Tag: M.W=150-200

Hu, Zhaoming published the artcileCobalt-Catalyzed Addition of Ethyl Bromofluoroacetate to Alkynes, Application In Synthesis of 401-55-8, the publication is ChemistrySelect (2021), 6(43), 12276-12279, database is CAplus.

A cobalt-catalyzed oxidative monofluoroalkylation of alkynes with Et bromofluoroacetate was reported. This method enabled direct and facile access to Et bromomonofluoroallyl acetate EtOC(O)CCHFR₁C=CBrR² [R¹ = H, Me, n-Pr, n-Bu, Ph; R² = n-Pr, Ph, 3-pyridyl, etc.] from abundant alkynes with excellent functional group compatibility. Moreover, this cobalt/ethyl bromofluoroacetate protocol could further create a series of radical monofluoroalkylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CFHCOOEt bonds.

ChemistrySelect published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grant, Thomas M. published the artcileTowards eco-friendly marine antifouling biocides – Nature inspired tetrasubstituted 2,5-diketopiperazines, SDS of cas: 111-83-1, the publication is Science of the Total Environment (2022), 152487, database is CAplus and MEDLINE.

Marine biofouling plagues all maritime industries at vast economic and environmental cost. Previous and most current methods to control biofouling have employed highly persistent toxins and heavy metals, including tin, copper, and zinc. These toxic methods are resulting in unacceptable environmental harm and are coming under immense regulatory pressure. Eco-friendly alternatives are urgently required to effectively mitigate the neg. consequence of biofouling without causing collateral harm. Amphiphilic micropeptides have recently been shown to exhibit excellent broad-spectrum antifouling activity, with a non-toxic mode of action and innate biodegradability. The present work focused on incorporating the pharmacophore derived from amphiphilic micropeptides into a 2,5-diketopiperazine (DKP) scaffold. This privileged structure is present in a vast number of natural products, including marine natural product antifoulants, and provides advantages of synthetic accessibility and adaptability. A novel route to sym. tetrasubstituted DKPs was developed and a library of amphiphilic 2,5-DKPs were subsequently synthesized. These biodegradable compounds were demonstrated to be potent marine antifoulants displaying broad-spectrum activity in the low micromolar range against a range of common marine fouling organisms. The outcome of planned coating and field trials will dictate the future development of the lead compounds

Science of the Total Environment published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, SDS of cas: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kalyavin, V. A. published the artcileOn the rearrangement of radicals formed in the decomposition of β-bromocarboxylic acids, SDS of cas: 56970-78-6, the publication is Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya (1999), 40(6), 384-389, database is CAplus.

Hydrobrominating RCH:CR¹CO₂H (R = Me, Ph, R¹ = H; R = H, R¹ = Me) with HBr in AcOOH gave 57-83% yields of the corresponding RCHBrCHR¹CO₂H, which reacted with SOCl₂ to give the acid chlorides and then with H₂O₂ in pyridine to give the corresponding (RCHBrCHR¹CO)₂O₂ (I) in ≤75% yield. I underwent thermolysis at 80° or UV photolysis in C₆H₆ or PhMe to give complex mixtures via rearrangement of the initially formed primary radicals to secondary ones via a 1,2-shift of the Br atom.

Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, SDS of cas: 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gualandi, Andrea published the artcileApplication of coumarin dyes for organic photoredox catalysis, Related Products of bromides-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(72), 10044-10047, database is CAplus and MEDLINE.

Here we report the application of readily prepared and available coumarin dyes for photoredox catalysis, which are able to mimic powerful reductant [Ir(III)] complexes. Coumarin derivatives I and II, (9 and 10 , resp.), were employed as photoreductants in pinacol coupling and in other reactions, in the presence of Et₃N as a sacrificial reducing agent. As the electronic, photophys., and steric properties of coumarins could be varied, a wide applicability to several classes of photoredox reactions is predicted.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hmamouchi, Mohammed published the artcileSynthesis and polymerization of racemic and optically active substituted β-propiolactones. V. α-Methyl-β-propiolactone, Application In Synthesis of 56970-78-6, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (1988), 26(6), 1593-607, database is CAplus.

R(+) And S(-) enantiomers of α-methyl-β-propiolactone (I) were synthesized from the corresponding α-Me β-hydroxymethylpropionates and racemic I from Me methacrylate. The corresponding racemic and optically active polylactones (II) were prepared by anionic polymerization, in bulk and in solution, as well as II of intermediate optical purities. Racemic II was amorphous whereas optically active II was semicrystalline for optical purities >51%. Melting temperatures and enthalpies of fusion of the semicrystalline II varied with optical purity whereas glass transition temperatures remained invariant for all polymers, at about -28°.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Application In Synthesis of 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Verma, Suryadev K. published the artcileManganese-Catalyzed C(sp²)-H Alkylation of Indolines and Arenes with Unactivated Alkyl Bromides, Recommanded Product: 1-Bromooctane, the publication is Chemistry – An Asian Journal (2022), 17(9), e202200103, database is CAplus and MEDLINE.

Selective C(sp²)-H bond alkylation of indoline like 2,3-dihydro-1-(2-pyridinyl)-1H-indole, carbazole like 9-(2-pyridinyl)-9H-carbazole and (2-pyridinyl)arenes I (R¹ = H, 4-Me, 4-OMe, 3-F₃C) with unactivated alkyl bromides R²(CH₂)₂Br (R² = Et, Pr, 4-(9H-carbazol-9-yl)butyl, etc.) is achieved using MnBr₂ catalyst in the absence of an external ligand. The alkylation uses a simple LiHMDS base and avoids the necessity of Grignard reagent, unlike other Mn-catalyzed C-H functionalization. This reaction proceeded either through a five- or less-favored six-membered metallacycle, and tolerated diverse functionalities, including alkenyl, alkynyl, silyl, aryl ether, pyrrolyl, indolyl, carbazolyl and alkyl bearing fatty alc. and polycyclic-steroid moieties. Alkylation follows a single electron transfer (SET) pathway involving 1e oxidative addition of alkyl bromide and rate-limiting C-H metalation.

Chemistry – An Asian Journal published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C4H6N2, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Xiao Long published the artcileSynthesis of the Major Metabolites of Febuxostat, Safety of 3-Bromo-2-methylpropanoic acid, the publication is Letters in Organic Chemistry (2015), 12(3), 217-221, database is CAplus.

Total synthesis of three Febuxostat metabolites, named 67M-1, 67M-2, and 67M-4,is described in this article. Through condensation of the key intermediate compound I with different side chains, and then oxidation and hydrolysis, we obtained three target compounds with an overall yield of 19.5%-28.0%.

Letters in Organic Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Safety of 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Basak, Shubhajit published the artcilePalladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation, SDS of cas: 111-83-1, the publication is Organic Letters (2022), 24(2), 554-558, database is CAplus and MEDLINE.

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles was accomplished using a readily available arene at moderate temperature The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications were the important practical features.

Organic Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, SDS of cas: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Jimoh, Tajudeen A. published the artcileBiological evaluation and docking study of synthesized derivatives of benzotriazole and benzimidazole as antibacterial agents, Product Details of C8H17Br, the publication is Chemistry Africa (2022), 5(3), 509-523, database is CAplus.

To tackle the menace of multi-resistant bacteria which pose challenges to scientist, four benzotriazole derivatives and three benzimidazole derivatives were synthesized via two routes due to the importance of heterocyclic compound in medicinal chem. Two protein target DNA gyrase with PDB ID 2XCT and PDB ID 3ILW were docked with the synthesized compound and compared with the two standard drugs sparfloxacin and ciprofloxacin. For benzotriazole derivatives, the reaction in acetonitrile resulted in lower yields (18-25%) than with dimethylformamide/potassium hydroxide (DMF/KOH), which generated higher yields (68-92%) in shorter reaction time. Those of benzimidazole were comparable. The products were characterized by FTIR, 1H, and 13C NMR, while the association between atoms was shown in 2D NMR. The synthesized compounds were docked against two DNA gyrase with PDB ID 2XCT and PDB ID 3ILW. It was observed that 1-butyl-1H-benzotriazole (- 13.716) and 1-butyl-3-octyl-1H-benzotriazolium (- 12.324) were the most active against PDB ID 2XCT and PDB ID 3ILW, resp. However, they were both less active than the standard drugs used. Using the agar diffusion technique, the synthesized compounds demonstrated broad-spectrum antibacterial activity against gram-pos. and gram-neg. pathogenic bacteria strains. Notably, all the compounds were of varying potency; with inhibition zones ranging from 24 to 30 mm and MIC ranging from 25 to 50 μg/mL. The benzotriazole and benzimidazole derivatives were synthesized successfully. This research revealed that the synthesized compounds were active against organisms with activity, the docking results revealed that the synthesized compounds have relatively low binding energy when compared with the standard drug used as well as those reported earlier. Thus, it will give better interaction on the binding site of the protein. These synthesized compounds could be a source of new drugs that could be used to treat multi-resistance bacteria.

Chemistry Africa published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Product Details of C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Prabu, Selvam published the artcileFerrocene appended Y-shaped imidazole aldehyde chromophores: Synthesis, the effect of alkyl chain in the second order nonlinear optical properties and theoretical studies, Recommanded Product: 1-Bromooctane, the publication is Journal of Molecular Structure (2022), 133137, database is CAplus.

Two new Y-shaped ferrocene (Fc) conjugated imidazole (IM) aldehyde [(D-π)2-IM-π-A] type chromophores [(Fc-CH:CH)₂-IM-R-C₆H₄-CHO] {R= H (1); C₈H₁₇ (2)} have been synthesized and characterized with the aid of anal. and spectroscopic techniques [FT-IR, ESI-Mass, ¹H and ¹³C NMR]. The thermal stability of the chromophores 1 and 2 were investigated using thermogravimetric anal. (TGA), and the chromophores were stable up to 160°C. The solvatochromic studies of the chromophores 1 and 2 show a pos. solvatochromism due to the more polarizable and greater stabilization in the excited state than ground state, when solvent polarity was increased from non-polar to polar. The redox behavior of the chromophores were determined by cyclic voltammetry, and the exptl. observed HOMO and LUMO energy levels were good agreement with the DFT. The second harmonic generation efficiencies (SHG) were investigated by the Kurtz-Perry powder technique using potassium dihydrogen phosphate (KDP) as a standard The SHG efficiencies of the chromophore 2 is 2.5 times greater than that of the chromophore 1, because of the presence of n-octyl group which reduces the anti-parallel alignments in mol. packing of the chromophore 2. In addition, the dipole moment (μ) and hyperpolarizability (β₀) were calculated using different functionals (B3LYP, CAM-B3LYP and LC-BLYP), and the B3LYP-hybrid functional is overestimated when compared with long-range CAM-B3LYP and LC-BLYP functionals, because of the uncorrected long-range charge transfer behavior between donor and acceptor in the d-π-A systems. The chromophore 2 shows higher β₀ values in all the different functionals than the 1, due to the presence of the n-octyl group, which restricts the mol. mobility and makes effective charge transfer process of the chromophore 2. The theor. observed results followed the same trend as exptl. results.

Journal of Molecular Structure published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary