Tag: M.W=100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Methyl β-(m-chloroanilino)acrylate》. Authors are Gray, F. W.; Mosher, Harry S.; Whitmore, F. C.; Oakwood, T. S..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).COA of Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

HCCCO2Me (9.5 g.) and 9.0 g. m-ClC6H4NH2 (I) stirred 70 hrs. at 25-30°, and the mixture chilled and filtered yielded 11.2 g. Me β-(m-chloroanilino)acrylate (II), colorless needles from MeOH, m. 148-50° (m.p. greatly dependent on rate of heating), cyclized to 4-hydroxy-7-chloroquinoline (IIA) (Price, et al. (C.A. 40, 5741.1)). I.HCl (19.8 g.) in 150 cc. water at 10° treated with 17.7 g. (MeO)2CHCH2CO2Me, and the mixture warmed to 25° after 15 min. and stirred overnight yielded 24 g. material (III), m. 123-6° (from MeOH), analyzing correctly for II, but attempted cyclization by heating 2 g. with Ph2O gave only a small amount (0.15 g.) of 1,3-bis(m-chlorophenylurea) (IV), m. 248°. I (5.1 g.) and 4.5 g. MeOCH:CHCO2Me heated 1 hr. at 100° and 740 mm., then 1 hr. at 50° and 15 mm., the solution added dropwise to 150 cc. boiling Ph2O, the mixture refluxed 1 hr., cooled, left at room temperature 4 hrs., and filtered yielded 2 g. IV, white, crystalline needles from MeOH, m. 250°. EtOCH:CHCO2Et (7.6 g.) and 6.8 g. I yielded 1.3 g. IV, m. 250°. This method for preparing IIA offers another method for synthesizing antimalarials of the chloroquine type.

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Radl, Stanislav; Blahovcova, Michaela; Tkadlecova, Marcela; Havlicek, Jaroslav published the article 《Synthetic studies connected with the preparation of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a zaleplon regioisomer》. Keywords: chloropyrazolopyrimidincarbonitrile boronate Suzuki Miyaura coupling; zaleplon regioisomer preparation.They researched the compound: Ethyl 3-Ethoxy-2-Propenoate( cas:1001-26-9 ).Related Products of 1001-26-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1001-26-9) here.

N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a principal impurity of zaleplon, was prepared by Suzuki-Miyaura cross-coupling of appropriate boronates with 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile. Various methods of preparation of both components were described, as well as approaches based on the final modification of the 5-(3-aminophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile moiety prepared by Suzuki-Miyaura cross-coupling. All the prepared compounds were unambiguously identified by NMR. IR, UV, and mass spectra of these compounds were also given.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 33216-52-3, is researched, SMILESS is C1=NC=C(C(=C1Cl)Cl)Cl, Molecular C5H2Cl3NJournal, Tetrahedron called Microwave-assisted synthesis of 4-amino-3,5-dihalopyridines, Author is Pichowicz, Mark; Crumpler, Simon; McDonald, Edward; Blagg, Julian, the main research direction is amino halopyridine preparation; microwave assisted nucleophilic aromatic substitution halopyridine primary secondary amine.Application In Synthesis of 3,4,5-Trichloropyridine.

4-Amino-3,5-dihalopyridines have been efficiently prepared via microwave-assisted nucleophilic aromatic substitution of 3,4,5-trihalopyridines using 1-1.1 equiv of primary and secondary amines. The reaction is also applicable to electron rich arylamines.

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Application In Synthesis of Ethyl 3-Ethoxy-2-Propenoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Schiff bases of mixed β-dicarbonyl compounds as tetradentate ligands in unsymmetrical chelate complexes. Author is Jaeger, Ernst G.; Seidel, Dietrich.

1,2-Benzenediamine was condensed with 1-methoxy-1-butene-3-one or Et 2-(ethoxymethylene)acetate (I) and then with I, 3-(ethoxymethylenepentane-2,4-dion, or di-Et ethoxymethylenemalonate to give CH3C(O)CR:CHNHC6H4(NHCH:CR1C(O)R2-2) (R = H, R1 = CH3, R2 = CO2Et; R = CO2Et, R1 = Me, R2 = COMe; R = CO2Et, R1 = OEt, R2 = CO2Et). The unsym. Schiff bases form Ni and Co complexes.

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Category: bromides-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Development of orally active nonpeptidic inhibitors of human neutrophil elastase. Author is Ohmoto, Kazuyuki; Yamamoto, Tetsuya; Okuma, Motohiro; Horiuchi, Toshihide; Imanishi, Hirotoshi; Odagaki, Yoshihiko; Kawabata, Kazuhito; Sekioka, Tomohiko; Hirota, Yasushi; Matsuoka, Shozo; Nakai, Hisao; Toda, Masaaki; Cheronis, John C.; Spruce, Lyle W.; Gyorkos, Albert; Wieczorek, Maciej.

5-Amino-2-phenylpyrimidin-6-ones, some desamino derivatives, miscellaneous derivatives, and oxadiazoles were synthesized and biol. evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. The aminophenylpyrimidinones contained an α-keto-1,3,4-oxadiazole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE), an enzyme whose excess is believed to contribute to inflammatory diseases such as emphysema. Many of the aminophenylpyrimidinones tested showed useful pharmacokinetic profiles when given orally to rats. Oxadiazolyl pyrimidine I was selected for clin. evaluation based on its oral potency, duration of action, enzyme selectivity, safety profile, and ease of synthesis. Structure-activity relationships of the inhibition of aminophenylpyrimidinone derivative binding to HNE are discussed.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, New Journal of Chemistry called Synthesis, theoretical conformational study and x-ray structures of 2,2′-dimethyl-4,4′-bipyrimidine and 6,6′-dimethyl-2,2′-bipyrazine, Author is Regnouf de Vains, J.-B.; Lehn, J.-M.; Ghermani, N. E.; Dusausoy, O.; Dusausoy, Y.; Papet, A.-L.; Marsura, A.; Friant, P.; Rivail, J. L., which mentions a compound: 1001-26-9, SMILESS is O=C(OCC)/C=C/OCC, Molecular C7H12O3, Application of 1001-26-9.

The synthesis of 2,2′-dimethyl-4,4′-bipyrimidine (I) and 6,6′-dimethyl-2,2′-bipyrazine is described. In these compounds the s-trans mol. conformation has been observed and could be interpreted in terms of weak C-H…N interactions. The crystal stacking in the two compounds is formed by parallel mol. planes which are 3.46 Å apart. A semi-empirical calculation shows that, irresp. of the medium, the mols. conserve this preferential conformation.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about PS-BQ: an efficient polymer-supported cocatalyst for the Wacker reaction in supercritical carbon dioxide.Related Products of 1001-26-9.

Using polystyrene-supported benzoquinone (PS-BQ) as cocatalyst with palladium chloride, the acetalization of terminal olefins with electron-withdrawing groups, i.e., acrylate esters, acrylonitrile, Me vinyl ketone and acrolein, was carried out smoothly in supercritical carbon dioxide under oxygen atm.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Ultraviolet spectra of the chloropyridines and chlorinated pyridines possessing a sulfur (0SR), nitrogen (-NR2), or oxygen (-OR) substituent in either the 2 or 4 position. Convenient method for distinguishing such positional isomers, published in 1974, which mentions a compound: 33216-52-3, Name is 3,4,5-Trichloropyridine, Molecular C5H2Cl3N, Recommanded Product: 33216-52-3.

A correlation is established between the position (2 versus 4) of the S, N, or O substituent on the chlorinated pyridines and their uv spectra. The chlorinated pyridines with S, N, or O substitution at the 2-position give uv spectra whose longest wavelength absorption maxima are enhanced (moved to a greater wavelength and an increased extinction coefficient) when compared to the spectra of the 4-substituted isomers. The number of Cl atoms, and not their position, is the more significant factor in determining the overall character of the spectra.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 33216-52-3, is researched, Molecular C5H2Cl3N, about Reissert compound studies. XLIX. An improved synthesis of the pyridine Reissert analog and its utilization in the regiospecific preparation of 2-substituted pyridines, the main research direction is pyridine Reissert compound preparation alkylation; alkylpyridine; pyridylphenylcarbinol; oxazolopyridine.Formula: C5H2Cl3N.

Pyridine Reissert compounds I [R = H(II), 3-CN, 2-PhCH2, 3-Me, 4-Me, R1 = H] were prepared by stirring pyridines in CH2Cl2 at room temperature with equimolar amounts of Me3SiCN and ClCO2Et in the presence of AlCl3. Addition of NaH to II in DMF at 0° gave carbanion III, which was alkylated with alkyl halides to give I (R1 = Me, Et, PhCH2), treatment of which in HMPT at 100-120° with NaI gave the corresponding 2-alkylpyridines. Pyridinecarbinols IV (R2 = H, Me) were prepared by condensation of 2-R2C6H4CHO with III, and oxazolopyridine V was obtained by treatment of II with BuLi in THF at -78° in the presence of PhCHO.

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SDS of cas: 33216-52-3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3,4,5-Trichloropyridine, is researched, Molecular C5H2Cl3N, CAS is 33216-52-3, about Use and qualification of primary and secondary standards employed in quantitative 1H NMR spectroscopy of pharmaceuticals.

Standards are required in quant. NMR (qNMR) to obtain accurate and precise results. In this study acetanilide was established and used as a primary standard Six other chems. were selected as secondary standards: 3,4,5-trichloropyridine, dimethylterephthalate, maleic acid, 3-sulfolene, 1,4-bis(trimethylsilyl)benzene, and 1,3,5-trimethoxybenzene. The secondary standards were quantified using the primary standard acetanilide. A protocol for qualification and periodic checks of these secondary standards was developed, and used for evaluation of the stability of the compounds Periodic monitoring of purity was performed for several years. The purity was higher than 99% for all secondary standards All standards maintained the initial purity during the time period of monitoring, with very small variations in purity (0.3-0.4%). The selected secondary standards were shown to be suitable qNMR standards and that periodic requalification of the standards by qNMR ensures reliable anal. results. These standards were used in the authors’ laboratory for compliance testing of pharmaceutical active substances and approved medicinal products as well as for anal. of suspected illegal medicines. In total more than 1000 samples were tested using both internal and external standardization and examples are given.

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