Tag: M.W=300-400

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, A new synthetic method of this compound is introduced below., Formula: C10H13Br2N

To a stirring solution of 2,6-dibromo-4-tert-butylaniline in 115 mL of EtOH was added 11.5 mL of concentrated H2SO4. To the stirring solution at 90 0C was added 8.8 g of NaNO2 in several portions. After 37 h, EtOAc and 120 mL of H2O were added, and the layers separated. The organic layer was washed with 40 mL of brine, dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (hexanes) provided 8.15 g of l,3-dibromo-5-tert-butylbenzene as a yellow-brown oil with some impurity.

The synthetic route of 10546-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-39-1, name is 1,3,5-Tribromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C6H3Br3

In a 100 mL-flask, 3.84 g (30 mmol) of compound 15, 3.14 g (10 mmol) of compound 16, 2 mol/L of potassium carbonate 4 mL, 60 mL of tetrahydrofuran were added, and then oxygen was removed by bubbling for 30 min, and then 0.1 g was added.(0.09 mmol) tetrakistriphenylphosphine palladium, stirred under nitrogen at 80 C under reflux for 12h, cooled, then added ethyl acetate 20mL, the organic phase was washed with ice water 3 times, dried over anhydrous sodium sulfate, and then filtered to evaporate the filtrate The crude product was purified by silica gel column chromatography to give 2.36 g of compound 17, a yield of 73%.

The synthetic route of 626-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hebei Normal University; Liu Bo; Wang Yajun; Zhang Fengyu; Zhang Xiaomin; (11 pag.)CN107915733; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 126930-72-1,Some common heterocyclic compound, 126930-72-1, name is 1-Bromo-4-dodecylbenzene, molecular formula is C18H29Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(0236) To a suspension of 1-bromo-4-dodecylbenzene (2.2 g, 6.8 mmol) in anhydrous tetrahydrofuran (50 cm3) at -78 C. was added dropwise tert-butyllithium (7.2 cm3, 14 mmol, 1.9 M in pentane) over 30 minutes. After addition, the reaction mixture was stirred at -78 C. for 1 hour. 5,5?-Bis-triisopropylsilanyl-[2,2?;5?,2?]ter[thieno[3,2-b]thiophene]-3?,6?-dicarboxylic acid diethyl ester 3 (1.0 g, 1.1 mmol) was then added in one portion. The reaction mixture was then stirred at -78 C. for 2 hours and at 23 C. for 17 hours. The reaction mixture was poured into water (150 cm3) and the organics extracted with diethyl ether (5¡Á50 cm3). The combined organics were washed with brine (100 cm3), dried over anhydrous magnesium sulphate, filtered and the solvent removed in vacuo. The crude was purified by column chromatography (n-pentane) to give {6?[bis-(4-dodecyl-phenyl)-hydroxy-methyl]-5,5?-bis-triisopropylsilanyl-[2,2?;5?,2?]ter[thieno[3,2-b]thiophene]-3?-yl}-bis-(4-dodecyl-phenyl)-methanol 4 (800 mg, 40%) as a colourless oil. (0237) 1H-NMR (300 MHz, CDCl3) 0.84-0.92 (12H, m), 1.06-1.17 (36H, m), 1.21-1.37 (78H, m), 1.54-1.66 (8H, m), 2.53-2.63 (8H, m), 3.45 (2H, s), 6.50 (2H, s), 7.08 (8H, d, J 8.3), 7.17 (2H, s), 7.20 (8H, d, J 8.3)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-dodecylbenzene, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; MITCHELL, William; D’LAVARI, Mansoor; WANG, Changsheng; SPARROWE, David; (45 pag.)US2016/301008; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 24468-88-0 as follows. HPLC of Formula: C11H15Br2N

To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15 mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for 18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). The combined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2 (0.752 g, 14.9%). The compound was characterized by the following spectroscopic data: MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89 (m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).

According to the analysis of related databases, 24468-88-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 250 mL round bottom flask was added D1 (1.80 g, 10.64 mmol),G3 (3.78 g, 11.70 mmol), Tris (dibenzylideneacetone) dipalladium (0) (0.15 g, 0.16 mmol),(BINAP) (0.20 g, 0.32 mmol) and sodium tert-butoxide (1.43 g, 14.89 mmol) were added to a solution of (¡À) -2,2′-Bis (diphenylphosphino) -1,1′- binaphthaleneAfter dissolving in toluene (100 mL)After stirring for 24 hours at 100 C in a bath, when the reaction is completeToluene was removed, and the residue was extracted with dichloromethane and water. The residue was subjected to vacuum distillation. The residue was subjected to silica gel column, and the solvent was distilled off under reduced pressure to obtain Compound G4 (3.05 g, 7.41 mmol).

Statistics shows that 4-(4-Bromophenyl)dibenzo[b,d]furan is playing an increasingly important role. we look forward to future research findings about 955959-84-9.

Reference:
Patent; LG Display Co., Ltd.; Pin Jong-gwan; Lee Na-yeon; Seo Bo-min; Ryu Yeong-ju; (43 pag.)KR2018/61825; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: bromides-buliding-blocks

General procedure: The triolborate, dibromides (0.2 mmol), palladium acetate (10 mol %), BIPHEP (11 mol), and CuCl (0.4 equiv) were placed in a flask under an atmosphere of nitrogen. DMF (15 mL) was added, and heated at 80 C for 14 h. After cooling to room temperature, 15 mL water was added, extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on silica gel.

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.21 g of palladium(II) acetate, xylene (20 mL), and 0.76 g of tri-tert-butylphosphine are added,Stirred at 60 ¡ãC for 30 minutes.The above solution was added to a flask heated to 60¡ãC under nitrogen to give the above compound 2 (7,9-Dihydrobenzo[4,5]furo[2,3-g]benzofurano[2′,3′:4,5]indolo[2,3-b]carbazole 7.4g), 4-(4-Bromophenyl)dibenzo[b,d]furan (13.2 g) and sodium tert-butoxide 5.2 g (54 mmol) were added to the above solution together with xylene (180 mL). Then, it heated up at 130 ¡ãC, and it heat-stirred for 6 hours. After cooling to room temperature, 200 mL of water was added. After the organic layer was extracted with chloroform, the organic layer was dried over MgSO 4 , the solvent was removed, and silica gel column chromatography was performed to give Compound A-9 (7.4 g, 47percent).

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. LG Chemical; Hong Wanshao; He Zaicheng; Xu Shangde; Jin Zhengfan; Li Zaizhuo; Jin Yuanhuan; (73 pag.)CN108017654; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, A new synthetic method of this compound is introduced below., COA of Formula: C12H8Br2

An integrated flow microreactor system consisting of four T-shaped micromixers (M1,M2, M3 and M4), four microtube reactors (R1, R2, R3 and R4), and five microtube units [P1(inner diameter = 1000 m, length l = 100 cm), P2 (= 1000 m, l = 50 cm), P3 (= 1000m, l = 100 cm), P4 (= 1000 m, l = 50 cm), P5 (= 1000 m, l = 100 cm)] was used. Thewhole flow microreactor system was dipped in a water bass (24 ). A solution of 5,6-dibromoacenaphthene (0.10 M) in THF (flowrate = 6.00 mL min-1) and a solution of BuLi (0.50 M) in hexane (flow rate = 1.20 mL min-1) were introduced to M1 (= 250 m). The resulting solution was passed through R1 (phi= 500 mum, l = 3.5 cm) and was mixed with a solution of benzophenone (0.20 M) in THF (flow rate = 3.00 mL min-1) in M2 (phi= 500 mum). The resulting solution was passed through R2 (phi= 1000 mum, l = 200 cm) and was introduced to M3 (phi= 500 mum) where the solution was mixed with a solution of BuLi (0.50 M) in hexane (flow rate = 1.44 mLmin-1). The resulting solution was passed through R3 (phi= 1000 mum, l = 200 cm) and was introduced to M4 (phi= 500 mum) where the solution was mixed with a solution of 4,4′-difluorobenzophenone (0.20 M) in THF (flow rate = 3.60 mL min-1). The resulting solution was passed through R4 (phi= 1000 mum, l = 200 cm). After a steady state was reached, the product solution was collected for 130 s and was stirred for 4 h at 22 C under argon. Then the mixture was treated with BuLi (1.59 M) in hexane (6.8 mL) to consume excess ketones at -78 C. The resultant solution was further stirred for 2 h, and was treated with water.

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Suzuki, Takanori; Uchimura, Yasuto; Nagasawa, Fumika; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Murakoshi, Kei; Fukushima, Takanori; Nagaki, Aiichiro; Yoshida, Jun-Ichi; Chemistry Letters; vol. 43; 1; (2014); p. 86 – 88;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4101-68-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4101-68-2, name is 1,10-Dibromodecan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,10-Bisazidodecane NaN3 (1.30 g, 20.0 mmol) was suspended in a solution of 1,10-dibromodecane (2.42 g, 10.0 mmol) in dry dimethylformamide (15 mL). After stirring for 12 h at 60 C. water (15 mL) was added and the mixture was extracted with diethyl ether (3*100 mL). The organic layer was washed with water (3*50 mL), dried over Na2SO4 and evaporated. The crude product was purified by chromatography on silica gel (0%?20% ethyl acetate in cyclohexane). Yield: 6.82 mmol, 68% yellowish oil. 1H: [300 MHz, CDCl3] delta=1.30-1.54 (m, 12H), 1.51-1.68 (m, 4H), 3.26-3.35 (m, 4H) ppm. HRMS: [C10H20N6] m/z cal. [M+H]+=225.1822 m/z found [M+H]+=225.1821.

The synthetic route of 1,10-Dibromodecan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Arenz, Christoph; Davies, Brian Patrick; Neubacher, Saskia; Klemm, Claudine Mercedes; US2009/92980; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 24468-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24468-88-0, name is N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). Thecombined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. Theresidue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2(0.752 g, 14.9%). The compound was characterized by the following spectroscopic data:MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89(m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary