Tag: M.W=200-300

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Bromo-3-methyl-1H-indole( cas:1219741-50-0 ) is researched.Computed Properties of C9H8BrN.Zhao, Sen; Li, Chunpu; Xu, Bin; Liu, Hong published the article 《Cp*Rh (III)-catalyzed C-H 3,3-difluoroallylation of indoles and N-iodosuccinimide-mediated cyclization for the synthesis of fluorinated 3,4-dihydropyrimido[1,6-a]indol-1(2H)-one derivatives》 about this compound( cas:1219741-50-0 ) in Youji Huaxue. Keywords: alkoxycarbamoylindole bromodifluoropropene rhodium catalyst difluoroallylation; difluoroallyl alkoxycarbamoylindole preparation iodosuccinimide promoter heterocyclization; difluoroiodomethyl alkoxy pyrimidoindolone preparation. Let’s learn more about this compound (cas:1219741-50-0).

A mild and facile two-step strategy was developed for the synthesis of fluorinated 3,4-dihydropyrimido[1,6-a]indol-1(2H)-ones through Cp*Rh (III)-catalyzed C-H 3,3-difluoroallylation and N-iodosuccinimide (NIS)-mediated cyclization. This strategy featured broad synthetic generality, unique versatility and high efficiency, which provided a potential tool for the construction of fluorine-containing heterocycles for drug discovery.

Different reactions of this compound(6-Bromo-3-methyl-1H-indole)Computed Properties of C9H8BrN require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 8-Bromooctanoic acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Deoxyfluorination of Carboxylic, Sulfonic, Phosphinic Acids and Phosphine Oxides by Perfluoroalkyl Ether Carboxylic Acids Featuring CF2O Units. Author is Zhao, Shiyu; Guo, Yong; Su, Zhaoben; Wu, Chengying; Chen, Wei; Chen, Qing-Yun.

The synthesis of acyl fluorides RCOF [R = Br(CH2)6CH2, Ph, 1-naphthyl, etc.], sulfonyl fluorides R1SO2F [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.] and phosphoric fluorides R2PO(F)R3 [R2 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R3 = Me, F, Ph, etc.] could be realized via carbonic difluoride (COF2) generated in situ from thermal degradation of the PFECA salt. The use of potassium salts of perfluoroalkyl ether carboxylic acids (PFECA) was reported featuring CF2O units as deoxyfluorination reagents, which were generated mainly as byproducts in the manufacture of hexafluoropropene oxide (HFPO).

Different reactions of this compound(8-Bromooctanoic acid)Name: 8-Bromooctanoic acid require different conditions, so the reaction conditions are very important.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 2645-22-9. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Copper-Catalyzed Cycloaddition of Heterobicyclic Alkenes with Diaryl Disulfides to Synthesize Dihydrobenzo[b]thiophene Derivatives.

A novel copper-catalyzed cycloaddition of diaryl disulfides RSSR (R = Ph, naphthalen-1-yl, pyridin-4-yl, etc.) to heterobicyclic alkenes I [R1 = H, F, Me, OMe; R2 = H, F, OMe; R3 = H, Me, C(O)OMe; R4 = H, Me, C(O)OMe; X = O, CH2, NTs, NBoc] has been developed. The C-S and C-C bonds can be formed simultaneously on the C=C bond of the olefins via a single-step cycloaddition to afford a series of 2,3-dihydrobenzo[b]thiophene derivatives II [R5 = H, F, OMe; R6 = H, OMe, Cl; R5R6 = -CH=CH-CH=CH-; R7 = H, F, Me, Ph, etc.; R8 = H, OMe, Cl; R7R8= -CH=CH-CH=CH-] and III. This reaction exhibits excellent diastereoselectivity and relatively broad substrate scope. Various functional groups attached to the substrates are tolerated in this protocol to give the corresponding exo adducts II and III in moderate yields.

《Copper-Catalyzed Cycloaddition of Heterobicyclic Alkenes with Diaryl Disulfides to Synthesize Dihydrobenzo[b]thiophene Derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(4,4-Dipyridyl Disulfide)Recommanded Product: 2645-22-9.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Ke; Bai, Bing; Liu, Yu-Hsuan; Lowary, Todd L. published the article 《Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii》. Keywords: antibacterial Mycobacterium kansasii antigen tridecasaccharide pathogen mycobacteria tuberculosis immunomodulator; BSA bovine serum albumin structure activity lipooligosaccharide tridecasaccharide bioconjugate; antigens; complex glycans; lipooligosaccharides; mycobacteria; total synthesis.They researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).Category: bromides-buliding-blocks. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17696-11-6) here.

The outer surfaces of mycobacteria, including the organism that causes tuberculosis, are decorated with an array of immunomodulatory glycans. Among these are lipooligosaccharides (LOSs), a class of mols. for which the function remains poorly understood. We describe the chem. synthesis of the glycan portion of a tridecasaccharide LOS from the opportunistic pathogen Mycobacterium kansasii. The target contains a number of unusual structural motifs that complicate its assembly and is the most complex mycobacterial LOS glycan to be synthesized to date when considering size and number of unique monosaccharides and glycosidic linkages. These studies not only provide a road-map for the preparation of addnl. members of this family of glycans, but also provides a valuable probe for use in structure-activity relationship investigations.

《Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctanoic acid)Category: bromides-buliding-blocks.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1219741-50-0, is researched, SMILESS is CC1=CNC2=C1C=CC(Br)=C2, Molecular C9H8BrNJournal, ChemCatChem called Chiral Broensted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles, Author is Zhou, Ji; Li, Tian-Zhen; Sun, Yu-Wen; Du, Bai-Xiang; Tan, Wei; Shi, Feng, the main research direction is methyl indolyl aryl benzofuranyl benzenesulfonamide preparation enantioselective; benzofuranyl azadiene indole asym addition chiral Bronsted acid catalyst.Safety of 6-Bromo-3-methyl-1H-indole.

A chiral phosphoric acid-catalyzed asym. 1,4-addition of benzofuran-derived azadienes I (R = H, 3-F, 4-Cl, 3-Me, etc.) with 3-substituted indoles II (R1 = Me, Et, Bn, Ph, 2-thienyl; R2 = H, 5-Cl, 6-Br, 7-Me, etc.) has been established, which offered enantioenriched tri(hetero)arylmethane products (S)-III in generally good yields (up to 98%) and high enantioselectivities (up to 99:1 er). This reaction has not only realized the application of chiral phosphoric acid as a competent catalyst in the asym. transformations of benzofuran-derived azadienes I, but also has accomplished the task of developing chiral Bronsted acid-catalyzed asym. 1,4-additions of benzofuran-derived azadienes I, which will enrich the research contents of chiral phosphoric acid catalysis and the chem. of benzofuran-derived azadienes I.

《Chiral Broensted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Bromo-3-methyl-1H-indole)Safety of 6-Bromo-3-methyl-1H-indole.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 837-52-5. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Arylpiperazines displaying preferential potency against chloroquine-resistant strains of the malaria parasite Plasmodium falciparum. Author is Molyneaux, Carrie-Anne; Krugliak, Miriam; Ginsburg, Hagai; Chibale, Kelly.

Arylpiperazines in which the terminal secondary amino group is unsubstituted were found to display a mefloquine-type antimalarial behavior in being significantly more potent against the chloroquine-resistant (W2 and FCR3) strains of Plasmodium falciparum than against the chloroquine-sensitive (D10 and NF54) strains. Substitution of the aforementioned amino group led to a dramatic drop in activity across all strains as well as abolition of the preferential potency against resistant strains that was observed for the unsubstituted counterparts. The data suggest that unsubstituted arylpiperazines are not well-recognized by the chloroquine resistance mechanism and may imply that they act mechanistically differently from chloroquine. On the other hand, 4-aminoquinoline-based heteroarylpiperazines in which the terminal secondary amino group is also unsubstituted, were found to be equally active against the chloroquine-resistant and chloroquine-sensitive strains, suggesting that chloroquine cross-resistance is not observed with these two 4-aminoquinolines. In contrast, two 4-aminoquinoline-based heteroarylpiperazines are pos. recognized by the chloroquine resistance mechanism. These studies provide structural features that determine the antimalarial activity of arylpiperazines for further development, particularly against chloroquine-resistant strains.

《Arylpiperazines displaying preferential potency against chloroquine-resistant strains of the malaria parasite Plasmodium falciparum》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(7-Chloro-4-(piperazin-1-yl)quinoline)Application of 837-52-5.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group, published in 2012-08-15, which mentions a compound: 837-52-5, mainly applied to antidiabetic DPP4 inhibitor heteroarylpiperazine prolylthiazolidine preparation structure activity, Application of 837-52-5.

Hypoglycemic agents with a mechanism of dipeptidyl peptidase IV (DPP-4) inhibition are suitable for once daily oral dosing. It is difficult to strike a balance between inhibitory activity and duration of action in plasma for inhibitors bearing an electrophilic nitrile group. We explored fused bicyclic heteroarylpiperazine substituted at the γ-position of the proline structure in the investigation of L-prolylthiazolidines lacking the electrophilic nitrile. Among them, 2-trifluoroquinolyl compound 8g is the most potent, long-lasting DPP-4 inhibitor (IC50 = 0.37 nmol/L) with high selectivity against other related peptidases. X-ray crystal structure determination of 8g indicates that CH-π interactions generated between the quinolyl ring and the guanidinyl group of Arg358 enhances the DPP-4 inhibitory activity and selectivity.

The article 《Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group》 also mentions many details about this compound(837-52-5)Application of 837-52-5, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 837-52-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines. Author is Vennerstrom, Jonathan L.; Ager, Arba L. Jr.; Dorn, Arnulf; Andersen, Steven L.; Gerena, Lucia; Ridley, Robert G.; Milhous, Wilbur K..

N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediamines I [R = HN(CH2)2O(CH2)2NH, HN(CH2)3O(CH2)4O(CH2)3NH, HN(CH2)6NH(CH2)6NH, etc.] were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. These bisquinolines had IC50 values from 1 to 100 nM against P. falciparum in vitro. Six of the 11 bisquinolines were significantly more potent against the chloroquine-resistant W2 clone compared to the chloroquine-sensitive D6 clone. For bisquinolines I, there was no relationship between the length of the bisquinoline heteroalkane bridge and antimalarial activity and no correlation between in vitro and in vivo antimalarial activities. Bisquinolines with alkyl ether and piperazine bridges were substantially more effective than bisquinolines with alkylamine bridges against P. berghei in vivo. Ten of the bisquinolines were potent inhibitors of hematin polymerization with IC50 values falling in the narrow range of 5-20 μM, and there was a correlation between potency of inhibition of hematin polymerization and inhibition of parasite growth. Compared to alkane-bridged bisquinolines (Vennerstrom et al., 1992), none of these heteroalkane-bridged bisquinolines had sufficient antimalarial activity to warrant further investigation of the series.

The article 《Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines》 also mentions many details about this compound(837-52-5)Application of 837-52-5, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Ionic cocrystals of dithiobispyridines: the role of I···I halogen bonds in the building of iodine frameworks and the stabilization of crystal structures. Author is Wzgarda-Raj, Kinga; Nawrot, Martyna; Rybarczyk-Pirek, Agnieszka J.; Palusiak, Marcin.

It has been confirmed that mercaptopyridines undergo spontaneous condensation in redox reaction with iodine-forming dithiopyridines. In the solid state, these compounds are protonated at the N atoms and cocrystallize with iodine forming salt structures, namely, 2-[(pyridin-2-yl)disulfanyl]pyridinium triiodide sesquiiodine, C10H9N2S2+·I3-·1.5I2, and 4,4′-(disulfanediyl)dipyridinium pentaiodide triiodide, C10H10N2S22+·I5-·I3-. Dithiopyridine cations are packed among three-dimensional frameworks built from iodide anions and neutral iodine mols., and are linked by hydrogen, halogen and chalcogen interactions. Quantum chem. computations indicated that dithiopyridines exhibit anomalously high nitrogen basicity which qualify them as potential proton sponges.

The article 《Ionic cocrystals of dithiobispyridines: the role of I···I halogen bonds in the building of iodine frameworks and the stabilization of crystal structures》 also mentions many details about this compound(2645-22-9)Application In Synthesis of 4,4-Dipyridyl Disulfide, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about New piperazine-derived nnrtis as anti-HIV agent: synthesis, biological evaluation and molecular docking studies. Author is Kushwaha, Ram Najar; Debnath, Utsab; Singh, Pankaj; Saxena, Reshu; Gupta, Satish Kumar; Tripathi, Raj Kamal; Siddiqui, Hefazat Husain; Katti, Seturam Bandhacharya.

A new series of piperazine-derived compounds were synthesized and evaluated as HIV-1 reverse transcriptase (HIV-1 RT) inhibitors. Flexibility of the piperazine structure plays an importance role for its diverse pharmacol. properties and medicinal potentialities. Compounds having better inhibitory activities against HIV-1 RT were tested for their anti-HIV activity in TZM-bl cell line. Among tested compounds, 9k exhibited better anti-HIV activity with an IC50 value of 13.18 ± 1.62 μg/mL and a therapeutic index value of 2.26 in TZM-bl cell line. Furthermore, mol. docking anal. revealed the similar binding modes of 9k and delavirdine with HIV-1 RT in which carbonyl group of 9k established hydrogen bonding with Lys103 residue as delavirdine, and other hydrophobic groups were stabilized with hydrophobic area (TRP229, LEU100, TYR188, PHE227, VAL106, PRO236, TYR181, TYR188, TRP229, and TYR318 residues) of HIV-1 RT. Present study suggests that compound 9k may serve as a new lead template for further modification to obtain therapeutically useful mol. for the treatment of HIV infection.

The article 《New piperazine-derived nnrtis as anti-HIV agent: synthesis, biological evaluation and molecular docking studies》 also mentions many details about this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline, you can pay attention to it, because details determine success or failure

Reference:
Bromide – Wikipedia,
bromide – Wiktionary