Tag: 100-200

Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain was written by Farina, Carlo;Gagliardi, Stefania;Ghelardini, Carla;Martinelli, Marisa;Norcini, Monica;Parini, Carlo;Petrillo, Paola;Ronzoni, Silvano. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Recommanded Product: 3-Bromo-4-fluorotoluene This article mentions the following:

Chem. modifications of dimiracetam (I), a bicyclic analog of the nootropic drug piracetam, afforded a small set of novel derivatives that were investigated in in vivo models of neuropathic pain. Compounds 5, 7 and 8 displayed a very promising antihyperalgesic profile in rat models of neuropathic pain induced by both chronic constriction injury of the sciatic nerve and streptozotocin. The compounds completely reverted the reduction of pain threshold evaluated by the paw pressure test. Importantly these derivatives did not induce any behavioral impairment as evaluated by the rotarod test. These results suggest that compounds 5, 7 and 8 might represent novel and well-tolerated therapeutic agents for the relief of neuropathic pain. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Recommanded Product: 3-Bromo-4-fluorotoluene).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 3-Bromo-4-fluorotoluene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic carboxylate salt-enabled alternative synthetic routes for bio-functional cyclic carbonates and aliphatic polycarbonates was written by Watanabe, Yuya;Takaoka, Shunya;Haga, Yuta;Kishi, Kohei;Hakozaki, Shunta;Narumi, Atsushi;Kato, Takashi;Tanaka, Masaru;Fukushima, Kazuki. And the article was included in Polymer Chemistry in 2022.Quality Control of 1-Bromo-4-methoxybutane This article mentions the following:

Simple and efficient synthetic routes for functionalized cyclic carbonates are indispensable for the practical application of side-chain bio-functionalized aliphatic polycarbonates as biodegradable functional biomaterials. In this study, a six-membered cyclic carbonate with a triethylammonium carboxylate has been prepared in one step from 2,2-bis(methylol)propionic acid (bis-MPA). We have demonstrated the suitability of the organic carboxylate salt of the bis-MPA cyclic carbonate for esterification with alkyl bromides via the S_N2 mechanism, leading to the formation of functionalized cyclic carbonate monomers. The esterification of the organic carboxylate salt proceeds efficiently when alkyl bromides with 浼?carbonyl, allyl, and benzyl groups are used. This approach enables a two-step synthesis of functionalized cyclic carbonates from bis-MPA. The organocatalyzed ring-opening polymerization of the resultant functionalized cyclic carbonates is effectively controlled, indicating that the synthetic process involving the organic carboxylate salt does not influence their polymerizability. The ether-functionalized aliphatic polycarbonates obtained from the organic carboxylate salt exhibit good antiplatelet properties, comparable to those of a previously developed blood-compatible aliphatic polycarbonate. The synthetic pathways exploiting organic carboxylate salts enable alternative shortcuts to functionalized cyclic carbonates from bis-MPA. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Quality Control of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On-Surface Debromination of 2,3-Bis(dibromomethyl)- and 2,3-Bis(bromomethyl)naphthalene: Dimerization or Polymerization? was written by Tang, Yanning;Ejlli, Barbara;Niu, Kaifeng;Li, Xuechao;Hao, Zhengming;Xu, Chaojie;Zhang, Haiming;Rominger, Frank;Freudenberg, Jan;Bunz, Uwe H. F.;Muellen, Klaus;Chi, Lifeng. And the article was included in Angewandte Chemie, International Edition in 2022.Electric Literature of C4H4BrNO2 This article mentions the following:

We describe the on-surface dehalogenative homocoupling of benzylic bromides, namely bis-bromomethyl- and bis-gem-(dibromomethyl) naphthalene as a potential route to either hydrocarbon dimers or conjugated polymers on Au(111). While bis-gem-(dibromomethyl) naphthalene affords different dimers with naphthocyclobutadiene as the key intermediate, bis-bromomethyl naphthalene furnishes a poly(o-naphthylene vinylidene) as a non-conjugated polymer which undergoes dehydrogenation toward its conjugated derivative poly(o-naphthylene vinylene) upon mild annealing. A combination of scanning tunneling microscopy, non-contact at. force microscopy and d. functional theory calculations provides deep insights into the prevailing mechanisms. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Electric Literature of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs) was written by Bailey, Nick;Bamford, Mark J.;Brissy, Delphine;Brookfield, Joanna;Demont, Emmanuel;Elliott, Richard;Garton, Neil;Farre-Gutierrez, Irene;Hayhow, Thomas;Hutley, Gail;Naylor, Antoinette;Panchal, Terry A.;Seow, Hui-Xian;Spalding, David;Takle, Andrew K.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Category: bromides-buliding-blocks This article mentions the following:

Acid pump antagonists (APAs) such as the imidazo[1,2-a]pyridine AZD-0865 I have proven efficacious at low oral doses in acid related gastric disorders. Herein some of the broader SAR in this class of mol. are described and detail the discovery of an imidazo[1,2-a]pyridine II which has excellent efficacy in animal models of gastric acid secretion following oral administration, as well as a good overall developability profile. The discovery strategy focuses on use of heteroaryl and heterocyclic substituents at the C-6 position and optimization of developability characteristics through modulation of global physico-chem. properties. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Category: bromides-buliding-blocks).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 was written by Kurz, Thomas;Schlueter, Katrin;Kaula, Uwe;Bergmann, Baerbel;Walter, Rolf D.;Geffken, Detlef. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Safety of 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

Fosmidomycin is a promising antimalarial drug candidate with a unique chem. structure and a novel mode of action. Chain substituted pivaloyloxymethyl ester derivatives of Fosmidomycin and its acetyl analog FR900098 have been synthesized and their in vitro antimalarial activity vs. the Chloroquine sensitive strain 3D7 of Plasmodium falciparum has been determined In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Safety of 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Formal Dehydration Polymerization of Propargylic Alcohols via Cumulene Intermediates was written by Wu, Bin;Su, Hao-Ze;Wang, Zi-Yuan;Yu, Zi-Di;Sun, Han-Li;Yang, Fan;Dou, Jin-Hu;Zhu, Rong. And the article was included in Journal of the American Chemical Society in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

Here we report a copper-catalyzed formal dehydration polymerization of propargylic alcs. Copper catalysis allows for efficient in situ generation of [n]cumulenes (n = 3, 5) by a soft deprotonation/灏?elimination pathway and subsequent polymerization via organocopper species. Alkyne polymers (M_n up to 36.2 kg/mol) were produced with high efficiency (up to 95% yield) and excellent functional group tolerance. One-pot synthesis of semiconducting head-to-head poly(phenylacetylene) was demonstrated through a polymerization-isomerization sequence. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Ladder-Type 9,9′-Bifluorenylidene-Based Conjugated Oligomers via a Pd-Catalyzed Tandem Suzuki Coupling/Heck Cyclization Approach was written by Zhu, Xiaoyan;Liu, Feng;Ba, Xinwu;Wu, Yonggang. And the article was included in Organic Letters in 2022.Computed Properties of C4H4BrNO2 This article mentions the following:

For new ladder-type oligomers and polymers with versatile and robust synthetic strategies, in this study, four fully conjugated ladder-type overcrowded 9,9′-bifluorenylidene-based compounds and oligomers (BFY1, BFY2, BFY3, and BFY4) were synthesized via a Pd-catalyzed tandem Suzuki coupling/Heck cyclization reaction. By monomer screening and route optimization, the target products were obtained in high yields and characterized by ¹H and ¹³C NMR spectroscopy and high resolution mass spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Computed Properties of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery and structure-activity relationships of spiroindolines as novel inducers of oligodendrocyte progenitor cell differentiation was written by Katayama, Katsushi;Arai, Yoshikazu;Murata, Kenji;Saito, Shoichi;Nagata, Tsutomu;Takashima, Kouhei;Yoshida, Ayako;Masumura, Makoto;Koda, Shuichi;Okada, Hiroyuki;Muto, Tsuyoshi. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Name: 4-Amino-3-bromophenol This article mentions the following:

A novel series of spiroindoline derivatives was discovered for use as inducers of oligodendrocyte progenitor cell (OPC) differentiation, resulting from optimization of screening hit 1. Exploration of structure-activity relationships led to compound 18, which showed improved potency (rOPC EC₅₀ = 0.0032娓璏). Furthermore, oral administration of compound 18 significantly decreased clin. severity in an exptl. autoimmune encephalomyelitis (EAE) model. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Name: 4-Amino-3-bromophenol).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 4-Amino-3-bromophenol

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Desulfonylative Coupling of Alkylsulfones with gem-Difluoroalkenes by Visible-Light Photoredox Catalysis was written by Nambo, Masakazu;Ghosh, Koushik;Yim, Jacky C.-H.;Tahara, Yasuyo;Inai, Naoto;Yanai, Takeshi;Crudden, Cathleen M.. And the article was included in ACS Catalysis in 2022.HPLC of Formula: 18791-79-2 This article mentions the following:

The desulfonylative radical addition of tertiary alkyl groups I [R¹ = 2-phenylethyl, 1,3-dioxolan-2-ylmethyl, prop-2-en-1-yl, etc. R² = Me, 3-chloropropyl, 2-(tert-butoxy)-2-oxoethyl, etc.; R¹ = R² = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-, 2,3-dihydro-1H-inden-2-ylidene; R³ = H, Me] to gem-difluoroalkenes F₂C=CHR⁴ (R⁴ = 4-(4-chlorophenyl)phenyl, naphthalen-2-yl, 1-benzothiophen-3-yl, etc.) by photoredox Ir-catalyst was described. This method exhibits broad substrate scope, affording structurally diverse (E)-fluoroalkene derivatives (R¹)(R²)R³CC(F)=CHR⁴ in a highly stereoselective manner. The resulting (E)-fluoroalkenes were converted into complex fused cyclic compounds e.g., II by intramol. cyclization reactions. Control experiments and theor. calculations are consistent with a single Ir catalyst playing the dual role of generating radical species from sulfones via single electron transfer and mediating Z/E isomerization via energy transfer. A subset of fluoroalkenes provided Z stereoisomers with <90% selectivity, but the same alkenes could also be obtained as E isomers (R¹)(R²)R³CC(F)=CHR⁴ (R¹ = 2-phenylethyl, R² = R³ = Me, R⁴ = m-OMe, m-Br, p-Me.) with high selectivity by taking advantage of a secondary Z to E photoisomerization. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2HPLC of Formula: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oxacyclanes was written by Kirrmann, A.;Hamaide, N.. And the article was included in Bulletin de la Societe Chimique de France in 1957.Quality Control of 1-Bromo-6-methoxyhexane This article mentions the following:

Oxacyclanes were formed by heating 绾? 鏈? or 钄?methoxylated alkyl bromides with FeCl₃. NaOMe (1 mole) in MeOH added slowly with stirring to 1 mole dibromoalkane at 60鎺? the mixture boiled gently 4 hrs. and cooled, the washed and dried product distilled, and the bromo methoxy alkane fraction carefully redistilled in vacuo gave MeO(CH₂)₆Br, b₁₄ 94鎺? n_D²⁰ 1.458, d₂₀ 1.1942, MeCH(OMe)CH₂CH₂CHBrMe, b₃₅ 100鎺? n_D²⁰ 1.441, d₂₀1.1824, MeO(CH₂)₅Br, b₁₅ 76鎺? n_D²⁰ 1.455, d₂₀ 1.2420, and MeO(CH₂)₄Br (I), b₁₅ 60鎺? n_D²⁰ 1.452, d₂₀ 1.3052, in 56, 53, 55, and 57% yields, resp. Regulated mild distillation of these products in the presence of a few mg. FeCl₃ gave the oxacyclanes (compound, % yield, b.p., n_D²⁰, d₂₀, 浣?in 娓?: tetrahydrofuran, 100, 67鎺? 1.407, 0.8874, 3.34, 6.85, 9.34; tetrahydropyran, 100, 88鎺? 1.4205, 0.8851, 3.30, 6.92, 9.12, 11.46, 12.26; hexamethylene oxide, 70, 116鎺? 1.4355, 0.895, 3.42, 6.90, 8.80, 9.02, 10.04, 10.30, 12.22, 12.44; 2,5-dimethyltetrahydrofuran, 80, 96鎺? 1.410, 0.8373, 3.3, 6.8, 7.2, 9.1, 11.3, 11.94, 12.1. The MeBr formed in the cyclization of I was condensed at -15鎺?with anhydrous Et₂O and Mg, the MeMgBr treated with BzH and the MePhCHOH formed identified as the phenylurethan. The mechanism of the reaction was interpreted through the intermediary formation of a tertiary oxonium salt. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Quality Control of 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary