Tag: M.W=200-250

Hattori, Tomohiro; Takakura, Ryoya; Ichikawa, Tomohiro; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao published the artcile< Switching the Cleavage Sites in Palladium on Carbon-Catalyzed Carbon-Carbon Bond Disconnection>, Electric Literature of 3893-18-3, the main research area is palladium catalysis regioselective carbon bond cleavage cinnamaldehyde; styrene benzaldehyde derivative preparation.

We have demonstrated a palladium on carbon-catalyzed approach to regioselectively alter the cleavage sites of the C-C bonds of cinnamaldehyde derivatives by a slight change in the reaction conditions in isopropanol under an O2 atmosphere. Styrene derivatives could be selectively formed by the addition of Na2CO3 in association with the dissociation of carbon monoxide, while benzaldehyde derivatives were generated by the addition of CuCl and morpholine instead of Na2CO3.

Journal of Organic Chemistry published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mao, Wenhui; Zhao, He; Zhang, Min published the artcile< Hydride transfer-initiated synthesis of 3-functionalized quinolines by deconstruction of isoquinoline derivatives>, Category: bromides-buliding-blocks, the main research area is aminomethyl phenyl quinoline preparation; isoquinolinium halide amino benzaldehyde hydride transfer initiated deconstruction.

Under transition metal catalyst-free conditions,presented a hydride transfer-initiated construction of novel 3-(2-aminomethyl)aryl quinolines from N-isoquinolinium salts and 2-aminobenzaldehydes, proceeding with the merits of operational simplicity, high step and atom efficiency, good substrate and functional group compatibility, and mild conditions. The products were formed by reacting with the isoquinolyl motif as a two-carbon synthon along with the cleavage of its C3-N bond. Given the interesting applications of 3-aryl quinolines, the developed chem. was anticipated to be further applied to develop new functional products.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (aryl). 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Choi, Anthony; Meijer, Anthony J. H. M.; Silvestri, Ilaria Proietti; Coldham, Iain published the artcile< Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is disubstituted piperidine preparation enantioselective; aryl methylenepiperidine kinetic resolution deprotonation.

The base n-BuLi with sparteine allows a kinetic resolution of N-Boc-2-aryl-4-methylenepiperidines. The 2,2-disubstituted products and recovered starting materials were isolated with high enantiomer ratios. From VT-NMR spectroscopy and DFT studies, the rate of rotation of the N-Boc group is fast. Lithiation and trapping of the enantioenriched starting materials gave 2,2-disubstituted piperidines with retention of stereochem. Functionalization of the 4-methylene group led to a variety of 2,4-disubstituted piperidines without loss of enantiopurity that could be useful building blocks for drug discovery.

Journal of Organic Chemistry published new progress about Deprotonation. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vishnumurthy, Kodumuru; Makriyannis, Alexandros published the artcile< Novel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling>, Reference of 6942-39-8, the main research area is dibenzopyranone preparation; bromoarylcarboxylate hydroxyarylboronic acid Suzuki Miyaura coupling lactonization.

Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogs from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogs bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields.

Journal of Combinatorial Chemistry published new progress about Aromatic carboxylic acids, salts Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Reference of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Patel, Harun; Chaudhari, Kavita; Jain, Pritam; Surana, Sanjay published the artcile< Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis>, Application In Synthesis of 82-73-5, the main research area is pyridinyl hydrazide preparation antitubercular activity SAR; Schiff base pyridinyl preparation antitubercular activity SAR; Cytotoxicity; MDR-MTB; Mycobacterium tuberculosis; Synthesis.

Synthesis and the biol. activity of isoniazid and pyridine derivatives were successfully carried out with elaborated characterization by spectral data. Amongst the synthesized compounds; I and II displayed encouraging antimycobacterial activity with IC50 of 3.2μM and 1.5μM against the H37Rv strain. The MIC of test compounds I and II were also assessed against the 5 drug resistant isolates (FQ-R1, INH-R1, INH-R2, RIF-R1 and RIF-R2) of MTB strains under aerobic conditions and compound I [MIC = 3.2μM for FQ-R1; MIC = 140μM for INH-R1; MIC = 160μM for INH-R2; MIC = 2.4μM towards RIF-R1; MIC = 4.2μM for RIF-R2] and II [MIC = 3.3μM for FQ-R1; MIC = 170μM for INH-R1; MIC = 190μM for INH-R2; MIC = 1.8μM for RIF-R1; MIC = 8.4μM for RIF-R2] have shown significant activity at non-cytotoxic concentration in comparison to the standard drug.

Bioorganic Chemistry published new progress about Drug toxicity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jeffs, P. W.; Hansen, J. F.; Brine, G. A. published the artcile< Photochemical synthesis of 6,7-dihydro-5H-dibenz[c,e]azepine and 5,6,7,8-tetrahydrodibenz[c,e]azocine derivatives>, Synthetic Route of 17100-65-1, the main research area is dibenzoxepine; dibenzazepine; dibenzazocine; cyclization iododibenzylamine; photolysis iododibenzylamine; benzylamine iodo cyclization; iododibenzylamine cyclization; conformation dibenzazocine.

Photolysis of several substituted 2-iododibenzylamine hydrochlorides in aqueous solution provided convenient syntheses of the corresponding 6,7-dihydro-5H-dibenz[c,e]azepines in useful yields. Thus, irradiation of o-IC6H4CH2NHCH2Pb gave 57% dibenzazepine I. Irradiation of o-IC6H4CH2NHCH2C6H3(OMe)2-3.5 yielded only 2,4,6-(MeO)2CHOCH2)C6H2C6H4CH2OH-o together with a small amount of dibenzoxepine II. Photolysis of three N-(2-halogenobenzyl)-β-phenethylamine hydrochlorides provided convenient syntheses of the corresponding 5,6,7,8-tetrahydrodibenz[c,e]azocines. Thus, irradiation of O-IC6H4CH2NHCH2CH2Pb gave 33% dibenzazocine III. NMR examination of the dibenzazocines confirmed that they existed in a skewed biphenyl conformation, and that inversion of the system by rotation through the planar biphenyl was hindered.

Journal of Organic Chemistry published new progress about Cyclization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Synthetic Route of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chengcheng; Wang, Yang; Wang, Guanyang; Huang, Chusen; Jia, Nengqin published the artcile< A new mitochondria-targeting fluorescent probe for ratiometric detection of H2O2 in live cells>, Category: bromides-buliding-blocks, the main research area is mitochondria fluorescent probe hydrogen peroxide live cell; Hydrogen peroxide; Live cell imaging; Mitochondria; Quantitative detection; Ratiometric fluorescent probe.

With this research the authors presented a ratiometric and mitochondria-target fluorescent probe (Mito-HT) (I) for detection of H2O2 both in vitro and in live cells. Mito-HT was constructed by direct conjugation of aryl boronate to fluorophore with three synthetic steps. The borate group is cleaved from Mito-HT in the presence of H2O2, resulting in the exposure of the hydroxyl group of the electron donating group. Then the ICT mechanism was turned on, and the fluorescence emission of Mito-HT at 493 nm was red shifted to 562 nm, thereby achieving radiometric detection of H2O2. Mito-HT exhibited a highly selectivity towards H2O2, and this interaction can be completed within 40 min. Mito-HT could be used for quant. detection of H2O2 (0-200μM) through ratiometric fluorescence signal readout. And limit of detection (LOD) is ∼0.33μM. The relatively high stability and medium fluorescence quantum yield of Mito-HT (0.39) and Mito-HT-OH (0.43) enable clear mitochondria localization and dual-channel fluorescence imaging of H2O2 in live cells with confocal microscopy.

Analytica Chimica Acta published new progress about Fluorescence imaging. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reddy, Kancharla Rajendar; Rajanna, Kamatala C.; Venkateswarlu, Marri; Saiprakash, P. K. published the artcile< Mild benzylic monobromination of methyl toluates in aqueous CTAB>, Synthetic Route of 128577-47-9, the main research area is bromomethyl toluate preparation; methyl toluate cetyltrimethylammonium bromide catalyst regioselective bromination microwave irradiation; cetyltrimethylammonium bromide cationic micelle catalyst.

A strategy for the regioselective monobromination of Me toluates by using tert-butylhydrogen peroxide and potassium bromide (TBHP/KBr) in a cetyltrimethylammonium bromide (CTAB) micellar medium was developed. Ultrasonic and microwave-assisted protocols were recorded and observed high rates and product yields under mild reaction conditions, coupled with a straightforward isolation procedure.

Synlett published new progress about Aralkyl bromides Role: SPN (Synthetic Preparation), PREP (Preparation). 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Synthetic Route of 128577-47-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, Yeseul; Kim, Sanghun; Cho, Kiu-Hyung; Lee, Jin-Hyung; Lee, Jintae published the artcile< Antibiofilm Activities of Cinnamaldehyde Analogs against Uropathogenic Escherichia coli and Staphylococcus aureus>, Product Details of C9H7BrO, the main research area is Escherichia coli Staphylococcus aureus cinnamaldehyde uropathogenic antibiofilm activity; Staphylococcus aureus; antibiofilm; cinnamaldehyde; uropathogenic Escherichia coli.

Bacterial biofilm formation is a major cause of drug resistance and bacterial persistence; thus, controlling pathogenic biofilms is an important component of strategies targeting infectious bacterial diseases. Cinnamaldehyde (CNMA) has broad-spectrum antimicrobial and antibiofilm activities. In this study, we investigated the antibiofilm effects of ten CNMA derivatives and trans-CNMA against Gram-neg. uropathogenic Escherichia coli (UPEC) and Gram-pos. Staphylococcus aureus. Among the CNMA analogs tested, 4-nitrocinnamaldehyde (4-nitroCNMA) showed antibacterial and antibiofilm activities against UPEC and S. aureus with min. inhibitory concentrations (MICs) for cell growth of 100 mug/mL, which were much more active than those of trans-CNMA. 4-NitroCNMA inhibited UPEC swimming motility, and both trans-CNMA and 4-nitroCNMA reduced extracellular polymeric substance production by UPEC. Furthermore, 4-nitroCNMA inhibited the formation of mixed UPEC/S. aureus biofilms. Collectively, our observations indicate that trans-CNMA and 4-nitroCNMA potently inhibit biofilm formation by UPEC and S. aureus. We suggest efforts be made to determine the therapeutic scope of CNMA analogs, as our results suggest CNMA derivatives have potential therapeutic use for biofilm-associated diseases.

International Journal of Molecular Sciences published new progress about Antibiofilm agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Noole, Artur; Malkov, Andrei V.; Kanger, Tonis published the artcile< Asymmetric organocatalytic synthesis of spiro-cyclopropaneoxindoles>, Related Products of 3893-18-3, the main research area is spiro cyclopropaneoxindole enantioselective preparation; dicarbonyl compound alkylidene oxindole cascade enantioselective reaction organocatalyst.

Straightforward cascade reactions for the synthesis of spiro-cyclopropaneoxindoles are described. The target compounds are obtained in high yields and in good enantio- and diastereoselectivities via hydrogen bonding or iminium catalysis.

Synthesis published new progress about Enantioselective synthesis. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary