Tag: M.W=200-350

Rice, Kenneth D. published the artcilePyrazolopyrimidines as dual Akt/p70S6K inhibitors, SDS of cas: 74896-66-5, the main research area is pyrazolopyrimidine preparation Akt p70S6K inhibitor SAR.

Activation of the PI3K/Akt/mTOR kinase pathway is frequently associated with human cancer. Selective inhibition of p70S6 Kinase, which is the last kinase in the PI3K pathway, is not sufficient for strong tumor growth inhibition and can lead to activation of upstream proteins including Akt through relief of a neg. feedback loop. Targeting multiple sites in the PI3K pathway might be beneficial for optimal activity. In this manuscript we report the design of dual Akt/p70S6K inhibitors and the evaluation of the lead compound 11b (I) in vivo, which was eventually advanced into clin. development.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, SDS of cas: 74896-66-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Quan-Fang published the artcileDesign, synthesis and biological evaluation of novel 1-phenyl phenanthridin-6(5H)-one derivatives as anti-tumor agents targeting TOPK, Synthetic Route of 211315-53-6, the main research area is OTS964 phenanthridin synthesis antitumor apoptosis TOPK colorectal cancer; 1-Phenyl phenanthridin-6(5H)-one; Colorectal cancer; Pharmacokinetics; Structure activity relationship; TOPK inhibitor.

T-lymphokine-activated killer cell-originated protein kinase (TOPK) is a serine-threonine mitogen-activated protein kinase that is highly expressed in many types of human cancer. Due to its important role in cancer progression, TOPK is becoming an attractive target in chemotherapeutic drug design. In this study, a series of 1-Ph phenanthridin-6(5H)-one derivatives have been identified as a novel chem. class of TOPK inhibitors. Some of them displayed very potent anti-cancer activity with IC50s less than 100 nM, superior than reference compound OTS964. The most potent compound, 9g suppressed the growth of cancer cells by apoptosis and specifically inhibited the activities of TOPK. Oral administration of 9g effectively suppressed tumor growth with TGI >79.7% in colorectal cancer xenograft models, demonstrating superior efficacy compared to OTS964. Pharmacokinetic studies reveal its good oral bioavailability. Our findings therefore show that 9g is a specific inhibitor of TOPK both in vitro and in vivo that may be further developed as a potential therapeutic agent against colorectal cancer.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 211315-53-6 belongs to class bromides-buliding-blocks, name is (R)-tert-Butyl (2-(4-bromophenyl)propyl)carbamate, and the molecular formula is C14H20BrNO2, Synthetic Route of 211315-53-6.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jung, Christian M. published the artcileSyntheses and first crystal structures of rhenium complexes derived from ω-functionalized fatty acids as model compounds of technetium tracers for myocardial metabolism imaging, Computed Properties of 56523-59-2, the main research area is rhenium fatty acid thiolate Schiff oxo carbonyl preparation structure; crystal structure rhenium fatty acid thiolate Schiff oxo carbonyl; technetium radiopharmaceutical tracer myocardial metabolism imaging model preparation structure.

In an attempt to develop new technetium-based radiopharmaceuticals for the noninvasive diagnosis of myocardial metabolism, the authors synthesized three examples of novel metal-containing fatty acid derivatives according to the “”3+1″” mixed-ligand and the Schiff base/tricarbonyl design, Re:O[S(CH2)2S(CH2)2S][S(CH2)11S(CH2)4CO2H] (7), Re:O[S(CH2)2NMe(CH2)2S][S(CH2)14CO2H] (10) and ReBr(CO)3[2-py-CH:N(CH2)11CO2H] (14). The chelates contain the metal core in the oxidation states +5 (7 and 10) and +1 (14) and are attached to the end-position of a fatty acid chain. The complex formation was accomplished by ligand-exchange reactions with three different rhenium precursors, whereas the inactive rhenium metal was used as a surrogate of the technetium radionuclide. The mol. structures of the fatty acid complexes 7, 10 and 14 were determined by single-crystal x-ray diffraction analyses and impressively show a general problem in technetium tracer research, the significant structural alterations of bioactive mols. by coordination even to small metal chelates.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Computed Properties of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sindt, Ammon J. published the artcileGuest Inclusion Modulates Concentration and Persistence of Photogenerated Radicals in Assembled Triphenylamine Macrocycles, Category: bromides-buliding-blocks, the main research area is macrocycle self assembly crystal guest radicals.

Substituted triphenylamine (TPA) radical cations show great potential as oxidants and as spin-containing units in polymer magnets. Their properties can be further tuned by supramol. assembly. Here, we examine how the properties of photogenerated radical cations, intrinsic to TPA macrocycles, are altered upon their self-assembly into one-dimensional columns. These macrocycles consist of two TPAs and two methylene ureas, which drive the assembly into porous organic materials. Advantageously, upon activation the crystals can undergo guest exchange in a single-crystal-to-single-crystal transformation generating a series of isoskeletal host-guest complexes whose properties can be directly compared. Photoinduced electron transfer, initiated using 365 nm light-emitting diodes, affords radicals at room temperature as observed by ESR (EPR) spectroscopy. The line shape of the EPR spectra and the quantity of radicals can be modulated by both polarity and heavy atom inclusion of the encapsulated guest. These photogenerated radicals are persistent, with half-lives between 1 and 7 d and display no degradation upon radical decay. Re-irradiation of the samples can restore the radical concentration back to a similar maximum concentration, a feature that is reproducible over several cycles. EPR simulations of a representative spectrum indicate two species, one containing two N hyperfine interactions and an addnl. broad signal with no resolvable hyperfine interaction. Intriguingly, TPA analogs without bromine substitution also exhibit similar quantities of photogenerated radicals, suggesting that supramol. strategies can enable more flexibility in stable TPA radical structures. These studies will help guide the development of new photoactive materials.

Journal of the American Chemical Society published new progress about Crystal structure. 183994-94-7 belongs to class bromides-buliding-blocks, name is 4-(Bromomethyl)-N,N-diphenylaniline, and the molecular formula is C19H16BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Heal, William P. published the artcileBioorthogonal chemical tagging of protein cholesterylation in living cells, Name: 15-Bromopentadecanoic acid, the main research area is bioorthogonal tagging protein cholesterylation living cell.

The authors report the first chem. probe for bioorthogonal chem. tagging of post-translationally cholesterylated proteins with an azide in living cells. This enables rapid multiplexed fluorescence detection and affinity labeling of protein cholesterylation, as exemplified by Sonic hedgehog protein, opening up new approaches for the de novo identification of cholesterylated proteins.

Chemical Communications (Cambridge, United Kingdom) published new progress about Affinity labeling. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Name: 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Park, Chul Soon published the artcileRobust Maleimide-Functionalized Gold Surfaces and Nanoparticles Generated Using Custom-Designed Bidentate Adsorbates, Formula: C15H29BrO2, the main research area is maleimide functionalized gold surface nanoparticle adsorbate self assembled monolayer.

A series of custom-designed alkanethioacetate ligands were synthesized to provide a facile method of attaching maleimide-terminated adsorbates to gold nanostructures via thiolate bonds. Monolayers on flat gold substrates derived from both mono- and dithioacetates, with and without oligo(ethylene glycol) (OEG) moieties in their alkyl spacers, were characterized using XPS, polarization modulation IR reflection-absorption spectroscopy, ellipsometry, and contact angle goniometry. For all adsorbates, the resulting monolayers revealed that a higher packing d. and more homogeneous surface were generated when the film was formed in EtOH, but a higher percentage of bound thiolate was obtained in THF. A series of gold nanoparticles (AuNPs) capped with each adsorbate were prepared to explore how adsorbate structure influences aqueous colloidal stability under extreme conditions, as examined visually and spectroscopically. The AuNPs coated with adsorbates that include OEG moieties exhibited enhanced stability under high salt concentration, and AuNPs capped with dithioacetate adsorbates exhibited improved stability against ligand exchange in competition with dithiothreitol (DTT). Overall, the best results were obtained with a chelating dithioacetate adsorbate that included OEG moieties in its alkyl spacer, imparting improved stability via enhanced solubility in water and superior adsorbate attachment owing to the chelate effect.

Langmuir published new progress about Adsorbed substances. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Davey, Tim W. published the artcileSynthesis of ω-hydroxy quaternary ammonium bolaform surfactants, Related Products of bromides-buliding-blocks, the main research area is hydroxy quaternary ammonium bolaform surfactant synthesis.

Several members of a novel class of ω-substituted asym. bolaform surfactants were synthesized to investigate their surfactant and biol. properties. The ω-hydroxy trialkylammonium and pyridinium surfactants have significant antimicrobial and antifungal activity relative to their conventional analogs. For conventional quaternary ammonium alkyl surfactants, increasing the hydrocarbon chain length causes a decrease in the surfactant monomer solubility and a corresponding decrease in the biol. activity. No such trend is observed for the ω-hydroxy quaternary ammonium bromide series.

Australian Journal of Chemistry published new progress about Antimicrobial agents. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tuxen, Jens published the artcileHighly Fluorous Porphyrins as Model Compounds for Molecule Interferometry, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate, the main research area is porphyrin perfluoroalkyl preparation quantum interference.

The synthesis and characterization of seven tailor-made highly fluorous porphyrin derivatives are described, as large perfluoroalkyl-functionalized organic mols. are the most complex objects for which the quantum wave nature has been observed so far. We have found, in particular, that tetrakis(pentafluorophenyl)porphyrin is a suitable starting point for a modular synthesis that is geared towards porphyrin derivatives with many peripheral fluorous chains. This allows us to tailor and optimize the sublimation features of these compounds for mol. interferometry. We have analyzed the evaporation process of one member of the series by determining the enthalpy of evaporation, as the creation of a sufficiently intense, slow mol. beam is crucial for quantum interference experiments We present the quantum fringe pattern of a second member of the series, which we could obtain in a Kapitza-Dirac-Talbot-Lau interferometer.

European Journal of Organic Chemistry published new progress about Evaporation enthalpy. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Recommanded Product: Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Choi, Yunsoo published the artcileFunctionalized N-Heterocyclic Carbene Monolayers on Gold for Surface-Initiated Polymerizations, Safety of 15-Bromopentadecanoic acid, the main research area is heterocyclic carbene adsorbed monolayer surface polymerization; N-heterocyclic carbenes (NHCs); azo surface initiator; benzimidazolium methanesulfonates; photoinitiated radical polymerization; polymer brushes; self-assembled monolayers (SAMs); surface-initiated polymerization; thickness control.

Although N-heterocyclic carbenes (NHCs) are superior to thiol adsorbates in that they form remarkably stable bonds with gold, the generation of NHC-based self-assembled monolayers (SAMs) typically requires a strong base and an inert atm., which limits the utility of such films in many applications. Herein, we report the development and use of bench-stable NHC adsorbates, benzimidazolium methanesulfonates, for the direct formation of NHC films on gold surfaces under an ambient atm. at room temperature without the need for extraordinary precautions. The generated NHC SAMs were fully characterized using ellipsometry, XPS, polarization modulation IR reflection-absorption spectroscopy (PM-IRRAS), and contact angle measurements, and they were compared to analogous SAMs generated from an NHC bicarbonate adsorbate. Based on these findings, a unique radical initiator α,ω-bidentate azo-terminated NHC adsorbate, NHC15AZO[OMs], was designed and synthesized for the preparation of SAMs on gold surfaces with both NHC headgroups bound to the surface. The adsorbate mols. in NHC15AZO SAMs can exist in a hairpin or a linear conformation depending on the concentration of the adsorbate solution used to prepare the SAM. These conformations were studied by a combination of ellipsometry, XPS, PM-IRRAS, and scanning tunneling microscopy using gold nanoparticles (AuNPs) as a tag material. Moreover, the potential utility of these unique radical-initiating NHC films as surface-initiated polymerization platforms was demonstrated by controlling the thickness of polystyrene brush films grown from azo-terminated NHC monolayer surfaces simply by adjusting the reaction time of the photoinitiated radical polymer growth process.

ACS Applied Materials & Interfaces published new progress about Adsorbed monolayers. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Safety of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Salomon, Adi published the artcileStable Room-Temperature Molecular Negative Differential Resistance Based on Molecule-Electrode Interface Chemistry, COA of Formula: C15H29BrO2, the main research area is stable room temperature mol neg resistance mol electrode interface.

The authors show reproducible, stable neg. differential resistance (NDR) at room temperature in mol.-controlled, solvent-free devices, based on reversible changes in mol.-electrode interface properties. The active component is the cyclic disulfide end of mols. adsorbed onto Hg. As this active component is reduced, the Hg-mol. contact is broken, and an insulating barrier at the mol.-electrode interface is formed. Therefore, the alignment of the mol. energy levels, relative to the Fermi levels of the electrodes, is changed. This effect results in a decrease in the current with voltage increase as the reduction process progresses, leading to the so-called NDR behavior. The effect is reproducible and repeatable over >50 scans without any reduction in the current. The stability of the system, which is in the solid state except for the Hg, is due to the mol. design where long alkyl chains keep the mols. aligned with respect to the Hg electrode, even when they are not bound to it any longer.

Journal of the American Chemical Society published new progress about Adsorbed substances. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, COA of Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary