Tag: 100-200

Palladium-catalyzed C-H alkylation of 2-phenylpyridines with alkyl iodides was written by Wang, Xiaoling;Ji, Xiaoming;Shao, Changdong;Zhang, Yu;Zhang, Yanghui. And the article was included in Organic & Biomolecular Chemistry in 2017.Synthetic Route of C5H11BrO This article mentions the following:

Palladium-catalyzed C-H alkylation reaction of 2-phenylpyridines with alkyl iodides was successfully developed. The palladacycles obtained from 2-phenylpyridines act as the key intermediates in the alkylation reaction. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Synthetic Route of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Host-guest supramolecular amphiphile enhanced photodecomposition with responsive room-temperature phosphorescence signals was written by Li, Teng;Ma, Xiang. And the article was included in Dyes and Pigments in 2018.Recommanded Product: 4457-67-4 This article mentions the following:

Photolyzable matric belongs to photo-responsive system that experiences irreversible decomposition after irradiation While the self-aggregation of photosensitizers in aqueous media often results in lower photosensitizing ability. In this work, an enhanced photolyzable system is constructed through host-guest recognition between amphiphilic 6-bromoisoquinoline functionalized alkoxyanthracene (AnBq) and cucurbit[7]uril (CB[7]). In addition, a visible room-temperature phosphorescence (RTP) signal occurs along with the photolysis reaction as the suppression of intramol. photoinduced electron transfer (PET) process from the anthracene moiety to phosphorous 6-bromoisoquinoline moiety. The formation of the host-guest assembly and the photolysis of AnBq are clearly corroborated through UV-Vis, NMR and MS spectroscopy. This photo-responsive host-guest assembly provides some hints for the design of photodegradable materials. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Multifunctional Two-Dimensional Polymers for Perovskite Solar Cells with Efficiency Exceeding 24% was written by Fu, Qiang;Liu, Hang;Tang, Xingchen;Wang, Rui;Chen, Mingqian;Liu, Yongsheng. And the article was included in ACS Energy Letters in 2022.Recommanded Product: 128-08-5 This article mentions the following:

The passivation of the intrinsic surface defects of perovskites by organic functional materials has a great potential to retard charge recombination and enhance charge extraction However, unsatisfactory device performance and a lack of in-depth understanding of the defect passivation mechanism make rational mol. design for efficient solar cells a great challenge. Herein, two solution-processable two-dimensional (2D) conjugated polymers, namely, 2DP-F and 2DP-O, have been synthesized for perovskite solar cells (PSCs). It is found that these materials could passivate surface defects, transport and extract hole carriers, hamper moisture invasion, and impede diffusion of Li⁺ cations into the perovskite film. As a result, champion efficiencies of 23.31% and 24.08% were achieved for 2DP-F- and 2DP-O-based devices, resp., coupled with dramatically improved stability. These results indicate that our proposed 2D polymers could be promising multifunctional materials for further boosting the efficiency and improving the stability of PSCs. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Study on synthesis technology of sodium ozagrel was written by Wang, Yuting. And the article was included in Jinzhou Yikedaxue Xuebao in 2022.Application of 128-08-5 This article mentions the following:

Objective In response to the deficiency of existing synthesis process, to explore an industrial preparation of sodium ozagrel, which features safe and environmental protection, low production cost, easy operation, and recycle of solvent. Methods Me cinnamate and sodium imidazolate were used resp. as the starting materials. The reaction material ratio, solvent selection, reaction temperature, reaction time, post-treatment method and product purification and other conditions were studied. Results The sodium ozagrel prepared by this method can meet the quality standard Conclusion The production process has been determined to be reasonable and feasible, and the optimal production conditions have been obtained, which are convenient for production In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Cross-Electrophile C(sp³)-Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes was written by Duan, Jicheng;Wang, Yuquan;Qi, Liangliang;Guo, Peng;Pang, Xiaobo;Shu, Xing-Zhong. And the article was included in Organic Letters in 2021.Recommanded Product: 1-Bromo-4-methoxybutane This article mentions the following:

Cross-electrophile C-Si coupling has emerged as a promising tool for the construction of organosilanes, but the potential of this method remains largely unexplored. Herein, we report a C(sp³)-Si coupling of unactivated alkyl bromides with vinyl chlorosilanes. The reaction proceeds under mild conditions, and it offers a new approach to alkylsilanes. Functionalities such as Grignard-sensitive groups (e.g., acid, amide, alc., ketone, and ester), acid-sensitive groups (e.g., ketal and THP protection), alkyl fluoride and chloride, aryl bromide, alkyl tosylate and mesylate, silyl ether, and amine were tolerated. Incorporation of the -Si(vinyl)R₂ moiety into complex mols. and the immobilization of a glass surface by formed organosilanes were demonstrated. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ni-Catalyzed reductive arylalkylation of unactivated alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Chemical Science in 2019.SDS of cas: 4457-67-4 This article mentions the following:

In this protocol Ni-catalyzed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides was accomplished, which provided a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes I [R¹ = Me, Et, i-Pr, cyclohexyl; R² = H, Me, Et; R³ = 5-OMe, 5-F, 4-Cl, etc.; R⁴ = CN, OAc, F, etc.; X = CH₂, NH, NMe, O; m = 0,3,4,5,6; n = 0,1]. Notably, this new method circumvented the pregeneration of organometallics and demonstrated high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggested a reaction pathway with an intermediate reduction In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4SDS of cas: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.SDS of cas: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zirconium-Catalyzed Remote Defunctionalization of Alkenes was written by Matt, Christof;Kern, Christoph;Streuff, Jan. And the article was included in ACS Catalysis in 2020.Synthetic Route of C5H11BrO This article mentions the following:

This work introduces a catalytic zirconium chain-walk reaction that in combination with a 閻?heteroatom elimination step enables the cleavage of remote nonactivated carbon-heteroatom bonds. The result is a controlled defunctionalization reaction, which takes place with excellent site selectivity and can be applied to sym. and unsym. alkene chains with ether, amine, and thioether groups. The approach can be used for remote functional group substitution as well, and a preliminary investigation indicates a dissociative chain-walk mechanism. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Synthetic Route of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-based design of high-affinity fluorescent probes for the neuropeptide Y Y₁ receptor was written by Mueller, Christoph;Gleixner, Jakob;Tahk, Maris-Johanna;Kopanchuk, Sergei;Laasfeld, Tonis;Weinhart, Michael;Schollmeyer, Dieter;Betschart, Martin U.;Luedeke, Steffen;Koch, Pierre;Rinken, Ago;Keller, Max. And the article was included in Journal of Medicinal Chemistry in 2022.Recommanded Product: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The recent crystallization of the neuropeptide Y Y₁ receptor (Y₁R) in complex with the argininamide-type Y₁R selective antagonist UR-MK299 (2) opened up a new approach toward structure-based design of nonpeptidic Y₁R ligands. We designed novel fluorescent probes showing excellent Y₁R selectivity and, in contrast to previously described fluorescent Y₁R ligands, considerably higher (~100-fold) binding affinity. This was achieved through the attachment of different fluorescent dyes to the diphenylacetyl moiety in 2 via an amine-functionalized linker. The fluorescent ligands exhibited picomolar Y₁R binding affinities (pK_i values of 9.36-9.95) and proved to be Y₁R antagonists, as validated in a Fura-2 calcium assay. The versatile applicability of the probes as tool compounds was demonstrated by flow cytometry- and fluorescence anisotropy-based Y₁R binding studies (saturation and competition binding and association and dissociation kinetics) as well as by widefield and total internal reflection fluorescence (TIRF) microscopy of live tumor cells, revealing that fluorescence was mainly localized at the plasma membrane. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 4-fluoro-3-phenoxytoluene was written by Zhao, Wen-xian;Wang, De-kun;Zhou, Yan-li. And the article was included in Jingxi Huagong in 2004.Application of 452-62-0 This article mentions the following:

4-Fluoro-3-phenoxytoluene (I) was synthesized by Ullmann coupling reaction of 3-bromo-4-fluorotoluene (II) and phenol. When the molar ratio of PhONa to II was 3:1 with 15% (mol) of CuO as catalyst and DMA as solvent, the reaction ran at 160 閳?165 鎺矯 for 5 h to give I in 88% yield. The structure of I was confirmed by elementary anal., ¹HNMR, IR, and MS. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Application of 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photoswitchable Diazocine-Based Estrogen Receptor Agonists: Stabilization of the Active Form inside the Receptor was written by Ewert, Julia;Heintze, Linda;Jorda-Redondo, Mireia;von Glasenapp, Jan-Simon;Nonell, Santi;Bucher, Goetz;Peifer, Christian;Herges, Rainer. And the article was included in Journal of the American Chemical Society in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

Photopharmacol. is an emerging approach in drug design and pharmacol. therapy. Light is used to switch a pharmacophore between a biol. inactive and an active isomer with high spatiotemporal resolution at the site of illness, thus potentially avoiding side effects in neighboring healthy tissue. The most frequently used strategy to design a photoswitchable drug is to replace a suitable functional group in a known bioactive mol. with azobenzene. Our strategy is different in that the photoswitch moiety is closer to the drug閳ョ灚 scaffold. Docking studies reveal a very high structural similarity of natural 17灏?estradiol and the E isomers of dihydroxy diazocines, but not their Z isomers, resp. Seven dihydroxy diazocines were synthesized and subjected to a biol. estrogen reporter gene assay. Four derivatives exhibit distinct estrogenic activity after irradiation with violet light, which can be shut off with green light. Most remarkably, the photogenerated, active E form of one of the active compounds isomerizes back to the inactive Z form with a half-life of merely several milliseconds in water, but nevertheless is active for more than 3 h in the presence of the estrogen receptor. The results suggest a significant local impact of the ligand-receptor complex toward back-isomerization. Thus, drugs that are active when bound but lose their activity immediately after leaving the receptor could be of great pharmacol. value because they strongly increase target specificity. Moreover, the drugs are released into the environment in their inactive form. The latter argument is particularly important for drugs that act as endocrine disruptors. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary