Tag: M.W=300-400

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: bromides-buliding-blocks

13.6 g of phenylboronic acid and 32.6 g of 4.6-dibromo-dibenzofuran were added to a 2 L three-necked flask and 700 mL was added thereto.Dissolve toluene and 150 mL of ethanol, purge with nitrogen for 15 minutes, add 150 mL of K2CO3 (3.0 eq., 2M) in water, and finally add2.3g Pd(PPh3)4 (2mol%). The temperature was raised to 110C and the reaction was completed overnight. Add activated carbon adsorption, suction filtration, remove solvent, dryDrying, recrystallization from toluene and ethanol gave 29.7 g of intermediate AB with a yield of 92%.

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Shen Nan; Wang Xiaowei; (87 pag.)CN107880055; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52997-43-0, name is 7-(Bromomethyl)pentadecane, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 52997-43-0

To the reaction flask was added 3,6-dibromofluorene (3.24 g, 10.0 mmol)6.7 mL of 1-bromo-2-hexyl decane,0.1 g of tetrabutylammonium iodide (catalyst),10 mL of a 50% aqueous solution of sodium hydroxide and 15 mL of DMSO.And heated to 100 C for 18 hours under nitrogen protection.After the raw material is completely reacted, the reaction will be quenched by adding water,Then washed with water, extracted with petroleum ether,The resulting organic phase was dried over anhydrous magnesium sulfate and filtered,The crude product was concentrated, separated by silica gel column chromatography, and petroleum ether was used as eluent and dried in vacuo to give compound 1,A total of 6.41 g, the yield was 8

According to the analysis of related databases, 52997-43-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wuhan University of Technology; Xiao, Shengqiang; Yang, Mingyan; You, Wei; Zhan, Chun; (11 pag.)CN104557972; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1295502-53-2, A common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dried 50 mL three-necked flask, 25 mL of re-distilled toluene was added,Compound 2 (1. 05 g, 2 mmol),Pd (PPh3) 4 (46. 2 mg, 0.04 mmol) was added to the solution of 4,7-dimethoxy-5,6-dioxo benzo [c] [1,2,5] thiadiazole (221 mg, 0.67 mmol) Stirring dissolved; after nitrogen after 5 minutes,Using vacuum chestnut nitrogen 3 times;The solution was heated to 110 C for 72 hours. After cooling to room temperature, the solution was poured into 200 mL of methanol,The crude product was precipitated on a silica gel column using dichloromethane: petroleum ether (1: 1 by volume) as eluant,The red solid component was obtained as the object product (642 mg, yield 69%);

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; National Center for Nanoscience and Technology (NCNST); Wei, Zhixiang; Yuan, liu; (22 pag.)CN105315273; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 19190-91-1,Some common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dibromo-1,2-dihydroacenaphthylene, its application will become more common.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1, A common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, molecular formula is C6H3Br3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

500 mL reactor to tribromobenzene 25 g (79 mmol), phenyl boronic acid 23.3 g (191 mmol), potassium carbonate 32.9 g (238 mmol), tetrakistriphenylphosphinepalladium, 6.12 g (3 mmol), distilled water 50 In the mL, 125 mL toluene and 125 mL 1,4dioxaneis stirred and refluxed for 24 hours. After completion of the reaction by separating the reaction layer and the organic layer was concentrated under reduced pressure. Recrystallized with toluene and methanol to give the 8-a 21 g. (85% yield)

The synthetic route of 626-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC Co.,Ltd; Yang, Byung Son; Lee, Say Jin; Lee, Bong Hyang; Oh, Hyun Ju; Yu, Jong Ho; Hwang, Mun Chan; (67 pag.)KR2015/130797; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 18648-66-3

General procedure: A flask was charged with a mixture of 3-(4-vinylphenyl)-9-ethylcarbazole (1, 0.3 g, 1.01 mmol), 2-(4-bromophenyl)-1,1-diphenylethylene (triPE, 0.28 g, 0.84 mmol), palladium acetate(Pd(OAc)2, 2.3 mg, 0.01 mmol), P(o-tolyl)3 (15 mg, 0.05 mmol),dimethylformamide (8 mL) and trimethylamine (3 mL). The flaskwas degassed and purged with argon. The reaction mixture washeated at 90 C for 4 h under argon atmosphere. Then, it wasfiltered, and was purified by column chromatography using hexane/ethyl acetate (50/1) as an eluent. The target product wasrecrystallized from the eluent mixture of solvents. The yield ofyellow crystals was 43% (0.2 g).

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tomkeviciene; Sutaite; Volyniuk; Kostiv; Simkus; Mimaite; Grazulevicius; Dyes and Pigments; vol. 140; (2017); p. 363 – 374;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 10016-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(3) Synthesis of Compound (300) [0266] [0267] Into a three-necked flask, 3.80 g (10.2 mmol) of Compound (300-b), 1.39 g (4.25 mmol) of Compound (291-a), 15 ml of a 2 M aqueous solution of sodium carbonate, 30 ml of 1,2-dimethoxyethane, and 0.368 g (0.425 mmol)) of Pd(PPh3)4 were charged, and the contents were refluxed for 12 h in a nitrogen atmosphere. [0268] After the reaction, the reaction solution was added with 100 ml of methanol and ultrasonically washed for 10 min. The precipitate was separated by filtration and washed with methanol, water, and then hexane. The washed precipitate was dried, dispersed in ethyl acetate for washing, and recrystallized from toluene, to obtain a white solid. The identification was based on the molecular weight measurement by FD/MS, which showed m/e = 654 for the molecular weight of 654. The yield was 1.50 g and the percent yield was 54%.

The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Co., Ltd; NAKANO, Yuki; NUMATA, Masaki; NAGASHIMA, Hideaki; EP2711363; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 19190-91-1, A common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, A new synthetic method of this compound is introduced below., Safety of 4-(4-Bromophenyl)dibenzo[b,d]furan

In a dry 2L three-necked flask, 26.5 g (81 mmol, 1.1 eq.) of Intermediate-1 obtained in Reaction Formula 1 and 23.8 g (73.6 mmol, 1.0 eq.) of 4-(4-bromophenyl)-dibenzofuran were added. Then add dried and degassed 1000 ml of toluene as a solvent. Pass nitrogen for 15 minutes. Then add 10.6 g (110.4 mmol, 1.5 eq.) sodium tert-butoxide, A toluene solution (m/v, 10percent) of 1.3 g (2percent mol) of catalyst Pd2(dba)3 and 6.0 ml (4percent mol) P(t-bu)3. The temperature was raised to 90¡ãC and the reaction was carried out for 1.5 hours. After the reaction was completed, the mixture was cooled to room temperature, adsorbed on activated charcoal, suction filtered, and the solvent was removed by spin-drying. Recrystallization from toluene and ethanol gave 30.6 g of Intermediate 2 in 73percent yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Wang Xiaowei; Dai Peipei; (37 pag.)CN108101896; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 61921-39-9, name is 4-Bromotetraphene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Bromotetraphene

Example 27 Synthesis of 4-(benz[a]anthracen-4-yl)benz[a]anthracene Preparation analogous to Example 7. 9-Bromo-10-(2-naphthyl)anthracene is replaced by 15.4 g (50 mmol) of 4-bromobenz[a]anthracene. Recrystallisation four times from o-dichlorobenzene (about 15 ml/g); sublimation (p=5*10-5 mbar, T=320 C.). Yield: 16.8 g (37 mmol), 74.0%, purity 99.9% (HPLC), Tg=130.3 C.

The synthetic route of 4-Bromotetraphene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Stoessel, Philipp; Buesing, Arne; Heil, Holger; US2010/187505; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary