Tag: M.W=300-400

3344-70-5, name is 1,12-Dibromododecane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C12H24Br2

General procedure: 5,5-dimethylhydantion (3.03 g, 23.6 mmol) and K2CO3 (12.05 g, 87.2 mmol) were dissolved in acetone. Then the mixture were stirred at ambient temperature for 30 min before addition of 3 equivalent 1,6-dibromohexane. After 3 h the acetone solvent was removed by evaporation. 100 mL ethyl acetate was added to extract the product, which were further purified by column chromatography eluting with EtOAc/hexane (3:10, v/v). Compound 8 was obtained as a white powder (6.01 g, 87.7percent). 1H NMR (500 MHz, CDCl3) delta 6.03 (s, H), 3.49 (t, J = 7.0 Hz, 2H), 3.40 (t, J = 6.0 Hz, 2H), 1.89-1.82 (m, 2H), 1.67-1.60 (m, 2H), 1.52-1.41 (m, 8H), 1.37- 1.30 (m, 2H); 13C NMR (126 MHz, CDCl3) delta 177.4, 156.6, 58.7, 38.4, 33.8, 32.6, 27.9, 27.7, 25.8, 25.1. HRMS m/z: [M+H]+ calcd. for C11H20BrN2O2+, 291.0703; found: 291.0700.

The synthetic route of 3344-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Lingdong; Zhao, Yuebiao; Zhou, Hao; Ning, Anhong; Zhang, Fengxiang; Zhao (Kent), Zongbao; Tetrahedron Letters; vol. 58; 4; (2017); p. 321 – 325;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 955959-84-9, The chemical industry reduces the impact on the environment during synthesis 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

Intermediate To a round bottom flask M-1 31.9g (98.7mmol), acetamide 2.6g (44.42mmol), into potassium carbonate 24.5g (177.66mmol) was dissolved in 200ml of xylene was added. Here insert of copper iodide (I) 1.69g (8.88mmol) and N, N- dimethylethylene diamine to 1.56g (17.77mmol) in turn and then the mixture was stirred under reflux for 48 hours under a nitrogen atmosphere. After the reaction extracted with distilled water and toluene and the organic layer was dried with magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The product n- hexane / ethyl acetate (7: 3 by volume), purified by silica gel column chromatography to give the M-31 as 24.05g (93percent yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)dibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JANG, YU NA; HONG, JIN SEOK; KIM, YOUNG KWON; YU, EUN SUN; KIM, CHANG WOO; KIM, HUN; MIN, SOO HYUN; CHO, PYEONG SEOK; (38 pag.)KR2016/12846; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 201138-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The 80g (245 mmole) of 4,6-dibromo-dibenzofuran been dissolved by heating in a dry flask 500ml of dry THF. The reaction mixture was cooled to -78 . At this temperature was slowly added dropwise 57ml of n-phenyl lithiumDibutyl ether (115 mmol) of 1.9M solution. The batch was stirred for another hour at -73 deg.] C. Then 65g of 2-chloro-4,6-diphenyl-1,3,5-triazine (245 mmol) was dissolved in 150ml of THF and added dropwise at -70 deg.] C. When the addition was complete, the reaction mixture was slowly warmed to room temperature and stirred at room temperature overnight, quenched with water and then evaporated in a rotary evaporator, during which a white solid precipitated. The batch was then cooled to room temperature, filtered off by suction and has precipitated solid was rinsed with methanol. The yield was 40g (84 mmole), corresponding to 34% of the theoretical.

The synthetic route of 4,6-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Patent GmbH; Parham, Amir Hossain; Martynova, Irina; Jatsch, Anja; Eberle, Thomas; Kroeber, Jonas Valentin; Pflumm, Christof; (94 pag.)CN105636959; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 955959-84-9

In a stream of argon, 5.9 g of acetamide, 32.3 g of the intermediate 3 , 2.70 g of copper iodide, 40.8 g of potassium carbonate, 6.3 g of N’N-dimethylethylenediamine, and 300 mL of xylene were loaded, and then the mixture was subjected to a reaction at 175¡ãC for 19 hours. Further, 38.5 g of the intermediate 1 were loaded into the resultant, and then the mixture was subjected to a reaction at 175¡ãC for 19 hours. After the resultant had been cooled, water was added so that the resultant was filtrated. The residue was washed with acetone, methanol, and water three times each. Thus, 28.4 g of an acetamide body of the intermediate 13 were obtained. 28.4 g of the acetamide body of the intermediate 13, 26.3 g of potassium hydroxide, 25 mL of water, and 40 mL of xylene were loaded, and then the mixture was subjected to a reaction at 175¡ãC for 5 hours. After the resultant had been cooled, water was added so that the resultant was filtrated. The residue was washed with acetone, methanol, and water three times each, and was then purified with a short column (developing solvent: toluene). The resultant solid was washed with n-hexane and dried under reduced pressure. Thus, 16.6 g of a white solidwere obtained. The white solidwas identified as the intermediate 13 by FD-MS analysis.

The synthetic route of 955959-84-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2502908; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, molecular formula is C20H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C20H15Br

(1) Synthesis of 2-(2-biphenylyl)-9,10-bis(4-(2,2-diphenylvinyl)phenyl)-9,10-dihydroxy-9,10-dihydro anthracene; [Compound (B1-0)]; Under an atmospheric argon gas flow, 4-(2,2-diphenylvinyl)-1-bromobenzene in an amount of 9.8 g (29 mmol, 3 eq) was dissolved into a mixed solvent of anhydrous toluene in an amount of 45 milliliter and anhydrous THF in an amount of 45 milliliter, followed by cooling down to the temperature of – 20 C by means of dry ice / methanol bath. Adding hexane solution of n-butyllithium in an amount of 19 milliliter (1.59 mol/litter, 30 mmol; 1.04 eq), the resultant solution was stirred at the temperature of -20 C for 1 hour. Into the resultant solution, 2-(2-biphenylyl)-9,10-anthraquinone [Compound (A)] in an amount of 3.5 g (9.7 mmol) was added and after stirring at the room temperature for 2 hours, it was stood alone for a night. The resultant reaction mixture was deactivated with the use of saturated ammonium chloride aqueous solution in an amount of 50 milliliter, and the resultant solid was separated. The solid was washed use of the mixed solvent of hexane : dichloromethane = 1:1 (capacity ratio) and as a result, 5.0 g of white solid compound was obtained (yield: 59 %). The white solid was identified as the Compound (B1-0) in accordance with 1H-NMR. The measurement results of 1 H-NMR are shown as the following: 1H-NMR (CDCl3, TMS) delta 2.17 (1H, s), 2.66 (1H, s), 6.21 (2H, d, J=8Hz), 6.51 (2H, d, J=8Hz), 6.55 (4H, s), 6.80 (2H, d, J=4Hz), 7.0-7.4 (3H, m), 7.6-7.7 (3H, m)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 18648-66-3, its application will become more common.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1695952; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 4101-68-2, The chemical industry reduces the impact on the environment during synthesis 4101-68-2, name is 1,10-Dibromodecan, I believe this compound will play a more active role in future production and life.

General procedure: The bromide or iodide salts of 1,n-bis(isoquinolinium)alkane dications (n = 2, 4, 5, 6, 8, 9, 10 and 12) and alpha,alpha’-bis(isoquinolinium)-p-xylene dibromide were prepared using modifications of a method outlined by Kuca et al.. A mixture of the appropriate 1,n-bis(isoquinolinium)alkane dibromide or diiodide (1.0 mmol) or alpha,alpha’-dibromo-p-xylene (1.0 mmol) and isoquinoline (9.0 mmol) in DMF was heated at 70 C for 1-4 days. The addition of diethyl ether to the cooled solution resulted in a light brown precipitate, which was filtered and washed with diethyl ether.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,10-Dibromodecan, other downstream synthetic routes, hurry up and to see.

Reference:
Conference Paper; Kwok, Julian C.; Macartney, Donal H.; Supramolecular Chemistry; vol. 26; 3-4; (2014); p. 182 – 191;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 201138-91-2 as follows. Recommanded Product: 4,6-Dibromodibenzo[b,d]furan

6.48 g (20 ml) of 4,6-dibromodibenzo[b,d]furan was dissolved in 100 ml of THF, and 8 ml (2.5 M in hexane) of normal butyllithium was added thereto at about -78 C. After one hour, 1.36 ml (10 mmol) of dichlorophenylphosphine was slowly added dropwisely and stirred for about 3 hours. The temperature was increased to room temperature, water was added, and then, the solution was washed with ethyl acetate (30 ml) three times. The washed ethyl acetate layer was dried with magnesium sulfate (MgSO4) and dried at a reduced pressured to produce a crude product. The crude product thus obtained was separated by silica gel column chromatography to obtain 4.19 g of Intermediate I-23(yield 70%). The product thus obtained was identified by LC-MS (C30H17Br2O2P: M+1 598.0).

According to the analysis of related databases, 201138-91-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung Display Co., Ltd.; PARK, Junha; SIM, Mun-ki; LEE, Hyoyoung; JEONG, Eunjae; KIM, Youngkook; HWANG, Seokhwan; (71 pag.)US2018/166639; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 201138-91-2, A common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

10.43 g (32 mmol) of B-(9-phenyl-9H-carbazole-3-yl)boronic acid, 8.9 g (31.6 mmol) of 4,6-dibromodibenzofuran and 31 mL (63 mmol) of Na2CO3 (2 M solution) was then suspended in 120 mL of toluene and 120 mL ethanol. To this suspension, it was added 0.73 g (0.63 mmol) of Pd(PPh3)4 and heat the reaction mixture for 16 hours under reflux. After cooling, remove the organic phase, after filtration, washed three times with 200 mL through silica gel, and concentrated until dry. Recrystallization of the residue from toluene. The yield for the 73% of theory, 11.4 g

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck patent GmbH; Hussain, Farham Amir; Martinopa, Irina; Yachi, Anya; Avelluley, Thomas; Kuriba, JonasFallentine; (111 pag.)KR2016/38006; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 88223-35-2, These common heterocyclic compound, 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of benzoyl chloride (1.05 ml; 13.5 mmol), AlCl3 (2 g; 15 mmol) and2-bromo-9,9-dibutyl-9H-fluorene (4.0 g; 9.0 mmol) in CS2 (80 mL) was prepared and purged with argon. Themixture was stirred for 16 h under argon. After the solvent was evaporated, the aqueous layer was extractedwith DCM. The combined organic layer was washed with water and dried over MgSO4. The residue waspurified by column chromatography on silica gel (hexane : DCM = 1 : 1).Yield: white solid (415 mg; 9.0 mmol; 99 %).1H-NMR (300 MHz, DMSO-d6): delta 7.84-7.73 (m, 5H), 7.65-7.58 (m, 2H), 7.52-7.48 (m, 4H), 2.07-1.89 (m, 4H),1.16-1.03 (m, 4H), 0.68 (t, 6H), 0.66-0.54 (m, 4H).

Statistics shows that 2-Bromo-9,9-dibutyl-9H-fluorene is playing an increasingly important role. we look forward to future research findings about 88223-35-2.

Reference:
Article; Wada, Atsushi; Nishida, Jun-Ichi; Maitani, Masato M.; Wada, Yuji; Yamashita, Yoshiro; Chemistry Letters; vol. 43; 3; (2014); p. 296 – 298;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 20191-76-8, A common heterocyclic compound, 20191-76-8, name is 2,4-Dibromonaphthalen-1-amine, molecular formula is C10H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The requisite naphthols were prepared as shown in Schemes 1 – 4. Thus, 4-bromo- 2-naphthol 1 was prepared by sequential bromination, diazotisation and reduction of 1- naphthylamine according to the published procedure (M. S. Newman, V. Sankaran and D. Olson, J. Am. Chem. Soc, 1976, 98, 3237) as shown in Scheme 1.

The synthetic route of 20191-76-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D’OPTIQUE); WO2008/28930; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary