Tag: 400-500

Catalytic Enantioselective 1,2-Diboration of 1,3-Dienes: Versatile Reagents for Stereoselective Allylation was written by Kliman, Laura T.;Mlynarski, Scott N.;Ferris, Grace E.;Morken, James P.. And the article was included in Angewandte Chemie, International Edition in 2012.Recommanded Product: 28322-40-9 This article mentions the following:

A catalytic enantioselective 1,2-diboration of 1,3-dienes has been described. The 1,2-bis(boronate) products can be employed in versatile stereoselective allylation reactions and deliver a range of functionalized chiral building blocks. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and the mass and nuclear magnetic resonance spectra of side chain isomers of cholesta-5,22-dien-3灏?ol and cholesta-5,22,24-trien-3灏?ol was written by Hutchins, Roderick F. N.;Thompson, Malcolm J.;Svoboda, James A.. And the article was included in Steroids in 1970.Electric Literature of C23H26BrP This article mentions the following:

The previously unknown 22-cis-cholesta-5,22-dien-3灏?ol, 22-cis and 22-trans isomers of cholesta-5,22,24-trien-3灏?ol, 20-iso-22-trans-cholesta-5,22,24-trien-3灏?ol, 22,24-trans,-trans-26-homocholesta-5,22,24-trien-3灏?ol, and the known 22-trans-dehydrocholesterol were synthesized. Their IR, mass and NMR spectra are presented. These compounds undergo fragmentation processes that are governed primarily by the site of the unsaturation and not by their stereochemistry. However, the C-methyl resonances in the NMR spectra are influenced by their chem. environment. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Electric Literature of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electrostatic effects accelerate decatungstate-catalyzed C-H fluorination using [¹⁸F]- and [¹⁹F]NFSI in small molecules and peptide mimics was written by Yuan, Zheliang;Yang, Hua;Malik, Noeen;Colovic, Milena;Weber, David S.;Wilson, Darryl;Benard, Francois;Martin, Rainer E.;Warren, Jeffrey J.;Schaffer, Paul;Britton, Robert. And the article was included in ACS Catalysis in 2019.Name: Isopentyltriphenylphosphonium bromide This article mentions the following:

The site-selective fluorination of unactivated C(sp³)-H bonds provides unique opportunities to rapidly alter drug properties or generate radiotracers for positron emission tomog. (PET) imaging. Toward this goal, photoactivated decatungstate (DT) is capable of generating carbon radicals through hydrogen atom transfer that subsequently undergo fluorination by reaction with N-fluorobenzenesulfonimide (NFSI) or [¹⁸F]NFSI. This process enables C(sp³)-H fluorination of a wide range of aliphatic compounds, though reaction rates can be highly variable and limit applications in radiotracer synthesis. Here, we demonstrate that cationic ammonium functions in aliphatic mols. promote formation of a precursor complex with DT that significantly increases the rate of C-H abstraction. The general utility of this rate-accelerating electrostatic effect is demonstrated on more than 30 ammonium-containing mols., including amino acids, heterocycles, and pseudopeptides. Moreover, this effect is highlighted in the rapid production of [¹⁸F]Glu-U-FHLeu, a ¹⁸F-labeled prostate specific membrane antigen (PSMA)-binding ligand. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Name: Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Name: Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Variation of the alkyl side chain in 铻?sup>8-THC was written by Huffman, John W.;Lainton, Julia A. H.;Dai, Dong;Jordan, Robert D.;Duncan, Sammy G. Jr.. And the article was included in Life Sciences in 1995.Category: bromides-buliding-blocks This article mentions the following:

The synthesis of (2’RS)-2′-methyl-, (3’RS)-, (3’S)-3′-methyl-, and 4′-methyl-铻?sup>8-THC has been carried out, and the pharmacol. of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2′-Me compound is somewhat more active than 铻?sup>8-THC, while the 4′-Me isomer is less active. The 3′-methyl-铻?sup>8-THC has approx. the same activity as the parent cannabinoid. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Category: bromides-buliding-blocks).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Analyzing Site Selectivity in Rh₂(esp)₂-Catalyzed Intermolecular C-H Amination Reactions was written by Bess, Elizabeth N.;DeLuca, Ryan J.;Tindall, Daniel J.;Oderinde, Martins S.;Roizen, Jennifer L.;Du Bois, J.;Sigman, Matthew S.. And the article was included in Journal of the American Chemical Society in 2014.Quality Control of Isopentyltriphenylphosphonium bromide This article mentions the following:

Predicting site selectivity in C-H bond oxidation reactions involving heteroatom transfer is challenged by the small energetic differences between disparate bond types and the subtle interplay of steric and electronic effects that influence reactivity. Herein, the factors governing selective Rh₂(esp)₂-catalyzed C-H amination of isoamylbenzene derivatives are investigated, where modification to both the nitrogen source, a sulfamate ester, and substrate are shown to impact isomeric product ratios. Linear regression math. modeling is used to define a relationship that equates both IR stretching parameters and Hammett 锜?sup>+ values to the differential free energy of benzylic vs. tertiary C-H amination. This model has informed the development of a novel sulfamate ester, which affords the highest benzylic-to-tertiary site selectivity (9.5:1) observed for this system. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Quality Control of Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Quality Control of Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Access to Planar Chiral Ferrocenes via N-Heterocyclic Carbene-Catalyzed Enantioselective Desymmetrization Reactions was written by Lv, Xiaokang;Xu, Jun;Sun, Cuiyun;Su, Fen;Cai, Yuanlin;Jin, Zhichao;Chi, Yonggui Robin. And the article was included in ACS Catalysis in 2022.Application of 28322-40-9 This article mentions the following:

Ferrocene-derived dicarbaldehydes bearing pro-chiral planes are desymmetrized under the catalysis of chiral N-heterocyclic carbene organic catalysts. The reaction features selective activation and reaction of one of the aldehyde moieties of the ferrocene derivative while leaving the other aldehyde unit untouched. The authors’ reaction affords enantiomerically enriched planar chiral ferrocene products obtained that are amenable for further transformations. Preliminary application studies show encouraging results when the authors’ products are explored for catalysis in chem. synthesis and for antimicrobial utilities in pesticide development. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Application of 28322-40-9).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 28322-40-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Conjugated Dienes as Prohaptens in Contact Allergy: In Vivo and in Vitro Studies of Structure-Activity Relationships, Sensitizing Capacity, and Metabolic Activation was written by Bergstroem, Moa Andresen;Luthman, Kristina;Nilsson, J. Lars G.;Karlberg, Ann-Therese. And the article was included in Chemical Research in Toxicology in 2006.Recommanded Product: Isopentyltriphenylphosphonium bromide This article mentions the following:

There is a great interest in developing in vitro/in silico methods for the prediction of contact allergenic activity. However, many proposed methods do not take the activation of prohaptens to sensitizers by skin metabolism into account. As a consequence, consumer products containing potent sensitizers could be marketed. To identify prohaptens, studies regarding their structure-activity relationships and the mechanisms of their activation must be conducted. In the present investigation, we have studied the structure-activity relationships for alkene prohaptens. A series of seven alkenes (1-7), all of the same basic structure but with variation in the number and position(s) of the double bond(s), were designed and screened for sensitizing capacity using the murine local lymph node assay. Compounds 1-7 were also incubated with liver microsomes in the presence of glutathione to trap and identify reactive metabolites. The metabolic conversion of three alkenes (9-11) to epoxides (12-15) was also studied along with comparison of their sensitizing capacity. Our results show that conjugated dienes in or in conjunction with a six-membered ring are prohaptens that can be metabolically activated to epoxides and conjugated with GSH. Related alkenes containing isolated double bonds and an acyclic conjugated diene were shown to be weak or nonsensitizers. For the first time, the naturally occurring monoterpenes 浼?phellandrene, 灏?phellandrene, and 浼?terpinene were demonstrated to be prohaptens able to induce contact allergy. The difference in sensitizing capacity of conjugated dienes as compared to alkenes with isolated double bonds was found to be due to the high reactivity and sensitizing capacity of the allylic epoxides metabolically formed from conjugated dienes. We recommend that these structure-activity relationship rules are incorporated into in silico predictive databases and propose that the prediction of contact allergenic activity of suspected prohaptens is based on assessment of susceptibility to metabolic activation and chem. reactivity of potential metabolites. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Domino recombinant 绾?isomerization and reverse Wacker oxidation of 绾?vinyl-绾?butyrolactone: Synthesis of (+)-trans-, (-)- and (+)-disparlures was written by Bethi, Venkati;Kattanguru, Pullaiah;Fernandes, Rodney A.. And the article was included in European Journal of Organic Chemistry in 2014.Recommanded Product: Isopentyltriphenylphosphonium bromide This article mentions the following:

A domino Pd-catalyzed recombinant 绾?isomerization and reverse Wacker oxidation of 绾?vinyl-绾?butyrolactone was explored. The strategy was used in the stereoselective synthesis of (+)-trans-, (-)- and (+)-disparlure. The synthesis was achieved in 7-8 steps from D-glucono-鏈?lactone with overall yields of 19.3, 20.7, and 22.6%, resp. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

2-Substituted-3H-indol-3-one-1-oxides: Preparation and radical trapping properties was written by Boyer, Jeremie;Bernardes-Genisson, Vania;Farines, Vincent;Souchard, Jean-Pierre;Nepveu, Francoise. And the article was included in Free Radical Research in 2004.Computed Properties of C23H26BrP This article mentions the following:

2-Alkyl and 2-aryl substituted-3H-indol-3-one-1-oxides were prepared and evaluated for their radical trapping properties. Spin trapping and ESR experiments demonstrate the ability of these indolone-1-oxides to trap hetero- and C-centered radicals. The most stable spin adducts (lifetime of several hours) were obtained with 2-alkyl substituted nitrones, e.g. 6-ethyl-7H-[1,3]dioxolo[4,5-f]indol-7-one 5-oxide and 2-isobutyl-3H-indol-3-one 1-oxide. These two nitrones are also sensitive to redox reactions in solution Therefore this indolone-1-oxide series lacking a 灏?H atom gives rise to highly stable adducts with free radicals. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Computed Properties of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Computed Properties of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stabilization of hyperactive molecules through complexation: 2-formylbutadieneiron tricarbonyl. Preparation, cleavage and reactivity was written by Franck-Neumann, Michel;Martina, Daniel;Heitz, Marie Paule. And the article was included in Journal of Organometallic Chemistry in 1986.Electric Literature of C23H26BrP This article mentions the following:

The Fe formylbutadiene complex I was prepared from isoprene by 2 routes, and resolved via chiral semioxamazone formation. Treating I with organolithium or organocuprate reagents gave products diastereospecifically. On the other hand, treating I with Grignard reagents or with MeTi(OCHMe₂)₃ gave mixtures of diastereoisomers. Horner-Emmons reaction of I with (MeO)₂P(O)CH₂CO₂Me gave a single isomer II. Treating II with Me₂CN₂ gave 铻?sup>1-pyrazoline-Fe diastereoisomers, as well as a 铻?sup>2-pyrazoline-Fe complex. Wittig reactions of I, followed by hydroboration, were also performed. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Electric Literature of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary