Tag: M.W=200-300

Computed Properties of C9H8BrN. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles. Author is Xie, Tao; Sui, Qi-Bang; Qin, Lu-Zhe; Wen, Xiaoan; Sun, Hongbin; Xu, Qing-Long; Zhen, Le.

A copper-mediated cyclization and dimerization of indole derived oxime acetate was developed to generate a series of biimidazo[1,2-a]indole scaffolds with two contiguous stereogenic quaternary carbons in one step.

The article 《Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles》 also mentions many details about this compound(1219741-50-0)Computed Properties of C9H8BrN, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents》. Authors are Kumar, Ashok; Srivastava, Kumkum; Raja Kumar, S.; Puri, S. K.; Chauhan, Prem M. S..The article about the compound:7-Chloro-4-(piperazin-1-yl)quinolinecas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3).Formula: C13H14ClN3. Through the article, more information about this compound (cas:837-52-5) is conveyed.

In the present study, new side chain modified 4-aminoquinoline derivatives and quinoline-acridine hybrids were synthesized and evaluated in vitro against NF 54 strain of Plasmodium falciparum. Among the evaluated compounds, one compound (MIC = 0.125 μg/mL) was equipotent to standard drug CQ (MIC = 0.125 μg/mL) and it showed the curative response to all the treated swiss mice infected with CQ-resistant N-67 strain of Plasmodium yoelii at the doses 50 mg/kg and 25 mg/kg for four days by i.p. route and was found to be orally active at the dose of 100 mg/kg for four days. Another compound (MIC = 0.031 μg/mL) was four times more potent than CQ. The promising antimalarial potency of these compounds highlight the significance of exploring the privileged 4-aminoquinoline class for new antimalarials.

The article 《Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents》 also mentions many details about this compound(837-52-5)Formula: C13H14ClN3, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C8H15BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control. Author is Linnebank, Pim R.; Ferreira, Stephan Falcao; Kluwer, Alexander M.; Reek, Joost N. H..

Herein, the redesign of a supramol. Rh-bisphosphite hydroformylation catalyst containing a neutral carboxylate receptor (DIM pocket) with a larger distance between the phosphite metal binding moieties and the DIM pocket was reported. For the first time regioselective hydroformylation of internal CH3(CH2)nCH:CH(CH2)7C(O)OH (n = 3, 5, 7), CH3CH:CH(CH2)nC(O)OH (n = 6, 7) and terminal CH2:CH(CH2)nC(O)OH (n = 2, 3, 4, etc.) alkenes containing a remote carboxylate directing group is demonstrated. For carboxylate substrates that possess an internal double bond at the Δ-9 position, regioselectivity was observed As such, the catalyst was used to hydroformylate natural monounsaturated fatty acids (MUFAs) in a regioselective fashion, forming of an excess of the 10-formyl product (10-formyl/9-formyl product ratio of 2.51), which is the first report of a regioselective hydroformylation reaction of such substrates.

The article 《Regioselective Hydroformylation of Internal and Terminal Alkenes via Remote Supramolecular Control》 also mentions many details about this compound(17696-11-6)Formula: C8H15BrO2, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage, Author is Nguyen, Suong T.; McLoughlin, Elizabeth A.; Cox, James H.; Fors, Brett P.; Knowles, Robert R., which mentions a compound: 17696-11-6, SMILESS is O=C(O)CCCCCCCBr, Molecular C8H15BrO2, SDS of cas: 17696-11-6.

The accumulation of persistent plastic waste in the environment is widely recognized as an ecol. crisis. New chem. technologies are necessary both to recycle existing plastic waste streams into high-value chem. feedstocks and to develop next-generation materials that are degradable by design. Here, we report a catalytic methodol. for the depolymerization of a com. phenoxy resin and high mol. weight hydroxylated polyolefin derivatives upon visible light irradiation near ambient temperature Proton-coupled electron transfer (PCET) activation of hydroxyl groups periodically spaced along the polymer backbone furnishes reactive alkoxy radicals that promote chain fragmentation through C-C bond β-scission. The depolymerization produces well-defined and isolable product mixtures that are readily diversified to polycondensation monomers. In addition to controlling depolymerization, the hydroxyl group modulates the thermomech. properties of these polyolefin derivatives, yielding materials with diverse properties. These results demonstrate a new approach to polymer recycling based on light-driven C-C bond cleavage that has the potential to establish new links within a circular polymer economy and influence the development of new degradable-by-design polyolefin materials.

The article 《Depolymerization of Hydroxylated Polymers via Light-Driven C-C Bond Cleavage》 also mentions many details about this compound(17696-11-6)SDS of cas: 17696-11-6, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Nayak, Rashmi Ashwathama; Bhat, Sachin A.; Shanker, G.; Rao, D. S. Shankar; Yelamaggad, C. V. published an article about the compound: 8-Bromooctanoic acid( cas:17696-11-6,SMILESS:O=C(O)CCCCCCCBr ).SDS of cas: 17696-11-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:17696-11-6) through the article.

Herein the authors report on the synthesis and characterization of four new series of optically active, nonsym. dimers in which cholesterol is covalently linked to a Schiff base core through an ω-oxyalkanoyl spacer. While the Schiff base core is substituted with n-butyloxy, n-hexyloxy, n-octyloxy, n-decyloxy and n-dodecyloxy tails, three even-parity spacers, namely, 4-oxybutanoyl, 6-oxyhexanoyl, 8-oxyoctanoyl, and an odd-parity spacer, namely, 5-oxypentanoyl, were used to join the two cores. The length and parity of the spacer and the length of the terminal tail play a vital role in deciding the phase sequences of the dimers. In general, the dimers possessing an even-parity spacer display enantiotropic LC phases such as chiral nematic (N*), twist grain boundary (TGB), smectic A (SmA), chiral smectic C (SmC*) and twist grain boundary phase with SmC* slabs (TGBC*). Some of these dimers display TGBC* over a wide temperature range. The dimers with an odd-parity (5-oxypentanoyl) spacer display, unlike their even-membered counterparts, blue phases (BPIII/II/I); besides, they stabilize N* and/or unknown smectic (SmX) phases. The CD measurements were carried out as a function of temperature on the planar texture formed by three even-membered dimers and an odd-membered dimer. The occurrence of a strong neg. CD band in the N* phase of the even-membered dimers suggests a left-handed screw sense of the macroscopic helical structure, and the scenario is opposite in the case of an odd-membered dimer.

The article 《Highly frustrated liquid crystal phases in optically active dimers: synthesis and rich phase transitional behavior》 also mentions many details about this compound(17696-11-6)SDS of cas: 17696-11-6, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 4,4-Dipyridyl Disulfide(SMILESS: C1(SSC2=CC=NC=C2)=CC=NC=C1,cas:2645-22-9) is researched.Computed Properties of C6H12N2O4Pt. The article 《Iron-Catalyzed Thiolation and Selenylation of Cycloalkyl Hydroperoxides via C-C Bond Cleavage》 in relation to this compound, is published in Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:2645-22-9).

A cheap iron-catalyzed C-C bond cleavage and thiolation/selenylation of cycloalkyl hydroperoxides I [R = Ph, 2-thienyl, 2-naphthyl, etc.; R1 = H, Me, n-heptyl; X = (CH2)n; n = 1-4, 8] are presented. This redox-neutral protocol provides efficient access to diverse distal keto-functionalized thioethers and selenium compounds II (R = n-pentyl, Ph, 2-thienyl, etc.; R1 = H, Me, n-heptyl; Ar = Ph, 4-MeC6H4, 2-pyridyl, etc.; X = (CH2)n; n = 1-4, 8; Y = S, Se). Remarkably, only some amounts of disulfides are required for this transformation.

After consulting a lot of data, we found that this compound(2645-22-9)Application In Synthesis of 4,4-Dipyridyl Disulfide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy.Formula: C8H15BrO2.

Sonodynamic therapy (SDT) is a prospective therapy for many tumors by activation of sonosensitizers to produce reactive oxygen species (ROS) by ultrasound (US). However, limited generation of ROS and low drug delivery efficiency of sonosensitizers to the tumor tissue still hinder the application of SDT. Herein, an amphiphilic rose bengal (ARB) conjugate was designed to fabricate rose bengal microbubbles (RB-MBs) with high drug-loading contents (~6.8%) and excellent contrast enhancement capability for US imaging, well suited for detecting tumor location and size. More importantly, RB-MBs could be successfully converted into RB-NPs by local US exposure, resulting in ~7.5 times higher drug accumulation at the tumor tissue through the sonoporation effect as compared to RB-NPs and RB-MBs without US sonication. Meanwhile, using RB as the MB shell facilitated US energy transfer by the US mediated collapse of MBs through either a sonoluminescence or pyrolysis process; thus, the ROS generation efficiency could be greatly enhanced, resulting in a significantly higher tumor inhibition rate for the RB-MBs + US (~76.5%) in the HT-29 tumor model as compared to conventional MBs + US and RB-NPs + US (~23.8% and ~49.2%), resp. All these results suggested that this novel sonosensitizer delivery system of RB-MBs combined with US is a powerful strategy for remarkably enhancing SDT therapeutic efficacy with minimal side effects, showing great potential in cancer theranostics.

After consulting a lot of data, we found that this compound(17696-11-6)Formula: C8H15BrO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 4,4-Dipyridyl Disulfide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Metal-free, oxidative decarboxylation of aryldifluoroacetic acid with the formation of the ArS-CF2 bond. Author is Zhang, Yifang; Wang, Qian; Peng, Yi; Gong, Haiying; Chen, Hua; Deng, Hongmei; Hao, Jian; Wan, Wen.

A metal-free, oxidative decarboxylative reaction of aryldifluoroacetic acids ArCF2C(O)OH (Ar = 4-methoxylphenyl, 2,4,6-trifluoromethylphenyl, 1-naphthyl, etc.) with diaryl disulfides RSSR (R = Ph, thiophen-2-yl, benzo[d]thiazol-2-yl, etc.) or thiols R1SH (R1 = 4-methylphenyl, thiophen-2-yl, pyridin-2-yl, etc.) under mild reaction conditions has been developed. This is an efficient and straightforward radical cross-coupling method for the synthesis of diverse aryldifluoromethylthio ethers ArCF2SR or ArCF2SR1 in moderate to excellent yields.

After consulting a lot of data, we found that this compound(2645-22-9)Quality Control of 4,4-Dipyridyl Disulfide can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Reference of 2-(Furan-2-yl)-2-oxoacetaldehyde. The article 《Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:837-52-5).

A series of 4-aminoquinoline-isoindoline-dione-isoniazid triads were synthesized and assessed for their anti-mycobacterial activities and cytotoxicity. Most of the synthesized compounds exhibited promising activities against the mc26230 strain of M. tuberculosis with MIC at 5.1-11.9μM and were non-cytotoxic against Vero cells. The conjugates lacking either isoniazid or quinoline core in their structural framework failed to inhibit the growth of M. tuberculosis; thus, further strengthening the proposed design of triads.

After consulting a lot of data, we found that this compound(837-52-5)Safety of 7-Chloro-4-(piperazin-1-yl)quinoline can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 837-52-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis, antimalarial activity evaluation and docking studies of some novel tetraoxaquines. Author is Kumawat, Mukesh Kumar; Parida, Pratap; Chetia, Dipak.

Tetraoxaquines, mol. hybrids of 1,2,4,5-tetraoxane and 4-aminoquinoline, were designed via mol. docking anal. against Falcipain-2. Among the studied compounds, 11 top scoring analogs showing low binding energy were further selected for synthesis and evaluated for their in vitro antimalarial activity. In inhibitory assay, five compounds showed significant activity against chloroquine-resistant strain of P. falciparum-RKL-9 with IC50 values of 3.906, 3.942, 4.272, 3.906, 4.814 μg/mL.

After consulting a lot of data, we found that this compound(837-52-5)Product Details of 837-52-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary