Tag: 300-400

Sum Frequency Generation Imaging Microscopy of Patterned Self-Assembled Monolayers with Terminal -CH₃, -OCH₃, -CF₂CF₃, -C=C-, -Phenyl, and -Cyclopropyl Groups was written by Cimatu, Katherine;Moore, H. Justin;Barriet, David;Chinwangso, Pawilai;Lee, T. Randall;Baldelli, Steven. And the article was included in Journal of Physical Chemistry C in 2008.Product Details of 56523-59-2 This article mentions the following:

Vibrational spectroscopic imaging is demonstrated for a variety of organic monolayer-functionalized surfaces patterned using microcontact printing. The images from sum frequency generation imaging microscopy (SFGIM) are analyzed using different contrast mechanisms in the interpretation of the transition from stamped to backfilled regions of interest. For this experiment, microcontact printing is used to spatially control the surface monolayers by using a patterned stamp and by varying the terminal functional group of the backfilling solutions Anal. by the three different methods suggests that significant mixing occurs between the stamped and backfilled regions, which influence the contrast in the images at the resonant peaks. The interference between the resonant peaks and nonresonant background also has an effect on the appearance of the image. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Glycerol-Based Bicontinuous Cubic Lyotropic Liquid Crystal Monomer System for the Fabrication of Thin-Film Membranes with Uniform Nanopores was written by Carter, Blaine M.;Wiesenauer, Brian R.;Hatakeyama, Evan S.;Barton, John L.;Noble, Richard D.;Gin, Douglas L.. And the article was included in Chemistry of Materials in 2012.Formula: C15H29BrO2 This article mentions the following:

This article present a new imidazolium-based gemini Lyotropic liquid crystal (LLC) monomer that forms a cross-linkable Q₁-phase with the low volatility and environmentally benign solvent, glycerol, instead of water. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Formula: C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Formula: C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides was written by Pedersen, Simon S.;Donslund, Aske S.;Mikkelsen, Jesper H.;Bakholm, Oskar S.;Papp, Florian;Jensen, Kim B.;Gustafsson, Magnus B. F.;Skrydstrup, Troels. And the article was included in Chemistry – A European Journal in 2021.Application In Synthesis of 15-Bromopentadecanoic acid This article mentions the following:

A series of pharmaceutically relevant small mols. and biopharmaceuticals bearing aliphatic carboxamides have been successfully labeled with carbon-13. Key to the success of this novel carbon isotope labeling technique is the observation that ¹³C-labeled Ni(II)-acyl complexes, formed from a ¹³CO insertion step with Ni(II)-alkyl intermediates, rapidly react in less than one minute with 2,2′-dipyridyl disulfide to quant. form the corresponding 2-pyridyl thioesters. Either the use of ¹³C-SilaCOgen or ¹³C-COgen allows for the stoichiometric addition of isotopically labeled carbon monoxide. Subsequent one-pot acylation of a series of structurally diverse amines provides the desired ¹³C-labeled carboxamides in good yields. A single electron transfer pathway is proposed between the Ni(II)-acyl complexes and the disulfide providing a reactive Ni(III)-acyl sulfide intermediate, which rapidly undergoes reductive elimination to the desired thioester. By further optimization of the reaction parameters, reaction times down to only 11 min were identified, opening up the possibility of exploring this chem. for carbon-11 isotope labeling. Finally, this isotope labeling strategy could be adapted to the synthesis of ¹³C-labeled liraglutide and insulin degludec, representing two antidiabetic drugs. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Application In Synthesis of 15-Bromopentadecanoic acid).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 15-Bromopentadecanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Characterization of Arsenolipids: Naturally Occurring Arsenic Compounds in Fish and Algae was written by Taleshi, Mojtaba S.;Seidler-Egdal, Rune K.;Jensen, Kenneth B.;Schwerdtle, Tanja;Francesconi, Kevin A.. And the article was included in Organometallics in 2014.Electric Literature of C15H29BrO2 This article mentions the following:

Arsenic-containing lipids (arsenolipids) are natural products present in fish and algae. Because these compounds occur in foods, there is considerable interest in their human toxicol. We report the synthesis and characterization of seven arsenic-containing lipids, including six natural products. The compounds comprise dimethylarsinyl groups attached to saturated long-chain hydrocarbons (three compounds), saturated long-chain fatty acids (two compounds), and monounsaturated long chain fatty acids (two compounds). The arsenic group was introduced through sodium dimethylarsenide or bis(dimethylarsenic) oxide. The latter route provided higher and more reproducible yields, and consequently, this pathway was followed to synthesize six of the seven compounds Mass spectral properties are described to assist in the identification of these compounds in natural samples. The pure synthesized arsenolipids will be used for in vitro experiments with human cells to test their uptake, biotransformation, and possible toxic effects. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

ω-Azido fatty acids as probes to detect fatty acid biosynthesis, degradation, and modification was written by Perez, Alexander J.;Bode, Helge B.. And the article was included in Journal of Lipid Research in 2014.Application In Synthesis of 15-Bromopentadecanoic acid This article mentions the following:

FAs play a central role in the metabolism of almost all known cellular life forms. Although GC-MS is regarded as a standard method for FA anal., other methods, such as HPLC/MS, are nowadays widespread but are rarely applied to FA anal. Here we present azido-FAs as probes that can be used to study FA biosynthesis (elongation, desaturation) or degradation (β-oxidation) upon their uptake, activation, and metabolic conversion. These azido-FAs are readily accessible by chem. synthesis and their metabolic products can be easily detected after click-chem. based derivatization with high sensitivity by HPLC/MS, contributing a powerful tool to FA anal., and hence, lipid anal. in general. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Application In Synthesis of 15-Bromopentadecanoic acid).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application In Synthesis of 15-Bromopentadecanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The Effect of Surface Polarity on the Electrochemical Double Layer and Its Influence on the Measurement of the Standard Rate Constant of Electron Transfer was written by Eggers, Paul K.;Hibbert, D. Brynn;Paddon-Row, Michael N.;Gooding, J. Justin. And the article was included in Journal of Physical Chemistry C in 2009.Product Details of 56523-59-2 This article mentions the following:

The influence of surface polarity and, hence, the elec. double layer on long-range electron transfer was studied using 35 different electrode constructs. These constructs were prepared using 5 different lengths of ferrocene-modified alkanethiols (of general formula HS(CH₂)_nCONHCH₂Fc where n was 7, 10, 11, 14, and 15 and Fc refers to ferrocene) mixed with an appropriate ratio of hydroxyl-terminated to Me-terminated alkanethiols as diluents. The mixtures of diluents in different ratios served not only to sep. and dilute the redox-active species but also to control the surface polarity of the self-assembled monolayer (SAM). The ratios of the 3 components in each SAM were 1:20:0, 1:16.6:3.4, 1:13.4:6.6, 1:10:10, 1:6.6:13.4, 1:16.6:3.4, and 1:0:20 of the ferrocene-, hydroxyl-, and Me-terminated species, resp. The formal redox potential and electron transfer rate constant were measured for each construct. It was found, 1st, that formal potentials changed according to the theory of interfacial potential distribution and, 2nd, that rate constants measured using cyclic voltammetry are strongly influenced by the Stern layer of the elec. double layer, which forms at the SAM-solution interface. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biodistribution studies of ^99mTc labeled fatty acid derivatives prepared via “Click approach” for potential use in cardiac imaging was written by Das, Soumen;Mathur, Anupam;Sakhare, Navin;Mallia, Madhava B.;Sarma, Haladhar Dev;Sachdev, Satbir Singh;Dash, Ashutosh. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2018.Reference of 56523-59-2 This article mentions the following:

¹²³I-Iodophenylpentadecanoic acid (IPPA) is a metabolic agent used in nuclear medicine for diagnosis of myocardial defects. Efforts are underway worldwide to develop a ^99mTc substitute of the above radiopharmaceutical for the aforementioned application. Herein, we report synthesis and biodistribution studies of ^99mTc labeled fatty acids (8, 11, and 15 carbons) obtained via “click chem.” for its potential use in myocardial imaging. ω-Bromo fatty acids (8C/11C/15C) were synthetically modified at bromo terminal to introduce a heterocyclic triazole with glycine sidearm in a five step procedure. Modified fatty acids were subsequently radiolabeled with preformed [^99mTc(CO)₃]⁺ synthon to yield the desired fatty acid complexes which were evaluated in Swiss mice. All the radiolabeled complexes were obtained with radiochem. purities >80%, as characterized by HPLC. Biodistribution studies of all three complexes in Swiss mice showed myocardial uptake of âˆ?-9% ID/g at 2 min post-injection, close to^*I-IPPA (âˆ?% ID/g). Complexes exhibited significant retention in the myocardium up to 30 min (âˆ?% ID/g) but were lower to the standard agent (âˆ?% ID/g). Similar uptake of activity in myocardium for the newly synthesized complexes in comparison to ¹²⁵I-IPPA along with favorable in vivo pharmacokinetics merits potential for the present “click” design of complexes for myocardial imaging. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Reference of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Reference of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A rapid response photochromic diarylethene material for rewritable holographic data storage was written by Zhang, Qi;Li, Jing Ming;Niu, Li Hong;Chen, Zi Hui;Yang, Lin;Zhang, Shi Man;Cao, Liang Cai;Zhang, Fu Shi. And the article was included in Chinese Science Bulletin in 2013.Quality Control of Dimethyl 4,5-dibromophthalate This article mentions the following:

A novel diarylethene, namely 4,5-(2,5-di-Me thiophene)phthalimide, was synthesized and successfully introduced to rewritable holog. data storage. Upon the alternative illumination of UV and visible light (λ>400 nm), this compound underwent rapid, reversible inter-conversion between colorless open-ring isomer and yellow-green ring-closed form in both solution and polymethyl methacrylate (PMMA) film. Subsequently, we investigated the characteristics of volume homog. recording of the diarylethene-doped PMMA film (1 μm thick). The maximum refractive index modulation (0.87â€? of the film during recording could be reached within just 120 s which gave the ability of fast recording. The high quality reconstruction after 50 write/erase cycles demonstrated its excellent fatigue-resistance and high resolution All those results indicated that this mol. was a reliable fast write/erase holog. storage material. In the experiment, the researchers used many compounds, for example, Dimethyl 4,5-dibromophthalate (cas: 859299-66-4Quality Control of Dimethyl 4,5-dibromophthalate).

Dimethyl 4,5-dibromophthalate (cas: 859299-66-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Quality Control of Dimethyl 4,5-dibromophthalate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Didehydroisobenzofuran: A New Reactive Intermediate for Construction of Isoacenofuran was written by Matsuoka, Suguru;Jung, Sunna;Miyakawa, Kaoru;Chuda, Yu;Sugimoto, Ryo;Hamura, Toshiyuki. And the article was included in Chemistry – A European Journal in 2018.Formula: C10H8Br2O4 This article mentions the following:

An efficient generation method of didehydroisobenzofuran, a new heteroaryne species, was developed by bromine/lithium exchange of the dibromoisobenzofuran. The reactive intermediate, thus generated, was trapped by appropriate arynophile to give the [2+2], [2+3], and [2+4] cycloadducts, resp. Moreover, the reaction could be applied to the syntheses of isoanthracenofurans (anthra[2,3-c]furans), a new class of heteroacenes, with isoelectoronic structure to the corresponding acenoheteroles (anthra[2,3-b]furans). In the experiment, the researchers used many compounds, for example, Dimethyl 4,5-dibromophthalate (cas: 859299-66-4Formula: C10H8Br2O4).

Dimethyl 4,5-dibromophthalate (cas: 859299-66-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C10H8Br2O4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Preparation and Evaluation of ^99mTc(CO)₃-Labeled Pentadecanoic Acid Derivative and Its Suspension in Lipiodol was written by Satpati, Drishty;Pandey, Usha;Sarma, H. D.;Venkatesh, Meera;Banerjee, Sharmila. And the article was included in Cancer Biotherapy and Radiopharmaceuticals in 2009.Electric Literature of C15H29BrO2 This article mentions the following:

Transarterial embolization by the intra-arterial administration of ¹³¹I-lipiodol is a modality used in the treatment of liver cancer. Long-chain fatty acids, being highly lipophilic, are also known to localize in the liver, thus constituting favorable vectors for this modality of treatment. Toward this, we envisaged the derivatization of 15-bromopentadecanoic acid, rendering it suitable for incorporation of a tridentate chelating moiety, for radiolabeling with the [^99mTc(CO)₃(H₂O)₃]⁺ precursor. The complex prepared, being lipophilic, was expected to behave as a lipiodol surrogate. The radiolabeled complex could be obtained in >95% radiochem. yield, as characterized by high-performance liquid chromatog. The i.v. injection of the radiolabeled complex in mice resulted in 23.5% ± 4.3% uptake of injected dose (ID) organ in the liver at 3 h postinjection. However, the uptake of the lipiodol suspension of the complex at 3 h postinjection in the liver was found to be 43.8 ± 13.4% ID/organ, when injected via the portal vein. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary