Tag: 200-300

Reference of 2,5-DibromothiopheneIn 2021 ,《Fabrication and assessment of an electrochromic and radar-absorbent dual device based on the new smart polythiophene-based/RGO/Fe3O4 ternary nanocomposite》 appeared in Chemical Engineering Journal (Amsterdam, Netherlands). The author of the article were Ahmadian-Alam, Leila; Jahangiri, Fatemeh; Mahdavi, Hossein. The article conveys some information:

Both polymeric electrochromic and radar absorption materials were considered as science hotspots over the past few decades. However, integrating both properties (electrochromic and radar absorption) in a single device was not addressed to fabricate a multifunctional device so far. Thus, here, the authors endeavor to shed light on this uncharted area by presenting a new smart ternary nanocomposite (polythiophene-based/RGO-Fe3O4) which can provide both electrochromic and microwave absorbent features simultaneously. In this regard, the authors synthesized the binary Fe3O4-RGO nanocomposites with different contents of Fe3O4 nanoparticles. Then, this binary nanocomposite is used in combination with a polythiophene-based conductive polymer as a tricolor (RGB) organic electrochromic material to synthesize the smart ternary nanocomposite through both in-situ polymerization and phys. mixing methods. The ternary nanocomposites containing different weight fractions of Fe3O4-RGO nanoparticles were used to assemble the rigid and flexible ECD devices using flat and fiber substrates such as glass-In Sn oxide (glass-ITO), polyethylene terephthalate-In Sn oxide (PET-ITO) and stainless steel wire (SSW). By applying a voltage of -2.1 to 2.1 v, a reversible color-switching ability was observed between green color (oxidized state), and red color (reduced state) for all ECDs. The average switching time and color memory for the SSW cell are ∼3 s and 155 min, and for both glass-ITO and PET-ITO cells to be 2 s and 210 min, resp. Addnl., the microwave absorption properties of the prepared ternary nanocomposites were characterized by measuring the electromagnetic parameters such as permittivity, permeability, and reflection loss. A ternary nanocomposite with 3 mm thickness filled with 50% Fe3O4-RGO exhibited a maximum reflection loss ≤-30.2 dB (92% absorption) at 12.3 GHz (in the range of x-bond) with 1.1 GHz bandwidth.2,5-Dibromothiophene(cas: 3141-27-3Reference of 2,5-Dibromothiophene) was used in this study.

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Reference of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Windsor, Madeline S. A.; Busse, Madleen; Morrison, Daniel E.; Baker, Robert W.; Hill, Leila R.; Rendina, Louis M. published an article in 2021. The article was titled 《Selective delivery of remarkably high levels of gadolinium to tumour cells using an arsonium salt》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Electric Literature of C8H8Br2 The information in the text is summarized as follows:

The use of a triphenylarsonium vector for tumor cell-targeting leads to a dramatic increase in Gd3+ uptake in human glioblastoma multiforme cells by up to an order of magnitude over the isosteric triarylphosphonium analog, with significant implications for ‘theranostic’ applications involving delivery of this important lanthanoid metal ion to tumor cells. In the experiment, the researchers used many compounds, for example, 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Electric Literature of C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of C8H8Br2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis and biological activity of substituted 4-methyl-7- [(5-phenyl-1, 3, 4-oxadiazolidin-2-yl) methoxy]-2H-chromen-2-ones》 were Anushree, A. M.; Bandhavya, H. D.; Shetty, S. Ramachandra; Namratha, T. V.; Chaluvaraju, K. C.. And the article was published in International Journal of Research in Pharmacy and Chemistry in 2019. SDS of cas: 586-76-5 The author mentioned the following in the article:

In the current study, a series of five novel substituted 4-methyl-7-[(5-aryl-1,3,4-oxadiazole-2-yl)methoxy]-2H-chromen-2-one I [R = H, Cl, Br, NH2, NO2] was synthesized by a synthetic protocol in 4 steps. The intermediate involved were acetate derivative of coumarin synthesized from 7-hydroxy 4-Me coumarin in the presence of K2CO3, acetohydrazide by reacting acetate derivative of coumarin with hydrazine hydrate. The final derivatives I were obtained from acetohydrazide in the presence of POCl3 by reacting it with substituted benzoic acids. All the reactions were carried out by conventional methods. All the synthesized compounds I were evaluated for their anticoagulant and anti-inflammatory activity by tail bleeding model and HRBC method resp. The results of the study revealed that compound I [R = NO2] having strong electron withdrawing group showed anticoagulant activity and compounds I [R = Br, Cl] showed anti-inflammatory activity comparable to that of standard warfarin and diclofenac resp. While the compound I [R = H], showed moderate activities. However, the compound I [R = NH2] having electron donating groups had neg. impact on the potency and showed less anticoagulant and anti-inflammatory activity as compared to other derivatives In addition to this study using 4-Bromobenzoic acid, there are many other studies that have used 4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.SDS of cas: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2,5-DibromothiopheneIn 2020 ,《Solution-Processed, Insoluble Thin Films through In Situ Chemical Polymerization of Semiconducting Native Polythiophene》 appeared in Physica Status Solidi A: Applications and Materials Science. The author of the article were Lebert, Jenny; Kratzer, Eva M.; Herzig, Eva M.. The article conveys some information:

The use of multilayer, solution-processed organic thin film devices can benefit strongly from the controlled deposition of insoluble thin films. Here, a solution-based in situ polymerization technique for semiconducting polythiophene thin films based on nonchlorinated solvents forming a range of large-scale structured or homogeneous, insoluble thin films is systematically developed. The high-quality nature of the resulting polythiophene thin films is demonstrated by successfully implementing the films in the active layer of bilayer heterojunction solar cells. It is possible to transfer this protocol to large-scale processing without addnl. changes to the material system. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Reference of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Reference of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Lamola, Jairus L.; Moshapo, Paseka T.; Holzapfel, Cedric W.; Maumela, Munaka Christopher published an article in Phosphorus, Sulfur and Silicon and the Related Elements. The title of the article was 《Designing biaryl phosphacyclic ligands: their characterization and evaluation in palladium-catalyzed Suzuki-Miyaura reactions of aryl bromides and chlorides》.Safety of 5-Bromobenzo[d][1,3]dioxole The author mentioned the following in the article:

Efficient palladium catalyst systems based on the combination of bench stable biaryl phosphacycles and Pd(OAc)2 are described for Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides. Notably, the electronically and sterically diametric biaryl phosphacycles allowed facile coupling of sterically hindered and heterocyclic substrates.5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Safety of 5-Bromobenzo[d][1,3]dioxole) was used in this study.

Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Safety of 5-Bromobenzo[d][1,3]dioxole

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stenger-Smith, Jenny; Chakraborty, Indranil; Ouattara, Ramatoulaye; Sameera, W. M. C.; Rue, Kelly; Mascharak, Pradip published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《CO release from Mn(I)-based photoCORMs with single photons in the phototherapeutic region》.Safety of Bromopentacarbonylmanganese(I) The article contains the following contents:

Both the instrumentation required for two photon excitation (TPE) and tissue damage possibility by high intensity laser lights could impede TPE-induced CO delivery in hospital settings. Herein we report two Mn(I)-based photoCORMs with a fac-{Mn(CO)3} moiety that exhibit facile CO release upon simple exposure to light within the phototherapeutic region (no TPE required). The experimental process involved the reaction of Bromopentacarbonylmanganese(I)(cas: 14516-54-2Safety of Bromopentacarbonylmanganese(I))

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Safety of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 17696-11-6In 2021 ,《Rose bengal conjugated gadolinium complex as a new multimodal imaging agent targeting presynaptic vesicular glutamate transporters》 was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands). The article was written by Kim, Soyeon; Kim, Hee-Kyung; Baek, Ah Rum; Sung, Bokyung; Yang, Byeong Woo; Kim, Yeoun-Hee; Lee, Jung-jin; Yang, Ji-ung; Shin, Chang-Hoon; Jung, Hoesu; Kim, Minsup; Cho, Art E.; Lee, Taekwan; Chang, Yongmin. The article contains the following contents:

Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters (VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase and late stage decrease in VGLUT expression were implicated in progressive Alzheimer′s disease (AD), VGLUTs can be a new imaging target for diagnosing AD. In this study, we have designed and synthesized a new multimodal gadolinium contrast agent conjugated with rose bengal to target VGLUTs (Gd-DO3A-RB). In addition to high kinetic and pH stability, magnetic resonance and fluorescence imaging using Gd-DO3A-RB showed high affinity to VGLUT1. Using the AD animal model (5XFAD), in vivo MRI with a Gd-DO3A-RB showed less MR signal enhancement in 5XFAD mouse brain than that of age-matched normal C57BL/6 mouse, suggesting a late stage decrease in VGLUT expression in AD animal model. Therefore, this new VGLUT targeting gadolinium contrast agent demonstrated a strong potential as a new diagnostic tool for AD with multimodal imaging capability. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6HPLC of Formula: 17696-11-6)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.HPLC of Formula: 17696-11-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Phosphine-based porous aromatic frameworks for gold nanoparticle immobilization with superior catalytic activities》 were Yang, Yuting; Wang, Tienan; Jing, Xiaofei; Zhu, Guangshan. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. Related Products of 623-24-5 The author mentioned the following in the article:

Triphenylphosphine (PPh3) and diphenyl-2-pyridylphosphine (PPh2Py), which are usually used as ligands to protect gold nanoparticles (AuNPs), were selected as monomers to build up porous aromatic frameworks (PAFs) with high surface areas for AuNPs immobilization. Using the cost-effective Friedel-Crafts alkylation reaction, phosphine-based PAFs (PAF-93 and PAF-94) were successfully synthesized, and they possessed high stabilities as well as high surface areas. AuNPs with sizes of smaller than 2 nm in Au@PAF-94 were obtained owing to the stronger interactions with P and N donors in PAF skeletons, thus leading to high catalytic activities. According to the pseudo-first-order kinetics, the kapp (apparent rate constant) value for Au@PAF-94 in the reduction reaction of 4-nitrophenol is 2.2 × 10-2 s-1, which is superior to most of the presently reported AuNP catalysts with solid supports under similar conditions. Addnl., Au@PAFs exhibited excellent recyclability and retained their high catalytic activities after five successful cycles.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Related Products of 623-24-5) was used in this study.

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Related Products of 623-24-5 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doufene, Koceila; Malki, Yohan; Vincent, Laure-Anais; Cuq, Pierre; Devoisselle, Jean-Marie; Masurier, Nicolas; Aubert-Pouessel, Anne published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021. The article was titled 《Vegetable Oil-based Hybrid Submicron Particles Loaded with JMV5038: A Promising Formulation against Melanoma》.Related Products of 586-76-5 The article contains the following contents:

The aim of this work was to carry out a preformulation study on JMV5038 as a new potent cytotoxic agent, and to develop its formulation within vegetable oil-based hybrid submicron particles (HNP) in order to obtain a versatile dosage form against melanoma. JMV5038 was first characterized through physico-chem. tests and it exhibited high m.p. and logP value, an important pH-sensitivity that led to the formation of well-identified degradation products at low pH, as well as a substantial solubility value in silylated castor oil (ICO). Then, JMV5038-loaded HNP were formulated through a thermostabilized emulsion process based on the sol-gel crosslinking of ICO. They showed high loading efficiency and their in vitro release kinetic assessed in a biorelevant PBS/octanol biphasic system showed a constant sustained release over one month. The cytotoxic activity and cytocompatibility of HNP were evaluated on A375 melanoma cells and NIH 3T3 cells, resp. JMV5038-loaded HNP exhibited a slightly enhanced cytotoxic activity of JMV5038 on melanoma cells while demonstrating their safety on NIH 3T3 cells. In conclusion, JMV5038-loaded HNP proved to be an efficient and safe drug s.c. delivery system that will be interesting to evaluate through preclin. studies. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 2,5-DibromothiopheneIn 2022 ,《Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy》 was published in Journal of Materials Chemistry B: Materials for Biology and Medicine. The article was written by Guo, Mengying; Zhou, Kun; Ding, Rui; Zhao, Xiaodan; Zhang, Yueyan; Zhang, Zixi; He, Gang. The article contains the following contents:

A series of water-soluble cationic thienoviologen derivative photosensitizers (nTPy-Rs) for photodynamic therapy (PDT) is reported. Cationic pyridine groups were introduced into the thiophene framework to enhance solubility and bacteria-binding ability, which effectively improved bacteriol. imaging and antibacterial activity. The optoelectronic properties of nTPy-Rs were regulated by adjusting the number of thiophene groups, and the differences in antibacterial activity due to the functional scaffolds were compared. The results showed that nTPy-Rs could generate reactive oxygen species (ROS, including macroscopic free radicals), efficiently inhibit bacterial growth, and achieve the min. inhibitory concentration (MIC) to the ng mL-1 level. Remarkably, 2TPyC6, containing two thiophene groups and modified by alkyl side chains, showed the best bacteriostatic performance, with the MIC of 20 ng mL-1 and 4.5 ng mL-1 for E. coli and S. aureus, resp., which are the lowest photosensitizer concentrations used in PDT to date. The low cell cytotoxicity and excellent antibacterial performance give nTPy-Rs great potential as PDT agents in vivo. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)

2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Safety of 2,5-Dibromothiophene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary