Tag: M.W=250-300

Chen, Xin published the artcileAcetic Acid Derivatives of 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide as a Novel Class of Potent Aldose Reductase Inhibitors, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Journal of Medicinal Chemistry (2010), 53(23), 8330-8344, database is CAplus and MEDLINE.

A series of novel benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of these derivatives, 17 compounds, having a substituted N2-benzyl group and a N4-acetic acid group on the benzothiadiazine, were found to be potent and selective aldose reductase inhibitors in vitro with IC₅₀ values ranging from 0.032 to 0.975 μM. I (R¹=Cl, R²=2,4,5-F₃) proved to be the most active in vitro. The eight top-scoring compounds coming from the in vitro test for ALR2 inhibition activity were then tested in vivo, whereby three derivatives, I (R¹=F, R²=2,4,5-F₃; R¹=Cl, R²=2-F,4-Br; R¹=Cl, R²=2,4,5-F₃) demonstrated a significantly preventive effect on sorbitol accumulation in the sciatic nerve in the 5-day streptozotocin-induced diabetic rats in vivo. Structure-activity relationship and mol. docking studies highlighted the importance of substitution features of N4-acetic acid group and halogen-substituted N2-benzyl group in the benzothiadiazine scaffold and indicated that substitution with halogen at C-7 had a remarkably strong effect on ALR2 inhibition potency.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhou, Lu published the artcileNi-catalyzed migratory fluoro-alkenylation of unactivated alkyl bromides with gem-difluoroalkenes, HPLC of Formula: 1997-80-4, the publication is Chemical Science (2019), 10(4), 1144-1149, database is CAplus and MEDLINE.

Nickel-catalyzed highly regio- and stereoselective migratory fluoro-alkenylation of unactivated alkyl bromides was reported. Catalytic cycle merged alkyl nickel chain-walking and defluorinative coupling enabled the introduction of a broad array of fluoroalkenyl moieties into carbon chains. Control experiments with other halogenated alkenes demonstrated the essential role of fluorine atoms in this reaction. The reaction proceeded under mild conditions and allowed for the synthesis of a variety of valuable monofluoroalkenes.

Chemical Science published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C8H5F3O3, HPLC of Formula: 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Luo, Qi published the artcileSynthesis of Conjugated Main-Chain Ferrocene-Containing Polymers through Melt-State Polymerization, Synthetic Route of 303734-52-3, the publication is Organometallics (2019), 38(15), 2972-2978, database is CAplus.

Two kinds of conjugated main-chain ferrocene (Fc)-containing polymers, PFcT8 and PFcTP8, were successfully prepared through the facile melt-state polymerization (MSP) of corresponding monomers which combine the Fc motif with thiophene or thiophene-methane groups. The simple, low-cost MSP was chosen as the method, while thiophene or thiophene-methane groups served as reactive sites for its feature of easy polymerization by a simple heating process. The prepared metallopolymers were characterized by ¹H NMR, FTIR, and photochem. and electrochem. anal., metal content, and thermal stability. The results show that metallopolymers with a regular backbone and nearly quant. metal content were obtained. In addition, the metallopolymer PFcTP8 has the smallest optical band gap (absorption edge at 1100 nm) and high thermal stability among reported Fc-containing polymers, which indicates the thiophene-methane-based Fc-containing structure is a good candidate to construct functional polymers through MSP. The low band gap and high thermal stability of prepared conjugated metallopolymers show their potential application in conducting materials with high working temperature

Organometallics published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Synthetic Route of 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Kai published the artcileSynthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, Related Products of bromides-buliding-blocks, the publication is ACS Sensors (2021), 6(4), 1543-1551, database is CAplus and MEDLINE.

Reliable and accurate glucose detection in biol. samples is of great importance in clin. diagnosis and medical research. Chem. probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has shown potential in glucose probing because of its high sensitivity. However, poor solubility limits its applications in aqueous media. In this work, we systemically modify P-DBA by introducing fluoro (F-), chloro (Cl-), methoxyl (MeO-), or cyano (CN-) substituents. Among these probes, the cyano-substituted probe (CN-DBA) displays the highest glucose-binding constant (6489.5 M^-1, 33% MeOH). More importantly, it shows good water solubility in the aqueous solution (0.5% MeOH), with ultrasensitive recognition with glucose (LOD = 1.51 μM) and robust sensing from pH 6.0 to 9.0. Based on these features, the CN-DBA is finally applied to detect glucose in cell lysates and plasma, with satisfactory recovery and precision. These results demonstrate that CN-DBA could serve as an accurate, sensitive fluorescent probe for glucose assays in biol. samples.

ACS Sensors published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C11H8O3, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Luo, Yin published the artcileSynthesis and antimicrobial evaluation of a novel class of 1,3,4-thiadiazole: Derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is European Journal of Medicinal Chemistry (2013), 54-61, database is CAplus and MEDLINE.

A series of novel 1,3,4-thiadiazole derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety were synthesized by the method of splicing active substructures. All the compounds were assayed for antimicrobial activities against five fungi strains and four bacteria strains. The preliminary results indicated that some compounds showed good antifungal activities against Physaclospora piricola and Rhizoctonia solani. Compound I [R = 3-NO₂-4-Me-Bn] exhibited good antifungal activities against Cercospora beticola and R. solani. Most of the compounds showed better antibacterial activities against Gram-neg. bacteria strains than Gram-pos. bacteria strains. Compounds I [R = 2-NO₂-4-Me-Bn, 2,6-F₂-Bn] showed the best activities against Pseudomonas fluorescence while compounds I [R = 2,4-F₂-Bn, 2-F-4-Br-Bn] showed good activities against Escherichia coli.

European Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Xin published the artcile1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry (2011), 19(23), 7262-7269, database is CAplus and MEDLINE.

Due to the importance of aldose reductase (ALR2) as a potential drug target in the treatment of diabetic complications, there are increasing interests in design and synthesis of ALR2 inhibitors. 1,2-Benzothiazine-4-acetic acid 1,1-dioxide derivatives were prepared and investigated for their inhibition activity. Most of these derivatives were active with IC₅₀ values ranging from 0.11 μM to 10.42 μM, and 2-[2-(4-bromo-2-fluorobenzyl)-1,1-dioxido-2H-1,2-benzothiazin-4(3H)-ylidene]acetic acid showed the most potent inhibition activity. Further, SAR and docking studies suggest that in comparison with the α,β-unsaturated derivatives, the saturated carboxylic acid derivatives had a greater binding affinity with the enzyme and thus an enhanced inhibition activity. Therefore, development of more powerful ARIs based on benzothiazine 1,1-dioxide by stereo-controlled synthesis could be expected.

Bioorganic & Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Penghui published the artcileDesign, synthesis and biological evaluation of benzimidazole-rhodanine conjugates as potent topoisomerase II inhibitors, Category: bromides-buliding-blocks, the publication is MedChemComm (2018), 9(7), 1194-1205, database is CAplus and MEDLINE.

In this study, a series of benzimidazole-rhodanine conjugates were designed, synthesized and investigated for their topoisomerase II (Topo II) inhibitory and cytotoxic activities. The results from Topo II-mediated pBR322 DNA relaxation and cleavage assays showed that the synthesized compounds might act as Topo II catalytic inhibitors. Certain compounds displayed potent Topo II inhibition at 10 muM. The cytotoxic activities of these compounds against HeLa, A549, Raji, PC-3, MDA-MB-201, and HL-60 cancer cell lines were evaluated. The results indicated that these compounds exhibited strong antiproliferative activity. A good relationship was observed between the Topo II inhibitory potency and the cytotoxicity of these compounds The structure-activity relationship revealed that the electronic effects, the Ph group, and the rhodanine moiety were particularly important for the Topo II inhibitory potency and cytotoxicity.

MedChemComm published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Jiang, Hong published the artcileSynthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(8), 1320-1323, database is CAplus and MEDLINE.

In this study, a series of carbazole-rhodanine conjugates was synthesized and evaluated for their Topoisomerase II inhibition potency as well as cytotoxicity against a panel of four human cancer cell lines. Among these thirteen compounds, I (R = 2-F-4-Br, 4-NO₂, 4-CN, 4-CF₃) possessed Topoisomerase II inhibition potency at 20μM. Mechanism study revealed that these compounds may function as Topo II catalytic inhibitors. It was found that the electron-withdrawing groups on the Ph ring of compounds played an important role on enhancing both enzyme inhibition and cytotoxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zeng, Xiao-Lan published the artcileQSPR study on octanol/water partition coefficient (lgK_ow) of substituted naphthalin compounds, Recommanded Product: 1,3-Dibromonaphthalene, the publication is Chinese Journal of Structural Chemistry (2007), 26(3), 281-286, database is CAplus.

Structural parameters of 24 substituted naphthalin compounds were computed at four levels using Hartree-Fock and DFT methods. Based on the exptl. data of octanol/water partition coefficient (lgK_ow), three-parameter (energy of the HOMO (E_HOMO), the most pos. at. net charges of mol. (q⁺) and mol. average polarizability (α)) dependent equations were developed using structural parameters as theor. descriptors. Especially, lgK_ow dependent equation calculated at the HF/6-311G** level is more advantageous than others in view of their correlation and predictive abilities. This dependent equation was validated by variance inflation factors (VIF) and t-test methods and used to predict lgK_ow of eight designed compounds Upon comparison, the predictive abilities of our work are all more advantageous than those calculated from mol. property calculator program.

Chinese Journal of Structural Chemistry published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C6H5BN2O3, Recommanded Product: 1,3-Dibromonaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tan, Wei published the artcile4-N-Methyl-N’-(2-dihydroxyboryl-benzyl)amino benzonitrile and its boronate analogue sensing saccharides and fluoride ion, Category: bromides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(9), 2629-2633, database is CAplus and MEDLINE.

Two DMABN (4-N,N-dimethylaminobenzonitrile) derivatives were designed as new ratiometric fluorescent sensors for saccharides and fluoride ion (F^–), resp., based on the TICT (twisted intramol. charge transfer) mechanism.

Bioorganic & Medicinal Chemistry Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C11H8O3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary