Bromides-buliding-blocks

Development of ¹⁸F-labeled radiotracers for PET imaging of the adenosine A₂A receptor: synthesis, radiolabeling and preliminary biological evaluation was written by Lai, Thu Hang;Schroder, Susann;Toussaint, Magali;Dukic-Stefanovic, Sladjana;Kranz, Mathias;Ludwig, Friedrich-Alexander;Fischer, Steffen;Steinbach, Jorg;Deuther-Conrad, Winnie;Brust, Peter;Moldovan, Rares-Petru. And the article was included in International Journal of Molecular Sciences in 2021.Related Products of 61150-57-0 This article mentions the following:

The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomog. (PET) radiotracer to monitor changes of receptor d. and/or occupancy during the A2AR-tailored therapy, authors designed a library of fluorinated analogs based on a recently published lead compound (PPY). Among those, the highly affine 4-fluorobenzyl derivate (K_i(hA_2AR) = 5.3 nM) and the 2-fluorobenzyl derivate (K_i(hA_2AR) = 2.1 nM) were chosen for ¹⁸F-labeling via an alc. enhanced copper-mediated procedure starting from the corresponding boronic acid pinacol ester precursors. Investigations of the metabolic stability of compound I (R = p-¹⁸F, o-¹⁸F) in CD-1 mice by radio-HPLC anal. revealed parent fractions of more than 76% of total activity in the brain. Specific binding of I (R = o-¹⁸F)on mice brain slices was demonstrated by in vitro autoradiog. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters was written by Hernandez-Olmos, Victor;Heering, Jan;Planz, Viktoria;Liu, Ting;Kaps, Alexander;Rajkumar, Rinusha;Gramzow, Matthias;Kaiser, Astrid;Schubert-Zsilavecz, Manfred;Parnham, Michael J.;Windbergs, Maike;Steinhilber, Dieter;Proschak, Ewgenij. And the article was included in Journal of Medicinal Chemistry in 2020.Product Details of 653-92-9 This article mentions the following:

The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented. The newly prepared derivatives showed promising in vitro wound-healing activity. In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Product Details of 653-92-9).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 653-92-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Enantioselective semireduction of allenes was written by Chen, Zhiwei;Dong, Vy M.. And the article was included in Nature Communications in 2017.Electric Literature of C9H11BrO This article mentions the following:

Herein, Rh-catalyzed regio- and enantioselective semiredn. of allenes to generate chiral benzylic motifs is reported. Rh-hydride catalysis solves a synthetic challenge by affording the enantioselective reduction of allenes, thereby yielding access to motifs commonly used in medicinal chem. A designer Josiphos ligand promotes the generation of chiral benzylic isomers, when combined with a Hantzsch ester as the reductant. This semiredn. proceeds chemoselectively in the presence of other functional groups, which are typically reduced using conventional hydrogenations. Isotopic labeling studies support a mechanism where the hydride is delivered to the branched position of a Rh-allyl intermediate. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Electric Literature of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Per-halogenation of primary hydroxy groups of 閻?cyclodextrin was written by Aoki, Nobuyoshi;Hattori, Kenjiro. And the article was included in Kenkyu Hokoku – Kanagawa-ken Sangyo Gijutsu Sogo Kenkyusho in 2005.HPLC of Formula: 53784-83-1 This article mentions the following:

Per-halogenation of primary hydroxyl groups of 閻?cyclodextrin (閻?CD) was investigated as an important way for the regioselective modification of 閻?CD. The high regioselectivity in the halogenation was discussed in terms of the reactivity to the S_N2 reaction at each position on the anhydroglucopyranose unit. The reaction using halogenating reagent, such as, methanesulfonyl chloride, thionyl chloride, and thionyl bromide, yielded the corresponding per-6-chloro-per-6-deoxy-閻?CD (80 and 90% yield) or per-6-bromo-per-6-deoxy-閻?CD (70% yield) after several hours. The obtained product was halogenated only at C-6 and the halogenation at a secondary position was not observed The reactivity at C-3 of 閻?CD was lower than the corresponding reaction of other saccharides, such as cellulose. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1HPLC of Formula: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The synthesis of oxa-analogs and homologs of naturally occurring polyamines was written by Lin, P. Kong Thoo;Kuksa, V. A.;Maguire, N. M.. And the article was included in Synthesis in 1998.Formula: C13H14BrNO2 This article mentions the following:

A number of polyamine oxa-analogs were synthesized. Spermidine oxa-analogs and homologs were made from N-(aminooxypropyl)phthalimide which was obtained either by deprotection of the corresponding Fmoc-protected compound or from the reaction between 3-Br(CH₂)₃NH₂ and N-hydroxyphthalimide, both reactions involving an unusual rearrangement mechanism. Sulfonated derivatives, upon Mitsunobu condensation with N-protected 3-HO(CH₂)₃NH₂ or N-alkylation with N-(bromoalkyl)phthalimides, afforded the fully protected spermidine and spermine oxa-analogs and homologs. Subsequent sequential deprotection gave spermidine analogs. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Formula: C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action was written by Nishida, Haruyuki;Arikawa, Yasuyoshi;Hirase, Keizo;Imaeda, Toshihiro;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Fujioka, Yasushi;Hamada, Teruki;Iida, Motoo;Nishitani, Mitsuyoshi;Imanishi, Akio;Fukui, Hideo;Itoh, Fumio;Kajino, Masahiro. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: 881676-32-0 This article mentions the following:

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative I as a lead compound As part of a comprehensive approach to identification of a new drug, we explored excellent compounds that have low lipophilicity by introducing a polar hetero-aromatic group at position 5 of the pyrrole ring. Among the compounds synthesized, fluoropyrrole derivativeII, which has a 2-fluoro-3-pyridyl group at the fifth position, lower pK_a, and much lower C log P and log D values than I does, showed potent gastric-acid suppressive action resulting from gastric H⁺,K⁺-ATPase inhibition in animal models. Its maximum intragastric pH elevation effect was strong in rats, and its duration of action was much longer than that of either lansoprazole or lead compound I in dogs. Therefore, compound II can be considered a promising new P-CAB with long duration of action. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals was written by Ul Lah, Hafiz;Mir, Shabir Ahmad;Hussain, Gulzar;Wani, Rafiq Ahmad;Yousuf, Syed Khalid. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.Name: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A highly chemo- and diastereoselective vic-dibromination of olefins was developed. The process employed a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Name: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Studies of Substituents Impact on the Photophysical Properties of 8-Hydroxyquinoline Derivatives was written by Gao, Li-Bin;Kang, Wu-Kui;Yan, Shi-Hai;Yang, Chun-Peng. And the article was included in Heteroatom Chemistry in 2016.SDS of cas: 18791-79-2 This article mentions the following:

Five new 8-hydroxyquinoline derivatives L1-L5 were synthesized and characterized by different techniques, such as NMR, electrospray ionization mass spectra, elemental anal., UV-visible, and photoluminescence spectra. The structure of (E)-2-{2-[5-(phenylethynyl) thiophen-2-yl]ethenyl}quinolin-8-ol (L3) was confirmed by x-ray crystallog. In this structure, intermol. hydrogen bonds were found between OH hydrogen donors of one monomer and the oxygen atom of the next one. Photophys. studies show that different substitutes affect the absorption wavelength and emission color. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2SDS of cas: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A carbon-13 NMR investigation of [5]metacyclophanes was written by Jenneskens, L. W.;De Kanter, F. J. J.;De Wolf, W. H.;Bickelhaupt, F.. And the article was included in Magnetic Resonance in Chemistry in 1986.COA of Formula: C8H8Br2 This article mentions the following:

¹³C NMR data of [5]metacyclophane, its 8,11-dihalosubstituted derivatives and of some model compounds are reported and discussed. A remarkable downfield shift is observed for the aromatic carbon between the bridging carbons; this is tentatively ascribed to long-range effects of the bridge and to the bending of the aromatic ring. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2COA of Formula: C8H8Br2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C8H8Br2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Antagonists of the human adenosine A_2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines was written by Gillespie, Roger J.;Cliffe, Ian A.;Dawson, Claire E.;Dourish, Colin T.;Gaur, Suneel;Jordan, Allan M.;Knight, Antony R.;Lerpiniere, Joanne;Misra, Anil;Pratt, Robert M.;Roffey, Jonathan;Stratton, Gemma C.;Upton, Rebecca;Weiss, Scott M.;Williamson, Douglas S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 3-(Bromomethyl)benzoic acid This article mentions the following:

A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A_2A antagonists is described. Many examples were highly selective against the human A₁ receptor sub-type and were active in an in vivo model of Parkinson’s disease. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Recommanded Product: 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary