Tag: M.W=200-350

Stelmach, John E. published the artcileDesign and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase, HPLC of Formula: 74896-66-5, the main research area is phenyl piperidinyl piperazino dichlorophenylquinazolinone preparation p38 MAP kinase inhibitor; chlorophenylquinazolinone piperidinyl piperazino preparation p38 MAP kinase inhibition pharmokinetic; piperidinylchlorofluorophenylquinazolinone tertbutyl preparation inhibitor p38 MAP kinase TNF; dichlorophenylquinazolinone preparation p38 MAP kinase inhibitor; quinazolinone dichlorophenyl preparation p38 MAP kinase inhibitor; human TNF alpha production inhibition chlorofluorophenylquinazolinone.

The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors I (R = CO2Me, R1 = H, Br, 2-FC6H4, etc.; R = OMe, R1 = 2-Cl-4-FC6H3, 2,4-F2C6H3, 2-ClC6H4), II (R1 = 2-Cl-4-FC6H3, 2,4-F2C6H3, 2-ClC6H4, X = none, O, NH, CH2, CO, Y = CH, N) and III (R2 = Me, Et, CHMe2, etc.) of p38α MAP kinase is described. For example, III (R2 = CMe3) was prepared via the Still coupling of I (R = OSO2CF3, R1 = 2-Cl-4-FC6H3) with 1-tert-butyl-4-(trimethylstannyl)-1,2,3,6-tetrahydropyridine. These analogs are hybrids of a pyridinylimidazole p38α inhibitor reported by Merck Research Laboratories and VX-745. Optimization of the C-5 Ph and the C-7 piperidinyl substituents led to the identification of III (R2 = CMe3) which gave excellent suppression of TNF-α production in LPS-stimulated whole blood (IC50=10 nM) and good oral exposure in rats (F=68%, AUCn PO=0.58 μM h).

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, HPLC of Formula: 74896-66-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sarkar, Ramkrishna published the artcilePrecise control of grafting density in periodically grafted amphiphilic copolymers: an alternate strategy to fine-tune the lamellar spacing in the sub-10 nm regime, Safety of 15-Bromopentadecanoic acid, the main research area is amphiphilic hydrocarbon rich polyester graft copolymer synthesis click chem; lamellar morphol thermal property.

A series of hydrocarbon-rich polyesters were prepared by condensing a long chain diol bearing a centrally located clickable propargyl group, with diacid chlorides of different lengths, ranging from oxalyl chloride to eicosanedioic acid chloride (C2 to C20). Hydrophilic PEG550 segments were then clicked onto the periodically located propargyl groups using the alkyne-azide click reaction; these amphiphilic graft copolymers underwent microphase separation via zigzag folding of the backbone, thereby generating a lamellar morphol., wherein inter-lamellar spacing was fine-tuned in the sub-10 nm level by the choice of the diacid comonomer. In contrast to our previous report (S. Chanda and S. Ramakrishnan, Macromols., 2016, 49, 3254-3263), here the crystallizable HC backbone was varied; the linear variation of the inter-lamellar spacing with the number of methylene units in the dicarboxylic acid permitted us to retrieve an increment of 0.127 nm per methylene unit, which matches remarkably well with the expected increment for an all-trans extended hydrocarbon chain. This observation not only provides strong evidence for the zigzag folded conformation of the polymer backbone within the lamellae but also demonstrates fine-tuning of lamellar dimension at the sub-nanometer level. The modular synthetic strategy presented here provides scope for easy variation of the pendant graft segments and, therefore, could be used to create other interesting periodically spaced functional materials.

Polymer Chemistry published new progress about Amphiphiles. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Safety of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sarkar, Ramkrishna published the artcileProbing Polymer Chain Folding in Solution Using Second Harmonic Light Scattering, Synthetic Route of 56523-59-2, the main research area is probing polymer chain folding solution harmonic scattering.

Periodically grafted amphiphilic copolymers (PGACs) were earlier shown by us to adopt a zigzag folded conformation in the solid state, which enabled the backbone and pendant segments to segregate and occupy alternate layers in a lamellar structure. The conformational transition from a random coil to a zigzag folded chain in solution is an interesting problem, which is largely unexplored. To examine this, an orthogonally clickable parent polyester was sequentially clicked with two types of poly(ethylene glycol) (PEG) segments: one is a simple PEG and the other is a PEG that carries a dipolar chromophore. These two hydrophilic PEG segments, installed in a periodic and alternating fashion along the hydrocarbon-rich (HC) polyester backbone, ensure that the Janus folded chains are formed upon folding and carry chromophoric dipoles oriented along the same direction, thereby generating a large net dipole. The folding-induced alignment of chromophores in solution was followed using second harmonic light scattering (SHLS), wherein the intensity of the frequency-doubled scattered light (I2ω) is measured. Folding was induced by adding a polar solvent, like methanol, to a chloroform solution of the polymer; methanol desolvates the HC backbone but solubilizes the pendant PEG segments, thus inducing folding. The second harmonic intensity (I2ω) increased initially with methanol concentration and then saturated; in contrast, I2ω remained invariant with the solvent composition in the case of an analogous model chromophore. Furthermore, in a model PGAC carrying chromophore-bearing PEG segments on every repeat unit, I2ω decreased with increasing methanol composition, revealing the formation of a centrosym. folded chain, wherein the chromophoric dipoles on either side cancel each other. Thus, this study clearly reveals that the zigzag chain folding of PGACs can be induced by a segment-selective solvent, resulting in the rather elusive directional ordering of chromophoric dipoles in solution

Langmuir published new progress about Amphiphiles. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Synthetic Route of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Galli, Carlo published the artcileRing closure reactions. IV. Quantitative approach to the synthesis of many-membered rings. Lactonization of some ω-bromo fatty acids, Application of 15-Bromopentadecanoic acid, the main research area is lactonization bromoalkanoic acid yield calculation; kinetics cyclization; fatty acid bromo lactonization.

A math. treatment, designed to predict the yields of cyclic compounds from α,ω-bifunctional precursors under dilute and high dilution conditions, was developed using a kinetic reaction scheme; a feed rate parameter was developed for yield optimization under high dilution conditions. The calculated and observed yields for the lactonization of ω-bromoalkanoic acids agreed under high dilution conditions.

Gazzetta Chimica Italiana published new progress about Cyclization. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Neu, Henrik published the artcileSynthesis of saturated fatty acids 11C(13C)-labeled in the ω-methyl position, Category: bromides-buliding-blocks, the main research area is fatty acid omega labeled preparation; zerovalent copper catalyst methylation.

A method for the preparation of ω-labeled saturated fatty acids 11C(13C)H3(CH2)nCO2H (n = 1,2,3,,6,10,14) is described. A highly reactive zerovalent copper complex was prepared from lithium naphthalenide reduced lithium(2-thienyl)iodocuprate. The labeling precursors were obtained by addition of tert-Bu ω-iodocarboxylates to the organocuprate and these were reacted with [11C]methyl iodide to form 11C-labeled, protected intermediates. The tert-Bu ester protecting group was rapidly removed with trifluoroacetic acid, affording fatty acids 11C-labeled in the ω-Me position. A solid phase extraction method was developed and preceded final HPLC purification In a typical run starting with 2.75 GBq of [11C]methyl iodide, 375 MBq (66%) [16-11C]palmitic acid was obtained within 46 min from the end of radionuclide production

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Methylation. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Najdek, Mirjana published the artcileFatty acid and phytoplankton compositions of different types of mucilaginous aggregates in the northern Adriatic, Synthetic Route of 56523-59-2, the main research area is fatty acid phytoplankton mucilaginous aggregate Adriatic Ocean.

The biomarkers (fatty acid proportions and ratios characteristic of phytoplankton and bacteria) and phytoplankton species in small (0.5-2.0 cm) and large (0.5-5 m) marine aggregates were determined in samples from the northern Adriatic Sea, during a mucilage event in 1997, as well as in 1993, 1994 and 1998, when events were not observed Types of aggregates were identified according to various biomarker relations, particularly those related to bacterial and phytoplankton activities and changes in the diatom species composition Aged mucilaginous aggregates (summer 1997) showed fatty acid proportions (16P/18P, 3.9-7.7) characteristic of the highest phytoplankton activities, and also showed the highest bacterial fatty acid proportions (13.3-17.1%) and ratios (C15:br/C15:0, 4.4-6.0). They showed an different diatom community (dominated by Cylindrotheca closterium) from that in surrounding waters. These characteristics suggest a continuous renewal of the aggregate organic matter, supporting the hypothesis that aggregate is a self-sustaining community. In contrast, both freshly formed marine snow, dominant during periods without mucilage events, and freshly formed mucilaginous aggregates presented biomarker proportions and ratios similar to those of suspended matter (bacterial fatty acids 3-6.7%, C15:br/C15:0 1.2-4.6, 16P/18P 0.4-4.0), and diatom composition similar to that of the ambient water. This indicates that marine snow sinks more rapidly than large aggregates, before significant changes can occur in its plankton composition Other aging aggregate types showed intermediate characteristics, suggesting that their residence times in the water column were still sufficient to develop organic production-decomposition cycles that modified to various extents their biochem. composition

Journal of Plankton Research published new progress about Bacillariophyta. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Synthetic Route of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Katz, Eugenii published the artcileElectron transfer in self-assembled monolayers of N-methyl-N’-carboxyalkyl-4,4′-bipyridinium linked to gold electrodes, Computed Properties of 56523-59-2, the main research area is electron transfer methylcarboxyalkylbipyridinium gold electrode; cystamine bipyridine derivative electrode modification; chemisorption adsorption electrode modification; redox electrochem tunneling electrode modification; alkylbipyridinium modification kinetics electron transfer.

Electron transfer processes in monolayer assemblies formed by covalent linkage of N-methyl-N’-carboxyalkyl-4,4′-bipyridinium (1) to cystamine, chemisorbed onto Au electrodes, are examined The resulting monolayer exhibits nonordered structure being reflected by a similar rate constant to the bipyridinium redox sites, that is independent of the bridging alkyl chain length, ket = 550 s-1. The nonordered structure is also confirmed by the low electron transfer coefficients αa and αc, corresponding to 0.25 ± 0.05 and 0.3 ± 0.05, resp. By treatment of the nonordered monolayer assembly with 1-hexadecanethiol, C16SH, a more densely packed organized monolayer is formed, where the alkyl-substituted bipyridinium sites are stretched in the monolayer configuration. In these assemblies the electron transfer rate constants to the bipyridinium sites depend on the alkyl chain length bridging the redox site to the electrode. The electron transfer rate constants follow Marcus theory and the electron tunneling coefficient corresponds to β = 0.006 A-1.

Langmuir published new progress about Chemical chains. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Computed Properties of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Geddes, Chris. D. published the artcileNew indolium and quinolinium dyes sensitive to aqueous halide ions at physiological concentrations, Application In Synthesis of 56523-59-2, the main research area is fluorescent dye indolium quinolinium preparation; halide ion physiol determination fluorescent indicator.

New highly fluorescent dyes have been produced by the reaction of two heterocyclic nitrogen bases (6-methoxyquinoline and harmane) with 8-bromooctanoic acid, 11-bromoundecanoic acid, and 15-bromopentadecanoic acid. The bromide counter ions of the first six dyes were also replaced with the tetraphenylborate ion. Unlike the bases themselves, the quaternary salts are water soluble and have fluorescence characteristics independent of pH in the pH range 7-11. Both the fluorescence intensity and fluorescence lifetime of the 12 dyes are reduced in the presence of aqueous halide ions allowing halide concentrations to be determined accurately at physiol. levels. All the dyes have been characterized in terms of steady state fluorescence spectra and steady-state Stern-Volmer anal.

Journal of Heterocyclic Chemistry published new progress about Cationic dyes. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application In Synthesis of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dey, Mishtu published the artcileCharacterization of Alkyl-Nickel Adducts Generated by Reaction of Methyl-Coenzyme M Reductase with Brominated Acids, SDS of cas: 56523-59-2, the main research area is methyl coenzyme M reductase active site electron transfer.

Methyl-coenzyme M reductase (MCR) from methanogenic archaea catalyzes the final step in the biol. synthesis of methane. Using coenzyme B (CoBSH) as the two-electron donor, MCR reduces methyl-coenzyme M (methyl-SCoM) to methane and the mixed disulfide, CoB-S-S-CoM. MCR contains coenzyme F430, an essential redox-active nickel tetrahydrocorphin, at its active site. The active form of MCR (MCRred1) contains Ni(I)-F430. When 3-bromopropane sulfonate (BPS) is incubated with MCRred1, an alkyl-Ni(III) species is formed that elicits the MCRPS EPR signal. Here we used EPR and UV-visible spectroscopy and transient kinetics to study the reaction between MCR from Methanothermobacter marburgensis and a series of brominated carboxylic acids, with carbon chain lengths of 4-16. All of these compounds give rise to an alkyl-Ni intermediate with an EPR signal similar to that of the MCRPS species. Reaction of the alkyl-Ni(III) adduct, formed from brominated acids with eight or fewer total carbons, with HSCoM as nucleophile at pH 10.0 results in the formation of a thioether coupled to regeneration of the active MCRred1 state. When reacted with 4-bromobutyrate, MCRred1 forms the alkyl-Ni(III) MCRXA state and then, surprisingly, undergoes “”self-reactivation”” to regenerate the Ni(I) MCRred1 state and a bromocarboxy ester. The results demonstrate an unexpected reactivity and flexibility of the MCR active site in accommodating a broad range of substrates, which act as mol. rulers for the substrate channel in MCR.

Biochemistry published new progress about Electron donors. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, SDS of cas: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quan, Cui published the artcileSynthesis of carbon nanotubes and porous carbons from printed circuit board waste pyrolysis oil, HPLC of Formula: 74896-66-5, the main research area is synthesis porous carbon printed circuit board waste pyrolysis oil; carbon nanotube synthesis printed circuit board waste pyrolysis oil.

The possibility and feasibility of using pyrolysis oil from printed circuit board (PCB) waste as a precursor for advanced carbonaceous materials is presented. The PCB waste was 1st pyrolyzed in a laboratory scale fixed bed reactor at 600° to prepare pyrolysis oil. The anal. of pyrolysis oil by gas chromatog.-mass spectroscopy indicated that it contained a very high proportion of phenol and phenol derivatives It was then polymerized in formaldehyde solution to synthesize pyrolysis oil-based resin which was used as a precursor to prepare C nanotubes (CNTs) and porous carbons. SEM and transmission microscopy investigation showed that the resulting CNTs had hollow cores with outer diameter of ∼338 nm and wall thickness of ∼86 nm and most of them were filled with metal nanoparticles or nanorods. X-ray diffraction reveals that CNTs have an amorphous structure. N adsorption isotherm anal. indicated the prepared porous carbons had a Brunauer-Emmett-Teller surface area of 1214 m2/g. The mechanism of the formation of the CNTs and porous carbons is discussed.

Journal of Hazardous Materials published new progress about Carbon nanotubes. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, HPLC of Formula: 74896-66-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary