Tag: M.W=200-250

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 823-78-9, formula is C7H6Br2, The most pervasive is the naturally produced bromomethane. Safety of 1-Bromo-3-(bromomethyl)benzene

Asgari, Mohammad S.;Azizian, Homa;Nazari Montazer, Mohammad;Mohammadi-Khanaposhtani, Maryam;Asadi, Mehdi;Sepehri, Saghi;Ranjbar, Parviz R.;Rahimi, Rahmatollah;Biglar, Mahmood;Larijani, Bagher;Amanlou, Massoud;Mahdavi, Mohammad research published 《 New 1,2,3-triazole-(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation》, the research content is summarized as follows. A new series of 1,2,3-triazole-(thio)barbituric acid hybrids 8a-n was designed and synthesized on the basis of potent pharmacophores with urease inhibitory activity. Therefore, these compounds were evaluated against Helicobacter pylori urease. The obtained result demonstrated that all the synthesized compounds, 8a-n, were more potent than the standard urease inhibitor, hydroxyurea. Moreover, among them, compounds 8a, 8c-e, 8g,h, and 8k,l exhibited higher urease inhibitory activities than the other standard inhibitor used: thiourea. Docking studies were performed with the synthesized compounds Furthermore, mol. dynamic simulation of the most potent compounds, 8e and 8l, showed that these compounds interacted with the conserved residues Cys592 and His593, which belong to the active site flap and are essential for enzymic activity. These interactions have two consequences: (a) blocking the movement of a flap at the entrance of the active site channel and (b) stabilizing the closed active site flap conformation, which significantly reduces the catalytic activity of urease. Calculation of the physicochem. and topol. properties of the synthesized compounds 8a-n predicted that all these compounds can be orally active. The ADME prediction of compounds 8a-n was also performed.

823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., Safety of 1-Bromo-3-(bromomethyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 823-78-9.

Asgari, Mohammad S.;Tahmasebi, Behnam;Mojtabavi, Somayeh;Faramarzi, Mohammad A.;Rahimi, Rahmatollah;Ranjbar, Parviz R.;Biglar, Mahmood;Larijani, Bagher;Rastegar, Hossein;Mohammadi-Khanaposhtani, Maryam;Mahdavi, Mohammad research published 《 Design, synthesis, biological evaluation, and docking study of new acridine-9-carboxamide linked to 1,2,3-triazole derivatives as antidiabetic agents targeting α-glucosidase》, the research content is summarized as follows. A new series of acridine-9-carboxamide-1,2,3-triazole derivatives I [R = H, 2-Me, 4-O₂N, etc.] were designed, synthesized and evaluated as novel α-glucosidase inhibitors. Compounds I were designed by combination of effective moieties from potent α-glucosidase inhibitors. Most of the synthesized compounds I were more potent than standard inhibitor acarbose. Among the synthesized compounds, the most potent compounds were I [R = 3-Br, 4-Br, H] with IC₅₀ values of 120.2 ± 1.0, 151.1 ± 1.4, and 157.6 ± 1.6μM, resp. (IC₅₀ value of acarbose = 750.0 ± 10.0μM). Docking study of the most potent compounds I [R = H, 3-Br, 4-Br] reported that these compounds formed stable complexes with α-glucosidase active site. Anti-α-amylase assay of compounds I [R = H, 3-Br, 4-Br] was performed and no activity was observed, meanwhile in-vitro cytotoxicity assay of the latter compounds revealed that these compounds were not cytotoxic toward human normal (HDF) and cancer (MCF-7) cell lines. ADME and toxicity prediction of compounds I [R = H, 3-Br, 4-Br] were also performed.

Reference of 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Name: 2-Bromo-4,5-dimethoxybenzaldehyde.

Asressu, Kesatebrhan Haile;Chan, Chieh-Kai;Wang, Cheng-Chung research published 《 TMSOTf-catalyzed synthesis of trisubstituted imidazoles using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions》, the research content is summarized as follows. A TMSOTf-catalyzed synthesis of trisubstituted imidazoles through the reaction of 1,2-diketones and aldehydes using hexamethyldisilazane as a nitrogen source under microwave heating and solvent-free conditions was developed. The chem. structures of representative trisubstituted imidazoles were confirmed using X-ray single-crystal diffraction anal. This synthetic method had several advantages including the involvement of mild Lewis acid, being metal- and additive-free, wide substrate scope with good to excellent yields and short reaction time. Furthermore, the application of the methodol. was demonstrated in the synthesis of biol. active imidazole-based drugs.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Name: 2-Bromo-4,5-dimethoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 2576-47-8.

Aldahdooh, Mohammed K.;Ali, Shaikh A. research published 《 Synthesis and application of a poly(bis-zwitterion) containing chelating motifs of N-(2-aminoethyl)iminodiacetic acid》, the research content is summarized as follows. A bis-cationic (+ +) diallyl monomer [(H₂C=CHCH₂)₂NH⁺(CH₂)₂NH⁺(CH₂CO₂H)₂·2Cl^–] (I) was prepared by a one-pot, two-step reaction of 2-bromoethylamine hydrobromide, Et bromoacetate and diallylamine to generate [(H₂C=CHCH₂)₂N(CH₂)₂N(CH₂CO₂Et)₂] followed by ester hydrolysis. I underwent cyclopolymn. to afford a unique poly(bis-zwitterion) (PBZ) (± ±) II, containing repeating unit embedded with chelating motifs of N-(2-aminoethyl)iminodiacetic acid in bis-zwitterionic form NH⁺(CH₂)₂NH⁺(CH₂CO^–₂)₂. Electroneutral II was found to be water-insoluble, while salts like NaCl imparted water-solubility The polymer was soluble outside a pH window of 1.5-3.5 owing to the equilibration of pH-responsive II to charge-imbalanced polymer chain. The ‘apparent’ pKas of the two NH⁺ centers were determined to be 5.89 and 10.57. At 2.5 ppm concentration, antiscalant PBZ II imparted 100% inhibition of CaSO₄ scale formation for 30 min from its supersaturated solution, while at 20 ppm concentration aided by KI, it demonstrated an outstanding synergistic 99% inhibition of mild steel corrosion in 1 M HCl.

Application In Synthesis of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 2576-47-8.

Aldahdooh, Mohammed K.;Ali, Shaikh A. research published 《 Synthesis and application of alternate cyclopolymers of β-diallylaminoethyliminodiacetic acid with maleic acid and sulfur dioxide》, the research content is summarized as follows. Bis-cationic monomer β-diallylaminoethyliminodiacetic acid dihydrochloride (I) underwent alternate cyclocopolymns. with SO₂ and maleic acid to give poly(bis-zwitterion) (PBZ) (± ±) II, and III, resp. The PBZs contained the chelating motifs of [NH⁺(CH₂)₂NH⁺(CH₂CO^–₂)₂] embedded in the pyrrolidine ring of each repeating unit. Both the PBZs were water-insoluble, however they became water-soluble with assistance from salts like NaCl. PBZs II and III, having the point of zero charge at pH 2.4, became water soluble outside the pH-windows of 0.81-4.46 and 1.49-3.35, resp., whereby the electroneutral pH-responsive polymers become charge-imbalanced. The ‘apparent’ pK_as of the protonated amine centers in II were found to be 5.18 and 9.92. As an antiscalant, PBZ III (2.5 ppm) demonstrated inhibition of CaSO₄ scale formation with 99% efficacy for over 180 min, while at 1.5 ppm inhibition efficiency was found to be 98% for 50 min. PBZ II at concentrations of 20 and 10 ppm demonstrated CaCO₃ scale inhibition of 98% for over 240 min and 95% for over 90 min, resp. A synergistic mixture of III (20 ppm) and KI (400 ppm) arrested corrosion of mild steel in 1 M HCl with a remarkable efficacy of 98% for 24 h at 60°C.

Application In Synthesis of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde.

Ali, Muhammad;Khan, Khalid Mohammed;Mahdavi, Mohammad;Jabbar, Abdul;Shamim, Shahbaz;Salar, Uzma;Taha, Muhammad;Perveen, Shahnaz;Larijani, Bagher;Faramarzi, Mohammad Ali research published 《 Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors》, the research content is summarized as follows. Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously been reported for wide range of bioactivities. The current study reports a series of pyridine based synthetic analogs for their α-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies. For this purpose, 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles 1-28 were synthesized and subjected to in vitro screening. Several analogs, including 1-3, 7, 9, 11-14, and 16 showed many folds increased inhibitory potential in comparison to the standard acarbose (IC₅₀ = 750 ± 10 μM). Interestingly, compound 7 (IC₅₀ = 55.6 ± 0.3 μM) exhibited thirteen-folds greater inhibition strength than the standard acarbose. Kinetic studies on most potent mol. 7 revealed a competitive type inhibitory mechanism. In silico studies have been performed to examine the binding mode of ligand (compound 7) with the active site residues of α-glucosidase enzyme.

Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Formula: C9H9BrO3.

Almaghrabi, Mohammed;Abiedalla, Younis;Dhanasakaran, Murali;DeRuiter, Jack;Randall Clark, C. research published 《 GC-MS and GC-IR of regioisomeric 4-N-bromodimethoxybenzyl derivatives of 3-trifluoromethylphenylpiperazine》, the research content is summarized as follows. The seven regioisomeric N-bromodimethoxybenzyl derivatives of 3-TFMPP were synthesized via reductive amination of the seven com. available bromodimethoxybenzaldehydes. The capillary GC elution profiles for these compounds generally follow the degree of methoxy group substituent crowding on the aromatic ring. The electron ionization mass spectra show a series of major fragment ions common to all seven regioisomeric compounds The base peak in the EI mass spectra for many of the seven regioisomers occurs at m/z 229 and is the result of contributions from two isobaric fragments, the trifluoromethylphenylpiperazine cation as well as the 79Br bromodimethoxybenzyl cation. Several low intensity ions are related to the specific regioisomeric substitution patterns for the bromodimethoxybenzyl moieties and provide some differentiation for this set of seven compounds These unique ions allow the seven compounds to be divided into sub-groups and in some cases allow specific isomer identification from only the EI-MS data. The 950 cm^-1 to 550 cm^-1 lower portion of the fingerprint region in the vapor phase IR spectra can be used to identify each of the bromodimethoxybenzyl regioisomers after EI-MS fragmentation patterns provide focus on the individual structural sub-groups of compounds in this study.

Formula: C9H9BrO3, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. SDS of cas: 5392-10-9.

Almalki, Ahmad J.;Clark, C. Randall;Abiedalla, Younis;DeRuiter, Jack research published 《 GC-MS analysis of N-(bromodimethoxybenzyl)-2-, 3-, and 4-methoxyphenethylamines: Inverse analogues of the psychoactive 25B-NBOMe drug》, the research content is summarized as follows. The substituted phenethylamine analogs in this study are derivatives of N-(2-methoxybenzyl)-4-bromo-2,5-dimethoxyphenethylamine (25B-NBOMe) having the reverse substitution pattern for two aromatic rings. The nine regioisomeric compounds were prepared from the regioisomeric 2-, 3-, and 4- methoxyphenethylamines via N-reductive alkylation with the three regioisomeric 2,4,5-substituted bromodimethoxybenzaldehydes. The EI-MS spectra of these regioisomers gave two major bromine containing ions at m/z 229/231 (base peak) and 258/260 and two non-brominated fragments at m/z 91 and 121. The relative abundance of the m/z 91 was higher for the 2-methoxyphenethylamine substituted isomers and relative abundance of the m/z 121 fragment was higher in the 4-methoxy substituted isomers. The gas chromatog. separation for the regioisomeric methoxyphenethylamines of each bromodimethoxybenzyl aromatic ring substitution pattern showed 2-methoxyphenethylamine substituted isomer eluted first followed by the 3-substituted isomer and 4-methoxyphenethylamine substituted isomer was last to elute and the three bromodimethoxybenzyl regioisomers for the 2-methoxyphenethylamine subseries were resolved as the trifluoroacetamides. The EI-MS for the TFA derivatives of the 2-bromo-4,5-dimethoxybenzyl substituted isomer gave unique fragment ions resulting from displacement of bromine from the mol. ion. This fragmentation pathway was confirmed using the model compounds N-(2-, 3- and 4-bromobenzyl)phenethylamine trifluoroacetamides.

SDS of cas: 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 3-Bromobenzoic acid.

AlNajjar, Yasmeen T.;Gabr, Moustafa;ElHady, Ahmed K.;Salah, Mohamed;Wilms, Gerrit;Abadi, Ashraf H.;Becker, Walter;Abdel-Halim, Mohammad;Engel, Matthias research published 《 Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects》, the research content is summarized as follows. A role of Dyrk1A in the progression of Down syndrome-related Alzheimer’s disease (AD) is well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson’s disease (PD) was much less studied, and it is not clear whether it would be promising to test Dyrk1A inhibitors in relevant PD models. Herein, we modified our previously published 1-(6-hydroxybenzo[d]thiazol-2-yl)-3-phenylurea scaffold of Dyrk1A inhibitors to obtain a new series of analogs with higher selectivity for Dyrk1A on the one hand, but also with a novel, addnl. activity as inhibitors of α-synuclein (α-syn) aggregation, a major pathogenic hallmark of PD. The Ph acetamide derivative b27 displayed the highest potency against Dyrk1A with an IC₅₀ of 20 nM and high selectivity over closely related kinases. Furthermore, b27 was shown to successfully target intracellular Dyrk1A and to inhibit SF3B1 phosphorylation in HeLa cells with an IC₅₀ of 690 nM. In addition, two compounds among the Dyrk1A inhibitors, b1 and b20, also suppressed the aggregation of α-synuclein (α-syn) oligomers (with IC₅₀ values of 10.5μM and 7.8μM, resp.). Both compounds but not the Dyrk1A reference inhibitor harmine protected SH-SY5Y neuroblastoma cells against α-syn-induced cytotoxicity, with b20 exhibiting a higher neuroprotective effect. Compound b1 and harmine were more efficient in protecting SH-SY5Y cells against 6-hydroxydopamine-induced cell death, an effect that was previously correlated to Dyrk1A inactivation in cells but not yet verified using chem. inhibitors. The presented dual inhibitors exhibited a novel activity profile encouraging for further testing in neurodegenerative disease models.

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Safety of 3-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. SDS of cas: 5392-10-9.

Amaike, Kazuma;Oshima, Tsuyoshi;Skoulding, Nicola Stephanie;Toyama, Yoshifumi;Hirota, Tsuyoshi;Itami, Kenichiro research published 《 Small Molecules Modulating Mammalian Biological Clocks: Exciting New Opportunities for Synthetic Chemistry》, the research content is summarized as follows. The circadian clock is an intrinsic time-keeping system that controls daily rhythms in almost all living organisms on the earth. Daily rhythms are observed in various life phenomena, such as sleep-wake cycles, body temperature, blood pressure, and hormone secretion in animals, and stomatal movements and photosynthetic activity in plants. Therefore, controlling the circadian clock in a precise manner will make significant contributions in the elucidation of their mol. mechanisms, as well as to medicine and agriculture. Genetic and mol. biol. studies have made substantial progress in understanding of mol. clock mechanisms. For further investigation of the basic mechanisms as well as for therapeutic applications, small-mol. compounds will provide unique opportunities. In this perspective, we highlight chem. biol. approaches toward mammalian circadian clock modulation by using small synthetic mols.

SDS of cas: 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary