Fu, Yiwei; Shi, Haoyu; Lei, Shengshu; Shi, Lei; Li, Hao published the artcile< Cu catalyzed [4 + 2] cycloaddition for the synthesis of highly substituted 3-fluoropyridines>, SDS of cas: 3959-07-7, the main research area is fluoro aryl nicotinoyl preparation; trifluoro aryl ethanimine acryloyloxazolidinone cycloaddition aromatization catalyst copper; propenoylimidazolidinone trifluoro aryl ethanimine cycloaddition aromatization catalyst copper.
A copper catalyzed annulation-aromatization of benzyl trifluoromethyl ketimines with 3-acryloyloxazolidin-2-ones for the synthesis of 3-fluoropyridines I [R = H, 3-Cl, 3-Me, etc.; R1 = H, 4-Cl, 4-MeO, etc.; R2 = 2-oxopyrrolidin-1-yl, 2-oxooxazolidin-3-yl, 2-oxo-3-phenyl-imidazolidin-1-yl, etc.] through double C-F bond cleavages had been developed. In this approach, the annulation occurred between the in situ formed dienes from trifluoromethyl ketimines via the first C-F bond cleavage and 3-acryloyloxazolidin-2-ones. Then the aromatization afforded 3-fluoropyridines I in moderate yields through the second C-F bond cleavage. The 3-fluoropyridine products I [R = R1 = H; R2 = 2-oxooxazolidin-3-yl] could be further hydrolyzed to multi-substituted 3-pyridinecarboxylic acids.
Organic & Biomolecular Chemistry published new progress about [4+2] Cycloaddition reaction. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary