Tag: M.W=200-250

Grenz, David C. published the artcileSpiroconjugated Tetraaminospirenes as Donors in Color-Tunable Charge-Transfer Emitters with Donor-Acceptor Structure, Recommanded Product: 4-Bromo-N-methyl-2-nitroaniline, the publication is Chemistry – A European Journal (2022), 28(6), e202104150, database is CAplus and MEDLINE.

Charge-transfer emitters are attractive due to their color tunability and potentially high photoluminescence quantum yields (PLQYs). Herein, the authors present tetraaminospirenes as donor moieties, which, in combination with a variety of acceptors, furnished 12 charge-transfer emitters with a range of emission colors and PLQYs of up to 99%. The spatial separation of their frontier MOs was obtained through careful structural design, and two donor-acceptor structures were confirmed by X-ray crystallog. A range of photophys. measurements supported by DFT calculations shed light on the optoelectronic properties of this new family of spiro-NN-donor-acceptor dyes.

Chemistry – A European Journal published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H7BrN2O2, Recommanded Product: 4-Bromo-N-methyl-2-nitroaniline.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Earle, Martyn J. published the artcileSynthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Bioorganic & Medicinal Chemistry Letters (1997), 7(17), 2187-2192, database is CAplus.

A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by >75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wall, Leo A. published the artcileReactions of polyfluorobenzenes with nucleophilic reagents, Safety of 4-Bromo-2,3,5,6-tetrafluorophenol, the publication is Journal of Research of the National Bureau of Standards, Section A: Physics and Chemistry (1963), 67A(5), 481-97, database is CAplus and MEDLINE.

A mixture of 26.5 g. C₆F₆, 26.5 g. 85% KOH, and 75 ml. H₂O was heated in a sealed bomb at 175° for 5 hrs. with agitation to give 33.1 g. C₆F₅OH, b. 144-5°. A mixture of 67 g. C₆F₅H, 21.6 g. KOH, 150 ml. pyridine, and 2 ml. H₂O was refluxed 1 hr., treated with 21.6 KOH, and refluxed 24 hrs. to give 21 g. 2,3,5,6-tetrafluorophenol, b₂₀ 47°. Similarly refluxing 36 g. C₆F₅Me and 28 g. KOH in 300 ml. tert-BuOH gave 12 g. 2,3,5,6-tetrafluoro-p-cresol, m. 52°. Reaction of 20 g. C₆F₅I with 2 g. KOH and 1 ml. H₂O in 100 ml. pyridine gave only one product, 2,3,5,6-tetrafluoro-4-iodophenol, m. 79-81°; benzoate m. 59-60.2°. Reaction of 66 g. C₆F₅Br with 28.5 g. KOH and 1 ml. H₂O in 150 ml. pyridine, however, gave a mixture of products: 3.5 g. 2-bromo-3,4,5,6-tetrafluorophenol, m. 41-3° (3,5-dinitrobenzoate, m. 104-5°); and 11.5 g. 4-bromo-2,3,5,6-tetrafluorophenol (3,5-dinitrobenzoate m. 131-3°). Similarly, 100 g. 2-chlorotetrafluoro-α,α,α-trifluorotoluene on treatment with 5.6 g. KOH and 1 ml. H₂O in 100 ml. pyridine gave 2.5 g. 2-chlorotrifluoro-α,α,α-trifluoro-o-cresol, b₁₅ 92-3°, n²⁴_D 1.4510; and 15 g. 2-chlorotrifluoro-α,α,α-trifluoro-p-cresol, b₁₅ 102-3°, n²⁴_D 1.4510. The reactions of polyfluorobenzenes were then studied with alkoxides. A solution of 123.5 g. C₆F₅Br in 70 ml. pyridine was treated with a solution of 11.5 g. Na in 150 ml. MeOH during 1.5 hrs. and the mixture refluxed 15 hrs. and acidified with 1 l. 10% HCl to give 66 g. 4-bromo-2,3,5,6-tetrafluoroanisole, b₅ 79-81°, n²⁵_D 1.4812. Similarly, a mixture of 10 g. C₆F₅I in 50 ml. pyridine and 0.8 g. Na in 15 ml. MeOH on refluxing for 3 hrs. gave 1.5 g. unchanged C₆F₅I and 5.5 g. 2,3,5,6-tetrafluoro-4-iodoanisole (I), b₂₀ 113-15°, n²²_D 1.5229. Refluxing 1 g. I with 1 g. activated Cu powder for 12 min. gave 0.2 g. octafluoro-4,4′-dimethoxybiphenyl, m. 90-1.2°. To a cold solution of 9 g. Na in 250 ml. PhCH₂OH was added 75 g. C₆F₆ and the mixture refluxed 24 hrs. to give 30 g. benzyl pentafluorophenyl ether (II), m. 44°. A better yield was obtained when a solution of 4.6 g. Na and 22 g. PhCH₂OH in 250 ml. tert-BuOH was refluxed with 40 g. C₆F₆ for 40 hrs. to give 33 g. II. A solution of 8 g. C₆F₆ in 30 ml. HCONMe₂ was treated with 5.28 g. PhOK and the mixture refluxed 0.5 hr. to give 1 g. 2,3,5,6-tetrafluoro-1,4-diphenoxybenzene, m. 147-9°, and 3.5 g. 2,3,4,5,6-pentafluorophenyl phenyl ether, (III), m. 29°. III was also obtained by heating a mixture of 11 g. C₆F₅OK, 15 g. PhBr, and 1 g. Cu at 210° in a sealed bomb. A solution of 6 g. C₆F₅OK and 12.8 g. C₆F₆ in 30 ml. HCONMe₂ was refluxed 14 hrs. to give 1.5 g. bis(perfluorophenyl) ether, m. 67-9°, and a second product, m. 145-8°, probably p-bis(pentafluorophenoxy)2,3,5,6-tetrafluorobenzene. Similarly, a solution of 0.6 g. Na in 50 ml. EtOH refluxed with 5.3 g. C₆F₅NMe₂ 2 hrs. gave 5.1 g. 4-ethoxy-2,3,5,6-tetrafluoro-N,N-dimethylaniline, b. 34°. Reactions with amines were next investigated. A mixture of 280 g. C₆F₆ and 400 ml. 28% aqueous NH₃ was rocked in a sealed bomb for 2 hrs. at 235° to give 236 g. C₆F₅NH₂, m. 34°, and 28 g. tetrafluorophenylenediamine (sublimed 75°/1 mm.) shown by its nuclear magnetic resonance spectrum to be essentially the meta isomer mixed with a small amount of the para isomer. Similarly, heating a mixture of 56 g. C₆F₆ and 110 ml. 30% aqueous MeNH₂ at 220° for 3 hrs. gave 59% C₆F₅NHMe, b. 170-2°, and 25% 2,3,5,6-tetrafluoro-N,N’-diphenylphenylenediamine, m. 94°. The reaction product obtained by heating 50 g. C₆F₆ and 110 ml. 25% aqueous Me₂NH at 235° for 1 hr. was distilled at 1 mm. pressure and five fractions were collected. The first fraction (65%), b₁ 88°, was C₆F₅NMe₂. Fraction 2, b₁ 88-126°, was shown by vapor phase chromatography to be C₆F₅NMe₂ with 3 other compounds Fraction 3, b₁ 126-134°, consisted of 3 isomers of bis(dimethylamino)tetrafluorobenzene with the meta-isomer predominating. Fraction 4, b₁ 134-40°, contained equal amounts of the meta and para isomers. Fraction 5, b₁ 140-8°, was pure para isomer. The meta and para isomers could be separated by vapor phase chromatography. Similarly, heating a mixture of 30 g. C₆F₅Br and 70 ml. 28% NH₄OH at 200° for 2 hrs. gave 22 g. p-bromotetrafluoroaniline, m. 61°. Heating 16 g. C₆F₅I and 30 ml. 8% NH₄OH at 165° for 2 hrs. gave 7.6 g. tetrafluoro-p-iodoaniline, m. 77°. Benzyl pentafluorophenyl ether (20 g.) was heated with large excess of 28% NH₄OH to give 3 g. p-(benzyloxy)tetrafluoroaniline, m. 97°. Similarly, heating 50 g. 2-chlorotetrafluoro-α,α,α-trifluorotoluene and 120 ml. 28% NH₄OH at 21° for 2 hrs. gave 22 g. 2-chlorotrifluoro-α,α,α-trifluoro-p-toluidine, which decomposed readily at room temperature in the presence of air. To 100 ml. anhydrous NH₃ at -70° were added 0.1 g. Fe(NO₃)₃ and 2.99 g. Na and, after disappearance of the blue color, 25 g. C₆F₅OMe during 45 min. After 5 hrs. at -70° the reaction mixture was worked up to give 7 g. unreacted C₆F₅OMe, 2.8 g. tetrafluoro-p-anisidine, m. 75-6.5°, 1.2 g. 4,4′-dimethoxyoctafluorodiphenylamine, m. 78-9°, and 2.2 g. 4,4′,4”-trimethoxydodecafluorotriphenylamine, b. 157-9°, n²³_D 1.5005. Diazotization of C₆F₅NH₂ required concentrated acids since the salts of the amine hydrolyzed very readily in dilute solutions In 48% HBr, diazotization of C₆F₅NH₂ gave C₆F₅N:NNHC₆F₅, probably owing to slow diazotization. The reaction was temperature-dependent, the diazoaminobenzene being formed much faster at 10° than at -10°. The product decomposed in warm HBr to give 5.4% C₆F₅Br and a mixture of o- and p-dibromotetrafluorobenzenes. In concentrated H₂SO₄ the reaction was very slow even at 25°. Addition of HOAc hastened it. Deamination with hypophosphorus acid gave a mixture probably of C₆F₅H and C₆H₂F₄. Better diazotization could be carried out in liquid HF and the diazo product underwent successful Sandmeyer reaction. A solution of 20 g. C₆F₅NH₂ in 75 ml. anhydrous HF at -20° was treated with 7.27 g. NaNO₂ during 30 min. After stirring for 1 hr. at -10° the mixture was treated with 17.6 g. KI during 30 min. and allowed to warm to 25° in 1 hr. to give 16.5 g. C₆F₅I, b₃₅ 77-9°. Use of 12 g. KBr and 15 g. Cu₂Br₂ instead of KI gave 35% C₆F₅Br. The reaction of diazotized amine with C₆F₅OLi gave C₆F₅N:N(O)C₆F₅, which decomposed on removal of solvent. The Sandmeyer nitrile synthesis was not successful. A solution of 10 g. C₆F₅NH₂ in 100 ml. HOAc was oxidized with 25 ml. 30% H₂O₂ at 25° for 24 hrs. to give decafluoroazoxybenzene (IV), m. 53-4°. A mixture of 5 g. IV, 15 g. Zn powder, 5 g. NH₄Cl, 10 ml. H₂O, and 75 ml. 95% EtOH refluxed 30 min. gave 2 g. decafluoroazobenzene, m. 57-9°. C₆F₆ reacted readily with organolithium compounds A solution of MeLi, prepared from 4.5 g. Li and 43 g. MeI in 50 ml. ether, was cooled to -10° to -20°, added dropwise to a solution of 60 g. C₆F₆ in 250 ml. pentane, and stirred for 17 hrs. at room temperature to give 34 g. C₆F₅Me, b. 115°. Similarly, reaction of BuLi, prepared from 1.86 g. Li and 18.3 g. BuBr in 30 ml. ether, with 25.3 g. C₆F₆ in 25 ml. ether gave 10.5 g. unreacted C₆F₆, 7 g. C₆F₅Bu, b₂₅ 86-7°, n²⁰_D 1.4229, and 2.5 g. of a compound, b₁ 230°, n²⁰_D 1.4683, probably impure tributyldifluorobenzene. Similarly, 32.7 g. C₆F₆ in 150 ml. ether with 0.18 mole PhLi in 250 ml. ether gave 8.5 g. 2,3,5,6-tetrafluoro-p-terphenyl, m. 220°, and 33 g. C₆F₅Ph, m. 69°. A similar reaction of 18.6 g. C₆F₆ and isopropenyllithium prepared from 12.1 g. 2-bromopropene gave 5 g. 2,3,4,5,6-pentafluoro-α-methylstyrene, b₅₂ 72-4°. With vinyllithium, prepared from 0.1 mole PhLi and 0.025 mole tetravinyltin, 18.6 g. C₆F₆ gave 4 g. unreacted C₆F₆ and 20% C₆F₅CH:CH₂, b₂₅ 34°. LiAlH₄ reduction of 21 g. C₆F₆ in ether gave 17 g. of a mixture of C₆F₆ and C₆F₅H which was separated by vapor phase chromatography to give 7.5 g. C₆HF₅. All the products in all above reactions were studied by infrared and nuclear magnetic resonance spectroscopy. The mechanism of reaction and the directional effects were discussed.

Journal of Research of the National Bureau of Standards, Section A: Physics and Chemistry published new progress about 1998-61-4. 1998-61-4 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzene,Phenol, name is 4-Bromo-2,3,5,6-tetrafluorophenol, and the molecular formula is C17H14O5, Safety of 4-Bromo-2,3,5,6-tetrafluorophenol.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gao, Ya published the artcileDefluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base, Application In Synthesis of 849062-12-0, the publication is Advanced Synthesis & Catalysis (2022), 364(13), 2241-2247, database is CAplus.

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.

Advanced Synthesis & Catalysis published new progress about 849062-12-0. 849062-12-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Bromo-5-methoxyphenyl)boronic acid, and the molecular formula is C7H8BBrO3, Application In Synthesis of 849062-12-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mistico, Laetitia published the artcileAccess to Silylated Pyrazole Derivatives by Palladium-Catalyzed C-H Activation of a TMS group, Formula: C7H8BBrO3, the publication is Chemistry – A European Journal (2016), 22(28), 9687-9692, database is CAplus and MEDLINE.

A simple and efficient approach to new silylated heterocycles of potential interest in medicinal chem. is presented. A set of bromophenyl trimethylsilyl pyrazole intermediates can be transformed by direct organometallic routes into two families of regioisomeric iodoaryl substrates; using either arylzinc or aryllithium chem., the TMS group remains on the pyrazole ring or translocates to the aryl moiety. These two families can then be efficiently transformed into benzo silino pyrazoles thanks to a single-step cyclization relying on the Pd-catalyzed activation of a nonactivated C(sp³)-H bond alpha to a Si atom. The exptl. conditions used, which are fully compatible with the pyrazole ring, suggest that this reaction evolves through a concerted metalation-deprotonation (CMD) mechanism.

Chemistry – A European Journal published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Formula: C7H8BBrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Maeda, Dean Y. published the artcileDiscovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2014), 57(20), 8378-8397, database is CAplus and MEDLINE.

The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure-activity studies that examined the effect of a novel series of S-substituted 6-mercapto-N-phenyl-nicotinamides on CXCL1-stimulated Ca²⁺ flux in whole human PMNs led to the discovery of 2-[5-(4-fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic acid (SX-517), a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibited CXCL1-induced Ca²⁺ flux (IC₅₀ = 38 nM) in human PMNs but had no effect on the Ca²⁺ flux induced by C5a, fMLF, or PAF. In recombinant HEK293 cells that stably expressed CXCR2, SX-517 antagonized CXCL8-induced [³⁵S]GTPγS binding (IC₅₀ = 60 nM) and ERK1/2 phosphorylation. Inhibition was noncompetitive, with SX-517 unable to compete the binding of [¹²⁵I]-CXCL8 to CXCR2 membranes. SX-517 (0.2 mg/kg iv) significantly inhibited inflammation in an in vivo murine model. SX-517 is the first reported boronic acid chemokine antagonist and represents a novel pharmacophore for CXCR1/2 antagonism.

Journal of Medicinal Chemistry published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ganis, Paolo published the artcileThe crystal structure of a new form of the cyclic condensation product of methyl succinate (dimethyl 2,5-dihydroxy-l,4-cyclohexadiene-1,4-dicarboxylate: crystal form II, Computed Properties of 594-81-0, the publication is Atti Accad. Naz. Lincei Rend. Classe Sci. Fis. Mat. Nat. (1963), 35(1-2), 68-79, database is CAplus.

A 2nd crystal form of the title compound was crystallized from AcOEt as thick irregular prisms. Weissenberg photographs taken along the 3 principal axes with Cu Kα radiation established the triclinic space group P1̅ and the cell constants a 8.45 ± 0.05, b 6.90 ± 0.05, c 4.97 ±: 0.03 A., α 118° ± 1°, β 94° ± 1°, γ 94° ± 1°; d. (calculated) is 1.52. Positional parameters for C and O atoms were obtained from Patterson maps and refined by Fourier methods to R factors of 12.5 and 16.1% for [001] and [010] projections, by using B factors of 2.5 A.². H atoms, placed in their stereochem. accepted positions, were included in structure-factor calculations but not refined. A list of 216 F₀ and F₀ is given. Bond distances and angles are within the accepted values reported for analogous structures. Contact distances exclude the possibility of intermol. H-bond formation. A very nearly planar mol. results, however, from intramol. H bonding between the OH and COOH groups adjacent on the planar cyclohexadiene nucleus. The C:C distance of 1.33 ± 0.04 A. is compatibile only with an enolic form of the compound

Atti Accad. Naz. Lincei Rend. Classe Sci. Fis. Mat. Nat. published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Weygand, Friedrich published the artcileDehalogenation with sodium mercaptides, Category: bromides-buliding-blocks, the publication is Rev. Chim., Acad. Rep. Populaire Roumaine (1962), 7(2), 1379-92, database is CAplus.

The reactions of vicinal dihalides with mercaptides, leading to olefins or bis(alkyl- or arylthio) compounds were investigated and interpreted. The results indicated that the olefin-forming dehalogenation of vicinal dihalides was especially easy in compounds substituted with electron-attracting groups. The NaSEt suspension used was prepared by conversion of Na in ether with 10% excess EtSH. Dropwise addition of Me dibromodihydrocinnamate in ether to the mercaptide suspension gave Me cinnamate in 100% yield, also obtained in 82% yield with NaSPh. Dibenzalacetone was obtained in a similar manner in 80% yield from dibenzalacetone tetrabromide, coumarin in 97%, yield from 3,4-dibromodihydrocoumarin, and cholesterol in 93% yield from 5,6-dibromocholesterol and NaSEt. Reactions of the thiophenolate with 2,3-dimethyl-2,3-dibromobutane gave tetramethylethylene in 100% yield, with 2,3-dibromobutane, 2-butene in 72% yield, with 1,2-diiodoethane (heating), ethylene in 76% yield and with hexachloroethane (heating), tetrachloroethylene in 69% yield. In order to examine the stereospecificity of the dehalogenation, the di-Me dl- and meso-dibromosuccinate were converted with NaSEt in ether, to give di Me maleate and fumarate, resp., indicating that trans elimination occurred. No elimination by olefin formation but substitution was the result when 1,2-dibromides were treated with NaSPh. In this manner 1,2-bis(phenylthio)propane was obtained in 83% yield, b_0.03 168°, from 1,2-dibromopropane, and 1,4-bis(phenylthio)-2-butene, m. 80°, in 93% yield from 1,4-dibromo-2-butene. Similar treatment of 1,2,3,4-tetrabromobutane gave olefin formation in the 2,3-position and substitution in the 1,4-position. Treatment of the 1-chloro-1-(ethylthio)acetophenone with NaSEt gave the 1,2-bis(ethylthio)-l,2-dibenzoylethane in 37% yield. Similar treatment of di-Et bromomalonate gave di-Et (ethylthio)malonate, b₁₁ 135-7°, and tetra-Et ethanetetracarboxylate, m. 76°. In the same way 2,2,3,3-tetracarbethoxybutane, n²⁰_D 1.4459 (55%), and di-Et methylmalonate, b. 83-6°, n²⁰_D – 1.4170 (34%), were obtained from di-Et methylbromomalonate. Analogous treatment of di-Et chloromalonate and di-Et dibromomalonate gave di-Et (ethylthio)malonate, b₁₁ 135°, 70% yield, tetra-Et ethylenetetracarboxylate, m. 56°, 55% yield. Tetracyanoethylene, m. 197°, was obtained in 36% yield from dibromomalononitrile-KBr complex; 1,1,2,2-tetracarbethoxycyclopropane, m. 42°, was obtained in 70% yield from 1,3-dibromo-1,1,3,3-tetracarbethoxypropane, and di-Et 1,2-bis(ethylthio)succinate, b_0.1 117-35°, in 52% yield from the addition product of di-Et fumarate and EtSCl. 1,2-Bis(phenylthio)cyclohexane, b_0.1 185-96°, was obtained in 49% yield by treatment of 2-chlorocyclohexyl Ph sulfide with NaSPh.

Rev. Chim., Acad. Rep. Populaire Roumaine published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C44H28ClFeN4, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Arora, Vinod K. published the artcileA novel ring oxidation of 4- or 5-substituted 2H-oxazole to corresponding 2-oxazolone catalyzed by cytosolic aldehyde oxidase, COA of Formula: C9H6BrNO, the publication is Drug Metabolism & Disposition (2012), 40(9), 1668-1676, database is CAplus and MEDLINE.

The ring oxidation of 2H-oxazole, or C2-unsubstituted oxazole, to 2-oxazolone, a cyclic carbamate, was observed on various 4- or 5-substituted oxazoles. Using 5-(3-bromophenyl)oxazole as a model compound, its 2-oxazolone metabolite M1 was fully characterized by liquid chromatog./tandem mass spectrometry and NMR. The reaction mainly occurred in the liver cytosolic fraction without the requirement of cytochrome P 450 enzymes and cofactor NADPH. Investigations into the mechanism of formation of 2-oxazolone using various chem. inhibitors indicated that the reaction was primarily catalyzed by aldehyde oxidase and not by xanthine oxidase. In addition, cytosol incubation of 5-(3-bromophenyl)oxazole in the medium containing H₂¹⁸O led to the ¹⁸O incorporation into M1, substantiating the reaction mechanism of a typical molybdenum hydroxylase. The rank order of liver cytosols for the 2-oxazolone formation was mouse > monkey >> rat and human liver cytosol, whereas M1 was not formed in dog liver cytosol. Because the reaction was observed with a number of 4- or 5-substituted 2H-oxazoles in mouse liver cytosols, 2H-oxazoles represent a new substrate chemotype for ring oxidation catalyzed by aldehyde oxidase.

Drug Metabolism & Disposition published new progress about 243455-57-4. 243455-57-4 belongs to bromides-buliding-blocks, auxiliary class Oxazole,Bromide,Benzene, name is 5-(3-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, COA of Formula: C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Farahat, Abdelbasset A. published the artcileExploration of larger central ring linkers in furamidine analogues: Synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties, Recommanded Product: 4-Bromo-N-methyl-2-nitroaniline, the publication is Bioorganic & Medicinal Chemistry (2011), 19(7), 2156-2167, database is CAplus and MEDLINE.

The effects of replacing the central furan ring of furamidine with indole and benzimidazole on their DNA binding affinity, antiparasitic activity and fluorescence are reported. The bis-cyanophenylindoles required to make the corresponding amidines were prepared by sequential Stille and/or Suzuki coupling reactions. The bis-cyanophenylbenzimidazoles were obtained by coupling 4-cyanobenzaldehydes with the appropriate cyano substituted phenylenediamine. The bis-nitriles were converted to the diamidines by reaction with LiN[Si(CH₃)₃]₂ or by Pinner methodol. Specifically, we have prepared new series of 2,6- and 2,5-diaryl indoles (6a,b, 12 and 17a-d) and the related benzimidazoles (24, 30 and 35). The new compounds bind in the DNA minor groove in DNA AT base pair sequences and eight of the ten new analogs exhibit ΔT _m values comparable to or higher than that of furamidine. Six of ten of the new compounds exhibit lower IC₅₀ values against Trypanosoma brucei rhodesiense (T. b. r.) and eight of ten exhibit lower IC₅₀ values against Plasmodium falciparum (P. f.) than furamidine. Four of the ten show greater efficacy than furamidine in the rigorous T. b. r. STIB900 mouse model for African trypanosomiasis. Generally, the fluorescence properties of the new analogs are similar to that of DAPI.

Bioorganic & Medicinal Chemistry published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H7BrN2O2, Recommanded Product: 4-Bromo-N-methyl-2-nitroaniline.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary