Tag: M.W=150-200

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Safety of Ethyl 3-bromo-2-oxopropanoate.

Bayaraa, Tenuun;Kurz, Julia L.;Patel, Khushboo M.;Hussein, Waleed M.;Bilyj, Jessica K.;West, Nicholas P.;Schenk, Gerhard;McGeary, Ross P.;Guddat, Luke W. research published 《 Discovery, Synthesis and Evaluation of a Ketol-Acid Reductoisomerase Inhibitor》, the research content is summarized as follows. Ketol-acid reductoisomerase (KARI), the second enzyme in the branched-chain amino acid biosynthesis pathway, is a potential drug target for bacterial infections including Mycobacterium tuberculosis. Here, we have screened the Medicines for Malaria Venture Pathogen Box against purified M. tuberculosis (Mt) KARI and identified two compounds that have K_i values below 200 nM. In Mt cell susceptibility assays one of these compounds exhibited an IC₅₀ value of 0.8μm. Co-crystallization of this compound, 3-((methylsulfonyl)methyl)-2H-benzo[b][1,4]oxazin-2-one (MMV553002), in complex with Staphylococcus aureus KARI, which has 56% identity with Mt KARI, NADPH and Mg²⁺ yielded a structure to 1.72 Å resolution However, only a hydrolyzed product of the inhibitor (i.e. 3-(methylsulfonyl)-2-oxopropanic acid, missing the 2-aminophenol attachment) is observed in the active site. Surprisingly, Mt cell susceptibility assays showed that the 2-aminophenol product is largely responsible for the anti-TB activity of the parent compound Thus, 3-(methylsulfonyl)-2-oxopropanic acid was identified as a potent KARI inhibitor that could be further explored as a potential biocidal agent and we have shown 2-aminophenol, as an anti-TB drug lead, especially given it has low toxicity against human cells. The study highlights that careful anal. of broad screening assays is required to correctly interpret cell-based activity data.

Safety of Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, Related Products of 5445-17-0

Beara, Ivana;Majkic, Tatjana;Fioravanti, Stefania;Trulli, Laura;Mimica-Dukic, Neda;Pellacani, Lucio;Saso, Luciano research published 《 The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages》, the research content is summarized as follows. Ever since the enrollment of COX-2, particularly overabundance of its main products prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) in numerous pathol. processes was recognized, it became a significant therapeutic target. Objective: The aim of this study was to examine the effects of synthesized organo-fluorine compounds on PGE2 and TXA2 production in the inflammation process. Methods: Trifluoromethyl compounds were synthesized from N-benzyl trifluoromethyl aldimine, com. available 2-Me or 2-Ph a-bromo esters (β-lactams trans-1 and trans-2 and trifluoromethyl β-amino ester, resp.) and Me 2-isocyanoacetate (2-imidazoline trans-4). The reactions proceeded with high geometric selectivity, furnishing the desired products in good yields. The influence of newly synthesized compounds on PGE2 and TXA2 production in human leukemic U937 macrophages on both enzyme activity and gene expression levels was observed Results: Among the tested trifluoromethyl compounds, Me trans-1-benzyl-5-(trifluoromethyl)- 4,5-dihydro-1H-imidazole-4-carboxylate (trans-4) can be distinguished as the most powerful antiinflammatory agent, probably due to its trifluoromethyl-imidazoline moiety. Conclusion: Some further structural modifications in tested compounds and particularly in the synthesis of different trifluoromethyl imidazolines could contribute to the development of new COX-2 inhibitors and potent anti-inflammatory agents.

Related Products of 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Bera, Shyamal Kanti;Boruah, Palash J.;Parida, Shraddha Saraswati;Paul, Amit K.;Mal, Prasenjit research published 《 A Photochemical Intramolecular C-N Coupling Toward the Synthesis of Benzimidazole-Fused Phenanthridines》, the research content is summarized as follows. Herein, we report a direct photochem. dehydrogenative C-N coupling of unactivated C(sp²)-H and N(sp²)-H bonds. The catalysts or additive-free transformation of 2-([1,1′-biphenyl]-2-yl)-1H-benzo[d]imidazole to benzo[4,5]imidazo[1,2-f]phenanthridine was achieved at ~350 nm of irradiation via ε-hydrogen abstraction. DFT calculations helped to understand that the N-H···π interaction was essential for the reaction to proceed at a lower energy than expected.

Category: bromides-buliding-blocks, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Category: bromides-buliding-blocks

Bhat, Sachin A.;Rao, D. S. Shankar;Prasad, S. Krishna;Yelamaggad, Channabasaveshwar V. research published 《 Chiral plasmonic liquid crystal gold nanoparticles: self-assembly into a circular dichroism responsive helical lamellar superstructure》, the research content is summarized as follows. Owing to their proven and promising potential in various technol. endeavors ranging from catalysis and sensing to invisibility cloaks made from metamaterials, chiral plasmonic superstructures resulting from the directed self-assembly of optically active metal nanoparticles (MNPs) have been pursued intensively in recent years. Several strategic efforts have emerged especially to accomplish advanced nanomaterials assembling into liquid crystalline (LC) helical structures, where MNPs are regularly packed in fluid/frozen arrays/layers or wires (columns). While the helical fluid columnar arrays (mol. wires) showing CD (CD) have been realized, the discovery of fluid chiral lamellar ordering, where the dielec. and conducting regimes are arranged alternatively, has hitherto remained highly elusive. Herein we report the first examples of monodisperse LC-gold NPs (LC-GNPs) self-assembling into a fluid/frozen lamellar structure exhibiting CD activity. Notably, these new, exceptional LC-GNPs have been realized by simple, hassle-free protocols that involve the room temperature addition of LC dimer-like arylamines to Au(III), where the amines not only reduce Au(III) to Au(0) but also bind strongly to the central GNP scaffold. Their mol. structure, mesomorphism, and ability to interact with circularly polarized light have been evidenced unambiguously and could play an important role in realizing metamaterials in the visible region.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine, Quality Control of 1575-37-7

Bhoi, Rahul T.;Rajput, Jamatsing D.;Bendre, Ratnamala S. research published 《 An efficient synthesis of rearranged new biologically active benzimidazoles derived from 2-formyl carvacrol》, the research content is summarized as follows. A new series of benzimidazole derivatives was synthesized by one-pot two-step reaction as a result of unexpected rearrangement during reaction of 2-formyl carvacrol and corresponding 2-phenylenediamines in DMF, by using Na₂S₂O₅ as an oxidizing reagent. The docking studies of all nine compounds were carried out against the active site of the Plasmodium falciparum dihydroorotate dehydrogenase enzyme. To inspect their antimalarial, antimicrobial, and antioxidant activity, all the synthesized compounds were screened in vitro for their antimalarial activity against the malaria parasite Plasmodium falciparum strain and four bacterial as well as three fungal strains. The biol. screening revealed that some synthesized compounds have very good antimalarial activity. The physicochem. properties were calculated for all the synthesized benzimidazoles and were found to be good oral bioavailability drugs as resolute by Lipinski’s rule.

Quality Control of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 629-04-9.

Bhowmik, Pradip K.;Noori, Omar;Chen, Si L.;Han, Haesook;Fisch, Michael R.;Robb, Christina M.;Variyam, Aaron;Martinez-Felipe, Alfonso research published 《 Ionic liquid crystals: Synthesis and characterization via NMR, DSC, POM, X-ray diffraction and ionic conductivity of asymmetric viologen bistriflimide salts》, the research content is summarized as follows. A series of asym. viologen bistriflimide salts I (R = n-pentyl, dodecyl, octadecyl, etc.) of both short and long alkyl chains were synthesized by the metathesis reaction of lithium triflimide salt with the resp. asym. viologen dibromide salts II in methanol. Their thermotropic liquid crystalline properties were determined by differential scanning calorimetry, polarizing optical microscopy and variable temperature X-ray diffraction techniques. These salts melt into highly-ordered smectic T phases i.e., crystal-to SmT transitions (Tms) at relatively low temperatures (lowest Tm at -12°C) and maintain liquid crystallinity in a wide range of temperatures (8-132°C), with excellent thermal stabilities up to 320°C as determined by thermogravimetric anal. These results differ with respect to the sym. viologen bistriflimide salts I. Ionic conductivity of these salts was also measured by dielec. impedance spectroscopy and found to be in the 10-2.5 S cm^-1 range, highlighting their potential as electrolytes at room temperature

HPLC of Formula: 629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Application In Synthesis of 4224-70-8.

Bhumireddy, Archana;Bandaru, N. V. M. Rao;Raghurami Reddy, B.;Gore, Suraj T.;Mukherjee, Subhendu;Balasubramanian, Wesley Roy;Sumanth Kumar, V.;Alapati, Krishna Satya;Venkata Gowri Chandra Sekhar, Kondapalli;Nellore, Kavitha;Abbineni, Chandrasekhar;Samajdar, Susanta research published 《 Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders》, the research content is summarized as follows. Multiple Splice variants of AR have been reported in the past few years. These splice variants are upregulated in most cases of CRPC resulting in poor prognosis. Most of these variants lack the ligand binding domain (LBD) but still bind to DNA resulting in constitutive activation of downstream targets. The AR-V7 splice variant has been characterized extensively and current clin. trials in CRPC are exploring the use of AR-V7 as a biomarker. New therapeutic mols. that selectively target AR-V7 are also being explored. However, there is a dearth of information available on the selectivity, phenotypic responses in AR-V7 dependent cell lines and pharmacokinetic properties of such mols. Using our proprietary computational algorithms and rational SAR optimization, we have developed a potent and selective AR-V7 degrader from a known AR DNA binding domain (DBD) binder. This mol. effectively degraded AR-V7 in a CRPC cell line and demonstrated good oral bioavailability in mouse PK studies. This tool compound can be used to evaluate the pharmacol. effects of AR-V7 degraders. Further exploration of SAR can be pursued to develop more optimized lead compounds

Application In Synthesis of 4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 629-04-9, formula is C7H15Br, Name is 1-Bromoheptane. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Category: bromides-buliding-blocks.

Bing, Shaosuo;Xian, Weipeng;Chen, Sifan;Song, Yanpei;Hou, Linxiao;Liu, Xiaolong;Ma, Shengqian;Sun, Qi;Zhang, Lin research published 《 Bio-inspired construction of ion conductive pathway in covalent organic framework membranes for efficient lithium extraction》, the research content is summarized as follows. As the most sophisticated separation system, biol. membranes have served as natural prototypes for the design of artificial membranes because they provide high permeability and solute selectivity, owing to the presence of specialized ion channels. However, developing stable and selective artificial ion channels remains a formidable challenge. Herein, we demonstrate the construction of lithium nanochannels in two-dimensional covalent organic frameworks (COFs) to create biomimetic membranes. Implanted lithiophilic oligoethers conferred specificity and facilitated Li+ diffusion along the pore pathway of the COF. The ion channel characteristics were indicated by reversal potential measurements, showing that the relative permeability decreased in the order Li⁺ > K⁺ > Na⁺ > Ca²⁺ > Mg²⁺. The Li⁺ transfer was enhanced, while other ions were obstructed, allowing for high selectivity and permeability. A Li⁺/Mg²⁺ separation factor of 64 was achieved, confirming high lithium affinity. This study may serve as a design principle to develop selective artificial membranes for effective ion separation

629-04-9, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 6911-87-1.

Biswas, Nandita;Srimani, Dipankar research published 《 Ru-Catalyzed Selective Catalytic Methylation and Methylenation Reaction Employing Methanol as the C1 Source》, the research content is summarized as follows. The activity of the acridine-derived SNS-Ru pincer for the activation of methanol to apply it as a C1 building block in different reactions was explored. Catalytic system showed great success toward the β-C(sp³)-methylation reaction of 2-phenylethanols to provide good to excellent yields of the methylated products RCH(CH₃)CH₂OH [R = Ph, 4-FC₆H₄, 2-thienyl, etc.]. The mechanistic details, kinetic progress and temperature-dependent product distribution, which revealed the slow and steady generation of in situ formed aldehyde, was the key factor to get the higher yield of the β-methylated product. To establish the environmental benefit of this reaction, green chem. metrics were calculated Furthermore, dimerization of 2-naphthol via methylene linkage to obtain methylated products I [R¹ = H, 3-MeO, 6-Ph, etc.] and formation of N-methylation of amine were also described in this study, which offers a wide range of substrate scope with a good to excellent yield of methylated products R²NHCH₃ [R² = (CH₂)₇CH₃, Ph, 2-BrC₆H₄, etc.].

Electric Literature of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 5445-17-0.

Azeri, Oezge;Schoenfeld, Dennis;Noirez, Laurence;Gradzielski, Michael research published 《 Structural control in micelles of alkyl acrylate-acrylate copolymers via alkyl chain length and block length》, the research content is summarized as follows. Amphiphilic copolymers with poly (alkyl acrylate) as hydrophobic and poly (acrylic acid) (AA) as hydrophilic block have been synthesized. The alkyl chain was varied from Bu to dodecyl, thereby varying systematically the polarity of the hydrophobic block whose length was between 35 and 70, while the PAA block had ∼ 100 units. Such relatively short amphiphiles should equilibrate quickly in aqueous solution, and their corresponding self-assembly properties were characterized by means of critical micelle concentration (cmc) determination Detailed information regarding the aggregate structures was obtained by static light scattering (SLS) and small angle neutron scattering (SANS). This could be correlated with the mol. architecture of the copolymers and the degree of ionization of the PAA block. Generally, it is found that the aggregation numbers become smaller upon fully charging the PAA head group and only for dodecyl acrylate really well-defined micellar aggregates are formed. This means that the extent of hydrophobicity of the alkyl acrylate block and its length determine in a clear fashion the propensity for micelle formation and the mass and aggregation number of the formed micelles.

Application In Synthesis of 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary