Tag: 100-200

Methylated 1,2,3-triazoles. II was written by Begtrup, Mikael;Pedersen, Christian. And the article was included in Acta Chemica Scandinavica (1947-1973) in 1966.Reference of 13273-53-5 This article mentions the following:

1-Methyl-5-methoxy-1,2,3-triazole (I) with MeI yielded 1,3-dimethyl-4-methoxy-1,2,3-triazolium iodide (II) which was also prepared from 1,3-dimethyl-1,2,3-triazol-4-one (III) with MeI or from 1,3-dimethyl-4-bromo-1,2,3-triazolium iodide (IV) with NaOMe. II heated or kept in CHCl3 at room temperature lost MeI to give III. The chloride analog (V) of IV with NaOH gave a compound believed to be the 5-Br derivative (VI) of III; it was also obtained by the bromination of III. 1-Methyl-4-bromo-1,2,3-triazole (417 mg.) and 2.5 cc. MeI heated 6 hrs. in a sealed tube, and the product stirred 2 hrs. in EtOH with excess AgCl gave 440 mg. V, m. 193鎺?(EtOH-Et2O). IV (98 mg.), 8.0 mg. Na, and 3.5 cc. MeOH heated 2 hrs. at 75鎺? treated with 70 mg. NaI, stirred 15 min., and filtered gave 3 mg. II; the mother liquors yielded 35 mg. III. V (70 mg.) and 0.17 cc. soln, of 220 mg. Na in 5 cc. EtOH heated 3 hrs. at 70鎺? neutralized with CO2, and worked up gave 63 mg. 1,3-dimethyl-4-ethoxy-1,2,3-triazolium chloride (VII), yellow, hygroscopic oil. III (30 mg.) refluxed 3 hrs. with 2 cc. EtI, and the product (74 mg.) stirred 1 hr. in EtOH with excess AgCl yielded 49 mg. yellowish, oily, hygroscopic VII. III (217 mg.) refluxed 3 hrs. with 2 cc. MeI gave 455 mg. yellow II, m. 111鎺?(MeOH-Et2O). II (19 mg.) in 0.5 cc. CDCl3 in an N.M.R. tube kept at room temperature showed after 4 days the spectrum of III; the solution evaporated gave 9 mg. III, m. 78-85鎺? VII in CHCl3 was unchanged, after 4 days at room temperature, but heated 1 hr. at 80鎺?gave III. I (50 mg.) in 0.5 cc. CDCl3 and 0.10 cc. MeI kept 6 weeks at room temperature in a N.M.R. tube and evaporated left 44 mg. III, m. 78-85鎺? a similar run gave during 48 hrs. 53% II. V (92 mg.) in 4 cc. N NaOH heated 16 hrs. at 100鎺?in a sealed tube and neutralized with N HCl, and the crude product chromatographed on silica gel yielded 22 mg. VI, m. 141鎺? III (112 mg.) in 1 cc. CHCl3 treated with 0.05 cc. Br in 5 cc. cold CHCl3 and filtered after 10 min., and the residue stirred 1 hr. in H2O with excess Amberlite IR-4B gave 84 mg. VI, m. 141鎺? the mother liquor residue treated similarly with Amberlite yielded 48 mg. VI, m. 141鎺? In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Reference of 13273-53-5).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 13273-53-5

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Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 9,10-dihydroanthracen-9,10-imines was written by Anderson, Paul S.;Christy, Marcia E.;Colton, C. Dylion;Halczenko, Wasyl;Ponticello, Gerald S.;Shepard, Kenneth L.. And the article was included in Journal of Organic Chemistry in 1979.Reference of 452-62-0 This article mentions the following:

The cycloaddition of benzynes with isoindoles to generate the 9,10-dihydroanthracen-9,10-imine system (I) was examined in detail. A versatile synthesis of these ring-strained heterocycles based on a detailed anal. of the 2,3-dihydro-1H-isoindol-1-one (phthalimidine) approach to the prerequisite isoindoles is presented. A variety of synthetic methods to phthalimidines were evaluated and developed including: reductive amination of o-acylbenzoic acids; amidoalkylation of benzoic acids; halogenation and amination of o-alkylbenzoic acids; and reduction of phthalimides. In addition, generation of benzynes from chlorobenzenes and Li tetramethylpiperidide greatly increase the scope of the Diels-Alder reaction to form the desired products. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Reference of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 452-62-0

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Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides was written by Lin, Tingzhi;Gu, Yuanyun;Qian, Pengcheng;Guan, Haixing;Walsh, Patrick J.;Mao, Jianyou. And the article was included in Nature Communications in 2020.Product Details of 4457-67-4 This article mentions the following:

A nickel-catalyzed generation of homoenolates, and their higher homologues, via decarbonylation of readily available cyclic anhydrides was developed. The utility of nickel-bound homoenolates and their higher homologues was demonstrated by cross-coupling with unactivated alkyl bromides, generated a diverse array of aliphatic acids. A broad range of functional groups was tolerated. Preliminary mechanistic studies demonstrated that the oxidative addition of anhydrides by the catalyst was faster than oxidative addition of alkyl bromides. The nickel bound metallocycles were involved in this transformation. The catalyst undergoes a single electron transfer (SET) process with the alkyl bromide. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Product Details of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 4457-67-4

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Bromide – Wikipedia,
bromide – Wiktionary

Reactivity of thienopyrroles. Synthesis of isomeric nitro and bromothienopyrroles was written by Eras, J.;Galvez, C.;Garcia, F.. And the article was included in Journal of Heterocyclic Chemistry in 1984.HPLC of Formula: 18791-79-2 This article mentions the following:

The isomeric thienopyrroles I and II (R = H, Br) were prepared by thermal cyclization of the azidothienylacrylates III and IV. III and IV were prepared from the corresponding thiophenecarboxaldehydes and N₃CH₂CO₂Et. I and II (R = NO₂) were prepared by nitration of I and II (R = H). In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2HPLC of Formula: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 18791-79-2

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Bromide – Wikipedia,
bromide – Wiktionary

Base strengths of (锠?methoxyalkyl)triphenyl- and (锠?methoxyalkyl)diphenylmethylsilanes was written by Bellama, Jon M.;Harmon, Linda A.. And the article was included in Inorganic Chemistry in 1978.Quality Control of 1-Bromo-4-methoxybutane This article mentions the following:

The basicity of MeO(CH₂)_nSiPh₃ (I) and of MeO(CH₂)_nSiMePh₂ (II), determined from the difference between their IR in Et₂O or MeOH-CCl₄, is n = 1 << n = 2 > n = 3. A combination of inductive, steric, hyperconjugative, and conjugative effects is responsible for this basicity order. The mass spectral fragmentation of I and II involved rearrangements of the O atom to Si. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Quality Control of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Quality Control of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodoxybenzoic acid (IBX) was written by Cheng, Huicheng;Pei, Yu;Leng, Faqiang;Li, Jingya;Liang, Apeng;Zou, Dapeng;Wu, Yangjie;Wu, Yusheng. And the article was included in Tetrahedron Letters in 2013.Name: 5-Bromothiophene-3-carbaldehyde This article mentions the following:

A 2-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcs. were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amounts of K₂CO₃. The trifluoromethyl alcs. were then oxidized conveniently and efficiently by 2-iodoxybenzoic acid (IBX) under mild conditions to give the desired functionalized aryl and heteroaryl trifluoromethyl ketones. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Name: 5-Bromothiophene-3-carbaldehyde).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 5-Bromothiophene-3-carbaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electrochemically stable carbazole-derived polyaniline for pseudocapacitors was written by Almtiri, Mohammed;Dowell, Timothy J.;Giri, Hari;Wipf, David O.;Scott, Colleen N.. And the article was included in ACS Applied Polymer Materials in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

Supercapacitor energy storage devices are well suited to meet the rigorous demands of future portable consumer electronics (PCEs) due to their high energy and power densities (i.e., longer battery-life and rapid charging, resp.) and superior operational lifetimes (10 times greater than lithium-ion batteries). To date, research efforts have been narrowly focused on improving the specific capacitance of these materials; however, emerging technologies are increasingly demanding competitive performance with regards to other criteria, including scalability of fabrication and electrochem. stability. In this regard, we developed a polyaniline (PANI) derivative that contains a carbazole unit copolymerized with 2,5-dimethyl-p-phenylenediamine (Cbz-PANI-1) and determined its optoelectronic properties, elec. conductivity, processability, and electrochem. stability. Importantly, the polymer exhibits good solubility in various solvents, which enables the use of scalable spray-coating and drop-casting methods to fabricate electrodes. Cbz-PANI-1 was used to fabricate electrodes for supercapacitor devices that exhibits a maximum areal capacitance of 64.8 mF cm^-2 and specific capacitance of 319 F g^-1 at a c.d. of 0.2 mA cm^-2. Moreover, the electrode demonstrates excellent cyclic stability (閳?83% of capacitance retention) over 1000 CV cycles. Addnl., we demonstrate the charge storage performance of Cbz-PANI-1 in a sym. supercapacitor device, which also exhibits excellent cyclic stability (閳?91% of capacitance retention) over 1000 charge-discharge cycles. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

High-Temperature and Dynamic RGB (Red-Green-Blue) Long-Persistent Luminescence in an Anti-Kasha Organic Compound was written by Zhang, Qiang-Sheng;Wang, Shi-Cheng;Xiong, Xiao-Hong;Fu, Peng-Yan;Zhang, Xiao-Dong;Fan, Ya-Nan;Pan, Mei. And the article was included in Angewandte Chemie, International Edition in 2022.Application of 128-08-5 This article mentions the following:

Organic LPL (long-persistent luminescence) materials have sparked extensive research interest due to the ultralong-lived triplet states. Although numerous organic LPL materials were reported, most of the triplet emission was static and monotonous. LPL materials with dynamic triplet emission are urgently required. 2,4,6-Tris(diphenylamino)-1,3,5-triazine (1) with dynamic long-persistent luminescence (LPL) was fabricated. The single-crystal structure shows that the abundant intermol. interactions and small free volume restrict the mol. motion and avoid the quenchers. Spectral and theor. calculations upheld the existence of multiple excited states in 1, and the migration of electrons between multiple excited states is sensitive to external stimuli. By modulating the stimulus, the residence of electrons in different triplet states can be manipulated to achieve RGB LPL. Blue LPL was achieved by manipulating the anti-Kasha emission. The red LPL can still be observed at high temperature In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Development of coumarin-based hydroxamates as histone deacetylase inhibitors with antitumor activities was written by Zhao, Na;Yang, Feifei;Han, Lina;Qu, Yuhua;Ge, Di;Zhang, Hua. And the article was included in Molecules in 2020.COA of Formula: C9H11Br This article mentions the following:

Histone deacetylases (HDACs) have been proved to be promising targets for the treatment of cancer, and five histone deacetylase inhibitors (HDACis) have been approved on the market for the treatment of different lymphomas. In our previous work, we designed a series of novel coumarin-containing hydroxamate HDACis, among which compounds 6 and 7 displayed promising activities against tumor growth. Based on a mol. docking study, we further developed 26 addnl. analogs with the aim to improve activity of designed compounds Several of these new derivatives not only showed excellent HDAC1 inhibitory effects, but also displayed significant growth inhibitory activities against four human cancer cell lines. Representative compounds, 13a and 13c, showed potent anti-proliferative activities against solid tumor cell lines with IC₅₀ values of 0.36-2.91 microM and low cytotoxicity against Beas-2B and L-02 normal cells. Immunoblot anal. revealed that 13a and 13c dose-dependently increased the acetylation of histone H3 and H4. Importantly, the two compounds displayed much better anti-metastatic effects than SAHA against the MDA-MB-231 cell line. Moreover, 13a and 13c arrested MDA-MB-231 cells at G2/M phase and induced MDA-MB-231 cell apoptosis. Finally, the mol. docking study rationalized the high potency of compound 13c. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7COA of Formula: C9H11Br).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.COA of Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1 was written by Spinck, Martin;Bischoff, Matthias;Lampe, Philipp;Meyer-Almes, Franz-Josef;Sievers, Sonja;Neumann, Heinz. And the article was included in Journal of Medicinal Chemistry in 2021.Quality Control of 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

Sirtuins are signaling hubs orchestrating the cellular response to various stressors with roles in all major civilization diseases. Sirtuins remove acyl groups from lysine residues of proteins, thereby controlling their activity, turnover, and localization. The seven human sirtuins, SirT1-7, are closely related in structure, hindering the development of specific inhibitors. Screening 170,000 compounds, we identify and optimize SirT1-specific benzoxazine inhibitors, Sosbo, which rival the efficiency and surpass the selectivity of selisistat (EX527). The compounds inhibit the deacetylation of p53 in cultured cells, demonstrating their ability to permeate biol. membranes. Kinetic anal. of inhibition and docking studies reveal that the inhibitors bind to a complex of SirT1 and NAD, similar to selisistat. These new SirT1 inhibitors are valuable alternatives to selisistat in biochem. and cell biol. studies. Their greater selectivity may allow the development of better targeted drugs to combat SirT1 activity in diseases such as cancer, Huntington’s chorea, or anorexia. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Quality Control of 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary