Tag: M.W=250-300

Krishanmoorthy, Sankarganesh; Schnell, Simon D.; Dang, Huong; Fu, Fang; Prakash, G. K. Surya published the artcile< Fluorodecarboxylation: Synthesis of aryl trifluoromethyl ethers (ArOCF3) and thioethers (ArSCF3)>, Reference of 2252-45-1, the main research area is aryl trifluoromethyl ether preparation; aryloxydifluoroacetic acid selectfluor fluorodecarboxylation; aryltrifluoromethyl thioether preparation; arylmercaptodifluoroacetic acid selectfluor fluorodecarboxylation.

Fluorodecarboxylation of aryloxydifluoroacetic acid (ArOCF2CO2H) [Ar = C6H5, 4-(CH3)3CC6H4, naphthalen-1-yl, etc.] and arylmercaptodifluoroacetic acid (RSCF2CO2H) [R = C6H5, 4-ClC6H4, 3,5-(CF3)2C6H3, etc.] towards RSCF3 and ArOCF3 using silver (I) salts in the presence of Selectfluor in a biphasic system with trifluoroacetic acid additive is discussed.

Journal of Fluorine Chemistry published new progress about Aromatic carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Reference of 2252-45-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liedholm, Brita published the artcile< Copper(I)-catalyzed replacement of bromine by chloride ion in bromobenzoic acids>, Related Products of 603-78-1, the main research area is copper catalyst bromine exchange; bromobenzoate chloride exchange reaction.

Kinetics of the exchange reactions of 2,3-dibromobenzoic acid and of 2-bromobenzoic acid, catalyzed by dichlorocuprate(I) ion, were determined A tetrahedral intermediate complex involving the dichlorocuprate anion and the Br atom undergoing replacement was suggested.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about Exchange reaction. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Related Products of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pocinho, Alexandre; Mallet-Ladeira, Sonia; Hureau, Christelle; Gras, Emmanuel published the artcile< N,N′-Bis(4-bromophenyl)-N,N′-dimethylurea>, Quality Control of 639520-70-0, the main research area is bisbromophenyl dimethylurea preparation crystal structure.

The structure of the title compound, C15H14Br2N2O, at 180 K has monoclinic (P21/n) symmetry. It was obtained unexpectedly from the decomposition of the parent 4-bromo-N-tert-butoxycarbonyl-N-methyl-aniline. It exhibits an ′endo′ conformation with angles between the two aromatic rings slightly lower than the average values found for similar compounds on the Cambridge Structural Database. In the crystal, C-H···O hydrogen bonds and short Br···Br halogen bonds [3.444 (1) Å] are observed

IUCrData published new progress about Crystal structure. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Quality Control of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Smith, Bradley D.; Goodenough-Lashua, DeeAnne M.; D’Souza, Carlisle J. E.; Norton, Kieran J.; Schmidt, Leslie M.; Tung, James C. published the artcile< Substituent effects on the barrier to carbamate C-N rotation>, Formula: C12H16BrNO2, the main research area is substituent effect barrier carbamate carbon nitrogen rotation.

Seven aryl-substituted t-Bu N-methyl-N-aryl carbamates were prepared, and in each case, the barrier to C-N bond rotation, ΔG‡, was determined in CDCl3 solution using variable temperature NMR. A linear free energy relationship is observed between ΔG‡ and the electronic stabilization effect of the substituent on the N-aryl ring. More specifically, electron donating groups increase ΔG‡, whereas withdrawing groups decrease ΔG‡. A plot against σ- was more linear (r2=0.96), than a plot against σ (r2 = 0.90) or σ+ (r2 = 0.88) and a value of ρ = 1.76 was obtained at 243 K. Thus, rotation about the carbamate C-N bond in weakly polar chloroform involves a decrease in pos. charge on the nitrogen.

Tetrahedron Letters published new progress about C-N bond. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Formula: C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cohen, Julius Berend; Zortman, Israel Hyman published the artcile< The relation of position isomerism to optical activity. V. The rotation of the menthyl esters of the isomeric dibromobenzoic acids>, Application In Synthesis of 603-78-1, the main research area is .

The esters were prepared by oxidizing the six dibromotoluenes to the corresponding acids, which were then converted into the acid chlorides, and the latter into the esters by heating with menthol. The preparation of menthyl 2:3-dibromobenzoate, menthyl 2:4-dibromobenzoate, menthyl 2:5-dibromobenzoate, menthyl 2:6-dibromobenzoate, menthyl 3:4-dibromobenzoate, and menthyl 3:5-dibromobenzoate are described.

Journal of the Chemical Society, Transactions published new progress about Boiling point. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application In Synthesis of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Wei; Wang, Biyun; Ji, Xinfei; Cao, Song published the artcile< Direct copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3>, Application of C7H4BrF3S, the main research area is arylboronic acid silver trifluoromethylthiolate copper catalyst trifluoromethylthiolation; aryl trifluoromethyl thioether preparation.

A copper-catalyzed direct oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3 was developed. This approach provided straightforward and efficient access to a variety of aryl trifluoromethyl sulfides from an easily prepared and stable nucleophilic trifluoromethylthiolation reagent AgSCF3, and readily available nucleophilic arylboronic acids, thus avoiding the preparation of electrophilic trifluoromethylthiolating reagents in advance. Preliminary mechanistic experiments indicated that AgSCF3 served as both a source of SCF3 and an oxidant.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Application of C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Martinelli, Joseph R.; Freckmann, Dominique M. M.; Buchwald, Stephen L. published the artcile< Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure>, SDS of cas: 639520-70-0, the main research area is Weinreb amide preparation; palladium catalyst aminocarbonylation aryl bromide; phosphine ligand palladium catalyst aminocarbonylation; benzamide methoxymethyl preparation.

The direct transformation of aryl bromides into the corresponding Weinreb amides via Pd-catalyzed aminocarbonylation at atm. pressure was reported. Thus, reaction of 3-BrC6H4CN and MeNHOMe.HCl with CO in toluene containing Pd(OAc)2, the bidentate P ligand Xantphos, and Na2Co3 at 80° gave 88% 3-BrC6H4CONMeOMe.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, SDS of cas: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nguyen, Julia; Chong, Andrea; Lalic, Gojko published the artcile< Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes>, HPLC of Formula: 639520-70-0, the main research area is alkene aryl halide anti Markovnikov hydroarylation regioselective nickel catalyst.

We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, HPLC of Formula: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thun-Hohenstein, Siegfried T. D.; Suits, Timothy F.; Malla, Tika R.; Tumber, Anthony; Brewitz, Lennart; Choudhry, Hani; Salah, Eidarus; Schofield, Christopher J. published the artcile< Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease>, Formula: C7H4Br2O2, the main research area is ebselen derivative SARS CoV2 main protease inhibitor COVID19; COVID-19; Mpro inhibition; SARS-CoV-2; ebselen; ebsulfur; nucleophilic cysteine protease..

The reactive organoselenium compound ebselen is being investigated for treatment of coronavirus disease 2019 (COVID-19) and other diseases. We report structure-activity studies on sulfur analogs of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), employing turnover and protein-observed mass spectrometry-based assays. The results reveal scope for optimization of ebselen/ebselen derivative- mediated inhibition of Mpro, particularly with respect to improved selectivity.

ChemMedChem published new progress about Anticoronaviral agents. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Formula: C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Malysheva, Yulia B.; Combes, Sebastien; Fedorov, Alexey Yu.; Knochel, Paul; Gavryushin, Andrei E. published the artcile< New method of synthesis and biological evaluation of some combretastatin A-4 analogues>, Formula: C12H16BrNO2, the main research area is combretastatin A4 analog stereoselective preparation antitumor.

A series of novel combretastatin A-4 analogs was synthesized in 36-64% yields by Negishi cross-coupling reaction under mild conditions. The prepared compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50 = 0.022-10.31 μM).

Synlett published new progress about Antitumor agents. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Formula: C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary