Tag: M.W=200-350

Ng, Cheng Yang published the artcileFluorogenic probes to monitor cytosolic phospholipase A2 activity, Recommanded Product: 15-Bromopentadecanoic acid, the main research area is fluorogenic probe monitor cytosolic phospholipase A.

Arachidonic acid derivatives equipped with either one or two fluorescent groups attached to the tip of the alkyl chains were synthesized and shown to function as inhibitor and substrate probes of cPLA2. The inhibitor probe was demonstrated to perform dual functions of inhibition and imaging while the substrate probe could be used for activity assay.

Chemical Communications (Cambridge, United Kingdom) published new progress about fluorogenic probe monitor cytosolic phospholipase A. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Recommanded Product: 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Satpati, Drishty published the artcilePreparation and Evaluation of 99mTc(CO)3-Labeled Pentadecanoic Acid Derivative and Its Suspension in Lipiodol, Application of 15-Bromopentadecanoic acid, the main research area is bromopentadecanoic acid lipiodol stability.

Transarterial embolization by the intra-arterial administration of 131I-lipiodol is a modality used in the treatment of liver cancer. Long-chain fatty acids, being highly lipophilic, are also known to localize in the liver, thus constituting favorable vectors for this modality of treatment. Toward this, we envisaged the derivatization of 15-bromopentadecanoic acid, rendering it suitable for incorporation of a tridentate chelating moiety, for radiolabeling with the [99mTc(CO)3(H2O)3]+ precursor. The complex prepared, being lipophilic, was expected to behave as a lipiodol surrogate. The radiolabeled complex could be obtained in >95% radiochem. yield, as characterized by high-performance liquid chromatog. The i.v. injection of the radiolabeled complex in mice resulted in 23.5% ± 4.3% uptake of injected dose (ID) organ in the liver at 3 h postinjection. However, the uptake of the lipiodol suspension of the complex at 3 h postinjection in the liver was found to be 43.8 ± 13.4% ID/organ, when injected via the portal vein.

Cancer Biotherapy and Radiopharmaceuticals published new progress about Blood. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Xicheng published the artcileStructure-activity relationship of pyrrole based S-nitrosoglutathione reductase inhibitors: Carboxamide modification, Quality Control of 1208318-08-4, the main research area is pyrrole derivative preparation nitrosoglutathione reductase inhibitor.

The enzyme S-nitrosoglutathione reductase (GSNOR) is a member of the alc. dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). GSNO and SNOs are implicated in the pathogenesis of many diseases including those in respiratory, gastrointestinal, and cardiovascular systems. The pyrrole based N6022 was recently identified as a potent, selective, reversible, and efficacious GSNOR inhibitor which is currently in clin. development for acute asthma. We describe here the synthesis and structure-activity relationships (SAR) of novel pyrrole based analogs of N6022 focusing on carboxamide modifications on the pendant N-Ph moiety. We have identified potent and novel GSNOR inhibitors that demonstrate efficacy in an ovalbumin (OVA) induced asthma model in mice.

Bioorganic & Medicinal Chemistry Letters published new progress about Asthma. 1208318-08-4 belongs to class bromides-buliding-blocks, name is Ethyl 7-(4-bromophenyl)-4,7-dioxoheptanoate, and the molecular formula is C15H17BrO4, Quality Control of 1208318-08-4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xiong, Wenjing published the artcileSynthesis and optoelectronic properties of a dinuclear iridium (III) complex containing a picolinic acid derivative by nonconjugated linkage with a D-A-D core, Related Products of bromides-buliding-blocks, the main research area is diiridium complex picolinic acid derivative preparation mol structure optimized; dinuclear iridium complex picolinic acid derivative organic electroluminescent device; electrochem electroluminescence photoluminescence OLED iridium picolinic acid complex preparation.

A novel dinuclear iridium (III) complex containing a non-conjugated bridging picolinic acid ligand of (C8TPAPhOC2FIrpic)2BT with a D-A-D core was synthesized and characterized, in which the D-A-D core consists of benzo[c][1,2,5]thiadiazole (BT) and triphenylamino (TPA) units. Its optophys., electrochem. and electroluminescent characteristics were primarily studied. It is found this dinuclear iridium (III) complex exhibited similar photoluminescent and electroluminescent profiles, but higher brightness and efficiency in compared with the picolinic acid ligand in the single-emissive-layer organic light-emitting devices. The maximum luminance of 7404 cd/m2 and current efficiency of 0.81 cd/A was obtained in the (C8TPAPhOC2FIrpic)2BT-based devices. The efficient energy transfer is observed from the terminal iridium complex unit to the picolinic acid ligand. This work demonstrates that the picolinic acid ligand with a D-A-D core can facilitate dinuclear iridium (III) complex to exhibit the ancillary ligand-based red emission.

Journal of Organometallic Chemistry published new progress about Band gap. 913836-27-8 belongs to class bromides-buliding-blocks, name is 2-(4-(2-Bromoethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C14H20BBrO3, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pedersen, Simon S. published the artcileA Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides, SDS of cas: 56523-59-2, the main research area is aliphatic carboxamide preparation; alkyl zinc halide methyldiphenylsilanecarboxylic acid amine thiocarbonylation nickel catalyst; aliphatic carboxamides; aminocarbonylation; isotope labeling; nickel; thioesters.

A series of pharmaceutically relevant small mols. and biopharmaceuticals bearing aliphatic carboxamides have been successfully labeled with carbon-13. Key to the success of this novel carbon isotope labeling technique is the observation that 13C-labeled Ni(II)-acyl complexes, formed from a 13CO insertion step with Ni(II)-alkyl intermediates, rapidly react in less than one minute with 2,2′-dipyridyl disulfide to quant. form the corresponding 2-pyridyl thioesters. Either the use of 13C-SilaCOgen or 13C-COgen allows for the stoichiometric addition of isotopically labeled carbon monoxide. Subsequent one-pot acylation of a series of structurally diverse amines provides the desired 13C-labeled carboxamides in good yields. A single electron transfer pathway is proposed between the Ni(II)-acyl complexes and the disulfide providing a reactive Ni(III)-acyl sulfide intermediate, which rapidly undergoes reductive elimination to the desired thioester. By further optimization of the reaction parameters, reaction times down to only 11 min were identified, opening up the possibility of exploring this chem. for carbon-11 isotope labeling. Finally, this isotope labeling strategy could be adapted to the synthesis of 13C-labeled liraglutide and insulin degludec, representing two antidiabetic drugs.

Chemistry – A European Journal published new progress about Acylation. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, SDS of cas: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Saeed, Aamer published the artcileMethyl 3,5-dibromo-4-methylbenzoate, Safety of Methyl 3,5-dibromo-4-methylbenzoate, the main research area is methyl dibromo methylbenzoate ester crystal structure; mol structure methyl dibromomethylbenzoate ester; weak hydrogen bond methyl dibromomethylbenzoate ester.

In the title compound, C9H8Br2O2, the mol. is essentially planar with an r.m.s. deviation of 0.0652 Å from the mean plane through all non-H atoms and a dihedral angle of 7.1 (2)° between the benzene ring plane and the carboxylate substituent. In the crystal structure, weak C-H…Br hydrogen bonds and weak intermol. O…Br contacts [3.095 (2) Å], link adjacent mols. into layers parallel to (102). Addnl. weak intermol. C-H…O hydrogen bond interactions stack the layers above and below the mol. plane and down the a axis. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Bromination. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Safety of Methyl 3,5-dibromo-4-methylbenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Das, Soumen published the artcileSynthesis and biodistribution studies of 99mTc labeled fatty acid derivatives prepared via “”Click approach”” for potential use in cardiac imaging, SDS of cas: 56523-59-2, the main research area is technetium 99m fatty acid derivative preparation cardiac imaging; 99mTc carbonyl core; click chemistry; fatty acid; myocardial imaging.

123I-Iodophenylpentadecanoic acid (IPPA) is a metabolic agent used in nuclear medicine for diagnosis of myocardial defects. Efforts are underway worldwide to develop a 99mTc substitute of the above radiopharmaceutical for the aforementioned application. Herein, we report synthesis and biodistribution studies of 99mTc labeled fatty acids (8, 11, and 15 carbons) obtained via “”click chem.”” for its potential use in myocardial imaging. ω-Bromo fatty acids (8C/11C/15C) were synthetically modified at bromo terminal to introduce a heterocyclic triazole with glycine sidearm in a five step procedure. Modified fatty acids were subsequently radiolabeled with preformed [99mTc(CO)3]+ synthon to yield the desired fatty acid complexes which were evaluated in Swiss mice. All the radiolabeled complexes were obtained with radiochem. purities >80%, as characterized by HPLC. Biodistribution studies of all three complexes in Swiss mice showed myocardial uptake of ∼6-9% ID/g at 2 min post-injection, close to*I-IPPA (∼9% ID/g). Complexes exhibited significant retention in the myocardium up to 30 min (∼1% ID/g) but were lower to the standard agent (∼7% ID/g). Similar uptake of activity in myocardium for the newly synthesized complexes in comparison to 125I-IPPA along with favorable in vivo pharmacokinetics merits potential for the present “”click”” design of complexes for myocardial imaging.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about Heart disease. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, SDS of cas: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gonzalez, Alvaro published the artcileFormation of macrocyclic lactones in microemulsions, Synthetic Route of 56523-59-2, the main research area is microemulsion lactone preparation; emulsion micro lactone preparation; macrocyclic lactone preparation microemulsion; bromoalkanoic acid lactonization microemulsion; hydroxyalkanoic acid lactonization microemulsion.

Macrocyclic lactones were prepared by using the reactants in detergentless microemulsions. A microemulsion of H2O, Me2CHOH, and PhMe was made 8 × 10-3M in 4-MeC6H4SO3H and treated with an identical microemulsion 1 × 10-2M in Me(CH2)5CH(OH)(CH2)10CO2H, HO(CH2)14CO2H, or HO(CH2)15CO2H over 2 h and the mixture heated at 65° 12 h to give 18-23% lactones I (R = benzyl, n = 10; R = H, n = 14, 15), 35-40% the iso-Pr esters, and 20% polymers. The above microemulsion was made 3 × 10-3M in Br(CH2)mCO2H (m = 10, 14) and an equivalent KOH added to form the K salt. This solution was heated at 65° 1 day to give 25 and 22% I (R = H, n = 9, 13) and 18 and 15% polymers.

Journal of Organic Chemistry published new progress about Lactonization. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Synthetic Route of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tomoi, Masao published the artcilePolymer-supported bases, 4. Macrolide synthesis from ω-bromocarboxylic acids using polymer-supported 1,8-diazabicyclo[5.4.0]undec-7-ene, Synthetic Route of 56523-59-2, the main research area is macrolide synthesis polymer diazabicycloundecene; bromo carboxylic acid lactonization.

The macrolide yield in the title synthesis is a function of the degree of ring substitution and of crosslinking, which governs the effective concentration of the fixed substrate within the polymeric reagent. The effect of the polystyrene matrix on the macrolide yield in the heterogeneous system was compared with the corresponding homogeneous reaction.

Makromolekulare Chemie published new progress about Lactonization. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Synthetic Route of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Manchand, Percy S. published the artcileA convenient synthesis of 3,5-dimethoxy-4-methylbenzoic acid, Product Details of C9H8Br2O2, the main research area is benzoic acid dimethoxymethyl; bromination toluic acid; methoxylation methyldibromobenzoate.

4-MeC6H4CO2Me, prepared in 95% yield from 4-MeC6H4CO2H, was stirred with AlCl3 and Br at room temperature 30 min and then at 80-8° 1 h to give 65% 3,5,4-Br2MeC6H2CO2Me (I). Treating I in pyridine with NaOMe in the presence of CuCl gave 81% 3,5,4-(MeO)2MeC6H2CO2Me, which was hydrolyzed to the title acid.

Synthesis published new progress about Methoxylation. 74896-66-5 belongs to class bromides-buliding-blocks, name is Methyl 3,5-dibromo-4-methylbenzoate, and the molecular formula is C9H8Br2O2, Product Details of C9H8Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary