Tag: 400-500

Badyal, Pragya Nand;Sharma, Chetan;Kaur, Navdeep;Shankar, Ravi;Pandey, Abhay;Rawal, Ravindra K. published 《Analytical techniques in simultaneous estimation: an overview》. The research results were published in《Austin Journal of Analytical and Pharmaceutical Chemistry》 in 2015.Synthetic Route of C14H21Br2ClN2 The article conveys some information:

A review. Simultaneous estimation plays a very important role in pharmaceutical world as it is very feasible and time saving. For the multi component anal. various techniques like spectrophotometric techniques (UV-VIS, IR, NMR and MASS spectrometry) and chromatog. techniques (Thin Layer Chromatog., High Performance Liquid Chromatog., Ultra-High Performance Liquid Chromatog., High Pressure Thin Layer Chromatog. and Gas Chromatog.) is used. These techniques provide high degree of specificity and selectivity and further provide the high degree of assurance that these techniques fit for the simultaneous estimation of the pharmaceutical dosage form. Chromatog. and spectrophotometric techniques together develop new hyphenated techniques which are useful for the simultaneous estimation and impurity profiling. The simultaneous anal. anal. provides specificity and assurance for the identification of the chem. entities in the pharmaceutical formulation. The main objective behind the anal. estimation is to provide the assurance that the particular formulation contains the equal amount of active pharmaceutical ingredient as mentioned in the label. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Synthetic Route of C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application In Synthesis of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride《Simultaneous UV-spectrophotometric estimation of bromhexine hydrochloride and salbutamol sulphate by area under curve method in combined dosage form》 was published in 2015. The authors were Rele, Rajan V., and the article was included in《Pharmacia Sinica》. The author mentioned the following in the article:

The objective of the study was to develop a simple, accurate, precise and rapid UV spectrophotometric, area under curve (AUC), method for simultaneous estimation of bromhexine hydrochloride and salbutamol sulfate from combined dosage form. The validation was carried out by using ICH guidelines for the determination of bromhexine hydrochloride and salbutamol sulfate by using 0.1N hydrochloric acid as the solvent in pharmaceutical dosage form. The proposed area under curve method involves the measurement of area at selected anal. wavelength ranges and performing the anal. using “Cramer’s rule and Matrix method”. The two anal. wavelengths ranges were used i.e. 240-250 nm and 220-230 nm for estimation of bromhexine hydrochloride and salbutamol sulfate resp. The linearity of the proposed method was found in the concentration range of 2-14 μg /mL (r2 = 0.9998) for bromhexine hydrochloride and salbutamol sulfate (r2 = 0.9999) resp. The percentage mean recovery was found to be 100.083% for bromhexine hydrochloride and 100.111 % for salbutamol sulfate resp. The method was statistically validated for its linearity, accuracy and precision as per ICH guidelines. Both intra and inter day variation showed less percentage (%) RSD values indicating high grade of precision of this method. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Application In Synthesis of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocks《Different spectrophotometric methods manipulating ratio spectra for simultaneous determination of salbutamol and bromhexine in binary mixture》 was published in 2016. The authors were Abdel, Khalid;Attia, Salam M.;Nassar, Mohammed W. I.;Osman, Ayman, and the article was included in《Analytical Chemistry: An Indian Journal》. The author mentioned the following in the article:

Four simple, specific, accurate and precise spectrophotometric methods manipulating ratio spectra were developed and validated for simultaneous determination of Salbutamol (SL) and Bromhexine (BH) namely; dual wavelength, ratio difference, ratio derivative, mean centering. The proposed spectrophotometric procedures do not require any preliminary separation step. The accuracy, precision and linearity ranges of the proposed methods were determined The four methods were applied for the determination of the cited drugs in tablets and the obtained results were statistically compared with a reported spectrophotometric method. The comparison showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Category: bromides-buliding-blocks

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 611-75-6《Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection》 was published in 2015. The authors were Mika, Jan;Moreira, Josino C.;Nemeckova, Andrea;Zima, Jiri;Barek, Jiri;Dejmkova, Hana, and the article was included in《Monatshefte fuer Chemie》. The author mentioned the following in the article:

Abstract: New electrochem. methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection anal. with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, volume/volume). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm³ min^-1, injected volume 0.1 cm³, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, volume/volume). Detection limit was 2.0 × 10^-6 mol dm^-3 for DPV and 3.1 × 10^-7 mol dm^-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Application of 611-75-6

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Mehta, P. S.;Patel, V. B. published 《RP-HPLC method for simultaneous estimation of bromohexine hydrochloride, dextromethorphan hydrobromide and guaiphenesin in soft gel capsules》 in 2013. The article was appeared in 《Asian Journal of Chemistry》. They have made some progress in their research.HPLC of Formula: 611-75-6 The article mentions the following:

A simple, precise, and accurate reverse phase high performance liquid chromatog. method was developed for simultaneous determination of guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride in their soft gel formulations. The chromatog. conditions were standardized using Phenomenex Luna C₁₈ (250 mm × 4.6 mm i.d., 5 μm particle size) with UV detection at 258 nm and mobile phase consisting of methanol: 0.05 M phosphate buffer pH 3.0 (60 : 40 volume/volume). Mobile phase was delivered at the flow rate of 1.3 mL/min and separation was completed within 8 min. The retention times of guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride were 3.1 min, 4.1 min and 6.8 min resp. Calibration curves were linear with correlation coefficient 0.998. 0.999 And 0.999 over a concentration range of 50-250, 5-25 and 1-6 μg/mL for guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride resp. Recoveries were between 97.04-100.15, 101.92-104.67 and 102.01-102.55 resp. The proposed method was validated and successfully applied to the determination of 3 drugs in combined soft gel formulation. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.HPLC of Formula: 611-75-6

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Lisnund, Sireerat;Blay, Vincent;Muamkhunthod, Pratchaya;Thunyanon, Kittiya;Pansalee, Jaruwan;Monkrathok, Jirawan;Maneechote, Pachara;Chansaenpak, Kantapat;Pinyou, Piyanut published 《Electrodeposition of Cobalt Oxides on Carbon Nanotubes for Sensitive Bromhexine Sensing》 in 2022. The article was appeared in 《Molecules》. They have made some progress in their research.Formula: C14H21Br2ClN2 The article mentions the following:

We develop an electrochem. sensor for the determination of bromhexine hydrochloride (BHC), a widely use mucolytic drug. The sensor is prepared by electrodeposition of cobalt oxides (CoO_x) on a glassy carbon electrode modified with carboxylated single-walled carbon nanotubes (SWCNT). A synergistic effect between CoOx and SWCNT is observed, leading to a significant improvement in the BHC electrooxidation current. Based on cyclic voltammetry studies at varying scan rates, we conclude that the electrochem. oxidation of BHC is under mixed diffusion-adsorption control. The proposed sensor allows the amperometric determination of BHC in a linear range of 10-500μM with a low applied voltage of 0.75 V. The designed sensor provides reproducible measurements, is not affected by common interfering substances, and shows excellent performance for the anal. of BHC in pharmaceutical preparations And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Formula: C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Siddappa, K.;Hanamshetty, Prashant C. published 《Spectrophotometric quantitative determination of bromhexine hydrochloride in bulk and pharmaceutical dosage form using p-nitrobenzaldehyde reagent》. The research results were published in《International Journal of Pharmaceutical Sciences Review and Research》 in 2016.Recommanded Product: 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article conveys some information:

An efficient, sensitive spectrophotometric method has been developed and validated for the determination of Bromhexine hydrochloride (BRH), in bulk drug and its pharmaceutical formulations. The method is based on the formation of Schiff base with pnitrobenzaldehyde (PNBZ) the reaction of drug with reagent gives a bright yellow color. The so formed colored species absorbance was measured at its absorption maximum (λmax) 410 nm. The Beer’s law has been obeyed in the concentration range 5-25 μg/mL. The optical parameters were calculated as 2.01561×10⁴ (L/mol/cm), 0.01866 (μg/cm²), molar absorptivity and Sandell sensitivity resp. The LOD and LOQ of the proposed method were calculated 0.1851 (μg/mL), 0.6165 (μg/mL) resp. All the variables were studied to optimize the reaction conditions. No interference was observed in the presence of common pharmaceutical excipients. The validity of the method was tested by analyzing BRH in its pharmaceutical formulations and critically tested for its accuracy by statistical tests. Good recoveries were obtained by the developed method; the obtained results were critically analyzed and successfully employed for the determination of BRH in its pharmaceutical dosage forms.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Recommanded Product: 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Socha, Ondrej;Hodgkinson, Paul;Widdifield, Cory M.;Yates, Jonathan R.;Dracinsky, Martin published 《Exploring Systematic Discrepancies in DFT Calculations of Chlorine Nuclear Quadrupole Couplings》 in 2017. The article was appeared in 《Journal of Physical Chemistry A》. They have made some progress in their research.Electric Literature of C14H21Br2ClN2 The article mentions the following:

Previous studies have revealed significant discrepancies between d. functional theory (DFT)-calculated and exptl. nuclear quadrupolar coupling constants (C_Q) for chlorine atoms, particularly in ionic solids. Various aspects of the computations are systematically investigated here, including the choice of the DFT functional, basis set convergence, and geometry optimization protocol. The effects of fast (fs) time-scale dynamics are probed using mol. dynamics (MD) and nuclear quantum effects (NQEs) are considered using path-integral MD calculations It is shown that the functional choice is the most important factor related to improving the accuracy of the quadrupolar coupling calculations, and that functionals beyond the generalized gradient approximation (GGA) level, such as hybrid and meta-GGA functionals, are required for good correlations with experiment The influence of mol. dynamics and NQEs is less important than the functional choice in the studied systems. A method which involves scaling the calculated quadrupolar coupling constant is proposed here; its application leads to good agreement with exptl. data. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Electric Literature of C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary