Tag: M.W=200-300

Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Author is Singh, Amandeep; Rani, Anu; Gut, Jiri; Rosenthal, Philip J.; Kumar, Vipan.

A series of piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates were prepared with a view to evaluate their activities against Plasmodium falciparum. The synthesized conjugates had in vitro IC50 values from 0.41 to 2.38 μM against chloroquine-resistant and mefloquine-sensitive W2 strain of P. falciparum. The submicromolar activities of most of the synthesized conjugates suggest that such mol. frameworks can act as therapeutic templates for the design and synthesis of new antimalarials.

The article 《Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation》 also mentions many details about this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
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Recommanded Product: 2645-22-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Response of a Zn(II)-based metal-organic coordination polymer towards trivalent metal ions (Al3+, Fe3+ and Cr3+) probed by spectroscopic methods. Author is Daga, Pooja; Manna, Priyanka; Majee, Prakash; Singha, Debal Kanti; Hui, Sayani; Ghosh, Ananta Kumar; Mahata, Partha; Mondal, Sudip Kumar.

A new zinc-based two-dimensional coordination polymer, [Zn(5-AIP)(Ald-4)]·H2O (5-AIP = 5-amino isophthalate, Ald-4 = aldrithiol-4), 1 , was synthesized at room temperature by the layer diffusion technique. Single-crystal X-ray diffraction anal. of 1 showed a two-dimensional bilayer structure. An aqueous suspension of 1 upon excitation at 300 nm displayed an intense blue emission at 403 nm. The luminescence spectra were interestingly responsive and selective to Al3+, Cr3+ and Fe3+ ions even in the presence of other interfering ions. The calculated detection limits for Al3+, Cr3+ and Fe3+ were 0.35μM (≡8.43 ppb), 0.46μM (≡22.6 ppb) and 0.30μM (≡15.85 ppb), resp. Notably, with the cumulative addition of Al3+ ions, the luminescence intensity at 403 nm decreased steadily with a gradual red shift up to 427 nm. Afterward, this red shifted peak showed a turn-on effect upon further addition of Al3+ ions. However, for Cr3+ and Fe3+ ions, there was only drastic luminescence quenching and a large red shift up to 434 nm. This indicated the formation of a complex between 1 and these metal ions, which was also supported by the UV-Visible absorption spectra of 1 that showed the appearance of a new band at 280 nm in the presence of these three metal ions. The FTIR spectra revealed that these ions interacted with the carboxylate oxygen atom of 5-AIP and the nitrogen atom of the Ald-4 ligand in the structure. The luminescence lifetime decay anal. manifested that a charge-transfer type complex was formed between 1 and Cr3+ and Fe3+ ions that resulted in huge luminescence quenching due to the efficient charge transfer involving the vacant d-orbitals, whereas for Al3+ ions having no vacant d-orbital, turn-on of luminescence occurred because of the increased rigidity of 1 upon complexation.

The article 《Response of a Zn(II)-based metal-organic coordination polymer towards trivalent metal ions (Al3+, Fe3+ and Cr3+) probed by spectroscopic methods》 also mentions many details about this compound(2645-22-9)Recommanded Product: 2645-22-9, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

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Related Products of 837-52-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about 7-Chloroquinoline-isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation.

A series of twenty piperazine-tethered 7-chloroquinoline-isatin hybrids have been synthesized via either direct nucleophilic substitution or Cu(Ι)Cl-mediated Mannich reaction. These new conjugates were evaluated for their antimalarial and antitubercular efficacy against a chloroquine-resistant strain of Plasmodium falciparum and Mycobacterium tuberculosis, resp., while the cytotoxic profiles were evaluated against 3T6 cell line, a permanent mouse embryonic fibroblast cell line. The most potent of the test compound with IC50 of 0.22 μm against W2 strain of P. falciparum and 31.62 μm against the embryonic fibroblast cell line (cytotoxicity) displayed a high selective index of 143.73.

The article 《7-Chloroquinoline-isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation》 also mentions many details about this compound(837-52-5)Related Products of 837-52-5, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctanoic acid( cas:17696-11-6 ) is researched.Synthetic Route of C8H15BrO2.Sanchez-Cadena, Lorena E.; Tersac, Gilles; Coqueret, Xavier; Gamino-Arroyo, Zeferino published the article 《Solvolysis of acrylate-urethane coatings cured by electron-beam and UV radiation》 about this compound( cas:17696-11-6 ) in Progress in Organic Coatings. Keywords: polyurethane acrylate cured electron beam UV radiation coating solvolysis. Let’s learn more about this compound (cas:17696-11-6).

Solvolysis was investigated for two different types of thermosetting polyacrylate-urethane resin coatings. One type of resin was cross-linked by ultra violet (UV) radiation and the other by electron beam (EB). The cured coatings were deposited on aluminum sheets. Solvolysis was carried out with diethylene glycol (DEG) catalyzed by KOH. The resins were characterized by FT-IR ATR spectroscopy prior to solvolysis. The kinetics of the solvolysis process were investigated, and the depolymerization products were studied by FT-IR ATR spectroscopy and size exclusion chromatog. The results show that total solvolysis is possible for both cured resins, albeit it is faster for resins cured by UV radiation.

The article 《Solvolysis of acrylate-urethane coatings cured by electron-beam and UV radiation》 also mentions many details about this compound(17696-11-6)Synthetic Route of C8H15BrO2, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Recommanded Product: 1001-26-9. The article 《Synthesis and characterization of impurities present in an antimalarial drug piperaquine phosphate》 in relation to this compound, is published in Indian Journal of Heterocyclic Chemistry. Let’s take a look at the latest research on this compound (cas:837-52-5).

Six impurities formed during the process development of piperaquine phosphate, were identified as 7-chloro-4-(piperazine-1-yl)quinoline, 3-(4-(7-chloroquinolin-4-yl)piperazine-1-yl)propan-1-ol, 7-chloro-4-(4-(3-ethoxypropyl)piperazine-1-yl)quinoline, 1,4-bis(7-chloro-4-quinolinyl)piperazine, I [X = (CH2)3] and II by LC-MS. The structures of these impurities were further confirmed by synthesis. HPLC anal. of piperaquine phosphate API showed impurities ranging from 0.05 to 0.22%.

Different reactions of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Reference of 7-Chloro-4-(piperazin-1-yl)quinoline require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Romanov, Semyon R.; Dolgova, Yana V.; Morozov, Maxim V.; Ivshin, Kamil A.; Semenov, Dmitriy A.; Bakhtiyarova, Yulia V.; Galkina, Irina V.; Kataeva, Olga N.; Galkin, Vladimir I. published the article 《New phosphonium salts based on 3-(diphenylphosphino)propanoic and ω-haloalkanoic acids》. Keywords: crystal structure mol phosphonium bromide diphenyl dicarboxy preparation.They researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).Reference of 8-Bromooctanoic acid. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17696-11-6) here.

Quaternization of 3-(diphenylphosphino)propanoic acid with ω-haloalkanoic acids affords novel phosphonium salts containing two carboxy groups. The phosphonium salts were treated with 1 M alkali solution to obtain corresponding carboxylate phosphabetaines. The structure of the compounds was established by IR and NMR spectroscopy, elemental anal. and X-ray single crystal diffraction.

Different reactions of this compound(8-Bromooctanoic acid)Reference of 8-Bromooctanoic acid require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about The Ca2+-ATPase (SERCA1) Is Inhibited by 4-Aminoquinoline Derivatives through Interference with Catalytic Activation by Ca2+, Whereas the ATPase E2 State Remains Functional.COA of Formula: C13H14ClN3.

Several clotrimazole (CLT) and 4-aminoquinoline derivatives were synthesized and found to exhibit in vitro antiplasmodial activity with IC50 ranging from nM to μM values. We report here that some of these compounds produce inhibition of rabbit sarcoplasmic reticulum Ca2+-ATPase (SERCA1) with IC50 values in the μM range. The highest affinity for the Ca2+-ATPase was observed with NF1442 (N-((3-chlorophenyl)(4-((4-(7-chloroquinolin-4-yl)piperazin-1-yl)methyl)phenyl)methyl)-7-chloro-4-aminoquinoline) and NF1058 (N-((3-chlorophenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methyl)-7-chloro-4-aminoquinoline),yielding IC50 values of 1.3 and 8.0 μM as demonstrated by measurements of steady state ATPase activity as well as single cycle charge transfer. Characterization of sequential reactions comprising the ATPase catalytic and transport cycle then demonstrated that NF1058, and similarly CLT, interferes with the mechanism of Ca2+ binding and Ca2+-dependent enzyme activation (E2 to E1·Ca2 transition) required for formation of phosphorylated intermediate by ATP utilization. On the other hand, Ca2+ independent phosphoenzyme formation by utilization of Pi (i.e. reverse of the hydrolytic reaction in the absence of Ca2+) was not inhibited by NF1058 or CLT. Comparative experiments showed that the high affinity inhibitor thapsigargin interferes not only with Ca2+ binding and phosphoenzyme formation with ATP but also with phosphoenzyme formation by utilization of Pi even though this reaction does not require Ca2+. It is concluded that NF1058 and CLT inhibit SERCA by stabilization of an E2 state that, as opposed to that obtained with thapsigargin, retains the functional ability to form E2-P by reacting with Pi.

Different reactions of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)COA of Formula: C13H14ClN3 require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 837-52-5, is researched, Molecular C13H14ClN3, about The synthesis of novel hybrid compounds containing 5-nitrothiazole moiety as potential antiparasitic agents, the main research direction is nitrothiazole hybrid compound preparation antiparasitic trichomoniasis giardiasis.Name: 7-Chloro-4-(piperazin-1-yl)quinoline.

Abstract: A number of novel compounds containing 5-nitrothiazole moiety as potential antiparasitic agents have been synthesized through known chem. routes. The structures of the new compounds were confirmed by spectroscopic techniques, 1H NMR, 13C NMR, and mass spectrometry, and by elemental analyses. The prepared compounds were evaluated in vitro for their antigiardial and antitrichomonal activities. All tested compounds exhibited remarkable antigiardial activity with IC50 values ranging from 2.2 to 6.9 μg/cm3 as compared to the reference drug metronidazole (IC50 = 7.3 μg/cm3). In addition, three of the prepared compounds exhibited significant antitrichomonal activity with IC50 values of 4.3, 5.0, and 7.9 μg/cm3, resp., as compared to the reference drug metronidazole (8.5 μg/cm3). Graphical abstract: [Figure not available: see fulltext.].

Different reactions of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Name: 7-Chloro-4-(piperazin-1-yl)quinoline require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Majee, Prakash; Singha, Debal Kanti; Daga, Pooja; Hui, Sayani; Mahata, Partha; Mondal, Sudip Kumar published the article 《Photophysical studies of a room temperature phosphorescent Cd(II) based MOF and its application towards ratiometric detection of Hg2+ ions in water》. Keywords: mercury ion ratiometric detection water photophys study.They researched the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ).Safety of 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2645-22-9) here.

A new cadmium based MOF [Cd(C5N1S1H4)(C6O5H3)] (C5N1S1H4 = 4MPy, C6O5H3 = HFDA), Cd_1, was synthesized by a solvothermal reaction using 2,5-furandicarboxylic acid (H2FDA) and 4-mercaptopyridine (4MPyH) formed in situ by the S-S bond rupture of the aldrithiol-4 ligand. Single crystal X-ray data of Cd_1 confirmed a two-dimensional structure arranged in an ABAB… fashion in three dimensions where the nitrogen atom of the pyridine ring of 4MPy remains free. The aqueous dispersion of Cd_1 showed room temperature phosphorescence at 520 nm upon excitation at 330 nm. Luminescence lifetime studies revealed that the emission at 520 nm originates from a triplet state which became populated through intersystem crossing (ISC) from the singlet excited state. A trace amount of Hg2+ ions interacted very strongly with Cd_1 and significantly altered its UV-vis absorption and luminescence spectra. After interacting with the Hg2+ ions, the emission of Cd_1 at 520 nm gradually disappeared with a concomitant increase of the low intensity fluorescence at 383 nm. The ISC is hampered by the coordination of Hg2+ ions with two S atoms of the 4MPy moiety of two adjacent 1D chains (inter-layer) and a huge reduction of the structure’s flexibility. On the other hand, the interactions between metal ions and Cd_1 via the free N atom of the pyridine moiety resulted in the increase of the fluorescence intensity at 383 nm, however the phosphorescence intensity did not change significantly. These studies indicate that the interactions between Hg2+ ions and S atoms are highly selective due to the soft-soft interaction whereas the interactions between the N atoms and all the metal ions are not selective. A ratiometric luminescence approach has been employed to establish Cd_1 as a detector of Hg2+ in aqueous medium selectively over other common metal ions. The estimated quenching constant and detection limit of Cd_1 for Hg2+ were found to be 1.15 x 106 M-1 and 37.5 nM (equivalent to 7.40 ppb) in water.

Different reactions of this compound(4,4-Dipyridyl Disulfide)Safety of 4,4-Dipyridyl Disulfide require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17696-11-6, is researched, Molecular C8H15BrO2, about The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, the main research direction is fluorescent HDAC inhibitor preparation tumor imaging; HDAC; NIR; Probe; Tumor imaging.Recommanded Product: 17696-11-6.

Histone deacetylases (HDACs) have been found to be biomarkers of cancers and the corresponding inhibitors have attracted much attention these years. Herein we reported a near-IR fluorescent HDAC inhibitor based on vorinostat (SAHA) and a NIR fluorophore. This newly designed inhibitor showed similar inhibitory activity to SAHA against three HDAC isoforms (HDAC1, 3, 6). The western blot assay showed significant difference in compared with the neg. group. When used as probe for further kinematic imaging, Probe 1 showed enhanced retention in tumor cells and the potential of HDAC inhibitors in drug delivery was firstly brought out. The cytotoxicity assay showed Probe 1 had some anti-proliferation activities with corresponding IC50 values of 9.20 ± 0.96μM on Hela cells and 5.91 ± 0.57μM on MDA-MB-231 cells. These results indicated that Probe 1 could be used as a potential NIR fluorescent in the study of HDAC inhibitors and lead compound for the development of visible drugs.

The article 《The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells》 also mentions many details about this compound(17696-11-6)Recommanded Product: 17696-11-6, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Bromide – Wikipedia,
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