Tag: 200-300

Synthetic Route of C5BrMnO5In 2020 ,《Bis[diphenylphosphino]methane and its bridge-substituted analogues as chemically non-innocent ligands for H2 activation》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Kireev, Nikolay V.; Filippov, Oleg A.; Gulyaeva, Ekaterina S.; Shubina, Elena S.; Vendier, Laure; Canac, Yves; Sortais, Jean-Baptiste; Lugan, Noel; Valyaev, Dmitry A.. The article conveys some information:

Deprotonation of fac-[(κ2P,P-Ph2PCH(R)PPh2)Mn(CO)3Br] (R = H, Me, Ph) produces the corresponding diphosphinomethanide derivatives fac-[(κ3P,C,P-Ph2PC(R)PPh2)Mn(CO)3], which are prone to activate H2 to form the hydride complexes fac-[(κ2P,P-Ph2PCH(R)PPh2)Mn(CO)3H]. The substitution of the dppm bridge improves dramatically the reaction efficiency and this was rationalized by DFT calculations In the experimental materials used by the author, we found Bromopentacarbonylmanganese(I)(cas: 14516-54-2Synthetic Route of C5BrMnO5)

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Synthetic Route of C5BrMnO5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells》 was written by Uchinomiya, Shohei; Matsunaga, Naoya; Kamoda, Koichiro; Kawagoe, Ryosuke; Tsuruta, Akito; Ohdo, Shigehiro; Ojida, Akio. Application In Synthesis of 8-Bromooctanoic acid And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, the authors report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence. After reading the article, we found that the author used 8-Bromooctanoic acid(cas: 17696-11-6Application In Synthesis of 8-Bromooctanoic acid)

8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Application In Synthesis of 8-Bromooctanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Kosikowska, Paulina; Bochno, Marta; Macegoniuk, Katarzyna; Forlani, Giuseppe; Kafarski, Pawel; Berlicki, Lukasz published 《Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase》.Journal of Enzyme Inhibition and Medicinal Chemistry published the findings.Synthetic Route of C6H5Br2N The information in the text is summarized as follows:

Inhibition of glutamine synthetase (GS) is one of the most promising strategies for the discovery of novel drugs against tuberculosis. Forty-three bisphosphonic and bis-H-phosphinic acids of various scaffolds, bearing aromatic substituents, were screened against recombinant GS from Mycobacterium tuberculosis. Most of the studied compounds exhibited activities in micromolar range, with N-(3,5-dichlorophenyl)-2-aminoethylidenebisphoshonic acid, N-(3,5-difluorophenyl)-2-aminoethylidene-bisphoshonic acid, and N-(3,4-dichlorophenyl)-1-hydroxy-1,1-ethanebisphosphonic acid showing the highest potency with kinetic parameters similar to the reference compound, L-methionine-S-sulfoximine. Moreover, these inhibitors were found to be much more effective against the pathogenic enzyme than against the human ortholog. Thus, with the bone-targeting properties of the bisphosphonate compounds in mind, this activity/selectivity profile makes these compounds attractive agents for the treatment of bone tuberculosis. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2004,Chemical Communications (Cambridge, United Kingdom) included an article by Moss, Rebecca J.; Wadsworth, Kelly J.; Chapman, Christopher J.; Frost, Christopher G.. Formula: C6H4BBrF3K. The article was titled 《Rhodium-catalyzed tandem conjugate addition-protonation: an enantioselective synthesis of 2-substituted succinic esters》. The information in the text is summarized as follows:

The rhodium-catalyzed addition of potassium trifluoro(organo)borates to di-Me itaconate generated an intermediate complex which on protonation provided enantioenriched succinic esters, e.g., I. After reading the article, we found that the author used potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8Formula: C6H4BBrF3K)

potassium (3-bromophenyl)trifluoroborate(cas: 374564-34-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Formula: C6H4BBrF3K

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C6H12Br2In 2022 ,《A cationic BODIPY photosensitizer decorated with quaternary ammonium for high-efficiency photodynamic inhibition of bacterial growth》 appeared in Journal of Materials Chemistry B: Materials for Biology and Medicine. The author of the article were Wang, Hongyu; Li, Chaonan; Wu, Qihang; Wen, Hui; Sun, Tingting; Xie, Zhigang. The article conveys some information:

On account of the constant evolution of antibiotic-resistant bacteria, the effects of existing antibacterial materials are being gradually weakened, and the difficulty in curing infectious diseases is increasing. Therefore, more novel antibacterial materials or methods are eagerly required to combat microbial infections. Recently, the advantages of photodynamic therapy in the antibacterial field have gradually been validated. Herein, a trimethylamine (TMA) salt-modified 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) photosensitizer (BODIPY-TMA) was synthesized for antibacterial applications. Due to the pos. charge of the TMA group, enhanced interactions were observed between the prepared BODIPY-TMA nanoparticles (BODIPY-TMA NPs) and neg.-charged bacterial membranes. The BODIPY-TMA NPs showed much better antibacterial effect toward both S. aureus and E. coli compared with their BODIPY-Br NPs counterpart without a pos. charge. Moreover, the BODIPY-TMA NPs efficiently prevented the formation of biofilms and destroyed pre-established biofilms. Thus, such pos.-charged photosensitizers may pave the way for the exploration of highly effective antibacterial agents.1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2) was used in this study.

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Qi; Zhang, Hai-Lin; Wang, Yi; Liu, Jing; Yang, Shi-Ping; Liu, Jin-Gang published an article in 2021. The article was titled 《Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic anticancer therapy》, and you may find the article in Journal of Materials Chemistry B: Materials for Biology and Medicine.Quality Control of Bromopentacarbonylmanganese(I) The information in the text is summarized as follows:

A multifunctional nanoplatform (1), MnCO@TPP@C-TiO2, which consists of a carrier of carbon-doped TiO2 nanoparticles with surface covalent functionalization of manganese carbonyls and a directing group of triphenylphosphine, was prepared for mitochondria-targeted carbon monoxide (CO) delivery combined with photodynamic therapy (PDT). MnCO@TPP@C-TiO2 selectively localized in the mitochondria of HeLa cells where the overexpressed-H2O2 triggered CO release resulting in mitochondrial damage. And singlet oxygen species generated upon 808 nm near IR light irradiation further destroyed the mitochondria and induced cancer cells apoptosis. Cytotoxicity assays revealed that the nanoplatform with mitochondria-targeted CO delivery and PDT exhibited the highest lethality against cancer cells in comparison with all the other control samples tested, and it showed good dark biocompatibility with normal cells that express low H2O2 levels. This work may provide new insights into combining CO-based gas therapy with traditional PDT for efficient cancer treatment.Bromopentacarbonylmanganese(I)(cas: 14516-54-2Quality Control of Bromopentacarbonylmanganese(I)) was used in this study.

Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.Quality Control of Bromopentacarbonylmanganese(I)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C6H12Br2In 2021 ,《Quaternary tannic acid with improved leachability and biocompatibility for antibacterial medical thermoplastic polyurethane catheters》 was published in Journal of Materials Chemistry B: Materials for Biology and Medicine. The article was written by Wang, Yue; Liu, Shuaizhen; Ding, Kaidi; Zhang, Yaocheng; Ding, Xuejia; Mi, Jianguo. The article contains the following contents:

The surfaces of indwelling catheters offer sites for the adherence of bacteria to form biofilms, leading to various infections. Therefore, the development of antibacterial materials for catheters is imperative. In this study, combining the strong antibacterial effect of a quaternary ammonium salt (QAS) and the high biocompatibility of tannic acid (TA), we prepared a quaternary tannic acid (QTA) by grafting a synthesized quaternary ammonium salt, di-Me dodecyl 6-bromohexyl ammonium bromide, onto TA. To prepare antibacterial catheters, QTA was blended with thermoplastic polyurethane (TPU) via melt extrusion, which is a convenient and easy-to-control process. Characterization of the TPU blends showed that compared with those of the QAS, dissolution rate and biocompatibility of QTA were significantly improved. On the premise that the introduction of QTA had only a slight effect on the original mech. properties of pristine TPU, the prepared TPU/QTA maintained satisfactory antibacterial activities in vitro, under a flow state, as well as in vivo. The results verified that the TPU/QTA blend with a QTA content of 4% is effective, durable, stable, and non-toxic, and exhibits significant potential as a raw material for catheters. In the experiment, the researchers used 1,6-Dibromohexane(cas: 629-03-8Formula: C6H12Br2)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Formula: C6H12Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 76006-33-2In 2012 ,《Synthesis, characterization and in vitro antimicrobial screening of quinoline nucleus containing some novel 1,3,4-oxadiazole derivatives》 appeared in Novel Science International Journal of Pharmaceutical Science. The author of the article were Maity, Supriya; Khan, Suroor A.; Ahmad, Shamim. The article conveys some information:

A novel series of 1,3,4-oxadiazole (3a-j) has been synthesized and characterized by means of TLC, m.p. and spectral data like IR, 1H-NMR & Mass spectroscopy. Synthesized compounds were screened for their antibacterial activity against four different strains like Staphylococcus aureus (NCIM 2079), Bacillus subtilis (NCIM 2708), Pseudomonas aeruginosa (NCIM 2242) and Escherichia coli (NCIM 2685) with standard drug ampicillin while antifungal activity was determined against strains like Candida albicans (NCIM 22491) with standard drug griseofulvin. On the basis of statistical anal., it was observed that compounds had significant co-relation. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2SDS of cas: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. SDS of cas: 76006-33-2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Zujin; Wu, Guifang; Gan, Cui; Cai, Guangmei; Zhang, Jianyong; Ji, Hongbing published their research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021. The article was titled 《Effective adsorption of arsenate, dyes and eugenol from aqueous solutions by cationic supramolecular gel materials》.Computed Properties of C8H8Br2 The article contains the following contents:

Developing efficient separation technologies for wastewater treatment and recovery of natural products is crucial in practical application. Covalent capture of supramol. gel materials and the further surface modification benefit for the improvement in adsorption performance. In the present paper, two kinds of supramol. gels, N,N’,N”-(3-methylpyridine) benzenetriamide (TMPTA) nanotube and N,N’,N”-(3-pyridyl) benzenetriamide (TPTA) nanofiber, were synthesized successfully by supramol. self-assembly of tripodal pyridines and then were further modified with α,α’-dibromo-p-xylene to obtain imidazolium-based gel materials, TMPTA-G-M and TPTA-G-M. They have stable porous structure and pos. charged surfaces with different morphologies. The synthesized gels are characterized by physico-chem. techniques, and the results show that the modification process does not cause significant changes in the morphol. TMPTA-G-M and TPTA-G-M are applied as adsorbents for the selective separation of anionic Congo Red (CR) and cationic dye Rhodamine B (RhB) from aqueous solutions Maximum adsorption amounts (qmax) on TPTA-G-M are 87.95 mg/g for CR and 85.83 mg/g for RB, and on TMPTA-G-M are 372.03 mg/g for CR and 45.64 mg/g for RB, resp. For the arsenate adsorption, TMPTA-G-M showed significantly better adsorption performance with qmax of 66.5 mg/g in solutions at pH = 9 in 10 min. Addnl., TMPTA-G-M is used for the selective separation of eugenol from eugenol acetate which coexist extensively in Clove oil, and it shows excellent adsorption selectivity for eugenol with qmax of 93.59 mg/g at pH = 11. The mechanism study suggests that the morphol. of the gels affects the distribution of charge and further affects the adsorption performance. And the adsorption may involve electrostatic interactions between adsorbent and adsorbate. The results indicate high adsorption ability and regeneration efficiency for TMPTA-G-M, implying the potential application in wastewater treatment and separation of natural product. In the part of experimental materials, we found many familiar compounds, such as 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Computed Properties of C8H8Br2)

1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Computed Properties of C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Hui; Hu, Wanshan; Zhang, Fei; Zhao, Changbo; Peng, Tingting; Zhu, Caizhen; Xu, Jian published their research in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2021. The article was titled 《AIE-active polyelectrolyte based photosensitizers: the effects of structure on antibiotic-resistant bacterial sensing and killing and pollutant decomposition》.Related Products of 629-03-8 The article contains the following contents:

A facile and effective multifunctional platform with high bacterial detection sensitivity, good antibacterial activity, and excellent dye decomposition efficiency holds great promise for wastewater treatment. To explore the design rationality and mechanism of material platforms with various integrated components into a single mol. for wastewater treatment applications, herein, four kinds of polyelectrolyte photosensitizers with aggregation-induced emission (AIE) fluorescent units are synthesized and systematically studied to investigate the structure-property relationship that influences the level of conjugation and the hydrophobicity-hydrophilicity balance. By improving the strength of the conjugation, the new AIE photosensitizers DBPVEs (including DBPVE-4 and DBPVE-6) generate a reactive oxygen species (ROS), and a decomposition efficiency of around 55% is obtained for dyes when they are exposed to DBPVEs under white light irradiation, which is higher than those of DBPEs (including DBPE-4 and DBPE-6). More importantly, owing to the longer and more flexible aliphatic chains of DBPVE-6 that facilitate efficient intercalation into cell membranes, the staining ability of DBPVE-6 for methicillin-resistant S. epidermidis (MRSE) is greatly enhanced as compared to that of DBPVE-4. It should be noted that the antibacterial experiment indicates that DBPVE-6 displays potent toxicity to MRSE with 99.9% killing efficiency under white light irradiation This work provides essential theor. and exptl. guidance on the designing of new photosensitizers for wastewater treatment. The results came from multiple reactions, including the reaction of 1,6-Dibromohexane(cas: 629-03-8Related Products of 629-03-8)

1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of solvent processable and conductive polyfluorene ionomers for alkaline fuel cell applications; synthesis of cross-linkable regioregular poly(3-(5-hexenyl)thiophene) (P3HNT) for stabilizing the film morphology in polymer photovoltaic cells.Related Products of 629-03-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary