M.W=250-300 Archives - Page 44 of 46 - Bromides-buliding-blocks

Menzel, Karsten’s team published research in Synlett in 2006-08-01 | 603-78-1

Synlett published new progress about Aromatic carboxylic acids Role: SPN (Synthetic Preparation), PREP (Preparation) (bromo-). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Recommanded Product: 2,3-Dibromobenzoic acid.

Menzel, Karsten; Dimichele, Lisa; Mills, Paul; Frantz, Doug E.; Nelson, Todd D.; Kress, Michael H. published the artcile< Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: the synthesis of 2-substituted 5-bromobenzoic acids>, Recommanded Product: 2,3-Dibromobenzoic acid, the main research area is substituted dibromoarene isopropylmagnesium chloride regioselective halogen metal exchange; bromoarene substituted preparation; bromobenzoic acid substituted preparation; regioselective halogen metal exchange reagent isopropylmagnesium chloride.

Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes, e.g., I. When the 3-substituent was either electron-withdrawing and/or possessed lone pair electrons that enabled chelation of isopropylmagnesium chloride, a high regioselectivity for the halogen-metal exchange adjacent to the 3-substituents resulted.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lambright, Alison L’s team published research in Organic Letters in 2021-01-15 | 639520-70-0

Organic Letters published new progress about Amides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (borylated cyclopentene derivatives). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Product Details of C12H16BrNO2.

Lambright, Alison L.; Liu, Yanyao; Joyner, Isaac A.; Logan, Kaitlyn M.; Brown, M. Kevin published the artcile< Mechanism-Based Design of an Amide-Directed Ni-Catalyzed Arylboration of Cyclopentene Derivatives>, Product Details of C12H16BrNO2, the main research area is borylated cyclopentane amide derivative preparation; crystal structure borylated cyclopentane amide derivative; mol structure borylated cyclopentane amide derivative; amide directed nickel catalyzed diastereoselective arylboration cyclopentene derivative.

A method for amide-directed Ni-catalyzed diastereoselective arylboration of cyclopentenes is disclosed. The reaction allows for the synthesis of sterically congested cyclopentane scaffolds that contain an easily derivatized boronic ester and amide functional handles. The nature of the amide directing group and its influence on the reaction outcome were studied and ultimately reflect a predictably selective reaction based on the solvent and base counterion.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koziakov, Denis’s team published research in European Journal of Organic Chemistry in 2017 | 2252-45-1

European Journal of Organic Chemistry published new progress about Diazonium compounds, arene, salts Role: RCT (Reactant), RACT (Reactant or Reagent). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Safety of (3-Bromophenyl)(trifluoromethyl)sulfane.

Koziakov, Denis; Majek, Michal; Jacobi von Wangelin, Axel published the artcile< Radical Aromatic Trifluoromethylthiolation: Photoredox Catalysis vs. Base Mediation>, Safety of (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is aryl trifluoromethyl sulfide preparation; arenediazonium salt bistrifluoromethyl disulfide photoredox trifluoromethylthiolation.

Trifluoromethyl aryl sulfides (Ar-SCF3) constitute highly attractive building blocks due to their exceptional lipophilicity and chem. properties. Related protocols of radical aromatic trifluoro-methylthiolation of arenediazonium salts were developed that are based on the facile generation of intermediate aryl radicals. Their reactions with com. F3CS-SCF3 under very mild conditions afforded a diverse set of Ar-SCF3 (< 90 % yield). Direct comparison of photoredox catalysis {eosin Y or [Ru(bpy)3]Cl2} with the weak base-mediated dark reaction documented higher synthetic efficiency of the former but higher operational simplicity of the latter strategy. European Journal of Organic Chemistry published new progress about Diazonium compounds, arene, salts Role: RCT (Reactant), RACT (Reactant or Reagent). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Safety of (3-Bromophenyl)(trifluoromethyl)sulfane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tashiro, Masashi’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1983-10-31 | 603-78-1

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Deuteration. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Product Details of C7H4Br2O2.

Tashiro, Masashi; Nakayama, Kouji; Fukata, Gouki published the artcile< Preparation of all the possible ring-deuteriated benzoic acids by reductive dehalogenation of the corresponding halobenzoic acids with Raney alloys in an alkaline deuterium oxide solution>, Product Details of C7H4Br2O2, the main research area is deuteration benzoate; bromobenzoate reduction deuteration.

All 19 possible ring-deuterated benzoic acids, except 2,3,4,5-D4C6HCO2H (I), were prepared by reduction of the corresponding bromobenzoic acids with Raney Cu-Al alloy in 10% NaOD-D2O. I was prepared by deuteration of tetrabromophthalic acid as above followed by decarboxylation with Hg(OAc)2 in aqueous AcOH.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Linstad, Ethan J’s team published research in Organic & Biomolecular Chemistry in 2017 | 639520-70-0

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Synthetic Route of 639520-70-0.

Linstad, Ethan J.; Vavere, Amy L.; Hu, Bao; Kempinger, Jayson J.; Snyder, Scott E.; DiMagno, Stephen G. published the artcile< Thermolysis and radiofluorination of diaryliodonium salts derived from anilines>, Synthetic Route of 639520-70-0, the main research area is aniline diaryliodonium salt preparation radiofluorination.

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex mols., such as flutemetamol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Deswal, Yogesh team published research on Research on Chemical Intermediates in 2022 | 90-59-5

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of 3,5-Dibromo-2-hydroxybenzaldehyde.

Deswal, Yogesh;Asija, Sonika;Kumar, Deepak;Jindal, Deepak Kumar;Chandan, Gourav;Panwar, Vivek;Saroya, Sonia;Kumar, Naresh research published 《 Transition metal complexes of triazole-based bioactive ligands: synthesis, spectral characterization, antimicrobial, anticancer and molecular docking studies》, the research content is summarized as follows. Abstract: In the present research work, four new heterocyclic Schiff base ligands (1–4) were synthesized by the condensation of 4-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)phenol with salicylaldehyde derivatives in 1:1 molar ratio. The synthesized Schiff base ligands were allowed for complexation with Co(II), Ni(II), Cu(II), Zn(II) metal ions. The structure of the newly synthesized compounds (1–20) was elucidated with the help of various spectral and physicochem. techniques. Spectroscopic data confirm the tridentate nature of ligands which coordinate to the metal via deprotonated oxygen, azomethine nitrogen and thiol sulfur. Conductivity data showed the non-electrolytic nature of complexes. Furthermore, the synthesized compounds were evaluated for their in-vitro antimicrobial activity against four pathogenic bacterial strains and two pathogenic fungal strains. The observed results of microbial activity reveals that compound 3 and its complexes (13–16) were found most potent against the pathogenic strains. In addition, the anticancer activity of all the synthesized compounds was evaluated against human carcinoma cell lines i.e. HCT-116, DU145 and A549 using MTT assay. Among the tested compounds 12, 19, and 20 show promising potency against the cancer cell lines. To rationalize the preferred modes of interaction of most potent compounds with the active site of human EGFR protein (PDB id: 5XGM), mol. docking studies were performed.

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Devi, Jai team published research on Applied Organometallic Chemistry in 2022 | 90-59-5

Application of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organic compounds having carbon bonded to bromine are called organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H4Br2O2.

Devi, Jai;Sharma, Som;Kumar, Sanjeev;Kumar, Binesh;Kumar, Deepak;Jindal, Deepak Kumar;Das, Souvik research published 《 Synthesis, characterization, in vitro antimicrobial and cytotoxic studies of Co(II), Ni(II), Cu(II), and Zn(II) complexes obtained from Schiff base ligands of 1, 2, 3, 4-tetrahydro-naphthalen-1-ylamine》, the research content is summarized as follows. The transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with bidentate Schiff base ligands (HL^1-5) were obtained from condensation of 1,2,3,4-tetrahydro-naphthalen-1-ylamine with methanolic solution of 3-hydroxy-salicylaldehyde, 4-hydroxy-salicylaldehyde, 5-bromo-salicylaldehyde, 3,5-dibromo-salicylaldehyde, and 2-hydroxy-1-naphthaldehyde. The synthesized compounds were structurally elucidated by spectral and phys. methods. The spectral characterization emphasized bidentate nature (NO) of Schiff base ligands which gets chelated with metal via nitrogen atom of imine group and deprotonated oxygen of salicylaldehyde/2-hydroxy-1-naphthaldehyde group to form octahedral geometry around metal atom. Thermal results supported that the complexes are stable up to 200° leaving metal oxide as an end products. The reported compounds (1–25) in this series were screened against the bacterial strains, i.e., two Gram pos.: Bacillus subtilis and Staphylococcus aureus, two Gram neg.: Pseudomonas aeruginosa and Escherichia coli, and two fungal strains: Candida albicans and Aspergillus niger and their results that indicated moderate to good activity with compounds 20 and 21 having good antimicrobial activity (min. inhibitory concentration [MIC] value 0.0269-0.0067μmol/mL) as compared with control drugs ciprofloxacine and fluconazole. Furthermore, cytotoxic studies of synthesized compounds were carried out against three human cancer cell lines: HCT-<116≥ (colon), A549 (alveolar), and MCF-7 (breast) using standard drug paclitaxel. Compounds 1 (IC₅₀ values = 12.93, 15.13, 17.24), 3 (11.9, 9.29, 12.64), 9 (17.06, 20.06, 22.87), 14 (16.21, 18.47, 20.00), and 25 (17.54, 17.21, 20.23) for three cancer cell lines are most potent candidates among the synthesized compounds

Application of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Devi, Jai team published research on Journal of Molecular Structure in 2021 | 90-59-5

Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Formula: C7H4Br2O2.

Devi, Jai;Yadav, Jyoti;Lal, Kashmiri;Kumar, Nikhil;Paul, Avijit Kumar;Kumar, Deepak;Dutta, Partha P.;Jindal, Deepak Kumar research published 《 Design, synthesis, crystal structure, molecular docking studies of some diorganotin(IV) complexes derived from the piperonylic hydrazide Schiff base ligands as cytotoxic agents》, the research content is summarized as follows. Inspired by the role of organotin(IV) complexes in inhibition of cancer cell growth and interaction with different target proteins, the authors synthesized new organotin(IV) complexes of Schiff base ligands of benzylidene benzohydrazide analogs. The structural elucidation of compounds was done by spectroscopic studies showing tridentate nature (NOO) of Schiff base ligands having pentacoordinated geometry around the central Sn metal. The x-ray crystallog. study of complex 9 (Me₂SnL²) revealed the distorted trigonal bipyramidal geometry (SnO₂NC₂). The cytotoxic activity of compounds was tested against human cancer cell lines A549, Hela, MCF7 and normal cell line L6 using MTT assay. Compound 12 (Ph₂SnL²), 14 (Et₂SnL³), 19 (Bu₂SnL⁴) was found most active against tested cell lines having IC₅₀ value 22.909-32.303μM. Further, mol. docking study was performed for the active compounds 12, 14 and 20 at 3-dimensional space of enzymes Tyrosine kinase and EGFR kinase domain.

Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Devi, Jai team published research on Phosphorus, Sulfur and Silicon and the Related Elements in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Devi, Jai;Pachwania, Sushila;Yadav, Jyoti;Kumar, Ashwani research published 《 Pentacoordinated diorganotin(IV) complexes resulting from tridentate (NOO) donor Schiff bases: Synthesis, characterization, in vitro antioxidant, antimicrobial activities, and QSAR studies》, the research content is summarized as follows. Diorganotin(IV) complexes R₂SnL, (R = Me, Et, Bu and Ph) were prepared by the reaction of tridentate (NOO) donor Schiff base ligands with diorganotin(IV) dichloride in an equimolar ratio. The products were characterized by various spectroscopic techniques and phys. and anal. methods (UV-visible, FTIR, NMR, fluorescence, elemental anal.). Spectroscopic data suggest that the Schiff base acts as a tridentate ligand (NOO) coordinated with a central Sn atom via two O and one imine N atom in a pentacoordinated fashion. The synthesized compounds were assayed for their in vitro antimicrobial activity against bacterial and fungal strains. All the compounds displayed promising results with the complexes being more potent than free ligands. The antioxidant activity of the compounds was determined by interaction with 2,2-diphenyl-1-picrylhydrazyl free radical. Complex Ph₂SnL³ () has the most potential antimicrobial activity against all tested strains and also exhibited excellent antioxidant activity. Quant. structure-activity relation of compounds was studied for antimicrobial activity with molar refractivity indexes as significant statistical parameter.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Devi, Jai team published research on Research on Chemical Intermediates in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Devi, Jai;Pachwania, Sushila;Kumar, Deepak;Jindal, Deepak Kumar;Jan, Suraya;Dash, Ashutosh K. research published 《 Diorganotin(IV) complexes derived from thiazole Schiff bases: synthesis, characterization, antimicrobial and cytotoxic studies》, the research content is summarized as follows. Organotin(IV) complexes are gaining major attention as drug candidates, accordingly we have synthesized a cluster of novel diorganotin(IV) complexes I (R³₂SnClL; R³ = Me, Et, Bu, Ph; R = H, Br; R¹ = H, OH; R² = NO₂, Br) of the corresponding Schiff base ligands (HL¹-HL⁴). The structural elucidation of the compounds was done by using different spectroscopic techniques (UV-Vis, FT-IR, ¹H, ¹³C and ¹¹⁹Sn NMR), mass spectrometry, m.p. and molar conductance measurement. The spectroscopic data recommend that Schiff bases are N,O-bidentate in nature and bind to tin metal via azomethine nitrogen, phenolic oxygen atom and create pentacoordinated environment around central tin metal. To check the biol. utility, the synthesized compounds were tested for antimicrobial activity against different bacterial and fungal strains using serial dilution method and inhibitory activity noted in terms of MIC values (μmol/mL) which displayed that the complexes were more efficient than corresponding Schiff bases and complex 20 (Ph₂SnClL⁴) was most active antimicrobial agent. The compounds were also evaluated for cytotoxic activity against human cancer cell lines- A549 (Lung), PC-3 (Prostate), MDA-MB-231 (Breast), MIA PaCa-2 (pancreas) and human normal cell line fR2 by using MTT method. The results of cytotoxic activity showed that some compounds are active and compounds 10 and 11 (R = H, R¹ = OH, R² = H, R³ = Et, Bu) having IC₅₀ values ranging from 0.01 to 1.42μM are almost equally potent to the standard drug doxorubicin against all examined cell lines and are even less toxic against normal cell line. Diorganotin(IV) complexes of 4-(4-bromophenyl)thiazol-2-amine and salicylaldehyde derivatives were synthesized and exhibited high antibacterial and antitumor activity.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary