol of water molecules and a corresponding amount of 1.6 M nBuLi solution 0 20 ml was added as a correction amount.) After stirring for 1 hour, 18.6 g of Exemplified Compound 2-7 was added dropwise over 10 min and stirred for 1 hour.During this time, the internal temperature was -10 C to 5 C.480 ml of THF, exemplary compound 4-5A solution prepared by dissolving 9.5 g and 16.8 g of potassium carbonate in 30 ml of pure water was added in this order, and nitrogen bubbling was performed for 20 minutes. To this suspension, 2.7 g of Pd (dba) 2 and 1.8 g of Exemplified Compound 10-1 were added and refluxed for 6 hours. After washing with saturated brine, the solvent was distilled off under reduced pressure. Recrystallization from cyclohexane gave 14.2 g of gray crystals (yield 81%, purity 99.3%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,2,4-Tribromobenzene.

Reference:
Patent; Konica Minolta Co., Ltd.; Sugita, Shuichi; Okubo, Kimihiko; Nishimura, Hiroshi; Hagiwara, Toshiyuki; (38 pag.)JP2019/99537; (2019); A;,
Bromide – Wikipedia,
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201138-91-2, The chemical industry reduces the impact on the environment during synthesis 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

Add 32.4g (100mmol) 4,6-dibromodibenzothiophene and 112.8g (300mmol) 2-formylbenzeneboronic acid to a freshly dried 3000mL two-necked bottle, add 62.1g (450mmol) under nitrogen protection Anhydrous potassium carbonate, 6.9 g (6 mmol) of tetratriphenylphosphine palladium, and 225 mL of water and 1500 mL of 1,4-dioxane. After the reaction, the temperature was lowered to room temperature, and the solvent of the reaction system was distilled off under reduced pressure. The crude product was dissolved in 500 mL of dichloromethane and washed with a large amount of water. The organic phase was dried over anhydrous sodium sulfate and concentrated. Dichloromethane: petroleum ether = 1: 1 was used as the eluent for column chromatography to obtain 30 g of off-white solid with a yield of 80%.

The chemical industry reduces the impact on the environment during synthesis 4,6-Dibromodibenzo[b,d]furan. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Wei Jinbei; Li Guomeng; Gao Wenzheng; Sun Lei; (35 pag.)CN110878054; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 10016-52-1

Example 1.11.15 9-(4′-(8-bromodibenzo[b,d]furan-2-yl)-[1,1′-biphenyl]-4-yl)-9H-carbazole (Compound 15) A mixture of 9-(4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-4-yl)-9H-carbazole (1.75 g, 4.42 mmol), 2,8-dibromodibenzo[b,d]furan (2.52 g, 7.74 mmol), tetrakis(triphenylphosphine) palladium(0) (0.25 g, 0.22 mmol), potassium carbonate (1.83 g, 13.26 mmol), 1,4-dioxane (40.00 mL), and water (8.00 mL) was degassed with bubbling argon for 30 minutes. The reaction mixture was then heated to 80 C. and was stirred overnight (16.5 hours), maintaining an argon atmosphere. Consumption of the starting material was confirmed by thin-layer chromatography and the reaction was cooled to room temperature. The product was extracted with dichloromethane, dried, and purified by silica gel column chromatography with dichloromethane in hexanes as the eluent. The product fractions were then dried and the product was collected to yield Compound 15 (1.09 g, 44%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10016-52-1.

Reference:
Patent; NITTO DENKO CORPORATION; Zheng, Shijun; (40 pag.)US9425408; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

201138-91-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below.

40.0 g (4-(9-phenyl-9H-carbazole-3-)phenyl) boric acid and 32.6 g 4,6-dibromo-dibenzofuran were added into a 2 L three-neck flask, followed by adding 700 mL toluene and 150 mL ethanol to dissolve. The reaction mixture was aerated with nitrogen gas for 15 minutes, then 150 mL aqueous K2CO3 solution (3.0 eq., 2M) and 2.3 g Pd(PPh3)4 (2 mol %) were sequentially added. The reaction mixture was heated up to 110 C. and reacted overnight. After the reaction finished, the residual was absorbed by the added activated carbon, filtered by suction filtration and removed with solvent by rotary evaporation, followed by drying and recrystallization with a mixture of toluene and ethanol, to produce 48.0 g Intermediate (52) at a yield of 85%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NANJING TOPTO MATERIALS CO.,LTD.; KIM, JIN WOO; QIAN, CHAO; GAO, PENGHUI; WANG, XIAOWEI; (157 pag.)US2018/105534; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., 10016-52-1

A single-mouth flask was taken, 3.26 g of 3,6-dibromodibenzothiophene was added, sealed and vacuum-dried with nitrogen three times, and 100 mL of anhydrous tetrahydrofuran (THF) was dissolved and dissolved under a nitrogen atmosphere.The device was then placed in a dry ice/acetone bath at -78 C for 15 min.13.75 mL of a n-hexane solution of n-butyllithium was weighed using a syringe.The mixture was added dropwise to a reaction flask, and reacted at -78 C for 1.5 h under a nitrogen atmosphere to obtain a reaction system.3.74 mL of diphenylphosphonium chloride was added to the reaction system, and the mixture was allowed to react at room temperature for 12 hours.The reaction solution was quenched with 50 mL of water and extracted with 3¡Á50 mL of dichloromethane.The organic phase was collected and dried over anhydrous sodium sulfate. The dichloromethane solution was spun off using a rotary evaporator.The crude product was then dissolved in 50 mL of dichloromethane, silica gel powder was added and the solvent was dried.Purification by chromatography gave an arylphosphine derivative. The obtained arylphosphine derivative and 0.6 gThe sulfur powder was dissolved in a dichloromethane solution and allowed to react at room temperature overnight.The dichloromethane solution was spun off using a rotary evaporator. Then the crude product was dissolved to 50 mLAdd silica gel to the dichloromethane and spin dry the solvent.Purification by chromatography gave 1.91 g of a white solid.The yield was 37.1%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing University of Posts and Telecommunications; Tao Ye; Li Huanhuan; Jiang Yunbo; Zhi Yibin; Chen Runfeng; Huang Wei; (11 pag.)CN109912654; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary