Tag: 100-200

Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols was written by Xia, Anjie;Qi, Xueyu;Mao, Xin;Wu, Xiaoai;Yang, Xin;Zhang, Rong;Xiang, Zhiyu;Lian, Zhong;Chen, Yingchun;Yang, Shengyong. And the article was included in Organic Letters in 2019.Application of 18791-79-2 This article mentions the following:

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Application of 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Studies of Substituents Impact on the Photophysical Properties of 8-Hydroxyquinoline Derivatives was written by Gao, Li-Bin;Kang, Wu-Kui;Yan, Shi-Hai;Yang, Chun-Peng. And the article was included in Heteroatom Chemistry in 2016.SDS of cas: 18791-79-2 This article mentions the following:

Five new 8-hydroxyquinoline derivatives L1-L5 were synthesized and characterized by different techniques, such as NMR, electrospray ionization mass spectra, elemental anal., UV-visible, and photoluminescence spectra. The structure of (E)-2-{2-[5-(phenylethynyl) thiophen-2-yl]ethenyl}quinolin-8-ol (L3) was confirmed by x-ray crystallog. In this structure, intermol. hydrogen bonds were found between OH hydrogen donors of one monomer and the oxygen atom of the next one. Photophys. studies show that different substitutes affect the absorption wavelength and emission color. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2SDS of cas: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals was written by Ul Lah, Hafiz;Mir, Shabir Ahmad;Hussain, Gulzar;Wani, Rafiq Ahmad;Yousuf, Syed Khalid. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.Name: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A highly chemo- and diastereoselective vic-dibromination of olefins was developed. The process employed a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Name: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action was written by Nishida, Haruyuki;Arikawa, Yasuyoshi;Hirase, Keizo;Imaeda, Toshihiro;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Fujioka, Yasushi;Hamada, Teruki;Iida, Motoo;Nishitani, Mitsuyoshi;Imanishi, Akio;Fukui, Hideo;Itoh, Fumio;Kajino, Masahiro. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: 881676-32-0 This article mentions the following:

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative I as a lead compound As part of a comprehensive approach to identification of a new drug, we explored excellent compounds that have low lipophilicity by introducing a polar hetero-aromatic group at position 5 of the pyrrole ring. Among the compounds synthesized, fluoropyrrole derivativeII, which has a 2-fluoro-3-pyridyl group at the fifth position, lower pK_a, and much lower C log P and log D values than I does, showed potent gastric-acid suppressive action resulting from gastric H⁺,K⁺-ATPase inhibition in animal models. Its maximum intragastric pH elevation effect was strong in rats, and its duration of action was much longer than that of either lansoprazole or lead compound I in dogs. Therefore, compound II can be considered a promising new P-CAB with long duration of action. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins was written by Pomplun, Sebastian;Sippel, Claudia;Haehle, Andreas;Tay, Donald;Shima, Kensuke;Klages, Alina;Uenal, Can Murat;Riess, Benedikt;Toh, Hui Ting;Hansen, Guido;Yoon, Ho Sup;Bracher, Andreas;Preiser, Peter;Rupp, Jan;Steinert, Michael;Hausch, Felix. And the article was included in Journal of Medicinal Chemistry in 2018.HPLC of Formula: 4457-67-4 This article mentions the following:

FK506-binding proteins (FKBPs) are evolutionarily conserved proteins that display peptidyl-prolyl isomerase activities and act as coreceptors for immunosuppressants. Microbial macrophage-infectivity-potentiator (Mip)-type FKBPs can enhance infectivity. However, developing druglike ligands for FKBPs or Mips has proven difficult, and many FKBPs and Mips still lack biol. useful ligands. To explore the scope and potential of C⁵-substituted [4.3.1]-aza-bicyclic sulfonamides as a broadly applicable class of FKBP inhibitors, we developed a new synthesis method for the bicyclic core scaffold and used it to prepare an FKBP- and Mip-focused library. This allowed us to perform a systematic structure-activity-relationship anal. across key human FKBPs and microbial Mips, yielding highly improved inhibitors for all the FKBPs studied. A cocrystal structure confirmed the mol.-binding mode of the core structure and explained the affinity gained as a result of the preferred substituents. The best FKBP and Mip ligands showed promising antimalarial, antileginonellal, and antichlamydial properties in cellular models of infectivity, suggesting that substituted [4.3.1]-aza-bicyclic sulfonamides could be a novel class of anti-infectives. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4HPLC of Formula: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Molecular-Shape-Controlled Nonfused Ring Electron Acceptors for High-Performance Organic Solar Cells with Tunable Phase Morphology was written by Wang, Xiaodong;Lu, Hao;Zhang, Andong;Yu, Na;Ran, Guangliu;Bi, Zhaozhao;Yu, Xiaodi;Xu, Xinjun;Liu, Yahui;Tang, Zheng;Zhang, Wenkai;Ma, Wei;Bo, Zhishan. And the article was included in ACS Applied Materials & Interfaces in 2022.Category: bromides-buliding-blocks This article mentions the following:

Two nonfused ring electron acceptors (NFREAs), BTh-OC8-2F and DTh-OC8-2F, with different mol. shapes are designed and synthesized. Both acceptors can form planar mol. shapes by the assistance of S閻犱警鍨甸惌鍓ф崉閻?intramol. interactions. Differently, BTh-OC8-2F, with a linear mol. backbone and two trans-arranged side chains at the core unit, exhibits much stronger crystallinity than DTh-OC8-2, with a C-shape mol. shape and two cis-arranged steric side chains at the core unit. Thus, the DTh-OC8-2F based blend film displays a better nanoscale phase separation, more suppressed charge recombination, more efficient exciton dissociation, and lower nonradiative energy loss. Organic solar cells based on DTh-OC8-2F can deliver a power conversion efficiency of 14.13%, which is much higher than BTh-OC8-2F based ones (11.95%) and is also one of the highest values reported for organic solar cells based on NFREAs. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stacked Reticular Frame Boosted Circularly Polarized Luminescence of Chiral Covalent Organic Frameworks was written by Du, Cong;Zhu, Xuefeng;Yang, Chenchen;Liu, Minghua. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Chiral covalent organic frameworks (COFs) with circularly polarized luminescence (CPL) are intriguing as advanced chiroptical materials but have not been reported to date. We constructed chiroptical COF materials with CPL activity through the convenient Knoevenagel condensation of formyl-functionalized axially chiral linkers and C3-sym. 1,3,5-benzenetriacetonitrile. Remarkably, the as-prepared chiral COFs showed high absorption and luminescent dissym. factors up to 0.02 (g_abs) and 0.04 (g_lum), resp. In contrast, the branched chiral polymers from the same starting monomers were CPL silent. Structural and spectral characterization revealed that the reticular frame was indispensable for CPL generation via confined chirality transfer. Moreover, reticular stacking boosted the CPL performance significantly due to the interlayer restriction of frame. This work demonstrates the first example of a CPL-active COF and provides insight into CPL generation through covalent reticular chem., which will play a constructive role in the future design of high-performance CPL materials. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Safety of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Desymmetrization of difluoromethylene groups by C-F bond activation was written by Butcher, Trevor W.;Yang, Jonathan L.;Amberg, Willi M.;Watkins, Nicholas B.;Wilkinson, Natalie D.;Hartwig, John F.. And the article was included in Nature (London, United Kingdom) in 2020.Application of 83902-02-7 This article mentions the following:

Tertiary stereogenic centers containing one fluorine atom are valuable for medicinal chem. because they mimic common tertiary stereogenic centers containing one hydrogen atom, but they possess distinct charge distribution, lipophilicity, conformation and metabolic stability^1-3. Although tertiary stereogenic centers containing one hydrogen atom are often set by enantioselective desymmetrization reactions at one of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocenters containing fluorine have not yet been constructed by the analogous desymmetrization reaction at one of the two carbon-fluorine (C-F) bonds of a difluoromethylene group³. Fluorine atoms are similar in size to hydrogen atoms but have distinct electronic properties, causing C-F bonds to be exceptionally strong and geminal C-F bonds to strengthen one another⁴. Thus, exhaustive defluorination typically dominates over the selective replacement of a single C-F bond, hindering the development of the enantioselective substitution of one fluorine atom to form a stereogenic center^5,6. Here the authors report the catalytic, enantioselective activation of a single C-F bond in an allylic difluoromethylene group to provide a broad range of products containing a monofluorinated tertiary stereogenic center. By combining a tailored chiral iridium phosphoramidite catalyst, which controls regioselectivity, chemoselectivity and enantioselectivity, with a fluorophilic activator, which assists the oxidative addition of the C-F bond, these reactions occur in high yield and selectivity. The design principles proposed in this work extend to palladium-catalyzed benzylic substitution, demonstrating the generality of the approach. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Application of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Features of molecular bromination of aromatic amines was written by Salahov, M. S.;Bagmanov, B. T.;Mustafayeva, F. A.. And the article was included in Azerbaidzhanskii Khimicheskii Zhurnal in 2014.Recommanded Product: 74440-80-5 This article mentions the following:

The peculiarities of mol. bromination of o-, m-, p-substituted anilines in organic media (CHCl₃, CCl₄) and phys.-chem. characteristics of the prepared substances (mono-, di-, tri-, and tetrabromoanilines) reflecting their composition and structure are presented. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Recommanded Product: 74440-80-5).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 74440-80-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation was written by Lian, Yajing;Burford, Kristen;Londregan, Allyn T.. And the article was included in Tetrahedron in 2015.Computed Properties of C3H4BrN3 This article mentions the following:

A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like mols. containing heterocyclic diversity and in the study of the gem-dialkyl effect. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Computed Properties of C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary