Tag: M.W=150-200

Organic compounds having carbon bonded to bromine are called organic bromides. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of C6H11BrO2.

Deng, Wenting;Wang, Lanying;Wang, Yunxia;Zhao, Junlong;Jia, Hongliang research published 《 New hexamethine indothia-cyanines: Synthesis and photophysical properties as well as both antitumor activity and imaging》, the research content is summarized as follows. Six new hexamethine indothia-cyanines were successfully synthesized by integrating a benzothiazole or naphthothiazole and indole unit using isophorone. These cyanines exhibited strong absorption and near-IR fluorescence with a large stokes shift, and showed excellent stability. And they were tested as novel anticancer agents in vitro against human breast cancer cells (MCF-7), and indothia-cyanine D1 could efficiently reduce MCF-7 viability and exhibited no toxicity against normal human immortalized epidermal cells (Hacat). Cyanine D1 was further studied for its antitumor activity in mice. The in vivo result indicated that D1 could significantly inhibit the growth of breast tumors from tumor-bearing mice, and had no effect on the normal functions of the vital organs in vivo. In addition, D1 could stain MCF-7 cells and emitted bright red fluorescence, being a potential functional agent with both imaging and antitumor activity.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Product Details of C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Quality Control of 4224-70-8.

Cooper, Elizabeth;Choi, Peter J.;Schweder, Patrick;Mee, Edward;Turner, Clinton;Faull, Richard;Denny, William A.;Dragunow, Mike;I-H. Park, Thomas;Jose, Jiney research published 《 Cytoprotective agent troxipide-cyanine dye conjugate with cytotoxic and antiproliferative activity in patient-derived glioblastoma cell lines》, the research content is summarized as follows. Cytoprotective agents are mainly used to protect the gastrointestinal tract linings and in the treatment of gastric ulcers. These agents are devoid of appreciable cytotoxic or cytostatic effects, and medicinal chem. efforts to modify them into anticancer agents are rare. A drug repurposing campaign initiated in our laboratory with the primary focus of discovering brain cancer drugs resulted in drug-dye conjugate 1, a combination of the cytoprotective agent troxipide and heptamethine cyanine dye MHI 148. The drug-dye conjugate 1 was evaluated in three different patient-derived adult glioblastoma cell lines, com. available U87 glioblastoma, and one paediatric glioblastoma cell line. In all cases, the conjugate 1 showed potent cytotoxic activity with nanomolar potency (EC50: 267 nM). Interestingly, troxipide alone does not show any cytotoxic and cytostatic activity in the above cell lines. We also observe a synergistic effect of 1 with temozolomide (TMZ), the standard drug used for glioblastoma treatment, even though the cell lines we used in this study were resistant to TMZ treatment. Herein we disclose the synthesis and in vitro activity of drug-dye conjugate 1 for treatment of difficult-to-treat brain cancers such as glioblastoma.

4224-70-8, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., Quality Control of 4224-70-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Product Details of C4H7BrO2.

Cooze, Morgan J.;Barr, Nathaniel R.;Hutchinson, Robin A. research published 《 Toward an Efficient Process for the Cu(0)-Mediated Synthesis and Chain Extension of Poly(methyl acrylate) Macroinitiator Using PMDETA as Ligand》, the research content is summarized as follows. Me₆TREN (tris[2-(dimethylamino)ethyl]amine) is commonly used in Cu(0)-mediated polymerization of acrylates due to its ability to promote high reaction rates while maintaining excellent control of chain growth. However, its cost presents a significant barrier to commercialization. Thus, the use of PMDETA (N,N,N’,N”,N”-pentamethyldiethylenetriamine), a ligand that is significantly less expensive than Me₆TREN but is known to reduce the polymerization rate as well as control, is explored. The continuous production of low mol. weight (MW) poly(Me acrylate) using PMDETA ligand in a copper tubular reactor is demonstrated, with conversions >70% achieved with a residence time of 32 min at 70°C. The resulting macroinitiator solution can be stored and chain extended with Me acrylate (MA) to high conversion in a semibatch reactor using either PMDETA or Me₆TREN as addnl. ligand, increasing the versatility of a newly developed process to efficiently produce block copolymers using either ligand, or a combination of the two. First results suggest that the two-step process can also be used to chain extend the macroinitiator with methacrylates, thus extending the range of materials that can be produced.

Product Details of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 5445-17-0.

Corbin, Daniel A.;Puffer, Katherine O.;Chism, Katherine A.;Cole, Justin P.;Theriot, Jordan C.;McCarthy, Blaine G.;Buss, Bonnie L.;Lim, Chern-Hooi;Lincoln, Sarah R.;Newell, Brian S.;Miyake, Garret M. research published 《 Radical Addition to N,N-Diaryl Dihydrophenazine Photoredox Catalysts and Implications in Photoinduced Organocatalyzed Atom Transfer Radical Polymerization》, the research content is summarized as follows. Photoinduced organocatalyzed atom transfer radical polymerization (O-ATRP) is a controlled radical polymerization methodol. catalyzed by organic photoredox catalysts (PCs). In an efficient O-ATRP system, good control over mol. weight with an initiator efficiency (I* = M_n,theo/M_n,exp x 100%) near unity is achieved, and the synthesized polymers possess a low dispersity (D). N,N-Diaryl dihydrophenazine catalysts typically produce polymers with low dispersity (D < 1.3) but with less than unity mol. weight control (I* ~60-80%). This work explores the termination reactions that lead to decreased control over polymer mol. weight and identifies a reaction leading to radical addition to the phenazine core. This reaction can occur with radicals generated through reduction of the ATRP initiator or the polymer chain end. In addition to causing a decrease in I*, this reactivity modifies the properties of the PC, ultimately impacting polymerization control in O-ATRP. With this insight in mind, a new family of core-substituted N,N-diaryl dihydrophenazines is synthesized from com. available ATRP initiators and employed in O-ATRP. These new core-substituted PCs improve both I* and D in the O-ATRP of MMA, while minimizing undesired side reactions during the polymerization Further, the ability of one core-substituted PC to operate at low catalyst loadings is demonstrated, with minimal loss of polymerization control down to 100 ppm (weight average mol. weight [M_w] = 10.8 kDa, D = 1.17, I* = 104% vs. M_w = 8.26, D = 1.10, I* = 107% at 1000 ppm) and signs of a controlled polymerization down to 10 ppm of the catalyst (M_w = 12.1 kDa, D = 1.36, I* = 107%).

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Application In Synthesis of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Safety of Methyl 4-bromobutanoate

Corcoran, David B.;Lewis, Thomas;Nahar, Kazi S.;Jamshidi, Shirin;Fegan, Christopher;Pepper, Chris;Thurston, David E.;Rahman, Khondaker Miraz. research published 《 Effects of systematic shortening of noncovalent C8 side chain on the cytotoxicity and NF-κB inhibitory capacity of pyrrolobenzodiazepines (PBDs)》, the research content is summarized as follows. The systematic shortening of the noncovalent element of a C8-linked pyrrolobenzodiazepine (PBD) conjugate (13 (I)) led to the synthesis of a 19-member library of C8-PBD monomers. The critical elements of I, which were required to render the mol. cytotoxic, were elucidated by an annexin V assay. The effects of shortening the noncovalent element of the mol. on transcription factor inhibitory capacity were also explored through an ELISA-based measurement of nuclear NF-κB upon exposure of JJN-3 cells to the synthesized mols. Although shortening the noncovalent interactive element of I had a less than expected effect upon compound cytotoxicity due to reduced DNA interaction, the transcription factor inhibitory capacity of the mol. was notably altered. This study suggests that a relatively short noncovalent side chain at the C8 position of PBD is sufficient to confer cytotoxicity. The shortened PBD monomers provide a new ADC payload scaffold because of their potent cytotoxicity and drug-like properties.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Safety of Methyl 4-bromobutanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 629-04-9, formula is C7H15Br, The most pervasive is the naturally produced bromomethane. Formula: C7H15Br

Cruickshank, Ewan;Strachan, Grant J.;Storey, John MD;Imrie, Corrie T. research published 《 Chalcogen bonding and liquid crystallinity: Understanding the anomalous behaviour of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles (nSCB)》, the research content is summarized as follows. The synthesis and characterization of the first eleven members of the 4′-(alkylthio)[1,1′-biphenyl]-4-carbonitriles, I [n = 1, 2, 3, etc.] was reported. All eleven members I showed monotropic liquid crystal behavior. The first six members were exclusively nematogenic, the seventh member showed nematic and smectic A phases and the higher homologues only smectic A behavior. A comparison of their transitional behavior with that of the corresponding alkyl and alkyloxy-cyanobiphenyls revealed a new pattern of behavior. Specifically, the nematic-isotropic transition temperatures showed a large decrease on passing from the methylthio to ethylthio homologues. This unexpected behavior was interpreted in terms of chalcogen bonding.

Formula: C7H15Br, 1-Bromoheptane is a useful research compound. Its molecular formula is C7H15Br and its molecular weight is 179.1 g/mol. The purity is usually 95%.
1-Bromoheptane is a reagent that is used for the preparation of alkylthiophienylzinc chloride.
1-Bromoheptane is a reactive compound that is used in the preparation of p-hydroxybenzoic acid, which is an intermediate in the synthesis of many natural compounds. 1-Bromoheptane has been shown to have biological properties and to inhibit mitochondrial membrane potential. It also causes cell lysis and hepatic steatosis in mice. This compound has been shown to inhibit the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. 1-Bromoheptane can be used as a model for studying the effects on congestive heart failure by increasing cardiac workloads or decreasing myocardial contractility., 629-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 1575-37-7.

Cui, Hao;Hong, Qianqian;Wei, Ran;Li, Hongmei;Wan, Chunyang;Chen, Xin;Zhao, Shuang;Bu, Haizhi;Zhang, Bingxu;Yang, Dexiao;Lu, Tao;Chen, Yadong;Zhu, Yong research published 《 Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics》, the research content is summarized as follows. Histone deacetylases (HDAC) are clin. validated and attractive epigenetic drug targets for human cancers. Several HDAC inhibitors have been approved for cancer treatment to date, however, clin. applications have been limited due to the poor pharmacokinetics, bioavailability, selectivity of the HDAC inhibitors and most of them need to be combined with other drugs to achieve better results. Here, we describe our efforts toward the discovery of a novel series of lactam-based derivatives as selective HDAC inhibitors. Intensive structural modifications lead to the identification of compound 24g as the most active Class I HDAC Inhibitor, along with satisfactory metabolic stability in vitro (t_1/2, human = 797 min) and the desirable oral bioavailability (F = 92%). More importantly, compound 24g showed good antitumor efficacy in a TMD-8 xenograft model (TGI = 77%) without obvious toxicity. These results indicated that Class I HDAC Inhibitor could be potentially used to treat certain diffuse large B-cell lymphoma therapeutics.

SDS of cas: 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C6H7BrN2.

Cui, Jingrui;Zhou, Liying;Zhang, Xiaokun;Wei, Xiaozhe;Yan, Hong research published 《 Revealing the regioselective N-acylation of 5-bromo-2-aminobenzimidazole using experiment and theoretical calculation》, the research content is summarized as follows. The N-acylation of 2-aminobenzimidazole is widely used in the synthesis of its derivatives, the products exhibit different regioselectivity when reacting with acylation reagents. 5-Bromo-2-aminobenzimidazole was acylated in our laboratory and found the more complex regioselectivity than 2-aminobenzimidazole. When the reaction temperature was at room temperature and using triethylamine as acid acceptor, 5-bromo-2-aminobenzimidazole afford the N-acylation product at primary amine by acyl chloride, while the products at tertiary amines were obtained by di-tert-Bu dicarbonate. To explain this regioselective N-acylation, the double descriptor (DD), condensed dual descriptor (CDD) of 5-bromo-2-aminobenzimidazole and mol. electrostatic potential (MEP) of reactants were calculated The possible N-acylation paths of the 5-bromo-2-aminobenzimidazole with different acylation agents was studied by d. functional theory (DFT) at M062X/def2TZVP//B3LYP-D3/def-SVP level.

Formula: C6H7BrN2, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Safety of Ethyl 3-bromo-2-oxopropanoate.

Cui, Yingjun;Zhang, Mengyi;Xu, Honglei;Zhang, Tingrong;Zhang, Songming;Zhao, Xiuhe;Jiang, Peng;Li, Jing;Ye, Baijun;Sun, Yuanjun;Wang, Mukuo;Deng, Yangping;Meng, Qing;Liu, Yang;Fu, Qiang;Lin, Jianping;Wang, Liang;Chen, Yue research published 《 Elastase inhibitor cyclotheonellazole A: Total synthesis and in vivo biological evaluation for acute lung injury》, the research content is summarized as follows. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the most common complications in COVID-19. Elastase has been recognized as an important target to prevent ALI/ARDS in the patient of COVID-19. Cyclotheonellazole A (CTL-A) is a natural macrocyclic peptide reported to be a potent elastase inhibitor. Herein, we completed the first total synthesis of CTL-A in 24 linear steps. The key reactions include three-component MAC reactions and two late-stage oxidations We also provided seven CTL-A analogs and elucidated preliminary structure-activity relationships. The in vivo ALI mouse model further suggested that CTL-A alleviated acute lung injury with reductions in lung edema and pathol. deterioration, which is better than sivelestat, one approved elastase inhibitor. The activity of CTL-A against elastase, along with its cellular safety and well-established synthetic route, warrants further investigation of CTL-A as a candidate against COVID-19 pathogeneses.

Safety of Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: Ethyl 3-bromo-2-oxopropanoate.

Damghani, Tahereh;Hadaegh, Saba;khoshneviszadeh, Mahsima;Pirhadi, Somayeh;Sabet, Razieh;Khoshneviszadeh, Mehdi;Edraki, Najmeh research published 《 Design, synthesis, in vitro evaluation and molecular docking study of N’-arylidene imidazo[1,2-a]pyridine -2-carbohydrazide derivatives as novel tyrosinase inhibitors》, the research content is summarized as follows. A novel series of imidazo[1,2-a]pyridine 2-carbohydrazide derivatives bearing different arylidene pendants I [R = 4-OH, 2-MeO, 3-OH-4-MeO, etc.] were designed, synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. It was found that compounds I [R = 3-NO₂, 4-OH] exhibited the best tyrosinase inhibitory activity with IC₅₀ values of 7.19 and 8.11μM, resp. These results were comparable to that of kojic acid as the reference drug (IC₅₀ = 9.64±0.5μM). Addnl., mol. docking anal. was performed to study the interactions and binding modes of compounds I [R = 3-NO₂, 4-OH, 2,4-di-OH] which showed the potential of two critical pi-pi interactions with His263 and Phe264 in the active site of tyrosinase. The results indicated that compounds I [R = 3-NO₂, 4-OH] could be introduced as potent tyrosinase inhibitors that might serve as promising candidates in medicine, cosmetics or food industry.

Name: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary