Tag: M.W=200-350

DeVries, Vern G. published the artcileHypolipidemic alkoxybenzoic acids, Application In Synthesis of 56523-59-2, the main research area is hypolipidemic alkoxybenzoic acid derivative; benzoic acid alkoxy derivative hypolipidemic.

A series of ∼90 p-alkoxybenzoic acids (I) with aromatic ring substituents or modified alkyl or unsaturated chains (R1), prepared by alkylation of the appropriate hydroxybenzoate ester followed by saponification, was screened in rats for serum-sterol and triglyceride lowering activity. Alkyl chain substituents such as chloro and oximino enhanced activity, while azido, thiol, and some alkylthio groups resulted in retention of activity. Some alkylthio substituents on the alkyl chain and aryl ring substituents abolished sterol-lowering activity. The effect of alkyl chain branching was variable, while unsaturation had no adverse effect on activity except when located near either end of the chain.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application In Synthesis of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kelly, Martha J. published the artcileDiscovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia, Related Products of bromides-buliding-blocks, the main research area is tetrahydrotriazinecarbonitrile derivative MGL3196 thyroid hormone receptor agonist dyslipidemia treatment.

The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). A pyridazinone series has been identified that is significantly more THR-β selective than earlier analogs. Optimization of this series by the addition of a cyanoazauracil substituent improved both the potency and selectivity and led to MGL-3196 (53), which is 28-fold selective for THR-β over THR-α in a functional assay. Compound 53 showed outstanding safety in a rat heart model and was efficacious in a preclin. model at doses that showed no impact on the central thyroid axis. In reported studies in healthy volunteers, 53 exhibited an excellent safety profile and decreased LDL cholesterol (LDL-C) and triglycerides (TG) at once daily oral doses of 50 mg or higher given for 2 wk.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zhiqiang published the artcilePhotoresponsive supramolecular coordination polyelectrolyte as smart anticounterfeiting inks, Synthetic Route of 913836-27-8, the main research area is photoresponsive supramol coordination polyelectrolyte anticounterfeiting ink.

While photoluminescence printing is a widely applied anticounterfeiting technique, there are still challenges in developing new generation anticounterfeiting materials with high security. Here we report the construction of a photoresponsive supramol. coordination polyelectrolyte (SCP) through hierarchical self-assembly of lanthanide ion, bis-ligand and diarylethene unit, driven by metal-ligand coordination and ionic interaction. Owing to the conformation-dependent photochromic fluorescence resonance energy transfer between the lanthanide donor and diarylethene acceptor, the ring-closure/ring-opening isomerization of the diarylethene unit leads to a photoreversible luminescence on/off switch in the SCP. The SCP is then utilized as security ink to print various patterns, through which photoreversible multiple information patterns with visible/invisible transformations are realized by simply alternating the irradiation with UV and visible light. This work demonstrates the possibility of developing a new class of smart anticounterfeiting materials, which could be operated in a noninvasive manner with a higher level of security.

Nature Communications published new progress about Inks (anticounterfeiting). 913836-27-8 belongs to class bromides-buliding-blocks, name is 2-(4-(2-Bromoethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H20BBrO3, Synthetic Route of 913836-27-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Patrick published the artcileEffects of structural modification of (alkyldiene-imidazolium bromide)-based gemini monomers on the formation of the lyotropic bicontinuous cubic phase, HPLC of Formula: 56523-59-2, the main research area is alkyldiene imidazolium bromide gemini monomer lyotropic bicontinuous cubic phase.

Seven homologues of an amphiphilic gemini monomer were synthesized and screened for the ability to form a bicontinuous cubic (Q) lyotropic liquid crystal phase. Four of these homologues form a Q phase with glycerol or water that can be cross-linked with retention of the nanoporous structure, with one exhibiting a well-ordered Q phase with a wider phase window than the parent monomer.

Soft Matter published new progress about Liquid crystals, lyotropic. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, HPLC of Formula: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Geddes, C. D. published the artcileFluorescent indolium dyes for applications in aqueous halide sensing-part 2: the repeated alkylation of Harmane post quaternisation, HPLC of Formula: 56523-59-2, the main research area is carboxyoctylation quaternization harmane fluorescent dye hallucinogen; methoxyquinoline carboxyoctylation quaternization.

The repeated alkylation of harmane (1-methyl-9H-pyrido[3,4-b]indole) after quaternization has been observed during fusion with 8-bromooctanoic acid (I). This can be explained by two possible competing mechanisms, the electrophilic addition of carboxyalkylating agent to the resonance enamine form of the initial quaternized product and/or oligoester formation between the quaternized product and I. The mechanisms are supported by 1H NMR, FTIR, and mass spectrometry anal., and by carboxyoctylation of 6-methoxyquinoline. The possibility for controlling the repeated alkylation in nanometer size silica pores, in essence restricted geometry nanometer size reaction vessels, is discussed.

Dyes and Pigments published new progress about Carboxyalkylation (repeated). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, HPLC of Formula: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Xicheng published the artcileDiscovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities, Application of Ethyl 7-(4-bromophenyl)-4,7-dioxoheptanoate, the main research area is SAR preparation pyrrole S nitrosoglutathione reductase inhibitor.

The pyrrole based N6022, e.g. I, was recently identified as a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is currently undergoing clin. development for the treatment of acute asthma. GSNOR is a member of the alc. dehydrogenase family (ADH) and regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). Reduced levels of GSNO, as well as other nitrosothiols (SNOs), have been implicated in the pathogenesis of many diseases including those of the respiratory, cardiovascular, and gastrointestinal systems. Preservation of endogenous SNOs through GSNOR inhibition presents a novel therapeutic approach with broad applicability. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on removal of cytochrome P 450 inhibition activities. We identified potent and novel GSNOR inhibitors having reduced CYP inhibition activities and demonstrated efficacy in a mouse ovalbumin (OVA) model of asthma.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 1208318-08-4 belongs to class bromides-buliding-blocks, name is Ethyl 7-(4-bromophenyl)-4,7-dioxoheptanoate, and the molecular formula is C15H17BrO4, Application of Ethyl 7-(4-bromophenyl)-4,7-dioxoheptanoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Hui-Yan published the artcileAssembly of Two Metal-Organic Frameworks Based on Distinct Cobalt Dimeric Building Blocks Induced by Ligand Modification: Gas Adsorption and Magnetic Properties, Related Products of bromides-buliding-blocks, the main research area is cobalt pyridinylbenzoate preparation porosity gas adsorption enthalpy antiferromagnetic exchange; crystal structure cobalt pyridinylbenzoate dimeric building block MOF.

Solvothermal reaction of 3,5-di(pyridin-4-yl)benzoic acid (HDPB) with Co(II) leads to a novel metal-organic framework, [Co2O(DPB)2(DMF)2]·xS (1), which represents a rare reo-type net with trigonal prismatic Co dimer, [Co2O(CO2)2N4] as building blocks to construct a 3-dimensional framework containing three different types of nanoscale M12L12 and M24L12 polyhedron cages. More interestingly, under the same condition, the assembly of 4-methyl-3,5-di(pyridin-4-yl)benzoic acid (HMDPB) with Co(II) facilitates the formation of a cationic framework, [Co2(MDPB)3(DMF)](NO3)·xS (2), with Co dimer, [Co2(CO2)3N4], as building blocks. Complex 2 represents the 1st example of a zeolite-like network with 48-nuclear SOD cage. The significant effect of subtle modification of ligand on the overall MOFs is discussed. Also, the gas adsorption studies reveal that 1 exhibits permanent porosity and selective CO2 uptake. Variable-temperature magnetic susceptibility measurements show that both 1 and 2 exhibit antiferromagnetic behavior.

Inorganic Chemistry published new progress about Adsorption enthalpy, isosteric. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huo, Zhaohui published the artcileCopolymeric films obtained by electropolymerization of porphyrins and dipyridyl-spacers including Dawson-type polyoxometalates, Product Details of C9H8Br2O2, the main research area is polyoxometalate porphyrin copolymer electropolymerization oxidation reduction potential.

This paper reports the formation of hybrid polyoxometalate-porphyrin copolymeric films obtained by the electro-oxidation of zinc-β-octaethylporphyrin (ZnOEP) in the presence of a functionalized Dawson-type polyoxometalate bearing two pyridyl groups (POMdbme3,3, Py-POM-Py) which will be compared to the copolymer obtained from ZnOEP and a dipyridyl compound without POM (ibme3,3). The resulting film has been characterized by UV-visible absorption spectroscopy, XPS, and at. force microscopy. Electrochem. quartz crystal microbalance was employed to investigate the poly-porphyrin-POMs deposition mass.

Journal of Solid State Electrochemistry published new progress about Electrochemical polymerization. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Product Details of C9H8Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lai, Holden W. H. published the artcileFunctionalized Rigid Ladder Polymers from Catalytic Arene-Norbornene Annulation Polymerization, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate, the main research area is ladder polymer arene norbornene annulation polymerization.

Rigid ladder polymers represent a unique polymer architecture but have limited synthetic accessibility and structural diversity. Using catalytic arene-norbornene annulation (CANAL) polymerization, we synthesized ladder polymers consisting of rigid and kinked norbornyl benzocyclobutene backbones and bearing various functional groups, such as alc., amine, ester, carbamate, amide, benzyl bromide, azide, and heterocycles. The incorporation of functional groups was achieved by either copolymerization of functionalized ladder-type dinorbornenes or postpolymn. functionalization. Functionalization of ladder polymers allows modification of their solubility, compatibility, and other properties, expanding their utilities. These ladder polymers remain microporous and highly glassy, which are desirable for separation and high-temperature applications.

ACS Macro Letters published new progress about Cyclization (polymerization). 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Geddes, Chris D. published the artcileNew fluorescent indolium and quinolinium dyes for applications in aqueous halide sensing, SDS of cas: 56523-59-2, the main research area is fluorescent cationic dye preparation halide sensor.

Bromide and teraphenylborate salts of six new highly fluorescent dyes, produced by the reaction of two heterocyclic nitrogen bases (6-methoxyquinoline and harman) with 8-bromooctanoic acid, 11-bromoundecanoic acid, and 15-bromopentadecanoic acid have been prepared Unlike the bases themselves, the quaternary salts are water soluble and have fluorescence characteristics independent of pH in the range 7-11. Both the fluorescence intensity and fluorescence lifetime of these dyes are reduced in the presence of aqueous halide ions, allowing halide concentrations to be determined accurately at concentrations of importance to both medicine and industry. All the dyes have been characterized in terms of steady state fluorescence spectra and steady-state Stern-Volmer anal. The Stern-Volmer constants for the dyes are compared to those obtained for some com. available dyes. The prospects for using these dyes in halide sensor devices are discussed.

Dyes and Pigments published new progress about Cationic dyes (fluorescent). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, SDS of cas: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary