Tag: M.W=250-300

Kieltsch, Iris; Eisenberger, Patrick; Togni, Antonio published the artcile< Mild electrophilic trifluoromethylation of carbon- and sulfur-centered nucleophiles by a hypervalent iodine(III)-CF3 reagent>, Application In Synthesis of 2252-45-1, the main research area is ketoester hypervalent iodine reagent electrophilic trifluoromethylation; nitroester hypervalent iodine reagent electrophilic trifluoromethylation; thiol hypervalent iodine reagent electrophilic trifluoromethylation; trifluoromethyl substituted derivative preparation; hypervalent iodine electrophilic trifluoromethylation reagent crystal structure.

Inexpensive, recyclable, and activable: these were the features of a new mild electrophilic trifluoromethylation reagent that could be used to transfer a CF3 group to C-centered nucleophiles, such as β-keto esters and α-nitro esters, and to S-centered nucleophiles.

Angewandte Chemie, International Edition published new progress about Esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-nitro). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Application In Synthesis of 2252-45-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Hong-Xing; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans>, Electric Literature of 1013031-65-6, the main research area is haloaralkyl ether aldehyde tandem intermol radical addition cyclization; benzofuran preparation.

An intermol. addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermol. alkyl radical addition to a carbonyl group followed by an intramol. alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR anal. The mechanism is investigated by KIE experiments and control experiments This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.

Organic Letters published new progress about Aldehydes Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Electric Literature of 1013031-65-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiao, Zhiwei; Beiger, Jason J.; Jin, Yushu; Ge, Shaozhong; Zhou, Jianrong Steve; Hartwig, John F. published the artcile< Palladium-Catalyzed Enantioselective α-Arylation of α-Fluoroketones>, Application of C12H16BrNO2, the main research area is palladium catalyst stereoselective arylation fluoroketone.

The transition-metal-catalyzed α-arylation of carbonyl compounds is a widely practiced method for C-C bond formation. Several enantioselective versions of this process have been reported, but intermol., enantioselective coupling reactions of aryl electrophiles with α-fluoro carbonyl compounds have yet to be disclosed. We report enantioselective coupling of aryl and heteroaryl bromides and triflates with α-fluoroindanones catalyzed by palladium complexes of a BINOL-derived monophosphine and Segphos, resp. The enolates were generated directly from α-fluoroindanones in the presence of potassium phosphate base during the reactions. We also report that reactions of α-fluorotetralones occur in high yields and enantioselectivities when conducted with enolates generated by elimination of trifluoroacetate from trifluoromethyl β-diketone hydrates. These reactions were catalyzed by palladium complexes of the com. available bisphosphine Difluorphos. Thus, the formation of enantioenriched α-aryl-α-fluoroketones can be readily achieved by C-C bond formation when the appropriate palladium catalyst and α-fluoro enolate precursor were used.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Application of C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bonin, Helene; Leuma-Yona, Rodrigue; Marchiori, Bruno; Demonchaux, Patrice; Gras, Emmanuel published the artcile< Highly practical boronic acid surrogates for the Suzuki-Miyaura cross-coupling>, Application In Synthesis of 639520-70-0, the main research area is biaryl preparation; Suzuki Miyaura cross coupling aryl bromide oxazaborocane boronic acid.

Boronic acids and esters are well known substrates for the Suzuki-Miyaura cross-coupling, yet their isolation can sometimes be tedious. We report here that the use of aryl dioxazaborocanes afford a simple isolation procedure while keeping a high efficiency in the cross-coupling process.

Tetrahedron Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Application In Synthesis of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ema, Tadashi; Tanida, Daisuke; Matsukawa, Tatsuya; Sakai, Takashi published the artcile< Biomimetic trifunctional organocatalyst showing a great acceleration for the transesterification between vinyl ester and alcohol>, Category: bromides-buliding-blocks, the main research area is biomimetic trifunctional organocatalyst transesterification vinyl ester alc.

Trifunctional organocatalysts (I) 1a (X = S) and 1b (X = O) mimicking the active site of serine hydrolases showed high catalytic activity with up to a 3700000-fold acceleration for the acyl-transfer reactions from vinyl trifluoroacetate to alc.

Chemical Communications (Cambridge, United Kingdom) published new progress about Enzyme mimics Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Blackhall, Alexander; Brydon, Donald L.; Javaid, Khalid; Sagar, Anthony J. G.; Smith, David M. published the artcile< Substitution reactions of phenylated aza heterocycles. Part 2. Bromination of some 2,5-diaryl-1,3,4-oxadiazoles>, Application In Synthesis of 603-78-1, the main research area is aryloxadiazole bromination; bromination diaryloxadiazole; oxadiazole diaryl bromination; nitrophenylphenyloxadiazole bromination regiochem.

2,5-Diaryl-1,3,4-oxadiazoles were brominated by either Br in oleum or Br and KBrO3 in HOAc-H2SO4. E.g., treatment of 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole and Br in concentrated H2SO4-HOAc by dropwise addition of aqueous KBrO3 gave the corresponding 2-, 3-, and 4-bromophenyl and 2,3-, 2,5-, and 2,6-dibromophenyl derivatives in 16, 14, 26, 1, 6, and 2% yield, resp.

Journal of Chemical Research, Synopses published new progress about Bromination. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application In Synthesis of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Giardina, Sarah F.; Werner, Douglas S.; Pingle, Maneesh; Feinberg, Philip B.; Foreman, Kenneth W.; Bergstrom, Donald E.; Arnold, Lee D.; Barany, Francis published the artcile< Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase>, SDS of cas: 1013031-65-6, the main research area is self assembling dimeric inhibitor human beta tryptase preparation; heterodimeric tryptase inhibitor mol modeling pharmacokinetics.

β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge two adjacent sites. Using diol, hydroxymethyl phenols or benzoyl Me hydroxamates, and boronic acid chemistries to reversibly join two [3-(1-acylpiperidin-4-yl)phenyl]methanamine core ligands, we have successfully produced a series of self-assembling heterodimeric inhibitors. These heterodimeric tryptase inhibitors demonstrate superior activity compared to monomeric modes of inhibition. X-ray crystallog. validated the dimeric mechanism of inhibition, and compounds demonstrated high selectivity against related proteases, good target engagement, and tryptase inhibition in HMC1 xenograft models. Screening 3872 possible combinations from 44 boronic acid and 88 diol derivatives revealed several combinations that produced nanomolar inhibition, and seven unique pairs produced greater than 100-fold improvement in potency over monomeric inhibition. These heterodimeric tryptase inhibitors demonstrate the power of target-driven combinatorial chem. to deliver bivalent drugs in a small mol. form.

Journal of Medicinal Chemistry published new progress about Homo sapiens. 1013031-65-6 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6Br2O, SDS of cas: 1013031-65-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luo, Ziwei; Yang, Xinkan; Tsui, Gavin Chit published the artcile< Perfluoroalkylation of Thiosulfonates: Synthesis of Perfluoroalkyl Sulfides>, Formula: C7H4BrF3S, the main research area is perfluoroalkyl sulfide synthesis perfluoroalkylation thiosulfonate.

A practical synthesis of perfluoroalkyl sulfides is described. The method employs stable and readily accessible thiosulfonates as new electrophiles with com. nucleophilic perfluoroalkylating reagents. The mild reaction conditions allow access to a wide variety of both aryl- and alkyl-substituted perfluoroalkyl sulfides amenable to pharmaceutical development. Furthermore, the reaction operation is straightforward, odorless, does not produce toxic wastes, and, therefore should appeal to practitioners in industrial-scale productions.

Organic Letters published new progress about Fluorocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (as alternative perfluoroalkylation agents). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Formula: C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yoshida, Suguru; Igawa, Kazunobu; Tomooka, Katsuhiko published the artcile< Nucleophilic Substitution Reaction at the Nitrogen of Arylsulfonamides with Phosphide Anion>, HPLC of Formula: 639520-70-0, the main research area is nucleophilic substitution arylsulfonamide phosphide anion; phosphamide preparation nucleophilic substitution arylsulfonamide phosphide anion; amine preparation nucleophilic substitution arylsulfonamide phosphide anion; protected amine preparation nucleophilic substitution arylsulfonamide phosphide anion.

A novel nucleophilic substitution reaction at the nitrogen of arylsulfonamides by means of phosphide anions has been described. This reaction allows for the efficient transformation of arylsulfonamides into synthetically valuable phosphamides, amines, and a variety of protected amines.

Journal of the American Chemical Society published new progress about Acid hydrolysis (of phosphinamide N-P bond). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, HPLC of Formula: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ha, Yeon Hee; Sohn, Sunyoung; Han, Seung-Hoon; Kim, Bong Gon; Ahn, Hyungju; Jung, Sungjune; Kwon, Soon-Ki; Kim, Yun-Hi published the artcile< New blue phosphorescence from trifluorosulfonyl-substituted iridium complexes>, Formula: C7H4BrF3S, the main research area is blue phosphorescence trifluorosulfonyl substituted iridium complex.

For color-pure phosphorescence organic light emitting diodes (PHOLEDs), we synthesized the trifluoromethyl sulfonyl substituted ligand and two new blue Iridium complexes with perfluoro-sulfonyl group (SOCF3pic and SOCF3mpic). The both iridium complexes showed similar photophys. and thermal properties while the HOMO energy leves of two Iridium complexes slightly differnet to be -5.84 eV for SOCF3pic and -5.74 eV for SOCF3mpic, resp. The device with the SOCF3mpic dopant exhibited higher device efficiencies of 7.17 cd/A and 3.7% compared to that with the SOCF3pic dopant (4.03 cd/A and 2.78%). Two-dimensional GIXD images of scattered X-ray intensity from surface to full depth for SOCF3pic-doped and SOCF3mpic-doped TCTA:4PTPS films were characterized for preferential orientation along the out-of-plane direction.

Dyes and Pigments published new progress about Band gap. 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Formula: C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary