Tag: M.W=300-400

Related Products of 615-54-3, These common heterocyclic compound, 615-54-3, name is 1,2,4-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) Synthesis of 2-bromo-N1,N1,N4,N4-tetraphenylbenzene-1,4-diamine 14.74 g of a product (yield: 60%) was obtained in the same manner as described in the synthesis method of intermediate 2-1 except that 1,2,5-tribromobenzene (15.74 g, 50 mmol), diphenylamine (16.92 g, 100 mmol), Pd2(dba)3 (2.75 g, 3 mmol), PPh3 (2.62 g, 10 mmol), NaOt-Bu (28.83 g, 300 mmol), and toluene (525 mL) were used.

The synthetic route of 615-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DUKSAN HIGH METAL CO., LTD.; US2012/217492; (2012); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 72678-19-4, name is 2,6-Dibromo-4-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H4Br2F3N

A mixture of 2,6-dibromo-4-trifluoromethylaniline (manufactured by Wako Pure Chemicals, 0.78 g, 2.45 mmol) and 95% sulfuric acid (1.5 mL) was cooled to an internal temperature of 0 C., and 40% nitrosylsulfuric acid (0.85 g, 2.67 mmol) was dropwise added thereto at the internal temperature kept at 0 C. This was stirred for 1 hour at an internal temperature of from -2 C. to 0 C., and with cooling with ice, this was poured into 5 mL of ice in water to give a diazo liquid. In a separate vessel, the intermediate A-1 (1.00 g, 2.67 mmol) was dissolved in acetic acid (2 mL), and dropwise added to the resultant diazo liquid at an internal temperature of 0 C. or lower. After the addition, this was left at 0 C. for 1 hour, then extracted with toluene, and the toluene layer was washed with water and saturated saline water, and dried with anhydrous sodium sulfate. This was concentrated under reduced pressure, and purified through silica gel column chromatography to give an intermediate C-1 (0.33 g, yield 19%) as a reddish tar-like substance.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MITSUBISHI CHEMICAL CORPORATION; SHIGA, Yasushi; AOBA, Mitsuya; TANAKA, Yuki; ISHIDA, Mio; US2015/191601; (2015); A1;,
Bromide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1347736-74-6, Computed Properties of C6HBr2FN2S

To a solution of 3-hexylthiophene (1) (5 g, 29.0 mmol) in anhydrous 40 mL of THF was added n-BuLi (1.6 M in hexane) (21.8 mL, 34.8 mmol) over 30 min at -40 C under argon atmosphere. After stirring for 1 h at room temperature, the reaction mixture was treated with dropwise addition of tributyltin chloride (9.9 mL, 36.3 mmol) at -40 C, followed by stirring at RT overnight. The mixture was poured into saturated NaHCO3 solution and the organic phase was extracted with diethyl ether and washed with water. The organic phase was dried over MgSO4 and solvent was removed under reduced pressure. Tributyl-(4-hexyl-2-thienyl)stannane (2) as yellow liquid was acquired and used in the next step without further purification. The solution of compound 5 (3.0 g, 9.7 mmol) and compound 2 (9.7 g, 29.0 mmol) in anhydrous 10 mL of THF was treated with Pd(PPh3)2Cl2 (5 mg, 0.05 mmol). After stirring for overnight at 100 C under argon atmosphere, the reaction mixture was concentrated under reduced pressure and purified by flash column chromatography to give compound 6, 0.9 g (19%). 1H NMR (300 MHz, CDCl3): delta (ppm) 8.1 (s, 1H), 8.0 (s, 1H), 7.75 (d, 1H, J = 12.9 Hz), 7.16 (s, 1H), 7.10 (s, 1H), 2.71 (t, 2H, J = 7.00 Hz), 2.68 (t, 2H, J = 7.00 Hz), 1.60-1.78 (m, 4H), 1.51-1.21 (m, 12H), 0.93 (t, 6H, J = 7.00 Hz), 0.91 (t, 3H, J = 7.1 Hz); 13C NMR (75 MHz, CDCl3): delta (ppm) 160.4, 157.0, 153.3 (d, 3JC-F = 10.4 Hz), 149.6, 144.4, 143.4, 137.5, 132.3 (d, 5JC-F = 5.7 Hz), 131.4 (d, 4JC-F = 8.1 Hz), 125.6 (d, 3JC-F = 10.4 Hz), 125.6 (d, 1JC-F = 255.4 Hz), 122.9 (d, 4JC-F = 7.0 Hz), 116.5 (d, 2JC-F = 33.6 Hz), 111.0 (d, 2JC-F = 17.3 Hz), 31.8, 30.6, 30.5, 30.4, 29.1, 28.3, 26.8, 22.7, 17.3, 14.2, 13.7.1. HRMS (m/z, EI+) calcd for C26H31FN2S3 486.1633 found 486.1635.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jeong, Ina; Chae, Sangmin; Yi, Ahra; Kim, Juae; Chun, Ho Hwan; Cho, Jung Hyeong; Kim, Hyo Jung; Suh, Hongsuk; Polymer; vol. 109; (2017); p. 115 – 125;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 344-03-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-03-6, name is 1,4-Dibromotetrafluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

A procedure similar to that used for the synthesis of compound 5a was followed. 5.03 g (16.3 mmol) of 1,4-dibromotetrafluoro benzene, 0.3774 g (0.33 mmol) of Pd[P(C6H5)3]4, 42.5 mL of an aqueous Na2CO3 2 M solution, and 2 g (6.53 mmol) of 4-dodecyloxyphenylboronic acid. Two products were obtained as white crystals: T4F (yield 22.8%) and 5b (yield 40%). 5b: 1H NMR (CDCl3, delta = ppm) 0.88 (t, CH3, 3H, J = 6.9 Hz), 1.22-1.52 (m, CH2, 18 H), 1.8 (m, O-CH2-CH2, 2 H), 4.02 (t, O-CH2-CH2, 2H, J = 6.5 Hz), 7.0 (d, Ar, 2H, J = 8.8 Hz), 7.38 (d, Ar, 2H, J = 8.8 Hz).

The chemical industry reduces the impact on the environment during synthesis 1,4-Dibromotetrafluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Valdes-Pech, Moises Alberto; Larios-Lopez, Leticia; Rodriguez-Gonzalez, Rosa Julia; Felix-Serrano, Isaura; Trejo-Carbajal, Nayely; Navarro-Rodriguez, Damaso; Journal of Fluorine Chemistry; vol. 218; (2019); p. 42 – 50;,
Bromide – Wikipedia,
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Application of 126930-72-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 126930-72-1 as follows.

A Schlenk tube was charged with Pd2dba3 (3.0 mg,0.32¡Á10-2 mmol, 8 mol%) and Xphos (3.1 mg, 0.65¡Á10-2 mmol, 16 mol%) in degassed toluene (2 mL). The reaction medium was heated under argon at 60 C for 10 min. To the violet solution was added, under a positive stream of argon, CLM1 (35 mg, 0.04 mmol, 1 eq.), 1-bromo-4-dodecylbenzene 2a (26 mg, 0.08 mmol, 2 eq.), and sodium-tert-butoxide(12 mg, 0.12 mmol, 3 eq.) in 2 mL of degassed toluene. The reaction mixture was heated at 95 C for 24 h. The solvent was evaporated under reduced pressure and the resulting mixture was extracted with DCM from a saturated aqueous solution of NaHCO3 (100 mL). The organic phase was washed with H2O (3¡Á100 mL), The desired product was purified by silica gel column chromatography with DCM/hexane (40:60 v/v) as eluent. Red solid (50 mg, 93%) 1H NMR (600 MHz, CD2Cl2, ppm): delta 7.56 (d, 4H, J=7.8 Hz, ArH), 7.12 (d, 8H, J=7.8 Hz,ArH), 7.03 (d, 12H, J=7.8 Hz, ArH), 2.95 (br, 12H, cyclohexyl-CH2,s),2.60 (t, 4H, J=7.8 Hz, CH2-(CH2)10CH3), 2.35 (s, 6H, CH3,s), 1.85 (br,12H, cyclohexyl-CH2,s), 1.65 (m, 4H, CH2-CH2(CH2)9CH3), 1.33 (m,36H, CH2-CH2(CH2)9CH3), 0.95-0.92 (m, 6H, CH2-CH2(CH2)9CH3); 13CNMR (150 MHz, CD2Cl2, ppm): delta 152.29, 148.39, 146.39, 146.29,137.39, 133.07, 132.63, 130.26, 129.57, 124.84, 124.55, 123.04,35.88, 32.53, 32.23, 30.28, 30.22, 30.13, 29.98, 29.96, 29.76, 26.78,23.29, 22.21, 21.06, 14.48. HR-MALDI-TOF; Calcd. for (M+)C80H104B2FeN8O6 1350.762; found 1350.525 UV-vis: (THF, 10-6 M),lambdamax [nm]=303, 448.

According to the analysis of related databases, 126930-72-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shetty, Suchetha; Baig, Noorullah; Al-Mousawi, Saleh; Al-Sagheer, Fakhreia; Alameddine, Bassam; Polymer; vol. 178; (2019);,
Bromide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126930-72-1, name is 1-Bromo-4-dodecylbenzene, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks

To a suspension of 1 -bromo-4-dodecylbenzene (3.626 g, 1 1 .15 mmol) in anhydrous tetrahydrofuran (48 cm3) at -78 C, ferf-butyllithium (13 cm3, 22 mmol, 1 .7 M in pentane) is added dropwise over 30 minutes. After 40 minutes the reaction is allowed to warm to -30 C before the reaction mixture is then re-cooled to -78 C. Additional 1 -bromo-4-dodecylbenzene (362 mg, 1 .1 1 mmol) is added and after 15 minutes ethyl 2-[5-(3- ethoxycarbonyl-2-thienyl)thieno[3,2-b]thiophen-2-yl]thiophene-3- carboxylate (1 .00 g, 2.23 mmol) is added in one portion to the reaction mixture. This mixture is then allowed to stir at -78 C for 20 minutes before removing allowing the mixture to warm to 23 C. Water (100 cm3) is added and the mixture stirred for 5 minutes. Diethyl ether (50 cm3) is then added and the organic layer extracted. The organic extract is then washed with saturated ammonium chloride solution (100 cm3), water (100 cm3) and brine (100 cm3), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The crude is purified by column chromatography eluting with a graded solvent system (40-60 petrol:dichloromethane; 1 :0 to 3:2) with final purification achieved by trituration with methanol (3 x 10 cm3), washing the filtered solid with 40-60 petrol (2 x 10 cm3), diethyl ether (10 cm3) and acetone (10 cm3) to give intermediate 38 (2.09 g, 70%) as a yellow solid. 1H NMR (400 MHz, CDCIs) 7.12 – 7.17 (10H, m), 7.07 – 7.12 (8H, m), 6.64 (2H, s), 6.45 (2H, d, J 5.2), 3.24 (2H, s), 2.60 (8H, t, J 7.7), 1 .57 – 1 .65 (8H, m), 1 .25 – 1 .35 (72H, m), 0.89 (12H, t, J 6.8).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 126930-72-1.

Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; NANSON, Lana; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (327 pag.)WO2018/65350; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Recommanded Product: 4101-68-2

Under nitrogen atmosphere, 1.23 g of compound 3, 2.97 g of 1,10-dibromodecane, 0.43 g of potassium hydroxide and 0.16 g Tetrabutylammonium bromide was added to a mixture of 10 ml of methylene chloride and 6.5 ml of water. After stirring at room temperature for 24 hours,Ml of water, washed once with 15 ml of saturated brine, the organic layer was separated, and dried over anhydrous sodium sulfate to remove water After which the solvent was removed on a rotary evaporator and purified using 200-300 mesh silica gel column chromatography (eluent ethyl acetate / petroleum ether volume 1: 30-1: 20) to give 1.41 g of the compound 4 as a colorless solid in a yield of 89%

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Yang, Liu; Liao, Peihai; Wang, Guixia; (8 pag.)CN106117227; (2016); A;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 401-84-3, name is 1,3-Dibromo-5-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C7H3Br2F3

With the magnetic force of the rotor to dry the reaction tube by sequentially adding a 9 H – pyrido [2, 3b] indole (5.04 g, 30 . 00 mmol, 1.0 eq), CuI (571.4 mg, 3 . 00 mmol, 0 . 01 eq), L – Proline (690.0 mg, 6 . 00 mmol, 0 . 02 eq) and K2CO3(8.29G,60 . 00mmol,2 . 0 eq). Replacing the nitrogen three times, then adding 1, 3 – dibromo -5 – trifluoromethylbenzene (10.94 g, 36.0 mmol, 1.2 eq) and solvent dimethyl sulfoxide (30 ml). The reaction mixture is 120 C oil bath reaction 1.5 days. Cooling to room temperature, add 100 ml ethyl acetate dilution, diatomaceous earth filter, and ethyl acetate full cleaning, add 50 ml water, liquid, ethyl acetate extraction the aqueous phase three times, the combined organic phase, drying the organic phase with anhydrous sodium sulfate, filtered, reduced pressure distillation to remove the solvent, the obtained crude product by silica gel column chromatography separation and purification, eluent (petroleum ether/dichloromethane=4:1 – 2:1), to obtain white solid 2 – Br – CF35. 15 G, yield 43%. The product can be directly used in the next step of the synthesis.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhejiang University of Technology; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Li Guijie; She Yuanbin; Zhao Xiangdong; Chen Shaohai; (38 pag.)CN108948096; (2018); A;,
Bromide – Wikipedia,
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Reference of 201138-91-2,Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

34.5 g Intermediate (18) and 39.1 g 4,6-dibromo dibenzofuran were added into a dry 2 L three-neck flask, followed by adding 800 mL dry and degassed toluene to dissolve. Then, 34.6 g sodium tert-butoxide (3.0 eq.), 0.554 g catalyst palladium diacetate (2% mol) and 3.0 g 1,1?-binaphthyl-2,2?-bis(diphenylphosphino) (BINAP, 4% mol) ligand were added. The reaction mixture was heated up to 110 C. and reacted overnight. After the reaction finished and the reaction mixture was cooled down to room temperature. The residual was absorbed by the added activated carbon, filtered by suction filtration and removed with solvent by rotary evaporation, followed by recrystallization with a mixture of toluene and ethanol, to produce 52.8 g Intermediate (19) at a yield of 87%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,6-Dibromodibenzo[b,d]furan, its application will become more common.

Reference:
Patent; NANJING TOPTO MATERIALS CO.,LTD.; KIM, JIN WOO; QIAN, CHAO; GAO, PENGHUI; WANG, XIAOWEI; (157 pag.)US2018/105534; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 615-54-3, These common heterocyclic compound, 615-54-3, name is 1,2,4-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon stream, 340 mg (1.08 mmol) of 1,2,4-tribromobenzene,100 mg (0.0865 mmol) of tetrakis (triphenylphosphine) palladium,And 4.86 mL (4.86 mmol) of 1 M potassium carbonate aqueous solution were dissolved in 12.5 mL of dioxane,And heated to 100 C.Therein was dissolved in 25 mL of dioxane1- [4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl] isoquinoline1.25 g (3.78 mmol) was added dropwise over 3 hours,And the mixture was further stirred for 1 hour.After cooling to room temperature, 400 mL of pure water was added and separation and extraction was performed with chloroform. After distilling off the solvent under reduced pressure, the obtained crude product was purified by silica gel column chromatography (developing solvent: chloroform: ethyl acetate = 7: 3)4 ‘- [4- (1-isoquinolyl) phenyl] -1,1’: 2 ‘, 1 “- terphenylOf pale yellow solid (yield 536 mg, yield 72.2%).

Statistics shows that 1,2,4-Tribromobenzene is playing an increasingly important role. we look forward to future research findings about 615-54-3.

Reference:
Patent; TOSOH CORPORATION; FUJITA, KANA; ARAI, NOBUMICHI; NOMURA, KEISUKE; IIDA, TAKASHI; TANAKA, TSUYOSHI; (76 pag.)JP6264877; (2018); B2;,
Bromide – Wikipedia,
bromide – Wiktionary