Tag: M.W=300-400

Synthetic Route of 268733-18-2, These common heterocyclic compound, 268733-18-2, name is 4-Bromo-3,5-bis(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) 300 mg of 4-bromo-3,5-bis(trifluoromethyl)aniline was dissolved in 2 mL of toluene, and 130 mg of 3-thiophene carboxyaldehyde and then a catalytic amount of pyridinium p-toluene sulfonate were added and reacted at about 100C overnight, and then the reaction solution was left to cool. To the reaction solution, 50 mg of sodium borohydride and 2 mL of ethanol were added and reacted at room temperature for about two hours. Then, water and ammonium chloride were added in proper amounts, followed by stirring. A crude solution obtained by extraction with ethyl acetate was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=2/1) to obtain 340 mg of N-(4-bromo-3,5-bis(trifluoromethyl)phenyl)-3-thiophene methanamine (melting point: 78-79C).

The synthetic route of 268733-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.; EP2172456; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 89523-51-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89523-51-3 as follows.

Argon atmosphere, 3-bromo-fluoranthene 12.3g, 2-chloroaniline 5.60g, tris-dibenzylideneacetone dipalladium (0) 0.732g, Tri-t-butylphosphine tetrafluoroborate dihydro 0.926g borate, -t- sodium butoxide, 7.68g, was stirred in a 400mL flask, and dehydrated toluene, heated at 80 8 hours. After cooling to room temperature (25 ), the reaction solution was extracted with toluene, and was filtered through Celite. Filtrate was concentrated, and the residue was purified by column chromatography on silica gel, 5- (2-chloro-2,3,4) benzo [c] phenanthrene was obtained a 11.32g.

According to the analysis of related databases, 89523-51-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Corporation; Kawamura, Masahiro; Mizuki, Yumiko; Ito, Hirokazu; Hayama, Tomoharu; Haketa, Tasuku; (69 pag.)KR2015/126340; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 30432-16-7, These common heterocyclic compound, 30432-16-7, name is 1,4-Dibromo-2,3-bis(bromomethyl)but-2-ene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Alkyl 4-hydroxy benzoate 2a,b (10 mmol) and potassium hydroxide (0.56 g, 10 mmol) were dissolved in absolute ethanol. 1,1,2,2-tetrayl-tetramethylene-tetrabromide (1) (1.00 g, 2.5 mmol) was then added into this solution. The reaction mixture was refluxed for 6 h. The mixture was cooled and filtrated. The white precipitate was filtered off and washed with H2O and crystallized from the appropriate solvent.

The synthetic route of 30432-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Er, Mustafa; De?irmencio?lu, Ismail; Tahtaci, Hakan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 139; 1; (2015); p. 68 – 74;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89523-51-3, name is 5-Bromobenzo[c]phenanthrene, A new synthetic method of this compound is introduced below., SDS of cas: 89523-51-3

a) Synthesis of benzo[c]phenanthrene-5-boronic acid 52 ml (130 mmol) of n-buthyllithium (2.5 M in n-hexane) are added dropwise to a suspension of 30.7 g (100 mmol) of 5-bromobenzo[c]phenanthrene in 1000 ml of THF at -78 C. with vigorous stirring, and the mixture is stirred for a further 2 h. 16.7 ml (150 mmol) of trimethyl borate are added to the red solution in one portion with vigorous stirring, the mixture is stirred at -78 C. for a further 30 min., then warmed to room temperature over the course of 3 h, 300 ml of water are added, and the mixture is stirred for 30 min. The organic phase is separated off and evaporated to dryness in vacuo. The solid is taken up in 100 ml of n-hexane, filtered off with suction, washed once with 100 ml of hexane and dried in vacuo. Yield: 24.8 g (91 mmol), 91%, purity about 90% (NMR) of boronic acid, with varying amounts of boronic anhydride and boronic acid. The boronic acid can be used in this form without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Merck Patent GmbH; US2011/288292; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 707-34-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-34-6, name is 1,3,5-Tribromoadamantane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE I Synthesis of 1,3,5-Triethynyladamantane Vinyl bromide (60 mL) was added, dropwise, over 1.5 h to a solution of 1,3,5-tribromoadamantane (43 g, 115 mmol) and aluminum chloride (10 g) in CH2 Cl2 (100 mL) at a rate such that the internal temperature did not exceed -20 C. The progress of reaction, as indicated by the disappearance of 1,3,5-tribromoadamantane, was monitored by GLC and 1 H NMR. The reaction mixture was stirred at -20 C. for 1.5 hours, diluted with dichloromethane and poured slowly over crushed ice and concentrated hydrochloric acid (40 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with water, dried (MgSO4) and filtered and solvent was evaporated under reduced pressure to give 80 g of crude 1,3,5-tris(2,2-dibromoethyl)adamantane. The crude material was dissolved in DMSO (350 mL) and potassium t-butoxide (80 g, 714 mmol) was added portion-wise over a period of 20 minutes. The mixture was stirred at ambient temperature for 48 h, diluted with dichloromethane and poured over crushed ice/water/concentrated hydrochloric acid (5 mL). The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic layers were washed with water and brine, dired (MgSO4), filtered and stripped of solvent under reduced pressure to give an oil. This oil was distilled under reduced pressure (120-130 C./0.5 mm) to give 14,6 g (61%) of 1,3,5-triethynyladamantane. An analytical sample was recrystallized from pentane: mp. 84-86 C; IR 3350 and 2150 cm-1; 1 H NMR delta 2.13 (s, 3 H, C CH) and 1,96 (s, 6 H) and 1.79 (m, 7 H); Anal. Calcd for C16 H16; C, 92.26; H, 7.74. Found: C, 92.10; H, 7.79.

The synthetic route of 1,3,5-Tribromoadamantane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Baum; Kurt; Archibald; Thomas G.; Malik; Aslam A.; US5017734; (1991); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 18869-30-2,Some common heterocyclic compound, 18869-30-2, name is (E)-1,2-Bis(4-bromophenyl)ethene, molecular formula is C14H10Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0106] (3) N,N,N?,N?-tetra(2-naphthyl)-4,4?-diaminostilbene was prepared. The reaction scheme is shown in the following: [0107] Into a 50 ml two-necked flask, 420 mg (1.56 mmol, 2.1 eq) of di-2-naphthylamine obtained in (2), 250 mg (0.741 mmol) of 4,4-dibromostilbene, 3.4 mg (0.0148 mmol, 2.0% by mole) of palladium acetate and 157 mg (1.63 mmol, 2.2 eq) of sodium t-butoxide were placed. A rubber cap was placed at the side opening of the flask. A coiled tube condenser for refluxing was attached to the central opening of the flask and a three-way stopcock attached with a balloon containing the argon gas was attached to the top of the coiled tube condenser. The atmosphere in the system was purged with the argon gas in the balloon 3 times using a vacuum pump. [0108] To the above system, 10 ml of dehydrated toluene and 13.4 ?l (0.0296 mmol, 4.0% by mole) of a 2.22 moles/liter toluene solution of tris-t-butylphosphine were added using a syringe through a rubber septum. Then, the flask was set into an oil bath and the temperature was raised slowly to 115 C. while the solution was stirred. Brownish white precipitates were formed in the reaction solution after 30 minutes. After heating at 115 C. for 6 hours under stirring, the flask was removed from the oil bath and left standing for one night. [0109] The formed precipitates were completely dissolved in 500 ml of dichloromethane. After the resultant fluid was transferred to a separation funnel and washed with 100 ml of a saturated aqueous solution of sodium chloride, the organic layer (yellow) was dried with anhydrous potassium carbonate. After filtration, the organic solvent was removed by distillation and 150 ml of toluene and 50 ml of ethanol were added to the obtained residue. After a drying tube was attached to the flask, the precipitates were dissolved to some degree by heating at 80 C. and the resultant mixture was slowly cooled to the room temperature. The crystals of the ivory color in the system were separated by filtration using a Kiriyama funnel. After the crystals were washed with small amounts of toluene and ethanol and dried at 60 C. for 3 hours in a vacuum drying chamber, 428 mg (0.600 mmol) of N,N,N?,N?-tetra(2-naphthyl)-4,4?-diaminostilbene was obtained at a yield of 81%. [0110] The results of the measurements of NMR and FD-MASS on the obtained N,N,N?,N?-tetra(2-naphthyl)-4,4?-diaminostilbene were as follows: [0111] NMR: ?90 MHz 6.9 to 7.9 (38H, m) [0112] FD-MASS: 714

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (E)-1,2-Bis(4-bromophenyl)ethene, its application will become more common.

Reference:
Patent; Iwakuma, Toshihiro; Moriwaki, Fumio; US2004/82813; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 6938-66-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6938-66-5, name is 1-Bromodocosane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In argon atmosphere, a DMF solution (2.0 ml) of Compound 23 (85 mg, 0.188 mmol) was ice-cooled, and sodium hydride (60% in oil, 27.0 mg, 0.675 mmol) was added thereto, followed by stirring for 10 minutes under ice-cooling. Then, bromodocosane (110 mg, 0.282 mmol) was added thereto, followed by stirring for 2 hours while gradually raising the temperature of the reaction solution to room temperature. The reaction solution was ice-cooled, and methanol (1 ml) was added dropwise thereto, followed by stirring for 30 minutes. The reaction solution was diluted with ethyl acetate, and saturated sodium bicarbonate water was added thereto, followed by stirring. Then, the organic layer was washed with saturated sodium bicarbonate water and saturated brine in this order and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (toluene : ethyl acetate = 3 : 1, 0.2% triethylamine) to obtain Compound 24-7 (70.2 mg, 49.1%). Developing solvent of Compound 24-7 (toluene : ethyl acetate = 2 : 1) Rf 0.38 C42H81NO10 MW: 760.10 1H-NMR (500 MHz, CDCl3) delta= 5.572 (br.d, 1H, H-5a), 4.909, 4.873 (2d, 2H, J = 6.6Hz, 6.8Hz, OCH2), 4.801-4.616 (m, 6H, 3OCH2), 4.190 (br.d, 1H), 4.112-4.035 (m, 3H), 3.736 (br.d, 1H), 3.406, 3.389, 3.365, 3.345 (4s, 12H, 4OCH3), 3.119 (m, 1H, NCH2), 2.887 (m, 1H, NCH2), 1.67-1.25 (m, 40H, 20CH2), 1.254 (s, 9H, CC(CH3)3), 0.880 (t, 3H, J= 7.1Hz, CH3)

The synthetic route of 1-Bromodocosane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SEIKAGAKU CORPORATION; EP1632476; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 268733-18-2,Some common heterocyclic compound, 268733-18-2, name is 4-Bromo-3,5-bis(trifluoromethyl)aniline, molecular formula is C8H4BrF6N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

synthesis of ethyl 5 -(4-amino-2, 6-bis(trifluoromethyl)phenyl)furan-2-carboxylate (143): 4-Bromo-3,5-bis(trifluoromethyl)aniline (142; 8 g, 26 mmol), 5- (ethoxycarbonyl)furan-2-ylboronic acid (7.2 g, 39 mmol), catalyst (2.1 g, 2.6 mmol) and K3P04 (16.5 g, 78 mmol) were added to a mixture of H20 (156 mL) and THF (300 mL). The mixture was degassed and stirred at room temperature for 2 h, extracted with EtOAc (300 mL X 2). The combined organic solvents were concentrated under reduced pressure and purified by silica gel chromatography (10-30% EtOAc/petroleum ether) to give 4.6 g of ethyl 5-(4- amino-2, 6-bi s(trifluoromethyl)phenyl)furan-2-carboxylate 143 as brown solid (48% yield). LCMS: m/z 368.0 [M+H], tR = 1.91 mm

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-3,5-bis(trifluoromethyl)aniline, its application will become more common.

Reference:
Patent; KARYOPHARM THERAPEUTICS INC.; BALOGLU, Erkan; SHACHAM, Sharon; SENAPEDIS, William; (153 pag.)WO2017/31213; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 1119-94-4, Name is Dodecyl trimethyl ammonium bromide, SMILES is CCCCCCCCCCCC[N+](C)(C)C.[Br-], in an article , author is Monteiro de Mendonca, Juliana Franca, once mentioned of 1119-94-4, Category: bromides-buliding-blocks.

Detection of Viable Salmonella Typhimurium and Staphylococcus aureus in Coalho Cheese by Real-Time PCR

Real-time PCR (qPCR) has been used for rapid identification of Salmonella Typhimurium and Staphylococcus aureus in dairy foods, but is unable to differentiate viable and unviable pathogens. Ethidium bromide monoazide (EMA), a DNA-intercalating agent, can detect only viable cells because selectively enter cells considered unviable and bind to their DNA, inhibiting its amplification during qPCR. The objective was to establish a protocol for detection of viable Salmonella Typhimurium and S. aureus, experimentally inoculated in coalho cheese, by the use of EMA combined with qPCR. The protocol was effective for the identification of viable Salmonella Typhimurium in coalho cheese but not for the S. aureus cells. Concentrations of viable Salmonella Typhimurium cells of 1 CFU/10 g of coalho cheese could be detected. The monoplex protocol enables the rapid and specific identification of viable Salmonella Typhimurium in coalho cheese, making it an alternative method for the quality and safety control of cheeses.

Interested yet? Read on for other articles about 1119-94-4, you can contact me at any time and look forward to more communication. Category: bromides-buliding-blocks.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1119-94-4, Name is Dodecyl trimethyl ammonium bromide, SMILES is CCCCCCCCCCCC[N+](C)(C)C.[Br-], belongs to bromides-buliding-blocks compound. In a document, author is Alam, Firoz, introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/1119-94-4.html.

Eu2+: A suitable substituent for Pb2+ in CsPbX3 perovskite nanocrystals?

Eu2+ is used to replace toxic Pb2+ in metal halide perovskite nanocrystals (NCs). The synthesis implies injection of cesium oleate into a solution of europium (II) bromide at an experimentally determined optimum temperature of 130 degrees C and a reaction time of 60 s. Structural analysis indicates the formation of spherical CsEuBr3 nanoparticles with a mean size of 43 +/- 7 nm. Using EuI2 instead of EuBr2 leads to the formation of 18-nm CsI nanoparticles, while EuCl2 does not show any reaction with cesium oleate forming 80-nm EuCl2 nanoparticles. The obtained CsEuBr3 NCs exhibit bright blue emission at 413 nm (FWHM 30 nm) with a room temperature photoluminescence quantum yield of 39%. The emission originates from the Laporte-allowed 4f (7)-4f (6)5d(1) transition of Eu2+ and shows a PL decay time of 263 ns. The long-term stability of the optical properties is observed, making inorganic lead-free CsEuBr3 NCs promising deep blue emitters for optoelectronics. Published under license by AIP Publishing.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1119-94-4 is helpful to your research. HPLC of Formula: https://www.ambeed.com/products/1119-94-4.html.