Tag: M.W=200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Bioorganic & Medicinal Chemistry Letters called Synthesis of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolyzate, Author is Srivastava, Sandhya; Tewari, Swati; Srivastave, Sanjay K.; Chauhan, P. M. S.; Bhaduri, A. P.; Puri, S. K.; Pandey, V. C., which mentions a compound: 837-52-5, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3, Formula: C13H14ClN3.

Synthesis of aminoquinoline derivatives and their in vitro effects on metHb formation and metHb reductase activity are delineated. Some of the screened compounds have shown considerable metHb toxicity. An example compound thus prepared was 2-[(7-chloro-4-quinolinyl)amino]ethanol.

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Bromide – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of novel hybrid molecules from precursors with known antiparasitic activity, the main research direction is nitrofuranylpropenoyl nitropyrazole chloropiperazinylquinoline hybrid preparation antiamoebic antigiardial antiparasitic activity.Product Details of 837-52-5.

Novel new compounds I, II, and III derived from antiparasitic precursors were synthesized and tested for their antiamoebic and antigiardial activities. On the basis of preliminary screening data for these new compounds, compound III exhibited potent lethal activities against Entamoeba histolytica and Giardia intestinalis; its IC50 (about 1 μM) was lower, at least by a factor of five, compared to the standard drug, metronidazole. In addition, the IC50 of compound III against the tested parasites was 600 times below that against Hep-2 and Vero cells. Compounds I and II also exhibited potent or moderate antiamoebic and antigiardial activities with IC50 values of about 5.5 μM, and 140 μM, resp., against the tested parasites. Hybrid mols. I and II were also non-cytotoxic at the lethal concentrations against the parasites.

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Bromide – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Reversal Agent and Linker Variants of Reversed Chloroquines: Activities against Plasmodium falciparum, published in 2010-01-28, which mentions a compound: 837-52-5, Name is 7-Chloro-4-(piperazin-1-yl)quinoline, Molecular C13H14ClN3, Application of 837-52-5.

We have shown that “”reversed chloroquine mols.”” constructed from chloroquine-like and resistance “”reversal-agent””-like cores can be powerful drugs against malaria. Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental.

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Sidorin, D. N.; Kozyukov, A. V.; Zakharova, V. A.; Porodenko, N. V.; Kryukov, L. N. published an article about the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3 ).Quality Control of 7-Chloro-4-(piperazin-1-yl)quinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:837-52-5) through the article.

Todd-Atherton phosphorylation of (1-piperazinyl)quinoline derivatives with di-Et phosphite afforded the corresponding quinoline piperazinylamidophosphate derivatives in 30-40% yield. Antidepressant activity (inhibition of reverse uptake of serotonin) of the amidophosphate derivatives exceeded that of the starting materials, with title compound I most active (IC50 2.0 nM).

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Bromide – Wikipedia,
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SDS of cas: 837-52-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity. Author is Bogdanov, Andrei V.; Vazykhova, Al’bina M.; Khasiyatullina, Nadezhda R.; Krivolapov, Dmitry B.; Dobrynin, Alexey B.; Voloshina, Alexandra D.; Mironov, Vladimir F..

A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-[(piperazinyl)methyl]isatins, which were further converted to isoindigo derivatives The antimicrobial activity of the obtained heterocycles was evaluated.

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Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctanoic acid( cas:17696-11-6 ) is researched.Related Products of 17696-11-6.Fisher, Louise M.; Kim, Eliana E.; Moskalev, Nicolai V.; Gribble, Gordon W. published the article 《Asymmetric syntheses of potential anti-malarial drugs designed from Fieser’s 2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione》 about this compound( cas:17696-11-6 ) in ARKIVOC (Gainesville, FL, United States). Keywords: naphthalene dione preparation antimalarial activity. Let’s learn more about this compound (cas:17696-11-6).

Asym. syntheses of the potential anti-malarial drugs (S)-2-(8-fluoro-2-methyloctyl)-3- hydroxynaphthalene-1,4-dione, (S)-2-hydroxy-3-(8-trifluoromethyl-2-methyloctyl)-3-hydroxynaphthalene-1,4-dione, and (S)-2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione, which are patterned after Fieser’s ”10576”, known to be active against the mosquito borne parasite Plasmodium falciparum were described.

Although many compounds look similar to this compound(17696-11-6)Related Products of 17696-11-6, numerous studies have shown that this compound(SMILES:O=C(O)CCCCCCCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ) is researched.Related Products of 837-52-5.El-Azzouny, Aida M. Abd El-Sattar; Aboul-Enein, Mohamed Nabil; Hamissa, Mohamed Farouk published the article 《Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives》 about this compound( cas:837-52-5 ) in Drug Development Research. Keywords: review quinoline antiHIV antimalarial antiparasitic agent medicinal chem; 7-chloro-4-(piperazin-1-yl)quinoline; anti-HIV; anticancer; antidiabetic; antimalarial. Let’s learn more about this compound (cas:837-52-5).

A review. The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chem. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacol. profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Base- and Catalyst-Induced Orthogonal Site Selectivities in Acylation of Amphiphilic Diols, published in 2020-05-15, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, SDS of cas: 17696-11-6.

Seeking to selectively functionalize natural and synthetic amphiphiles, we explored acylation of model amphiphilic diols. The use of a nucleophilic catalyst enabled a remarkable shift of the site selectivity from the polar site, preferred in background noncatalyzed or base-promoted reactions, to the apolar site. This tendency was significantly enhanced for organocatalysts comprising an imidazole active site surrounded by long/branched tails. An explanation of these orthogonal modes of selectivity is supported by competitive experiments with monoalc. substrates.

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Reference:
Bromide – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors.Computed Properties of C9H8BrN.

In previous work, we described 6-6′-bisindole compounds targeting a hydrophobic pocket on the N-heptad repeat region of viral glycoprotein-41 as effective inhibitors of HIV-1 fusion. Two promising compounds with sub-micromolar IC50’s contained a benzoic acid group and a benzoic acid ester attached at the two indole nitrogens. Here we have conducted a thorough structure-activity relationship (SAR) study evaluating the contribution of each of the ring systems and various substituents to compound potency. Hydrophobicity, polarity and charge were varied to produce 35 new compounds that were evaluated in binding, cell-cell fusion and viral infectivity assays. We found that (a) activity based solely on increasing hydrophobic content plateaued at ∼ 200 nM; (b) the bisindole scaffold surpassed other heterocyclic ring systems in efficacy; (c) a polar interaction possibly involving Gln575 in the pocket could supplant less specific hydrophobic interactions; and (d) the benzoic acid ester moiety did not appear to form specific contacts with the pocket. The importance of this hydrophobic group to compound potency suggests a mechanism whereby it might interact with a tertiary component during fusion, such as membrane. A promising small mol. 10b with sub-μM activity was discovered with mol. weight <500 da and reduced logP compared to earlier compounds The work provides insight into requirements for small mol. inhibition of HIV-1 fusion. Although many compounds look similar to this compound(1219741-50-0)Computed Properties of C9H8BrN, numerous studies have shown that this compound(SMILES:CC1=CNC2=C1C=CC(Br)=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Bromide – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Formula: C21H25BF4N2. The article 《Antiparasitic agents. Part VI. Synthesis of 7-chloro-4-(4-substituted-phenylamino)- and 7-chloro-4-(4-substituted-piperazin-1-yl)quinolines as potential antiparasitic agents》 in relation to this compound, is published in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:837-52-5).

Chloro(hydroxyphenylamino)quinolines I (R = H, CO2H, NO2, NH2, substituted carbamoyl, R1 = H, C6H4OMe-2, C6H4Me-3, C6H4Me-4), chloro(4-piperazinyl)quinolines II (R2 = H, substituted carbamoyl, substituted carbamoylmethyl), and other similar compounds were prepared and tested for their antimalarial, antifilarial and antimicrobial activities but none of them shows any noteworthy activity.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary