M.W=150-200 Archives - Page 144 of 156 - Bromides-buliding-blocks

Xia, Qing’s team published research in Organic Letters in 2020-09-18 | 3959-07-7

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Xia, Qing; Li, Yufei; Wang, Xinmin; Dai, Peng; Deng, Hongping; Zhang, Wei-Hua published the artcile< Visible Light-Driven α-Alkylation of N-Aryl tetrahydroisoquinolines Initiated by Electron Donor-Acceptor Complexes>, Related Products of 3959-07-7, the main research area is visible light alkylation aryltetrahydroisoquinoline electron donor acceptor complex.

The visible light-driven α-alkylation of N-aryl tetrahydroisoquinolines was initiated through electron donor-acceptor complex photochem. The reaction can proceed smoothly without the addition of any photocatalysts, transition-metal catalysts, or addnl. oxidants. The proposed mechanism was supported by various mechanistic studies, and the reactive open-shell alkyl radicals were generally produced from an alkylamine and underwent radical coupling for alkylating a wide range of N-aryl tetrahydroisoquinolines.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rettig, Irving D’s team published research in Dalton Transactions in 2019 | 576-83-0

Dalton Transactions published new progress about Oxidation kinetics. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, HPLC of Formula: 576-83-0.

Rettig, Irving D.; Van, Jackson; Brauer, Jacob B.; Luo, Wentai; McCormick, Theresa M. published the artcile< Tellurorhodamine photocatalyzed aerobic oxidation of organo-silanes and phosphines by visible-light>, HPLC of Formula: 576-83-0, the main research area is tellurorhodamine preparation photocatalyst aerobic oxidation organo silane phosphine visible; mesityl bisdimethylamino telluroxanthylium hexafluorophosphate preparation photocatalyst aerobic oxidation kinetics.

Tellurorhodamine, 9-mesityl-3,6-bis(dimethylamino)telluroxanthylium hexafluorophosphate (1), photocatalytically oxidizes aromatic and aliphatic silanes and tri-Ph phosphine under mild aerobic conditions. Under irradiation with visible light, 1 can react with self-sensitized 1O2 to generate the active telluroxide oxidant (2). Silanes are oxidized to silanols and tri-Ph phosphine is oxidized to tri-Ph phoshine oxide either using 2, or 1 with aerobic irradiation Kinetic experiments coupled with a computational study elucidate possible mechanisms of oxidation for both silane and phosphine substrates. First-order rates were observed in the oxidation of tri-Ph phosphine and methyldiphenyl silane, indicating a substitution like mechanism for substrate binding to the oxidized tellurium(IV). Addnl., these reactions exhibited a rate-dependence on water. Oxidations were typically run in 50 : 50 water/methanol, however, the absence of water decreased the rates of silane oxidation to a greater degree than tri-Ph phosphine oxidation Parallel results were observed in solvent kinetic isotope experiments using D2O in the solvent mixture The rates of oxidation were slowed to a greater degree in silane oxidation by 2 (kH/kD = 17.30) than for phosphine (kH/kD = 6.20). Various silanes and tri-Ph phosphine were photocatalytically oxidized with 1 (5%) under irradiation with warm white LEDs using atm. oxygen as the terminal oxidant.

Dalton Transactions published new progress about Oxidation kinetics. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, HPLC of Formula: 576-83-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Shujuan’s team published research in Journal of Colloid and Interface Science in 2022-03-15 | 3959-07-7

Journal of Colloid and Interface Science published new progress about Covalent organic frameworks. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Wu, Shujuan; Zhang, Yu-Fei; Ding, Huimin; Li, Xia; Lang, Xianjun published the artcile< Hydrazone-linked 2D porphyrinic covalent organic framework photocatalysis for visible light-driven aerobic oxidation of amines to imines>, Category: bromides-buliding-blocks, the main research area is hydrazone linked porphyrinic covalent organic framework catayst preparation; imine preparation; amine aerobic oxidation photocatalyst; Aerobic oxidation; Covalent organic frameworks; Hydrazone linkage; Imines; Visible light.

A hydrazone-linked 2D (two-dimensional) porphyrinic COF, Por-DETH-COF, was assembled from 5,10,15,20-tetrakis(4-benzaldehyde)porphyrin (p-Por-CHO) and 2,5-diethoxyterephthalohydrazide (DETH) and its photocatalytic activity was duly appraised with the aerobic oxidation of amines. Thereby, the red light-driven selective oxidation of benzyl amines to imines RCH=NR1 [R = Ph, 4-FC6H4, 2-thienyl, etc.; R1 = t-Bu, Bn, 4-MeC6H4CH2, etc.]was obtained in very high conversions and selectivities with ambient air as the oxidant. Importantly, the photocatalytic system exhibited remarkable compatibility of functional groups and extensive scope of benzyl amines. Notably, the Por-DETH-COF photocatalyst displayed outstanding recyclability after five successive cycles. This work suggests that 2D COFs could contribute a unique juncture for selective organic transformations by photocatalysis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Chao’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2017 | 188813-04-9

Chemical Communications (Cambridge, United Kingdom) published new progress about Allylation (chemoselective). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Reference of 188813-04-9.

Xu, Chao; Fyfe, James W. B.; Seath, Ciaran P.; Bennett, Steven H.; Watson, Allan J. B. published the artcile< A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system>, Reference of 188813-04-9, the main research area is biaryl chemoselective microwave irradiation; haloaryl aldehyde BPin allylation Suzuki Miyaura.

A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system was reported. An allylation/cross-coupling process of aryl/allyl BPins e.g., 2-propenylboronic acid pinacol ester, haloaryl aldehydes such as 4-bromobenzaldehyde, 6-bromonicotinaldehyde, (E)-5-iodopent-4-enal, etc. can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C-C bond formations without intervention to afforded biaryls e.g., I scaffold of products. This process offers efficient access to an array of functionalized products including pharmaceutical and natural product scaffolds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xuejing’s team published research in Chemistry – A European Journal in 2019 | 2725-82-8

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application of C8H9Br.

Li, Xuejing; Deng, Xingwang; Coyne, Anthony G.; Srinivasan, Rajavel published the artcile< meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation>, Application of C8H9Br, the main research area is meta nitroarene regioselective preparation; arene borylation nitration tandem iridium catalyst copper; C−H borylation; copper catalysis; nitration; nitro(hetero)arenes; one-pot reactions.

The meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C-H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes RNO2 [R = 4,5-di-ClC6H3, 3,4-di-BrC6H3, 5-Cl-3-pyridyl, etc.] in a one-pot fashion was reported. The reaction tolerated a wide array of ortho/para-directing groups, such as -F, -Cl, -Br, -CH3, -Et, -iPr -OCH3 and -OCF3. It also provided regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives The application of this method was demonstrated in the late-stage modification of complex mols. and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, showed that the nitro product obtained by this strategy could also be directly converted to the aniline or hindered amine through Baran’s amination protocol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Boontiem, Phongsakorn’s team published research in Inorganica Chimica Acta in 2020-06-01 | 576-83-0

Inorganica Chimica Acta published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Related Products of 576-83-0.

Boontiem, Phongsakorn; Kiatisevi, Supavadee published the artcile< Facile and economical Miyaura borylation and one-pot Suzuki-Miyaura cross-coupling reaction>, Related Products of 576-83-0, the main research area is biaryl preparation green chem; aryl bromide arylpinacol ester Miyaura borylation Suzuki coupling.

Facile and economical method for Miyaura borylation reaction between B2pin2 and aryl bromides is reported. The catalytic system containing 2 mol% PdCl2(PPh3)2 and KOAc serves to enable borylations to occur under solvent-free and atm. conditions. The developed protocol can be applied to synthesize sym. and unsym. biaryls via one-pot two-step Suzuki-Miyaura cross-coupling reaction and also offers the up-scalability.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Strekalova, Sofia’s team published research in RSC Advances in 2021 | 576-83-0

RSC Advances published new progress about Acetamides Role: SPN (Synthetic Preparation), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Formula: C9H11Br.

Strekalova, Sofia; Kononov, Alexander; Rizvanov, Ildar; Budnikova, Yulia published the artcile< Acetonitrile and benzonitrile as versatile amino sources in copper-catalyzed mild electrochemical C-H amidation reactions>, Formula: C9H11Br, the main research area is acetamide preparation; benzene benzonitrile acetonitrile carbon hydrogen amidation copper catalyst electrochem.

A mild, efficient electrochem. approach to the site-selective direct C-H amidation of benzene and its derivatives with acetonitrile and benzonitrile to form amides RNC(O)R1 [R = Ph, 2-BrC6H4, Bn, etc.; R1 = Me, Ph] was developed. It has been shown that joint electrochem. oxidation of various arenes in the presence of a copper salt as a catalyst and nitriles leads to the formation of N-phenylacetamide from benzene and N-benzylacetamides from benzyl derivatives (up to 78% yield). A favorable feature of the process was mild conditions (room temperature, ambient pressure, no strong oxidants) that meet the criteria of green chem.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fan, Qiangwen’s team published research in New Journal of Chemistry in 2021 | 3959-07-7

New Journal of Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Fan, Qiangwen; Zhu, Longwei; Li, Xuhuai; Ren, Huijun; Zhu, Haibo; Wu, Guorong; Ding, Jianhua published the artcile< Visible-light photocatalytic selective oxidation of amine and sulfide with CsPbBr3 as photocatalyst>, Formula: C7H8BrN, the main research area is imine aldehyde sulfoxide preparation; amine sulfide photocatalytic oxidation cesium lead bromide.

Using a readily accessible and high-efficiency photocatalyst for inducing chem. transformations is highly desirable. All inorganic lead halide perovskites (APbX3, X = Cl, Br, I) are utilized intensively in photovoltaics providing outstanding optoelectronic performance and are easy-to-process, but their use in organic synthesis is still in its infancy. Herein, a facile protocol for the photocatalytic oxidation of a series of amines and sulfides to their corresponding imines and sulfoxides with excellent yields and selectivity using CsPbBr3 as a visible-light catalyst is reported. The result show that amines bearing electron-donating groups give rise to aldehydes as the final products, while amines with electron-withdrawing groups afford imines as the major products. Reaction mechanism studies reveal that the photogenerated holes (h+), superoxide radicals (O2 ̇-) and singlet oxygen are involved in the reaction performed in air and O2 atmospheres. In addition, for the reaction conducted under anaerobic conditions, free radicals generated by amines plays a vital role in determining the transformation of amines to imines.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Canh Pham, Em’s team published research in ACS Omega in 2022-09-20 | 3959-07-7

ACS Omega published new progress about Absorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Canh Pham, Em; Truong, Tuyen Ngoc published the artcile< Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors>, SDS of cas: 3959-07-7, the main research area is naphthamide preparation microwave antibacterial antifungal anticancer DHFR VEGFR inhibitor.

Naphthamide is a common structural framework with diverse pharmacol. activities. Ten novel 2-naphthamide derivatives I (R = 3-(morpholin-4-yl)propyl, (4-methylphenyl)methyl, (4-methoxyphenyl)methyl, (4-bromophenyl)methyl, (4-chlorophenyl)methyl; R1 = H, OMe; R2 = H, OMe; R3 = H, OMe; R4 = H, OMe) have been designed, synthesized, and evaluated for their in vitro antibacterial, antifungal, and anticancer activities. The title compounds were synthesized from dimethoxybenzaldehyde derivatives such as 2,4-dimethoxybenzaldehyde and 3,5-dimethoxybenzaldehyde through a four-step microwave-assisted synthesis process. The structures were confirmed by 1H NMR, 13C NMR, and MS spectra. Compound I [R = (4-chlorophenyl)methyl ; R1 = R3 = H; R2 = R4 = OMe] (II) showed good antibacterial activity against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, resp., compared to ciprofloxacin (MIC = 8-16 μg/mL). Compounds I (R = (4-methylphenyl)methyl ; R1 = R3 = H; R2 = R4 = OMe)(III) (IC50 = 3.59-8.38 μM) and II (IC50 = 2.97-7.12 μM) exhibited good cytotoxic activity against C26, HepG2, and MCF7 cancer cell lines as compared to paclitaxel (IC50 = 2.85-5.75 μM). Moreover, compounds II and III exhibited better anticancer activity than PTX against the C26 cell line. In particular, compound II showed potent in vitro VEGFR-2 inhibitory activity with the IC50 value of 0.384 μM compared with sorafenib (IC50 = 0.069 μM). Therefore, compound II is the most potent compound for anticancer activity as indicated by in vitro cell line inhibition, in silico ADMET, mol. docking, and in vitro VEGFR-2 inhibition studies.

ACS Omega published new progress about Absorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Wei-Li’s team published research in Green Chemistry in 2021 | 3959-07-7

Green Chemistry published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Chen, Wei-Li; Li, Kun; Liao, Wei-Cong; Liang, Wang-Fu; Qiu, Pei-Wen; Liang, Cui; Su, Gui-Fa; Mo, Dong-Liang published the artcile< An iron(III)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives>, Category: bromides-buliding-blocks, the main research area is amino indole derivative green preparation diastereoselective; indole benzylamine dehydrogenative cross coupling iron catalyst.

A green cascade approach to prepare a variety of 3-aminoindole derivatives I [R1 = H, 7-Me, 6-Cl, etc.; R2 = H, Me; R3 = Ph, 3-BrC6H4, 2-naphthyl, etc.; R4 = Ph, 2-FC6H4, 3-pyridyl, etc.; R5 = H, Et, Ph] in good to excellent yields through an iron(III)-catalyzed dehydrogenative cross-coupling reaction of 2-arylindoles and primary benzylamines under mild reaction conditions was reported. The reaction showed a broad substrate scope of indoles and benzylamines and tolerated a wide range of functional groups. Moreover, the reaction was easily performed at the gram scale without producing waste after the reaction was completed. The present method highlighted readily available starting materials, a simple purification procedure and the usage of cheap, nontoxic and environmentally benign iron(III) catalyst.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary