Tag: M.W=200-300

89359-54-6, A common compound: 89359-54-6, name is 9-Bromo-1-nonene, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Synthesis of compound 19 ?CF2CF3 ^CF2CF3 19 A 5 ml flask was charged with alkene 6 (0.5 g, 2.44 mmol), thiol CF3CF2(CH2)3SH (0.47 g, 2.44 mmol), 2,2-dimethoxy-2-phenyl-acetophenone (12 mg, 0.05 mmol) and CHCI3 (1 .5 ml) and purged with nitrogen atmosphere. The mixture was stirred at room temperature and irradiated with UV black light for 3 h (lambda = 365-368 nm, 15W). The mixture was concentrated by evaporating the solvent. An oil was obtained (0.96 g, 192%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 9-Bromo-1-nonene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CRYSTAL PHARMA, S.A.U.; PEREZ ENCABO, Alfonso; TURIEL HERNANDEZ, Jose Angel; GALLO NIETO, Francisco Javier; LORENTE BONDE-LARSEN, Antonio; GARCIA ESCUDERO, Luis Angel; WO2015/181116; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, molecular formula is C6H2Br2F2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 327-51-5.

A solution of l,4-dibromo-2,5-difluorobenzene (640 mg, 2.35 mmol) in dry diethyl ether (10 mL) cooled in a dry ice-acetone bath was treated dropwise with 2.5 M n- butyllithium in hexanes (1.04 mL, 2.59 mmol). The solution was stirred at -78 C for 30 min, then was treated with a piece of dry ice. The cooling bath was removed after 5 min and the mixture was stirred for another 30 min while warming to room temperature. The mixture was diluted with EtOAc and water. The organic phase was separated and washed twice with saturated aqueous NaHCC . The combined aqueous phases were acidified with 1 M aqueous HCI, extracted twice with DCM, and the combined organic phases were dried and concentrated to give 4-bromo-2,5-difluorobenzoic acid as a white solid (297 mg, 53% yield).

The synthetic route of 1,4-Dibromo-2,5-difluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; TEBBEN, Andrew J.; AHMAD, Saleem; (95 pag.)WO2016/65222; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 58971-11-2, name is 3-Bromophenethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58971-11-2, 58971-11-2

3-fluoro-2- [5- (4-fluorophenyl) -1 H-pyrazol-3-yl] benzoic acid (0.057 g)In N, N-dimethylformamide (1.5 mL) was added2- (3-bromophenyl) ethylamine (0.038 g), 1-hydroxybenzotriazole monohydrate (0.035 g),1-Ethyl-3- (3-dimethylaminopropyl) carbodimiDehydrochloride (0.044 g) and triethylamine (0.058 g), and the mixture was stirred overnight at room temperature. Water was added to the reaction mixture, and the crude product was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate / methanol)N- [2- (3-bromophenyl) ethyl] -3-fluoro-2- [5- (4-fluorophenyl) -1 H-pyrazol-3-yl] benzamide (0.052 g).The product (0.052 g) In n-propanol (1.5 mL) was addedN-methylpyrrolidone (0.5 mL), triethylamine (0.033 g), 1,1′-bis (diphenylphosphino) ferrocene (0.006 g) and 1,1′-bis (diphenylphosphino) ferrocene palladium (II ) Dichloride dichloromethane adduct (0.009 g), and the mixture was stirred under a carbon monoxide atmosphere at 100 C. for 13 hours. After cooling the reaction mixture to room temperature, hydrochloric acid (1 mol / L) was added. The crude product was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatographyPurification by fee (elution solvent: ethyl acetate / n-hexane)3- (2- {3-fluoro-2- [5- (4-fluorophenyl) -1 H-pyrazol-3-yl] benzoylamino} ethyl)Benzoic acid propyl ester (0.026 g).An aqueous solution of sodium hydroxide (2 mol / L, 0.5 mL) was added to a methanol (0.5 mL) solution of the product (0.026 g), and the mixture was stirred at 60 C. for 2 hours. After cooling the reaction mixture to room temperature, hydrochloric acid (2 mol / L, 0.5 mL) was added. The precipitate was collected by filtration to give the title compound (0.021 g). Structural formula, spectral data and purification conditions are shown in Table 112.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; Hirasawa, Hideaki; Tanada, Fumiya; Mutai, Yousuke; Fushimi, Nobuhiko; Kobayashi, Junichi; Kijima, Yoshiro; (267 pag.)JP2018/108988; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary