Tag: M.W=200-300

Application of 837-52-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of piperazine tethered 4-aminoquinoline-pyrimidine hybrids as potent antimalarial agents. Author is Thakur, Anuj; Khan, Shabana I.; Rawat, Diwan S..

A series of 4-aminoquinoline-pyrimidine hybrids linked through piperazine were synthesized and evaluated for their in vitro antimalarial activity against chloroquine (CQ)-sensitive and chloroquine (CQ)-resistant strains of Plasmodium falciparum and cytotoxicity against mammalian cell line (Vero). Nine compounds (5e, 5f, 5g, 5h, 5i, 5j, 5k, 7a, 7d) displayed good antimalarial activity against both the strains out of which compound 5j was the most potent with IC50 values in the range of 0.13-0.14 μM. The antimalarial activity of 5j was 2.5 fold stronger than chloroquine in the CQ-resistant strain of P. falciparum. None of the compounds were found to be cytotoxic against Vero cells. The X-ray crystal structure of one of the compounds was also determined

There are many compounds similar to this compound(837-52-5)Application of 837-52-5. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 837-52-5, is researched, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3Journal, Medicinal Chemistry Research called Synthesis and biological activity of novel amidrazones incorporating 5-nitroimidazole, ciprofloxacin, and 7-chloro-4-piperazinylquinoline, Author is Saadeh, Haythem A.; Al-Qaoud, Khaled M.; Abu-Qatouseh, Luay F.; Shihab, Penelope A.; Kaur, Hargobinder; Goyal, Kapil; Sehgal, Rakesh; Mubarak, Mohammad S., the main research direction is amidrazone nitroimidazole ciprofloxacin chloropiperazinylquinoline preparation antitumor antibacterial parasiticide.Electric Literature of C13H14ClN3.

Series of new amidrazones incorporating 5-nitroimidazole (a), ciprofloxacin (b), and 7-chloro-4-piperazinylquinoline (c) moieties, were synthesized by reacting hydrazonoyl chlorides , derived from 4-fluoroaniline and 4-chloroaniline with the proper amine, in the presence of triethylamine. Structures of the prepared compounds were confirmed by 1H NMR, 13C NMR, and ESI-HRMS spectral data. The antitumor, antibacterial, and antiparasitic activities of the newly synthesized compounds were evaluated.

There are many compounds similar to this compound(837-52-5)Electric Literature of C13H14ClN3. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 837-52-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis, characterization and antimalarial activity of quinoline-pyrimidine hybrids. Author is Pretorius, Stefan I.; Breytenbach, Wilma J.; de Kock, Carmen; Smith, Peter J.; N’Da, David D..

The aim of this study was to synthesize a series of quinoline-pyrimidine hybrids and to evaluate their in vitro antimalarial activity as well as cytotoxicity. The hybrids were brought about in a two-step nucleophilic substitution process involving quinoline and pyrimidine moieties. They were screened alongside chloroquine (CQ), pyrimethamine (PM) and fixed combinations thereof against the D10 and Dd2 strains of Plasmodium falciparum. The cytotoxicity was determined against the mammalian Chinese Hamster Ovarian cell line. The compounds were all active against both strains. However, hybrid (I) featuring piperazine linker stood as the most active of all. It was found as potent as CQ and PM against the D10 strain, and possessed a moderately superior potency over CQ against the Dd2 strain (IC50: 0.157 vs 0.417 μM, ∼threefold), and also displayed activity comparable to that of the equimolar fixed combination of CQ and PM against both strains.

There are many compounds similar to this compound(837-52-5)Related Products of 837-52-5. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Uchinomiya, Shohei; Matsunaga, Naoya; Kamoda, Koichiro; Kawagoe, Ryosuke; Tsuruta, Akito; Ohdo, Shigehiro; Ojida, Akio published an article about the compound: 8-Bromooctanoic acid( cas:17696-11-6,SMILESS:O=C(O)CCCCCCCBr ).Computed Properties of C8H15BrO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17696-11-6) through the article.

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, the authors report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.

There are many compounds similar to this compound(17696-11-6)Computed Properties of C8H15BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Schaeker-Huebner, Linda; Warstat, Robin; Ahlert, Heinz; Mishra, Pankaj; Kraft, Fabian B.; Schliehe-Diecks, Julian; Schoeler, Andrea; Borkhardt, Arndt; Breit, Bernhard; Bhatia, Sanil; Huegle, Martin; Guenther, Stefan; Hansen, Finn K. researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).COA of Formula: C8H15BrO2.They published the article 《4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads》 about this compound( cas:17696-11-6 ) in Journal of Medicinal Chemistry. Keywords: antileukemia drug HDAC BET dual inhibitors BRD4 apoptosis anticancer. We’ll tell you more about this compound (cas:17696-11-6).

Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biol. evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Addnl., 61 (I) was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds

I hope my short article helps more people learn about this compound(8-Bromooctanoic acid)COA of Formula: C8H15BrO2. Apart from the compound(17696-11-6), you can read my other articles to know other related compounds.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 8-Bromooctanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Alkyl Carbagermatrane Enabled Synthesis of Seven-Membered Carbocycle-Fused Aromatics through Catellani Strategy. Author is Xie, Xiu-Ying; Jiang, Wei-Tao; Xiao, Bin.

Synthesis of seven-membered carbocycle-fused aromatics was realized by Catellani reaction using terminally brominated alkyl carbagermatranes through intermol. cyclization manner. Various functional groups were well tolerated and this transformation was also expanded to the synthesis of carbocycles of other size. The utility of the above method was demonstrated by modification of natural product derivatives and synthesis of bioactive mols.

I hope my short article helps more people learn about this compound(8-Bromooctanoic acid)Name: 8-Bromooctanoic acid. Apart from the compound(17696-11-6), you can read my other articles to know other related compounds.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines, published in 2010, which mentions a compound: 837-52-5, mainly applied to ferrocenyl aminoquinoline amide preparation cytotoxicity antimalarial activity, Safety of 7-Chloro-4-(piperazin-1-yl)quinoline.

Series of 4-aminoquinolines bearing an amino side chain linked to the ferrocene moiety through an amide bond were synthesized and evaluated for their antimalarial activity against both chloroquine-sensitive (D10, CQ-S) and chloroquine-resistant (Dd2, CQ-R) strains of Plasmodium falciparum. They were also tested for cytotoxicity against Chinese Hamster Ovarian (CHO) cells. Amide featuring Pr side chain linked to the ferrocene ring was the most active of all tested compounds With an IC50 value of 0.08 μg/mL, this amide showed 1.5-fold higher activity than chloroquine diphosphate (IC50 = 0.12 μg/mL) against the resistant strain, with a selectivity index of 550 indicating its high selectivity towards the parasite. Derivatives which were equipotent against both strains also showed up to ten-fold increase in activity compared to primaquine.

I hope my short article helps more people learn about this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Safety of 7-Chloro-4-(piperazin-1-yl)quinoline. Apart from the compound(837-52-5), you can read my other articles to know other related compounds.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 837-52-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis and biological evaluation of certain new cyclohexane-1-carboxamides as apoptosis inducers. Author is Abd-Allah, Walaa Hamada; Elshafie, Mohamed Fathy.

Series of 1-(N-phenyl-2-(heteroalicyclic-1-yl)acetamido)cyclohexane-1-carboxamide derivatives (5a-m) and 1-(phenyl(heteroalicyclic-1-ylmethyl)amino)cyclohexane-1-carboxamide (6a-f) were designed and synthesized with biol. interest through coupling of 1-(2-chloro-N-phenylacetamido)cyclohexane-1-carboxamide (4) and (phenylamino)cycloakanecarboxamide (2) with different amines. The structures of the target compounds were elucidated via IR, 1H and 13C NMR, MS, and microanal. Compounds 5a-m and 6a-f were evaluated for their in vitro antitumor activity against four different cancer cell lines, MCF-7, HepG2, A549, and Caco-2. Compound 5i exhibited a promising activity against breast cancer cell line (IC50 value = 3.25 μM) compared with doxorubicin (IC50 value = 6.77 μM). Results from apoptosis and cell cycle anal. for compound 5i revealed good antitumor activity against MCF-7 cancer cell line and potent inhibition.

From this literature《Synthesis and biological evaluation of certain new cyclohexane-1-carboxamides as apoptosis inducers》,we know some information about this compound(837-52-5)HPLC of Formula: 837-52-5, but this is not all information, there are many literatures related to this compound(837-52-5).

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Design, Synthesis, Biological Screening, and Molecular Docking Studies of Piperazine-Derived Constrained Inhibitors of DPP-IV for the Treatment of Type 2 Diabetes.Recommanded Product: 837-52-5.

Novel piperazine-derived conformationally constrained compounds were designed, synthesized, and evaluated for in vitro Dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. From a library of compounds synthesized, 1-(2-(4-(7-Chloro-4-quinolyl)piperazin-1-yl)acetyl)pyrrolidine (2g) was identified as a potential DPP-IV inhibitor exhibiting better inhibitory activity than P32/98, reference inhibitor. The in vivo studies carried out in STZ and db/db mice models indicated that the compound 2g showed moderate antihyperglycemic activity as compared to the marketed drug Sitagliptin. A two-week repeated dose study in db/db mice revealed that compound 2g significantly declined blood glucose levels with no evidence of hypoglycemia risk. Furthermore, it showed improvement in insulin resistance reversal and antidyslipidemic properties. Mol. docking studies established good binding affinity of compound 2g at the DPP-IV active site and are in favor of the observed biol. data. These data collectively suggest that compound 2g is a good lead mol. for further optimization studies.

Here is just a brief introduction to this compound(837-52-5)Recommanded Product: 837-52-5, more information about the compound(7-Chloro-4-(piperazin-1-yl)quinoline) is in the article, you can click the link below.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about A 2D Cu(II)-based coordination polymer: treatment effect on Parkinson′s disease by increasing dopamine and VMA content.SDS of cas: 2645-22-9.

By using a mixed-ligand approach, a new Cu(II)-based coordination polymer with the chem. formula of [Cu(4-dpds)(bdc)(H2O)2] · 4-dpds () (4-dpds = 4,4′-dipyridyldusulfide and H2bdc = benzenedicarboxylic acid) has been synthesized and structurally determined by single-crystal X-ray diffractometer, powder X-ray diffraction, elemental anal., IR spectra and thermogravimetric anal. Furthermore, the treatment effect of the synthetic compound was evaluated on the Parkinson′s disease animal model and the enzyme linked immunosorbent assay (ELISA) was performed to detect the content of dopamine content in the substantia nigra. Then, the high efficiency liquid phase chromatogram (HPLC) was conducted for the measurement of the vanillyl mandelic acid (VMA) in urine.

Here is just a brief introduction to this compound(2645-22-9)SDS of cas: 2645-22-9, more information about the compound(4,4-Dipyridyl Disulfide) is in the article, you can click the link below.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary