Tag: M.W=250-300

Ge, Shaozhong; Chaladaj, Wojciech; Hartwig, John F. published the artcile< Pd-Catalyzed α-Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes>, Related Products of 639520-70-0, the main research area is difluoroketone aryl heteroaryl bromide chloride arylation palladacycle catalyst; aryldifluoroketone preparation aryl acyl bond cleavage; difluoromethylarene difluoromethylheteroarene preparation.

We report the Pd-catalyzed α-arylation of α,α-difluoroketones with aryl and heteroaryl bromides and chlorides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)Cy2 as ligand. The combination of this Pd-catalyzed arylation and base-induced cleavage of the acyl-aryl C-C bond within the α-aryl-α,α-difluoroketone constitutes a one-pot, two-step procedure to synthesize difluoromethylarenes from aryl halides. A broad range of electronically varied aryl and heteroaryl bromides and chlorides underwent these two transformations, providing α-aryl-α,α-difluoroketones, difluoromethylarenes, and difluoromethylheteroarenes in high yields.

Journal of the American Chemical Society published new progress about Aralkyl halides Role: SPN (Synthetic Preparation), PREP (Preparation) (difluoromethyl arenes). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Related Products of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tashiro, Masashi; Nakayama, Kouji published the artcile< Preparation of bromobenzoic acids from the corresponding bromotoluenes via the Krohnke method>, Recommanded Product: 2,3-Dibromobenzoic acid, the main research area is benzoic acid dibromo; bromobenzoic acid; bromotoluene conversion bromobenzoic acid.

Bromotoluenes were converted to acids I (n = 2, 3) via N-benzylpyridinium salts II. Thus, 2,3-Br2C6H3Me was brominated to 2,3-Br2C6H3CH2Br, the latter and pyridine gave II (Brn = 2,3-Br2), the product was treated with 4-Me2NC6H4NO and then with HCl to yield 2,3-Br2C6H3CHO, and the aldehyde was oxidized by KMnO4 to give 2,3-Br2C6H3CO2H.

Organic Preparations and Procedures International published new progress about 603-78-1. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Recommanded Product: 2,3-Dibromobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Friis, Stig D.; Pirnot, Michael T.; Dupuis, Lauren N.; Buchwald, Stephen L. published the artcile< A Dual Palladium and Copper Hydride Catalyzed Approach for Alkyl-Aryl Cross-Coupling of Aryl Halides and Olefins>, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is palladium copper hydride catalyzed cross coupling aryl halide olefin; alkenes; copper; cross-coupling; homogeneous catalysis; palladium.

We report an efficient means of sp2-sp3 cross coupling for a variety of terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis [e.g., 4-bromoanisole + 4-phenyl-1-butene → MeOC6H4-4-(CH2)4Ph in presence of [Pd(cinnamyl)Cl]2, BrettPhos, CuCl.(R)-DTBM-SEGPHOS and Me2PhSiH]. In addition to its applicability to a range of aryl bromide substrates, this process was also suitable for electron-deficient aryl chlorides, furnishing higher yields than the corresponding aryl bromides in these cases. The optimized protocol does not require the use of a glove-box and employs air-stable Cu and Pd complexes as precatalysts. A reaction on 10 mmol scale further highlighted the practical utility of this protocol. Employing a similar protocol, a series of cyclic alkenes were also examined Cyclopentene was shown to undergo efficient coupling under these conditions. Lastly, deuterium-labeling studies indicate that deuterium scrambling does not take place in this sp2-sp3 cross coupling, implying that β-hydride elimination is not a significant process in this transformation.

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C7H4Br2O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application of C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Martinelli, Joseph R.; Watson, Donald A.; Freckmann, Dominique M. M.; Barder, Timothy E.; Buchwald, Stephen L. published the artcile< Palladium-Catalyzed Carbonylation Reactions of Aryl Bromides at Atmospheric Pressure: A General System Based on Xantphos>, Quality Control of 639520-70-0, the main research area is heteroaryl aryl bromide chloride dimethylhydroxylamine hydrochloride cyclic aliphatic amine; methanol palladium Xantphos aminocarbonylation alkoxycarbonylation; Weinreb amide benzamide methyl ester preparation; aminocarbonylation alkoxycarbonylation catalyst palladium Xantphos.

A method for the Pd-catalyzed carbonylation of aryl bromides has been developed using Xantphos as the ligand. This method is effective for the direct synthesis of Weinreb amides, 1° and 2° benzamides, and Me esters from the corresponding aryl bromides at atm. pressure. In addition, a putative catalytic intermediate, (Xantphos)Pd(Br)benzoyl, was prepared and an X-ray crystal structure was obtained revealing an unusual cis-coordination mode of Xantphos in this palladium-acyl complex.

Journal of Organic Chemistry published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Quality Control of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Li; Chen, Peng published the artcile< Development of first-stage co-liquefaction of Chinese coal with waste plastics>, Application of C7H4Br2O2, the main research area is liquefaction Chinese coal waste plastic.

Polyethylene (PE), polypropylene (PP), and polystyrene (PS), etc. were successfully converted to oil under typical direct liquefaction conditions (410-450°, reaction time of 60 min, 10 MPa of H2 cold) with Chinese coal. A series of liquefaction experiments were run using ground coal and plastic waste, individually and in combination. Results on individual plastics showed that high d. PE (HDPE) was by far the most difficult of the model plastics to convert, higher conversions could be obtained with higher temperatures Co-liquefaction experiments were performed on coal-plastic mixtures (usually 1:1 mixtures) using a Chinese Xianfeng lignite with the fly ash of molybdenum concentrates calcined (FAMo) as catalyst. The oil yields except Xianfeng lignite-HDPE co-liquefaction were as high as 60.3-78.1%, while the total conversions reached levels of over 95%. Anyway, oil yields for Chinese coal-plastic co-liquefaction were higher, typically by 5.1-22.6%, than the average of the oil yields for the coal and plastic alone, hydrogen consumption was also reduced by 7.7-17.9%, implying synergistic effects in co-liquefaction reaction of Chinese coal and waste plastics (WP).

Chemical Engineering and Processing published new progress about Coal hydroliquefaction. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application of C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Orlova, Raisa K.; Sokolenko, Liubov V.; Babadzhanova, Lesia A.; Filatov, Andrey A.; Yagupolskii, Yurii L. published the artcile< GLP (Good Laboratory Procedure) for SCF3 construction: Useful procedure for trifluoromethylation of thiols by reaction with trifluoromethyliodide>, Product Details of C7H4BrF3S, the main research area is thiol trifluoromethyl iodide trifluoromethylation; trifluoromethyl sulfide preparation.

A simple and effective preparative synthetic procedure for S-trifluoromethylation of various aliphatic, aromatic, and heteroaromatic thiols containing different substituents such as halogens, amino-, hydroxy- and acid derivatives was presented.

Journal of Fluorine Chemistry published new progress about Fluoroalkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Product Details of C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Ming; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published the artcile< Palladium-Catalyzed Oxidative Carbonylation of Aromatic C-H Bonds of N-Alkylanilines with CO and Alcohols for the Synthesis of o-Aminobenzoates>, Application In Synthesis of 639520-70-0, the main research area is palladium catalyzed oxidative carbonylation alkylaniline aminobenzoate preparation; alkylaniline aliphatic alc phenol monocarbonylation mild carbon monoxide pressure.

A Pd(II)-catalyzed C-H monocarbonylation of N-alkylanilines for the synthesis of o-aminobenzoates has been developed. Various aliphatic alcs. and phenol were tolerated in the reaction to afford the corresponding o-aminobenzoates in good yields under mild balloon pressure of CO.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Application In Synthesis of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Hong-Xing; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans>, Quality Control of 603-78-1, the main research area is haloaralkyl ether aldehyde tandem intermol radical addition cyclization; benzofuran preparation.

An intermol. addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermol. alkyl radical addition to a carbonyl group followed by an intramol. alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR anal. The mechanism is investigated by KIE experiments and control experiments This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.

Organic Letters published new progress about Aldehydes Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Quality Control of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Ya-Wei; Zheng, Hong-Xing; Yang, Bo; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< tBuOK-Promoted Cyclization of Imines with Aryl Halides>, COA of Formula: C7H4Br2O2, the main research area is imine aryl halide aminyl radical potassium tert butoxide cyclization; indole preparation.

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramol. coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Organic Letters published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, COA of Formula: C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary